pre-miRNA Information
pre-miRNA hsa-mir-5691   
Genomic Coordinates chr11: 9090312 - 9090379
Description Homo sapiens miR-5691 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-5691
Sequence 9| UUGCUCUGAGCUCCGAGAAAGC |30
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1042238449 3 dbSNP
rs554804494 11 dbSNP
rs1172229307 13 dbSNP
rs112511786 14 dbSNP
Putative Targets

Gene Information
Gene Symbol VPS8   
Synonyms KIAA0804
Description VPS8, CORVET complex subunit
Transcript NM_001009921   
Other Transcripts NM_015303   
Expression
Putative miRNA Targets on VPS8
3'UTR of VPS8
(miRNA target sites are highlighted)
>VPS8|NM_001009921|3'UTR
   1 TGACTCCATGGAGCCTGGCCCAGGAGAACCAGAGATGATCCCGAGGCAGCTGGGGAGAGGCCCCGCCTCTGGTGGGCTTG
  81 GCCTCCACCACCTCCCACGCTTCTGAGAAGAGGTTCCAAATTGGGCTTCTGTGCCCAGAGCGTCCACAGCACCATTCCCA
 161 GTGTAGACTCCCAGTCTTCTCCACATTGCTGTCATGGCGTCAGTTCACCAGACTCATTGATTTTGTTTTGCTTGTTAAGC
 241 AAAGGAATGTCACATACCTCTGTCCAGCTTTTTAGGAAATACATTTCGCCTATTGCGACTTTTTCCATTTACCCTGAAGC
 321 CTAGAAAGTAGGTGGAACTCACACAAATGGCATTCCAGAGTCTGCCATACTCCGTCTCCTCCAGCTGCTGGATAATACAG
 401 AGGAACTTCAACTTCTACAGGGAACAGTGGTTGGCCAGGCTGCAGTATAACTGAAGCATGCCTTGGAGAGAGCAGACACT
 481 GTGGGGGCCAGGGCCATCTCCCTTTAATGTGTTCATGTTAAAACCTATTTGAGTGTAAGACTTGCCCTTTCTAACAATAA
 561 ATGCTCCGTGTTTAAGTTCTGCAGGTCTCAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cgaAAGAGCCUCGAGUCUCGUu 5'
             ||||  | || ||||||: 
Target 5' ggcTTCT--GTGCCCAGAGCGt 3'
124 - 143 143.00 -15.40
2
miRNA  3' cgaaaGAGCCUCGAGUCUCGUu 5'
               ||:||||   |||||| 
Target 5' catgcCTTGGAG---AGAGCAg 3'
457 - 475 133.00 -17.80
3
miRNA  3' cgaAAGAGCC--UCGAGUCUCGUu 5'
             | || ||  | : ||||| | 
Target 5' agcTGCT-GGATAATACAGAGGAa 3'
383 - 405 112.00 -12.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28798512 99 COSMIC
COSN28661485 129 COSMIC
COSN30160377 130 COSMIC
COSN22108620 235 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs542748807 9 dbSNP
rs1266907148 10 dbSNP
rs1446125126 12 dbSNP
rs373632644 14 dbSNP
rs1252845653 15 dbSNP
rs1249388968 18 dbSNP
rs889661219 21 dbSNP
rs373927306 25 dbSNP
rs200593090 36 dbSNP
rs1306718232 39 dbSNP
rs752455281 42 dbSNP
rs755721064 43 dbSNP
rs777667528 44 dbSNP
rs1156989048 50 dbSNP
rs1016373658 53 dbSNP
rs1192582823 55 dbSNP
rs931808552 58 dbSNP
rs111337800 63 dbSNP
rs890380294 65 dbSNP
rs368402296 66 dbSNP
rs1052368466 75 dbSNP
rs1177372750 87 dbSNP
rs755856132 89 dbSNP
rs1435130103 96 dbSNP
rs2271257 99 dbSNP
rs1175871390 100 dbSNP
rs1419748924 120 dbSNP
rs1252507582 123 dbSNP
rs1175434970 125 dbSNP
rs960240908 127 dbSNP
rs2271258 129 dbSNP
rs1205151939 134 dbSNP
rs916059012 138 dbSNP
rs970282675 141 dbSNP
rs979354809 142 dbSNP
rs547034133 143 dbSNP
rs1309730881 147 dbSNP
rs934417464 148 dbSNP
rs1052678874 149 dbSNP
rs1222596308 150 dbSNP
rs754872974 156 dbSNP
rs933892268 161 dbSNP
rs565327285 162 dbSNP
rs1454776277 166 dbSNP
rs779022243 167 dbSNP
rs748187655 172 dbSNP
rs138150075 173 dbSNP
rs1336333658 175 dbSNP
rs1454330847 191 dbSNP
rs1347740200 192 dbSNP
rs1365637031 193 dbSNP
rs1049694487 200 dbSNP
rs1258077712 210 dbSNP
rs185264743 212 dbSNP
rs1005360677 217 dbSNP
rs1185266033 218 dbSNP
rs1459818191 240 dbSNP
rs1262565015 245 dbSNP
rs1359711751 249 dbSNP
rs1242082296 255 dbSNP
rs963075988 280 dbSNP
rs1486541180 287 dbSNP
rs973135470 288 dbSNP
rs569704078 289 dbSNP
rs931803091 294 dbSNP
