pre-miRNA Information | |
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pre-miRNA | hsa-mir-3622b |
Genomic Coordinates | chr8: 27701673 - 27701767 |
Description | Homo sapiens miR-3622b stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | ||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-3622b-3p | |||||||||||||||||||||||||||
Sequence | 58| UCACCUGAGCUCCCGUGCCUG |78 | |||||||||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||||||||
Experiments | Illumina | |||||||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | COQ7 | ||||||||||||||||||||
Synonyms | CAT5, CLK-1, CLK1, COQ10D8 | ||||||||||||||||||||
Description | coenzyme Q7, hydroxylase | ||||||||||||||||||||
Transcript | NM_016138 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on COQ7 | |||||||||||||||||||||
3'UTR of COQ7 (miRNA target sites are highlighted) |
>COQ7|NM_016138|3'UTR 1 AGTGTGTCCAGTTTTGCCTGTCTATAAAAGATGATAGTAATTTACCAAGTGACATTTGCAGAGAAACAGGTGTACAGTTA 81 TCGTTGTACTTTTGTACAATGTGAATTTTGTTAATAAATTATAAGGTTTGTTTTTTTTTTTTTAAACTCTGCAGTGTTGA 161 TTTTTCTCTGGGTTGTTTTTTCTGCCATGAGACCAACAGGTCACCAGCCTTGTTCAAGTTACAGCAAACGAAGCTGGGCC 241 TTGTTTGGTCTCATACTTAATTTTCTTTTATATACATGTTTTTCTTTTACATGCATATATATATATTTTATTTTATTTTA 321 TGTTTTTTGGAGACAGGGCCTCGCTCTTTTGTCCAGGCCGGGTCACAACTCACTGCAGCCTGGACCTCCTAGCCTCAAGC 401 AATCCACCCACCTCAGCCTTCCAAGTAGCTGGGACTACAGGTGTGCACCACCACAGCTGGCTAATTCTATTTTTTTATAG 481 AGGCGAAGTCTCACTATGTCGCCAGGCTGGTCTCTAACTCCTGGGCTCAGTGATCCTCCCGTTTCGACTTCCCAAAGTGC 561 TGGGATTACAGGTGTGAGCCACTTCACCAGGCCCATTTTCTCCTAAAACTTCAAGGACAAATCATTAATAATGTAACAGG 641 AATCTTTAGGAGAAAAAACAATTTGGTTTACTGATAACAAAAGATAATTGGAAACATGAGAGTATTTGAGATTGGCCAAG 721 CAGAACTATGAAGTCCATCAAGTAAGTCAAAGATCATCGTTTCTGTTTTGAATTGTGGGTGATAATGGGTGGGAGAGTGC 801 TACAGTCTGTATGTCTGTGTCTCCCTAGAATTCATACGATGAAATCTTCACTCTCAAGTTGATAGAAGGTGGGGCCCTTG 881 GGAAGTGTGAGGTCATGAGAGTGGAGCCCTCATGAATGGGATCAGTGCCTTATGAAAGGCCCTAGAGAGATACCTCATCC 961 TCTCCACAGTGTGAGACTTCAAGGGGAAGTATGAGACTTCTCTGAGGAAGCAGACCCTTCACAAGCAAAATCAGCCAGCA 1041 CTTTGATCACGGACTTCCCAGCCTCTAGGACTGTGAGCAATAAATGTTTGATGTTTATAAGCCACCCAGACTGTGGTATT 1121 TTGTTATAGCAGCCTGAACAGACTAAGACGGGGGTGTTGCTTCCATCAAAGGATGTACTAAGTTGTGGATTATTTGTGAA 1201 ATTGAATTACAACCTTTTCCTTAAGGTCTTTTACCACCTCCCCCCCAAAAAAATCCCCCAAAACTGATTCAGATTTTCAT 1281 ACTTTAATGAAATATTTTATAATTTGCAAATTTTTAAGTAATTTATGAAAAACCTAGATCAGTGGATCTCCTCTCTGGCT 1361 GCCCATTAGAATGTCCTGTGGAGATTAAACTTTTTTTTTTCAGTTTATGGACCAAGAGTTTTGATTTATTTAGGGTGGAG 1441 TTCAGGATCAGAATGGTTTCAGAAGCTCCCAGGTGATTCCGGAGTGAGTTGGAGCTGCAAGCCCCTGAGCTAGATTATAA 1521 GATGCTTCTGGGAAAGAACCACATTTTAGGAATTTGCTTCCCACCCAGTGCCCTGCATTTAATCAGCACCTGATGACTTG 1601 GCAGGACTTGCCCCACCAGGGTCTGGCTTTGAAGGGTAGTGGACACCAGGATCCTTTGGATTAATCCTCTGCCACCTCTC 1681 TCTTTTCCTCAACCGAGAGTGAATTTATGTAATTGAGTGAAAGTCTACGAATCATAATTGTAATAAATTAAGGCTGGGCA 1761 TTTGTTTGAAATTAGATAGGATAAAGCCAAAGGTTTGAACAAGTTGTGGATGGTTTGTAAAAATTAATCTTACAAAATAA 1841 ATGCTGTGTGTGAACACGTTGATTAAATTCAAAAGGGTATTATTTGGTTTTTCTGTAAATTGAACCTTGAAATAAAAGCA 1921 CAACAAGGTTTTCTTAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HeLa |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in Chi_124A_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + A
HITS-CLIP data was present in Chi_124B_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + B
HITS-CLIP data was present in Chi_ControlA_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control A
HITS-CLIP data was present in Chi_ControlB_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control B
... - Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature. |
Article |
- Chi SW; Zang JB; Mele A; Darnell RB - Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
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CLIP-seq Support 1 for dataset Chi_124A_2A8_130_50 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | HeLa / HeLa cell miR-124 + A |
Location of target site | ENST00000321998.5 | 3UTR | AUAGGAAAAAUACAGG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 19536157 / Chi_HITSCLIP |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset Chi_124B_2A8_130_50 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | HeLa / HeLa cell miR-124 + B |
Location of target site | ENST00000321998.5 | 3UTR | AUAGGAAAAAUACAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 19536157 / Chi_HITSCLIP |
CLIP-seq Viewer | Link |
CLIP-seq Support 3 for dataset Chi_ControlA_2A8_130_50 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | HeLa / HeLa cell Control A |
Location of target site | ENST00000321998.5 | 3UTR | AUAGGAAAAAUACAGG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 19536157 / Chi_HITSCLIP |
CLIP-seq Viewer | Link |
