pre-miRNA Information | |
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pre-miRNA | hsa-mir-4697 |
Genomic Coordinates | chr11: 133898504 - 133898581 |
Description | Homo sapiens miR-4697 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | ||||||||||||||||||||||
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Mature miRNA | hsa-miR-4697-5p | |||||||||||||||||||||
Sequence | 10| AGGGGGCGCAGUCACUGACGUG |31 | |||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||
Experiments | Illumina | |||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | MAPK8IP2 | ||||||||||||||||||||
Synonyms | IB-2, IB2, JIP2, PRKM8IPL | ||||||||||||||||||||
Description | mitogen-activated protein kinase 8 interacting protein 2 | ||||||||||||||||||||
Transcript | NM_012324 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on MAPK8IP2 | |||||||||||||||||||||
3'UTR of MAPK8IP2 (miRNA target sites are highlighted) |
>MAPK8IP2|NM_012324|3'UTR 1 CCTGCCCACCGCTCTGTCTCCTGGCCGTCTGCTCCAGGCGCAGCTGGGGCTGAGGATGTCTCAAGAGGCCACCATGGCTT 81 TGGCAAGGACTGGATTGGGGGGACATGGGACCTTACGCTTGTGGGGGTCTGCGGGCTGGGAACTCTCGTCCTCGGTCCCC 161 AGGGCGCAGCTGTTGGGGCTGCGGGGGAGTGGAGCCCCCGTGCCCCTGCTTTTCCTCAGATCCGTTCTTTCTCTGTGTTG 241 TCCTCCTCCTTCCCTTCCCAGTCTCCCTTTTCTCTCTCCTGGTGTCTCTGCCCCTCTCTGTGCCTGCAAACCTTATCCTC 321 TATTCTTCACTTTGGGGTCAGAACTTCGGGGGTGTGGAGGAGGTGCGGCTCTAGGGACAGGTAATGTCGGCTTCCAAGTG 401 ATGCCCTCCTGCCACTCCCCTGCGATTTATAAGGGAATTTTAATTTTTATAGTGAATCTCAAGGGATCATCCCATCCTTG 481 ACCACAGGGACAAGAGGGGCCCCCTCGCCCCAGCCCCACCCCACATGGAGCTCAGGGGGAAGCAGGGAGGGGTTCCCAAA 561 AGAGCCCTGCGGAGGCTAGGAGTGGTTCTTGATGCTCACCTGAAGCCCCTAGACGCTGCTAGGAGGGGGGGCCCTCCTGG 641 GCCCCCAATACCCCTCCGCTTGCCGCTGCTAGCGCACCCCTGCAGTCCAGCGTGCATCCACCCCACGCACGCCCCGTGCT 721 GTGTTCCTGGGCCCTGCCCATGGCCTCAATAAACTCTCTGCTTGGTGTGACATTGGCTGTTTCTAGAGGGTGCTAAGACA 801 TGGGGCCAGGTGCCCAGGGGCTGCCCATTGTGGTAGGGACAGAGTCCCCAGTGGCGGGAGTGTTGTGGCAATCTCACCCT 881 TTTAGCTCTTTCCGAAATTGTGCCGGGGGTCCCTGCGGTGCTGCTCTGGGGCCTTATCTGAGGTGCCGTATCTAGAAGCA 961 CCCTTGGGAATTCTCCCTAGATACACTCGATTGGCCACAGAGGAATCCGAGGCTGTGCAATGGGGTGTCCTTTCCACGTG 1041 CACGGACTGGGGGCCAGCACGGCTCAGGTCAGTGTGTAGTGGGGGCATGAACTCCTTGAAGAACAATCTGGCCGGGCACG 1121 GTGGCTCACGCTTGTAATCCCAACACTTTGGGAGGCCGAGCCGGGGCGTATCACCTGAGGTCAGGAGTTTGAGACCAGCT 1201 TGGCCAACATGGTGAAACCCCATCTCCACAAAAAATACAAAAATTAGCTAGGTGTCCTGGCGCACACCTGTAATCCCAGC 1281 TACTCAGGAGGCTAAGGCATGAGAATCGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCAAGATTGCACCACTGCACT 1361 CCAGCCTGGGCGACAGAGGGAGACTCCGTCTCAGAAAAAGGAAAAGAAAAACAATCTACTTAGATCTTAAAATGGATATT 1441 TAAAAAATTCTCCAGAGAAAGCCAGAAGAAAATAGGTGACTTTTTCACTATGTGCTTAGGTGACTGCAGATGCCCGGCAA 1521 TGTTCCCTCCCAGGCCCTCCTGGGTGAGCCCGCCTCCCAGGCAGGGGTCAGCATGGCCGGGGTCCCTCTGTCTGAGCCCA 1601 GGATTCGTGCAACACCAGGAAGACAACAGTTGAAGGTTCCTTAGTGAGCTAAGGGAAGTATACACAAACTTACTACATAA 1681 ACATTAGAAAGTGCTGTCCGTAAAAAACACGTCTTCACAGAGCCAACAAGCAGAGAAATAGCTGCCCAGTGTTAGGAAGT 1761 GCATCATGATCCAGAGGTTCAGCCCGTGTGCAGCGCACAGACCTGAGGCCCCAGAGAGACCGAGGACGCAGACCAGTGGC 1841 ACGACGGAAACGCAGAACGTTTATGAGAAAACTTTCCTACTAATTGAGATAAAGCTGTAAAGAGGCAGATAGCCCCACTG 1921 GGTGTGTACGTTTGAAACTTGTGCCCCCTGGGCTAGGGCATTCGGGGTGTGGCCCTCAGTCCCCTGTAGCTGCTGCCTGG 2001 AAACCGCTGCCACCCACCCACCTCCTCCCTCTGCTCTTCCACTCAGGTGAGAATTCTCCAAGCCCTGCCCTCCGGCGCCC 2081 CCGTCCCGCCCCTGCCCGGCCTGGCCCCGCCCCTGCCCGGCCCCGCCCCCCAACGTGTCTTCAGGTCTCTTTCCCTCCAG 2161 CCGGCCCTTAGGACGGCTGTTGGACGTGCTCGTGAGTCCTTCGCCTGTCTGCCTTCCACCTCTCTGCAGCTCCTTCTCCA 2241 ATCTCATGGTCTTCTTGAGCTTGGCCGCCCTCCACGCCCCATGCTGGGCTTGGTCGGTTCTGGGGTCTACCTCTCTGGCT 2321 TCATCCCTCCCACAGTTTCGAGGGTTTCCCTGTGCTCAGGCCCCTGGCAGCCGCCCCCTGTGCAGACCACTGGGCAGATC 2401 CAGCTGACCTCCAGGGGCACTTCCTCGGCTCATCACTGGGCCGGTGCTCTGCAGAATGAGCTGTGAGAGCCACTGTGGCT 2481 GGCCAGAGGGTGCCACTCACAGTCACTTCAGACTCACAGGAGCCTTCGTCCCGACCCCTGCATTCATCTGTGTTCTGTTT 2561 TATGTTTTTTCCCAGTCACCTGAGCTGCAGGCCTTGGTCACCCCAGACTCCTCCCTCCTGTCACCCTTATCCTCACCCCA 2641 