rs899215172 297 dbSNP
rs993584697 298 dbSNP
rs1314581461 306 dbSNP
rs536868459 312 dbSNP
rs1452964441 329 dbSNP
rs911752897 335 dbSNP
rs935246212 336 dbSNP
rs1026317670 338 dbSNP
rs960064447 339 dbSNP
rs1158764381 348 dbSNP
rs1429985547 348 dbSNP
rs915207256 356 dbSNP
rs747602444 358 dbSNP
rs1203967722 363 dbSNP
rs1014910142 368 dbSNP
rs1293072004 370 dbSNP
rs1225406197 373 dbSNP
rs772329757 374 dbSNP
rs1023242482 375 dbSNP
rs1293711018 385 dbSNP
rs1381661311 396 dbSNP
rs558680121 399 dbSNP
rs143891374 411 dbSNP
rs1304838313 413 dbSNP
rs1422715055 418 dbSNP
rs978916787 420 dbSNP
rs1168347110 427 dbSNP
rs1370928697 439 dbSNP
rs1442268424 443 dbSNP
rs1370924503 448 dbSNP
rs1303953644 452 dbSNP
rs1480454606 466 dbSNP
rs1270459421 470 dbSNP
rs190539711 471 dbSNP
rs1004461639 480 dbSNP
rs955786137 483 dbSNP
rs988553826 485 dbSNP
rs11555406 487 dbSNP
rs933695074 491 dbSNP
rs1249787897 495 dbSNP
rs1049880125 497 dbSNP
rs369865276 509 dbSNP
rs911112246 518 dbSNP
rs1211910115 526 dbSNP
rs1285332701 528 dbSNP
rs1324339987 528 dbSNP
rs1403017390 534 dbSNP
rs1330377017 542 dbSNP
rs1252434010 547 dbSNP
rs554250577 547 dbSNP
rs771190074 548 dbSNP
rs1392864167 552 dbSNP
rs1038172019 564 dbSNP
rs3332 568 dbSNP
rs147275966 569 dbSNP
rs1248206083 578 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_ControlB_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cgaaagagcCUCGA--GUCUCGUu 5'
                   ||| |  ||||||| 
Target 5' -----caaaGAGGUAGCAGAGCA- 3'
1 - 18
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_ControlB_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control B
Location of target site ENST00000287546.4 | 3UTR | CAAAGAGGUAGCAGAGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
91 hsa-miR-5691 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT091162 TBL1XR1 transducin beta like 1 X-linked receptor 1 2 2
MIRT242227 TTC9 tetratricopeptide repeat domain 9 2 4
MIRT246192 TXNIP thioredoxin interacting protein 2 2
MIRT251553 DCAF7 DDB1 and CUL4 associated factor 7 2 4
MIRT387267 SOX9 SRY-box 9 2 2
MIRT463486 ZC3H11A zinc finger CCCH-type containing 11A 2 12
MIRT494446 BTG2 BTG anti-proliferation factor 2 2 2
MIRT496478 ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif 17 2 2
MIRT501825 NCOA3 nuclear receptor coactivator 3 2 2
MIRT503072 C6orf120 chromosome 6 open reading frame 120 2 2
MIRT504755 TEP1 telomerase associated protein 1 2 4
MIRT505971 RAB11FIP1 RAB11 family interacting protein 1 2 4
MIRT511868 GOLGA7 golgin A7 2 6
MIRT512900 UBL4A ubiquitin like 4A 2 2
MIRT513048 LYPD6 LY6/PLAUR domain containing 6 2 6
MIRT523772 FAM83D family with sequence similarity 83 member D 2 2
MIRT525126 RPS11 ribosomal protein S11 2 2
MIRT525816 VIMP selenoprotein S 2 10
MIRT531222 HIST1H2BD histone cluster 1 H2B family member d 2 2
MIRT531729 SLC2A9 solute carrier family 2 member 9 2 2
MIRT536282 LIMA1 LIM domain and actin binding 1 2 2
MIRT537291 G3BP1 G3BP stress granule assembly factor 1 2 2
MIRT537724 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT547940 HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 2 2
MIRT554177 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT555015 RAB2B RAB2B, member RAS oncogene family 2 2
MIRT576717 Wars tryptophanyl-tRNA synthetase 2 2
MIRT607484 HEBP2 heme binding protein 2 2 2
MIRT610786 KLK2 kallikrein related peptidase 2 2 2
