pre-miRNA Information
pre-miRNA hsa-mir-4301   
Genomic Coordinates chr11: 113450023 - 113450088
Description Homo sapiens miR-4301 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4301
Sequence 11| UCCCACUACUUCACUUGUGA |30
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs184176277 2 dbSNP
rs1191324913 13 dbSNP
rs1369198005 15 dbSNP
rs1036973189 16 dbSNP
rs944900541 18 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol POLL   
Synonyms BETAN, POLKAPPA
Description DNA polymerase lambda
Transcript NM_001174084   
Other Transcripts NM_001174085 , NM_013274   
Expression
Putative miRNA Targets on POLL
3'UTR of POLL
(miRNA target sites are highlighted)
>POLL|NM_001174084|3'UTR
   1 CCCATGGCTGGGGGTGCTGAGGAGAGCCGAGTTGGACTGGCTACCCCTCCTGGCCACCCAGTACTCCCTCCAGCCTCAGC
  81 TGGCTGAACCTCGCCGCTCCAACCACCAGCTTCCTCAGCGAGCAGGGCCCAGGGCTCTGGGCCTGAAGCAAGAGCCAGCC
 161 CGGCTCCCAGTGTCTGCCCGGCTCCCAGTGTCTGCCCAGCCCTCTCCCAGACAGGAGCAGGCTGCCACCCCTTCTACCTC
 241 ACCACTGCCCCTCGAAGAATTTTGCAAATGGCCCCTTGCCCCATTTTAAGCAGGAGCAGGTGGCTGGTTTGAAGCCCCAG
 321 GTATCCCCCTTCCCTGCTATGGGAAAGGCCAAGCTGCTGGGTGGGGACAGAAGCTGCAGGGGAGAGGGAAGCAGCCGTGC
 401 TGTCAACATCATCCGGCACCCTCTGGGGTAGGAGAACAGCCATTCCACATGTGTTCCCTCTATCCGTCCTGCTTCCTGGG
 481 CAGCTGGTGGTGCTGGGAATGGGGTGCCCCAGCCTTGGTGAGGACAGTGTTGGGAGGCCCAGGGGCCCAGTAAAGTGCAT
 561 TTGACATTGAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' aguguuCACUUC-AUCACCcu 5'
                | | || |:||||  
Target 5' cttcctGGGCAGCTGGTGGtg 3'
472 - 492 110.00 -8.90
2
miRNA  3' agUGUUCACU-UCAUCACCCu 5'
            :::|| || |||: |||| 
Target 5' tgGTGAG-GACAGTGTTGGGa 3'
516 - 535 109.00 -13.50
3
miRNA  3' agUGUUCACUUC-AUCACCCu 5'
            | |:|  ||| |: |||| 
Target 5' ggAAAGGCCAAGCTGCTGGGt 3'
342 - 362 106.00 -7.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30477702 1 COSMIC
COSN30477656 2 COSMIC
COSN20076981 16 COSMIC
COSN30181484 40 COSMIC
COSN31662102 40 COSMIC
COSN26989807 53 COSMIC
COSN28845001 54 COSMIC
COSN30540283 64 COSMIC
COSN6475158 68 COSMIC
COSN31544813 214 COSMIC
COSN31608399 221 COSMIC
COSN32057869 480 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1376473757 5 dbSNP
rs1335197328 8 dbSNP
rs1274727451 10 dbSNP
rs1403831444 11 dbSNP
rs780401773 14 dbSNP
rs1304591231 19 dbSNP
rs368986507 21 dbSNP
rs750513472 22 dbSNP
rs534951407 24 dbSNP
rs761759829 27 dbSNP
rs201220584 28 dbSNP
rs764058785 29 dbSNP
rs1456268477 30 dbSNP
rs1479505951 32 dbSNP
rs897217124 33 dbSNP
rs1200228823 35 dbSNP
rs1384323530 37 dbSNP
rs762713679 39 dbSNP
rs1240551519 40 dbSNP
rs576043661 43 dbSNP
rs769478909 44 dbSNP
rs759111674 45 dbSNP
rs776146675 47 dbSNP
rs770372537 50 dbSNP
rs1225220530 55 dbSNP
rs905689454 59 dbSNP
rs1044293438 61 dbSNP
rs3730478 68 dbSNP
rs1263912391 74 dbSNP
rs1444185045 77 dbSNP
rs189360353 92 dbSNP
rs1237341270 93 dbSNP
rs903840920 95 dbSNP
rs1482050260 96 dbSNP
rs35264174 96 dbSNP
rs539579708 96 dbSNP
rs1280433720 97 dbSNP
rs1472082931 105 dbSNP
rs1176700649 113 dbSNP
rs925666383 119 dbSNP
rs1412203975 120 dbSNP
rs1333464827 131 dbSNP
rs1354990064 132 dbSNP
rs1344565102 139 dbSNP
rs761239786 141 dbSNP
rs978488661 143 dbSNP
rs55800099 144 dbSNP
rs1286274217 145 dbSNP
rs1230469413 148 dbSNP
rs1351122911 150 dbSNP
rs554432430 154 dbSNP
rs911386460 159 dbSNP
rs1287837158 161 dbSNP
rs1408500826 162 dbSNP
rs923319564 163 dbSNP
rs1040443802 164 dbSNP
rs1030338109 167 dbSNP
rs191817637 179 dbSNP
rs911077073 180 dbSNP
rs985767332 181 dbSNP
rs1482926085 188 dbSNP
rs952694295 191 dbSNP
rs961380222 194 dbSNP
rs187367528 196 dbSNP
rs1476769659 198 dbSNP
rs909301037 198 dbSNP
rs1171538790 200 dbSNP
rs984913364 201 dbSNP
rs972385425 204 dbSNP
rs1411659960 208 dbSNP
rs1306097034 218 dbSNP
rs1369728679 229 dbSNP
rs961339910 230 dbSNP
rs550119666 236 dbSNP
rs1304009859 245 dbSNP