GCACCTTTACGTCTGCCCCAGGCTCCATTTCCCCCTCTTCTGCCTGGATCAAACCACCCTGACTTTCCTGGGTCTTCGTG 2721 CAACAGCCTGCTCCGGCCGCTGCCTCACTGCACCTGCAAATCCACTTGCACCCACACCCAGGCCAGGGTTTTTAAACAGA 2801 AGCCTCAGCAGATCCCTCTCTCTGGCCAGCTCCCTGTTGAACCAGGAAGCAGGTCCCTGTTGAACCTCAGCATGACCCGC 2881 CCCCACCCCTGCATCCCACTTCTGCTCTGGGAGCCTCTGGGTTCCTGGGCGCACCTGCTGCCCTTCCCTGTTTGTCACTG 2961 GGTGACCTCCCGTCCTTGTGGGCGCTCCCGGGCCCTGGTCTCGGGCCTTCTGAGGACTTGCTCTCCTGGTAGCGGCTGCT 3041 GACTGTGAGCCCAGAGAGCAGGCGTGGCTGTTGACCTTAGGTCCTCCCAGAACCTGGCGGATCGCCTGGCTCCCAGGCAG 3121 GAGGCGCTGCATGACGCCTCCAACTTCCGCCAATCTAGCCCAAGGATGGCGTTCTAAATAAAACGCGTTCTACAGAAAAG 3201 TG Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HeLa |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in Chi_124A_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + A
HITS-CLIP data was present in Chi_124B_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + B
HITS-CLIP data was present in Chi_ControlA_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control A
HITS-CLIP data was present in Chi_ControlB_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control B
... - Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature. |
Article |
- Chi SW; Zang JB; Mele A; Darnell RB - Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
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CLIP-seq Support 1 for dataset Chi_124A_2A8_130_50 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | HeLa / HeLa cell miR-124 + A |
Location of target site | ENST00000399908.2 | 3UTR | CUCAGCAUGACCCGCC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 19536157 / Chi_HITSCLIP |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset Chi_124B_2A8_130_50 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | HeLa / HeLa cell miR-124 + B |
Location of target site | ENST00000399908.2 | 3UTR | CUCAGCAUGACCCGCC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 19536157 / Chi_HITSCLIP |
CLIP-seq Viewer | Link |
CLIP-seq Support 3 for dataset Chi_ControlA_2A8_130_50 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | HeLa / HeLa cell Control A |
Location of target site | ENST00000399908.2 | 3UTR | CUCAGCAUGACCCGC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 19536157 / Chi_HITSCLIP |
CLIP-seq Viewer | Link |
CLIP-seq Support 4 for dataset Chi_ControlB_2A8_130_50 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | HeLa / HeLa cell Control B |
Location of target site | ENST00000399908.2 | 3UTR | CUCAGCAUGACCCGCC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 19536157 / Chi_HITSCLIP |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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67 hsa-miR-4697-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT441332 | C19orf26 | CACN beta subunit associated regulatory protein | ![]() |
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2 | 4 | ||||||
MIRT451390 | FARSA | phenylalanyl-tRNA synthetase alpha subunit | ![]() |
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2 | 2 | ||||||
MIRT452310 | EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | ![]() |
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2 | 2 | ||||||
MIRT455043 | MEN1 | menin 1 | ![]() |
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2 | 2 | ||||||
MIRT455256 | DDX39B | DExD-box helicase 39B | ![]() |
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2 | 10 | ||||||
MIRT461279 | COX10 | COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor | ![]() |
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2 | 2 | ||||||
MIRT464945 | TXLNA | taxilin alpha | ![]() |
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2 | 4 | ||||||
MIRT468043 | SIK1 | salt inducible kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT472523 | NACC1 | nucleus accumbens associated 1 | ![]() |
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2 | 2 | ||||||