MIRT611491 ZNF440 zinc finger protein 440 2 2
MIRT613986 DBT dihydrolipoamide branched chain transacylase E2 2 2
MIRT615782 KIAA0319L KIAA0319 like 2 2
MIRT620563 WBSCR27 methyltransferase like 27 2 4
MIRT624157 DGKE diacylglycerol kinase epsilon 2 2
MIRT626088 MKLN1 muskelin 1 2 2
MIRT629481 GSN gelsolin 2 2
MIRT636645 CDK4 cyclin dependent kinase 4 2 2
MIRT638074 HS3ST1 heparan sulfate-glucosamine 3-sulfotransferase 1 2 2
MIRT638442 PLXDC2 plexin domain containing 2 2 2
MIRT641025 KLHL7 kelch like family member 7 2 2
MIRT641539 MOCOS molybdenum cofactor sulfurase 2 2
MIRT643004 ZNF829 zinc finger protein 829 2 2
MIRT643092 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT644979 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT645912 PLXNA3 plexin A3 2 2
MIRT646605 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT648033 FADS6 fatty acid desaturase 6 2 2
MIRT657491 HBEGF heparin binding EGF like growth factor 2 2
MIRT658381 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT659695 CD200 CD200 molecule 2 2
MIRT661276 TEX9 testis expressed 9 2 2
MIRT661348 DYRK4 dual specificity tyrosine phosphorylation regulated kinase 4 2 2
MIRT662948 JPH2 junctophilin 2 2 2
MIRT663225 PPY pancreatic polypeptide 2 2
MIRT663280 SPN sialophorin 2 2
MIRT663335 ZNF74 zinc finger protein 74 2 2
MIRT664344 C16orf45 chromosome 16 open reading frame 45 2 2
MIRT664855 TBRG4 transforming growth factor beta regulator 4 2 2
MIRT665484 VPS53 VPS53, GARP complex subunit 2 2
MIRT666428 SH2B3 SH2B adaptor protein 3 2 2
MIRT668162 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT670170 CCDC142 coiled-coil domain containing 142 2 2
MIRT671277 MTO1 mitochondrial tRNA translation optimization 1 2 2
MIRT672284 GP2 glycoprotein 2 2 2
MIRT672435 RAB10 RAB10, member RAS oncogene family 2 2
MIRT672646 SLC25A16 solute carrier family 25 member 16 2 4
MIRT672760 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT672834 AKR7L aldo-keto reductase family 7 like (gene/pseudogene) 2 2
MIRT672841 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT673080 AK1 adenylate kinase 1 2 2
MIRT673148 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT673323 THAP1 THAP domain containing 1 2 2
MIRT673893 DCTN6 dynactin subunit 6 2 2
MIRT674182 PLEKHM3 pleckstrin homology domain containing M3 2 2
MIRT674607 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT674740 SLC16A1 solute carrier family 16 member 1 2 2
MIRT675140 MOGAT1 monoacylglycerol O-acyltransferase 1 2 4
MIRT675194 NKPD1 NTPase KAP family P-loop domain containing 1 2 2
MIRT675886 SNAP29 synaptosome associated protein 29 2 2
MIRT679163 PSMB2 proteasome subunit beta 2 2 2
MIRT680337 ZNF281 zinc finger protein 281 2 2
MIRT706699 GPR155 G protein-coupled receptor 155 2 2
MIRT706911 THAP6 THAP domain containing 6 2 2
MIRT707880 SLC45A4 solute carrier family 45 member 4 2 2
MIRT709097 SEPT4 septin 4 2 2
MIRT709408 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT710845 FAM210A family with sequence similarity 210 member A 2 2
MIRT711358 VPS8 VPS8, CORVET complex subunit 2 2
MIRT718590 SCD5 stearoyl-CoA desaturase 5 2 2
MIRT723649 RPTN repetin 2 2
MIRT724208 NUP205 nucleoporin 205 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-5691 Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)

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