CLIP-seq Support 4 for dataset Chi_ControlB_2A8_130_50 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | HeLa / HeLa cell Control B |
Location of target site | ENST00000321998.5 | 3UTR | AUAGGAAAAAUACAGG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 19536157 / Chi_HITSCLIP |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||||||||||||||||||||||||||||||||||||||||||||
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102 hsa-miR-3622b-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT076713 | NUFIP2 | NUFIP2, FMR1 interacting protein 2 | ![]() |
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2 | 2 | ||||||
MIRT080212 | PRKACB | protein kinase cAMP-activated catalytic subunit beta | ![]() |
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2 | 2 | ||||||
MIRT081398 | GTPBP3 | GTP binding protein 3, mitochondrial | ![]() |
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2 | 2 | ||||||
MIRT107158 | ZBTB43 | zinc finger and BTB domain containing 43 | ![]() |
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2 | 2 | ||||||
MIRT254071 | BACH1 | BTB domain and CNC homolog 1 | ![]() |
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2 | 2 | ||||||
MIRT409790 | FOXO3 | forkhead box O3 | ![]() |
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2 | 2 | ||||||
MIRT448679 | MAPK9 | mitogen-activated protein kinase 9 | ![]() |
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2 | 2 | ||||||
MIRT450206 | ABHD15 | abhydrolase domain containing 15 | ![]() |
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2 | 2 | ||||||
MIRT486621 | PDK3 | pyruvate dehydrogenase kinase 3 | ![]() |
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2 | 2 | ||||||
MIRT489267 | TTLL1 | tubulin tyrosine ligase like 1 | ![]() |
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2 | 2 | ||||||
MIRT493117 | MKNK2 | MAP kinase interacting serine/threonine kinase 2 | ![]() |
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2 | 4 | ||||||
MIRT494570 | BAK1 | BCL2 antagonist/killer 1 | ![]() |
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2 | 2 | ||||||
MIRT497395 | RALY | RALY heterogeneous nuclear ribonucleoprotein | ![]() |
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2 | 2 | ||||||
MIRT504900 | CCDC86 | coiled-coil domain containing 86 | ![]() |
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2 | 2 | ||||||
MIRT505192 | USP46 | ubiquitin specific peptidase 46 | ![]() |
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2 | 4 | ||||||
MIRT506522 | MSANTD4 | Myb/SANT DNA binding domain containing 4 with coiled-coils | ![]() |
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2 | 6 | ||||||
MIRT508162 | ABCC5 | ATP binding cassette subfamily C member 5 | ![]() |
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2 | 8 | ||||||
MIRT508545 | PARVG | parvin gamma | ![]() |
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2 | 4 | ||||||
MIRT509850 | BIRC5 | baculoviral IAP repeat containing 5 | ![]() |
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2 | 6 | ||||||
MIRT510088 | PPWD1 | peptidylprolyl isomerase domain and WD repeat containing 1 | ![]() |
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2 | 8 | ||||||
MIRT512094 | CRK | CRK proto-oncogene, adaptor protein | ![]() |
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2 | 4 | ||||||
MIRT515381 | RPL7 | ribosomal protein L7 | ![]() |
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2 | 2 | ||||||
MIRT519176 | SCO1 | SCO1, cytochrome c oxidase assembly protein | ![]() |
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2 | 2 | ||||||
MIRT519964 | ZCCHC8 | zinc finger CCHC-type containing 8 | ![]() |
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2 | 2 | ||||||
MIRT522292 | NKAP | NFKB activating protein | ![]() |
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2 | 2 | ||||||
MIRT523160 | HMGB2 | high mobility group box 2 | ![]() |
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2 | 4 | ||||||
MIRT525314 | FANCA | Fanconi anemia complementation group A | ![]() |
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2 | 2 | ||||||
MIRT528194 | PLEKHM2 | pleckstrin homology and RUN domain containing M2 | ![]() |
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2 | 2 | ||||||
MIRT532885 | ZNF451 | zinc finger protein 451 | ![]() |
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2 | 2 | ||||||
MIRT538209 | CYR61 | cysteine rich angiogenic inducer 61 | ![]() |
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2 | 2 | ||||||
MIRT539497 | ACTN4 | actinin alpha 4 | ![]() |
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2 | 2 | ||||||