rs1332998690 248 dbSNP
rs531610846 249 dbSNP
rs1022791864 253 dbSNP
rs866556727 254 dbSNP
rs959511648 260 dbSNP
rs1340147884 265 dbSNP
rs570883276 274 dbSNP
rs1231330578 278 dbSNP
rs1033878040 279 dbSNP
rs558578691 283 dbSNP
rs530729914 288 dbSNP
rs773804871 292 dbSNP
rs1449552820 299 dbSNP
rs552249639 305 dbSNP
rs1043035299 306 dbSNP
rs1166651821 313 dbSNP
rs140528428 315 dbSNP
rs1425092948 321 dbSNP
rs1210775068 328 dbSNP
rs1330122377 329 dbSNP
rs1385378677 339 dbSNP
rs904187947 343 dbSNP
rs1042742293 347 dbSNP
rs901869653 356 dbSNP
rs1437317751 357 dbSNP
rs1040417492 361 dbSNP
rs943483891 376 dbSNP
rs777370803 378 dbSNP
rs1247308003 386 dbSNP
rs910330377 390 dbSNP
rs61874044 395 dbSNP
rs1208880052 396 dbSNP
rs1285230832 397 dbSNP
rs1465890078 405 dbSNP
rs1447956168 406 dbSNP
rs1049890794 408 dbSNP
rs934158724 410 dbSNP
rs565218057 414 dbSNP
rs1457168515 415 dbSNP
rs961664104 417 dbSNP
rs1162920718 419 dbSNP
rs909867158 425 dbSNP
rs1436787595 428 dbSNP
rs984151691 429 dbSNP
rs752432002 431 dbSNP
rs970101583 434 dbSNP
rs1387989447 435 dbSNP
rs1023489128 437 dbSNP
rs377487365 451 dbSNP
rs1014048903 453 dbSNP
rs1339078449 456 dbSNP
rs1244473821 462 dbSNP
rs184624589 465 dbSNP
rs765224846 466 dbSNP
rs998725572 476 dbSNP
rs1055362 477 dbSNP
rs1202120985 478 dbSNP
rs1055364 480 dbSNP
rs543367803 482 dbSNP
rs1423050745 485 dbSNP
rs1182317561 488 dbSNP
rs1413862055 490 dbSNP
rs961011245 493 dbSNP
rs1473732575 497 dbSNP
rs1157198318 499 dbSNP
rs1388012371 503 dbSNP
rs192410341 509 dbSNP
rs1305148260 510 dbSNP
rs917614595 512 dbSNP
rs34772059 515 dbSNP
rs1007190466 516 dbSNP
rs1309064513 529 dbSNP
rs1352710991 532 dbSNP
rs1472441762 535 dbSNP
rs769321791 542 dbSNP
rs1226253204 548 dbSNP
rs1287258431 549 dbSNP
rs1323631463 564 dbSNP
rs564115104 570 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_ControlB_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' aguguucacuucaUCACCCu 5'
                       |||||| 
Target 5' ------------aAGUGGGa 3'
1 - 8
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_ControlB_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control B
Location of target site ENST00000370168.3 | 3UTR | AAGUGGGAGGAUCACC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4301 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT081134 LDLR low density lipoprotein receptor 2 4
MIRT090911 ARHGEF26 Rho guanine nucleotide exchange factor 26 2 2
MIRT229436 MECP2 methyl-CpG binding protein 2 2 2
MIRT274717 CPSF6 cleavage and polyadenylation specific factor 6 2 2
MIRT350957 BACH1 BTB domain and CNC homolog 1 2 2
MIRT386722 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT446022 PEX3 peroxisomal biogenesis factor 3 2 2
MIRT481303 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 14
MIRT483959 ZNF354B zinc finger protein 354B 2 6
MIRT495667 TUBAL3 tubulin alpha like 3 2 2
MIRT496554 TBX15 T-box 15 2 2
MIRT497702 ARL6IP6 ADP ribosylation factor like GTPase 6 interacting protein 6 2 2
MIRT498105 RMND5A required for meiotic nuclear division 5 homolog A 2 2
MIRT512535 SEMA4D semaphorin 4D 2 2
MIRT512556 MFN2 mitofusin 2 2 6
MIRT521465 RABGAP1 RAB GTPase activating protein 1 2 6
MIRT526236 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT526743 HLA-DOB major histocompatibility complex, class II, DO beta 2 2
MIRT527578 BRD7 bromodomain containing 7 2 4
MIRT528038 WT1 Wilms tumor 1 2 2
MIRT528267 GPRIN2 G protein regulated inducer of neurite outgrowth 2 2 2
MIRT528505 HTR7 5-hydroxytryptamine receptor 7 2 4
MIRT528758 RPS27 ribosomal protein S27 2 6
MIRT528999 IPO9 importin 9 2 2
MIRT529701 MRPL30 mitochondrial ribosomal protein L30 2 2
MIRT529781 C17orf82 chromosome 17 open reading frame 82 2 2
MIRT533797 TMEM119 transmembrane protein 119 2 6