MIRT472929 | MSN | moesin | ![]() |
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2 | 2 | ||||||
MIRT473247 | MIDN | midnolin | ![]() |
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2 | 2 | ||||||
MIRT475828 | HDGF | heparin binding growth factor | ![]() |
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2 | 2 | ||||||
MIRT478744 | CS | citrate synthase | ![]() |
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2 | 2 | ||||||
MIRT480081 | CALR | calreticulin | ![]() |
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2 | 2 | ||||||
MIRT483482 | STMN3 | stathmin 3 | ![]() |
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2 | 4 | ||||||
MIRT483643 | QSOX2 | quiescin sulfhydryl oxidase 2 | ![]() |
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2 | 4 | ||||||
MIRT483721 | THSD4 | thrombospondin type 1 domain containing 4 | ![]() |
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2 | 2 | ||||||
MIRT484539 | BARHL1 | BarH like homeobox 1 | ![]() |
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2 | 6 | ||||||
MIRT486041 | WSCD1 | WSC domain containing 1 | ![]() |
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2 | 4 | ||||||
MIRT486142 | SIX5 | SIX homeobox 5 | ![]() |
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2 | 6 | ||||||
MIRT486498 | MYH11 | myosin heavy chain 11 | ![]() |
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2 | 2 | ||||||
MIRT486977 | STEAP3 | STEAP3 metalloreductase | ![]() |
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2 | 4 | ||||||
MIRT487279 | AGPAT6 | glycerol-3-phosphate acyltransferase 4 | ![]() |
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2 | 4 | ||||||
MIRT487742 | MIB2 | mindbomb E3 ubiquitin protein ligase 2 | ![]() |
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2 | 2 | ||||||
MIRT487987 | RXRB | retinoid X receptor beta | ![]() |
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2 | 2 | ||||||
MIRT488338 | PAX2 | paired box 2 | ![]() |
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2 | 2 | ||||||
MIRT488668 | WWP2 | WW domain containing E3 ubiquitin protein ligase 2 | ![]() |
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2 | 4 | ||||||
MIRT488752 | FXYD1 | FXYD domain containing ion transport regulator 1 | ![]() |
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2 | 2 | ||||||
MIRT488812 | TBC1D28 | TBC1 domain family member 28 | ![]() |
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2 | 2 | ||||||
MIRT489380 | RAB11B | RAB11B, member RAS oncogene family | ![]() |
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2 | 2 | ||||||
MIRT489744 | TACC3 | transforming acidic coiled-coil containing protein 3 | ![]() |
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2 | 2 | ||||||
MIRT489960 | GNB2 | G protein subunit beta 2 | ![]() |
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2 | 2 | ||||||
MIRT490418 | VPS51 | VPS51, GARP complex subunit | ![]() |
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2 | 4 | ||||||
MIRT490639 | FEM1A | fem-1 homolog A | ![]() |
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2 | 2 | ||||||
MIRT491086 | MSI1 | musashi RNA binding protein 1 | ![]() |
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2 | 4 | ||||||
MIRT491298 | VGF | VGF nerve growth factor inducible | ![]() |
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2 | 4 | ||||||
MIRT491366 | SLC12A5 | solute carrier family 12 member 5 | ![]() |
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2 | 2 | ||||||
MIRT492464 | RASD1 | ras related dexamethasone induced 1 | ![]() |
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2 | 4 | ||||||
MIRT492872 | NFIX | nuclear factor I X | ![]() |
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2 | 2 | ||||||