MIRT554600 | RRAGC | Ras related GTP binding C | ![]() |
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2 | 2 | ||||||
MIRT562444 | DCTN6 | dynactin subunit 6 | ![]() |
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2 | 2 | ||||||
MIRT562748 | AOC3 | amine oxidase, copper containing 3 | ![]() |
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2 | 2 | ||||||
MIRT565798 | SEC14L5 | SEC14 like lipid binding 5 | ![]() |
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2 | 2 | ||||||
MIRT565838 | SCML2 | Scm polycomb group protein like 2 | ![]() |
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2 | 2 | ||||||
MIRT566072 | RCC2 | regulator of chromosome condensation 2 | ![]() |
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2 | 2 | ||||||
MIRT566104 | RBPJ | recombination signal binding protein for immunoglobulin kappa J region | ![]() |
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2 | 2 | ||||||
MIRT572407 | MRPS14 | mitochondrial ribosomal protein S14 | ![]() |
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2 | 2 | ||||||
MIRT576198 | Vsig2 | V-set and immunoglobulin domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT576313 | Acbd7 | acyl-Coenzyme A binding domain containing 7 | ![]() |
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2 | 2 | ||||||
MIRT576651 | Mill2 | MHC I like leukocyte 2 | ![]() |
1 | 1 | |||||||
MIRT576859 | Socs6 | suppressor of cytokine signaling 6 | ![]() |
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2 | 2 | ||||||
MIRT606819 | BICD2 | BICD cargo adaptor 2 | ![]() |
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2 | 2 | ||||||
MIRT610738 | NUDT16 | nudix hydrolase 16 | ![]() |
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2 | 4 | ||||||
MIRT614798 | RORA | RAR related orphan receptor A | ![]() |
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2 | 2 | ||||||
MIRT619006 | NTMT1 | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | ![]() |
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2 | 2 | ||||||
MIRT619420 | NOS1AP | nitric oxide synthase 1 adaptor protein | ![]() |
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2 | 2 | ||||||
MIRT620405 | MYO1H | myosin IH | ![]() |
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2 | 2 | ||||||
MIRT624869 | ABHD13 | abhydrolase domain containing 13 | ![]() |
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2 | 2 | ||||||
MIRT633527 | ZFP30 | ZFP30 zinc finger protein | ![]() |
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2 | 2 | ||||||
MIRT633927 | DNAH9 | dynein axonemal heavy chain 9 | ![]() |
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2 | 2 | ||||||
MIRT636611 | CLIC5 | chloride intracellular channel 5 | ![]() |
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2 | 2 | ||||||
MIRT640616 | MIOX | myo-inositol oxygenase | ![]() |
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2 | 2 | ||||||
MIRT642605 | C14orf180 | chromosome 14 open reading frame 180 | ![]() |
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2 | 2 | ||||||
MIRT644624 | SRSF2 | serine and arginine rich splicing factor 2 | ![]() |
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2 | 2 | ||||||
MIRT655113 | PHLDA3 | pleckstrin homology like domain family A member 3 | ![]() |
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2 | 2 | ||||||
MIRT658976 | DNAJB5 | DnaJ heat shock protein family (Hsp40) member B5 | ![]() |
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2 | 4 | ||||||
MIRT661495 | CHMP1B | charged multivesicular body protein 1B | ![]() |
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2 | 2 | ||||||
MIRT662996 | TMEM59 | transmembrane protein 59 | ![]() |
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2 | 2 | ||||||
MIRT663075 | SFR1 | SWI5 dependent homologous recombination repair protein 1 | ![]() |
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2 | 2 | ||||||
MIRT665405 | WEE1 | WEE1 G2 checkpoint kinase | ![]() |
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2 | 2 | ||||||
MIRT666106 | SSR1 | signal sequence receptor subunit 1 | ![]() |
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2 | 2 | ||||||
MIRT669562 | ALDOA | aldolase, fructose-bisphosphate A | ![]() |
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2 | 2 | ||||||
MIRT670070 | ZNF783 | zinc finger family member 783 | ![]() |
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2 | 2 | ||||||
MIRT671192 | ZNF891 | zinc finger protein 891 | ![]() |
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2 | 2 | ||||||
MIRT675361 | KLHL26 | kelch like family member 26 | ![]() |