MIRT535308 PHF12 PHD finger protein 12 2 2
MIRT535917 MKL2 MKL1/myocardin like 2 2 2
MIRT544892 OSBPL1A oxysterol binding protein like 1A 2 2
MIRT555423 PPIC peptidylprolyl isomerase C 2 2
MIRT562068 KLHL15 kelch like family member 15 2 2
MIRT565623 SLC31A1 solute carrier family 31 member 1 2 2
MIRT565661 SIX1 SIX homeobox 1 2 2
MIRT570138 IL1RL2 interleukin 1 receptor like 2 2 2
MIRT571045 YRDC yrdC N6-threonylcarbamoyltransferase domain containing 2 2
MIRT621232 LMAN1 lectin, mannose binding 1 2 2
MIRT622272 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT623844 GAN gigaxonin 2 2
MIRT626158 NFYA nuclear transcription factor Y subunit alpha 2 2
MIRT626464 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT632087 ALDH1A2 aldehyde dehydrogenase 1 family member A2 2 2
MIRT637243 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT642710 FGFR1OP2 FGFR1 oncogene partner 2 2 2
MIRT643611 KANSL3 KAT8 regulatory NSL complex subunit 3 2 2
MIRT644270 PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 2 2
MIRT645470 SPIN3 spindlin family member 3 2 2
MIRT649193 DNPEP aspartyl aminopeptidase 2 2
MIRT650776 POP4 POP4 homolog, ribonuclease P/MRP subunit 2 2
MIRT651345 ZC2HC1C zinc finger C2HC-type containing 1C 2 2
MIRT652237 TRAPPC3L trafficking protein particle complex 3 like 2 2
MIRT652587 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT654591 PURA purine rich element binding protein A 2 2
MIRT654649 PTAFR platelet activating factor receptor 2 2
MIRT656842 KLF7 Kruppel like factor 7 2 2
MIRT657209 IKZF2 IKAROS family zinc finger 2 2 2
MIRT658513 ETV3 ETS variant 3 2 2
MIRT659448 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT668816 CYLD CYLD lysine 63 deubiquitinase 2 2
MIRT669067 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT677711 ELOF1 elongation factor 1 homolog 2 4
MIRT687146 PTPN12 protein tyrosine phosphatase, non-receptor type 12 2 2
MIRT698498 THOC2 THO complex 2 2 2
MIRT707930 PPP1R3D protein phosphatase 1 regulatory subunit 3D 4 2
MIRT708737 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT710031 POLL DNA polymerase lambda 2 2
MIRT712175 STK4 serine/threonine kinase 4 2 2
MIRT715297 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT716892 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT717378 RBM41 RNA binding motif protein 41 2 2
MIRT718082 CLIC5 chloride intracellular channel 5 2 2
MIRT718721 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT719152 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT719224 CAMK4 calcium/calmodulin dependent protein kinase IV 2 2
MIRT719528 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT719861 KLF2 Kruppel like factor 2 2 2
MIRT720326 CAMK2G calcium/calmodulin dependent protein kinase II gamma 2 2
MIRT721596 SREBF1 sterol regulatory element binding transcription factor 1 2 2
MIRT722020 NEBL nebulette 2 2
MIRT722484 QSOX1 quiescin sulfhydryl oxidase 1 2 2
MIRT722614 TEAD1 TEA domain transcription factor 1 2 2
MIRT723664 RPTN repetin 2 2
MIRT723939 SVOP SV2 related protein 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4301 Cisplatin 5460033 NSC119875 approved sensitive High Hepatocellular Carcinoma cell line (Hep3B, 97L)
hsa-miR-4301 Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-mir-4301 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-mir-4301 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-4301 Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-4301 Methotrexate 126941 NSC740 approved sensitive cell line (W1)
hsa-mir-4301 Topotecan 60699 NSC609699 approved sensitive cell line (W1)
hsa-miR-4301 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4301 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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