MIRT492951 | NEUROD2 | neuronal differentiation 2 | ![]() |
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2 | 2 | ||||||
MIRT493704 | H2AFX | H2A histone family member X | ![]() |
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2 | 2 | ||||||
MIRT493977 | EIF1 | eukaryotic translation initiation factor 1 | ![]() |
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2 | 4 | ||||||
MIRT500360 | ZNF385A | zinc finger protein 385A | ![]() |
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2 | 2 | ||||||
MIRT501154 | SLC10A7 | solute carrier family 10 member 7 | ![]() |
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2 | 6 | ||||||
MIRT509625 | RRP7A | ribosomal RNA processing 7 homolog A | ![]() |
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2 | 4 | ||||||
MIRT512232 | ATG2A | autophagy related 2A | ![]() |
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2 | 8 | ||||||
MIRT529822 | ARGFX | arginine-fifty homeobox | ![]() |
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2 | 4 | ||||||
MIRT531179 | SIGLEC12 | sialic acid binding Ig like lectin 12 (gene/pseudogene) | ![]() |
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2 | 2 | ||||||
MIRT538971 | BCL7A | BCL tumor suppressor 7A | ![]() |
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2 | 2 | ||||||
MIRT548357 | ENTPD5 | ectonucleoside triphosphate diphosphohydrolase 5 | ![]() |
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2 | 4 | ||||||
MIRT553634 | TJAP1 | tight junction associated protein 1 | ![]() |
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2 | 2 | ||||||
MIRT558050 | EVI5L | ecotropic viral integration site 5 like | ![]() |
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2 | 2 | ||||||
MIRT562548 | CCDC71L | coiled-coil domain containing 71 like | ![]() |
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2 | 4 | ||||||
MIRT568941 | RUNX3 | runt related transcription factor 3 | ![]() |
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2 | 2 | ||||||
MIRT569114 | ONECUT3 | one cut homeobox 3 | ![]() |
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2 | 2 | ||||||
MIRT573591 | CERS1 | ceramide synthase 1 | ![]() |
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2 | 2 | ||||||
MIRT619317 | ARHGAP18 | Rho GTPase activating protein 18 | ![]() |
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2 | 2 | ||||||
MIRT621202 | ARPC1B | actin related protein 2/3 complex subunit 1B | ![]() |
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2 | 2 | ||||||
MIRT628844 | FAM151B | family with sequence similarity 151 member B | ![]() |
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2 | 2 | ||||||
MIRT670497 | LYRM4 | LYR motif containing 4 | ![]() |
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2 | 2 | ||||||
MIRT670545 | SHISA2 | shisa family member 2 | ![]() |
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2 | 2 | ||||||
MIRT671026 | PCDHB2 | protocadherin beta 2 | ![]() |
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2 | 2 | ||||||
MIRT688989 | ATP6AP1 | ATPase H+ transporting accessory protein 1 | ![]() |
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2 | 2 | ||||||
MIRT709275 | MAPK8IP2 | mitogen-activated protein kinase 8 interacting protein 2 | ![]() |
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2 | 2 | ||||||
MIRT715084 | ELOF1 | elongation factor 1 homolog | ![]() |
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2 | 2 | ||||||
MIRT718348 | NPBWR1 | neuropeptides B and W receptor 1 | ![]() |
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2 | 2 | ||||||
MIRT737406 | MMP7 | matrix metallopeptidase 7 | ![]() |
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2 | 0 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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