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2 | 2 | ||||||
MIRT678857 | LINC00598 | long intergenic non-protein coding RNA 598 | ![]() |
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2 | 2 | ||||||
MIRT679443 | C19orf52 | translocase of inner mitochondrial membrane 29 | ![]() |
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2 | 2 | ||||||
MIRT684163 | ALDH1B1 | aldehyde dehydrogenase 1 family member B1 | ![]() |
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2 | 2 | ||||||
MIRT684543 | ZNF460 | zinc finger protein 460 | ![]() |
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2 | 2 | ||||||
MIRT684674 | SLC2A11 | solute carrier family 2 member 11 | ![]() |
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2 | 2 | ||||||
MIRT684971 | MINOS1 | mitochondrial inner membrane organizing system 1 | ![]() |
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2 | 2 | ||||||
MIRT686006 | NEK4 | NIMA related kinase 4 | ![]() |
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2 | 2 | ||||||
MIRT687758 | KIAA1328 | KIAA1328 | ![]() |
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2 | 2 | ||||||
MIRT688961 | ATXN3 | ataxin 3 | ![]() |
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2 | 2 | ||||||
MIRT689409 | UQCR11 | ubiquinol-cytochrome c reductase, complex III subunit XI | ![]() |
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2 | 2 | ||||||
MIRT690001 | MMP17 | matrix metallopeptidase 17 | ![]() |
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2 | 2 | ||||||
MIRT690165 | ELP3 | elongator acetyltransferase complex subunit 3 | ![]() |
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2 | 2 | ||||||
MIRT690202 | C5orf45 | MRN complex interacting protein | ![]() |
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2 | 2 | ||||||
MIRT690477 | ZNF33A | zinc finger protein 33A | ![]() |
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2 | 2 | ||||||
MIRT690566 | MICA | MHC class I polypeptide-related sequence A | ![]() |
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2 | 2 | ||||||
MIRT692160 | C10orf111 | chromosome 10 open reading frame 111 | ![]() |
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2 | 2 | ||||||
MIRT693430 | PLGLB2 | plasminogen-like B2 | ![]() |
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2 | 2 | ||||||
MIRT693547 | ZNF708 | zinc finger protein 708 | ![]() |
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2 | 2 | ||||||
MIRT693697 | PLGLB1 | plasminogen-like B1 | ![]() |
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2 | 2 | ||||||
MIRT695006 | HSPA6 | heat shock protein family A (Hsp70) member 6 | ![]() |
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2 | 2 | ||||||
MIRT698525 | TFRC | transferrin receptor | ![]() |
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2 | 2 | ||||||
MIRT699574 | SIKE1 | suppressor of IKBKE 1 | ![]() |
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2 | 2 | ||||||
MIRT703446 | FYTTD1 | forty-two-three domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT704397 | CTSS | cathepsin S | ![]() |
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2 | 2 | ||||||
MIRT704485 | CPT1A | carnitine palmitoyltransferase 1A | ![]() |
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2 | 2 | ||||||
MIRT709822 | STPG1 | sperm tail PG-rich repeat containing 1 | ![]() |
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2 | 2 | ||||||
MIRT710859 | COQ7 | coenzyme Q7, hydroxylase | ![]() |
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2 | 2 | ||||||
MIRT711893 | INSIG2 | insulin induced gene 2 | ![]() |
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2 | 2 | ||||||
MIRT713796 | CPLX2 | complexin 2 | ![]() |
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2 | 2 | ||||||
MIRT718800 | C1GALT1C1 | C1GALT1 specific chaperone 1 | ![]() |
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2 | 2 | ||||||
MIRT719501 | SEC24B | SEC24 homolog B, COPII coat complex component | ![]() |
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2 | 2 | ||||||
MIRT719722 | PDE6B | phosphodiesterase 6B | ![]() |
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2 | 2 | ||||||
MIRT722204 | URM1 | ubiquitin related modifier 1 | ![]() |
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2 | 2 | ||||||
MIRT723523 | CLPTM1L | CLPTM1 like | ![]() |
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2 | 2 | ||||||
MIRT725471 | GRAP2 | GRB2-related adaptor protein 2 | ![]() |
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2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||
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