pre-miRNA Information
pre-miRNA hsa-mir-6787   
Genomic Coordinates chr17: 82236668 - 82236728
Description Homo sapiens miR-6787 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6787-5p
Sequence 6| UGGCGGGGGUAGAGCUGGCUGC |27
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs778888046 4 dbSNP
rs772018061 5 dbSNP
rs760886644 6 dbSNP
rs776925052 7 dbSNP
rs760060985 8 dbSNP
rs1432528063 9 dbSNP
rs778772390 10 dbSNP
rs924024166 11 dbSNP
rs201523090 13 dbSNP
rs1451075810 17 dbSNP
rs1378844609 18 dbSNP
Putative Targets

Gene Information
Gene Symbol VASP   
Synonyms -
Description vasodilator stimulated phosphoprotein
Transcript NM_003370   
Expression
Putative miRNA Targets on VASP
3'UTR of VASP
(miRNA target sites are highlighted)
>VASP|NM_003370|3'UTR
   1 CCACAGGGACCCAGAAGACCCGCTTCTCCTTTCCGCACACCCGGCCTGTCACCCTGCTTTCCCTGCCTCTACTTGACTTG
  81 GAATTGGCTGAAGACTACACAGGAATGCATCGTTCCCACTCCCCATCCCACTTGGAAAACTCCAAGGGGGTGTGGCTTCC
 161 CTGCTCACACCCACACTGGCTGCTGATTGGCTGGGGAGGCCCCCGCCCTTTTCTCCCTTTGGTCCTTCCCCTCTGCCATC
 241 CCCTTGGGGCCGGTCCCTCTGCTGGGGATGCACCAATGAACCCCACAGGAAGGGGGAAGGAAGGAGGGAATTTCACATTC
 321 CCTTGTTCTAGATTCACTTTAACGCTTAATGCCTTCAAAGTTTTGGTTTTTTTAAGAAAAAAAAATATATATATATTTGG
 401 GTTTTGGGGGAAAAGGGAAATTTTTTTTTCTCTTTGGTTTTGATAAAATGGGATGTGGGAGTTTTTAAATGCTATAGCCC
 481 TGGGCTTGCCCCATTTGGGGCAGCTATTTAAGGGGAGGGGATGTCTCACCGGGCTGGGGGTGAGATATCCCCCCACCCCA
 561 GGGACTCCCCTTCCCTCTGGCTCCTTCCCCTTTTCTATGAGGAAATAAGATGCTGTAACTTTTTGGAACCTCAGTTTTTT
 641 GATTTTTTATTTGGGTAGGTTTTGGGGTCCAGGCCATTTTTTTTACCCCTTGGAGGAAATAAGATGAGGGAGAAAGGAGA
 721 AGGGGAGGAAACTTCTCCCCTCCCACCTTCACCTTTAGCTTCTTGAAAATGGGCCCCTGCAGAATAAATCTGCCAGTTTT
 801 TATAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cgUCGGUCGAGAUGGGGGCGGu 5'
            :||::|    :|||||||| 
Target 5' ttGGCTGGGGAGGCCCCCGCCc 3'
187 - 208 152.00 -24.70
2
miRNA  3' cgUCGGUCGAGAUGGGGGCGGu 5'
            | || |||:|  |||:||| 
Target 5' tcACCCTGCTTT--CCCTGCCt 3'
49 - 68 144.00 -21.70
3
miRNA  3' cgUCGGUCGAGAUGGGGGCGGu 5'
            :|: || | | ||||| || 
Target 5' ggGGTGAGATATCCCCCCACCc 3'
537 - 558 128.00 -19.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30114531 10 COSMIC
COSN30159920 22 COSMIC
COSN27004538 23 COSMIC
COSN30143464 27 COSMIC
COSN30462719 30 COSMIC
COSN30512116 37 COSMIC
COSN30138783 44 COSMIC
COSN30510308 82 COSMIC
COSN31549833 132 COSMIC
COSN31608524 144 COSMIC
COSN31602970 322 COSMIC
COSN31483201 377 COSMIC
COSN31562892 386 COSMIC
COSN26677738 485 COSMIC
COSN21366979 630 COSMIC
COSN32160028 659 COSMIC
COSN31526448 660 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs142223061 2 dbSNP
rs762689322 6 dbSNP
rs556429482 8 dbSNP
rs1315770806 9 dbSNP
rs1197803783 10 dbSNP
rs1258259949 18 dbSNP
rs932362597 19 dbSNP
rs1481435247 20 dbSNP
rs1343273566 23 dbSNP
rs1322735545 25 dbSNP
rs751116538 25 dbSNP
rs914691838 28 dbSNP
rs1266124595 30 dbSNP
rs759954072 33 dbSNP
rs768067345 35 dbSNP
rs753219936 36 dbSNP
rs756407032 38 dbSNP
rs767496273 40 dbSNP
rs576558738 41 dbSNP
rs754014244 43 dbSNP
rs1360910670 44 dbSNP
rs1284271813 45 dbSNP
rs545308879 46 dbSNP
rs778827106 52 dbSNP
rs1416020132 61 dbSNP
rs1014326052 66 dbSNP
rs1312154922 76 dbSNP
rs558744171 78 dbSNP
rs767944809 90 dbSNP
rs1044438771 91 dbSNP
rs55943437 94 dbSNP
rs62627134 94 dbSNP
rs572378878 97 dbSNP
rs928637929 98 dbSNP
rs1282623119 107 dbSNP
rs113695819 110 dbSNP
rs906334210 112 dbSNP
rs1470074025 113 dbSNP
rs541331441 118 dbSNP
rs1182674809 119 dbSNP
rs1476201078 127 dbSNP
rs773720700 133 dbSNP
rs1255536600 138 dbSNP
rs893499855 144 dbSNP
rs1010507497 145 dbSNP
rs1037303152 146 dbSNP
rs781379659 146 dbSNP
rs1453105190 150 dbSNP
rs897361130 156 dbSNP
rs560535112 163 dbSNP
rs1202948501 167 dbSNP
rs761023856 174 dbSNP
rs184649697 175 dbSNP
rs1234780180 176 dbSNP
rs1048537036 195 dbSNP
rs987203015 196 dbSNP
rs56391434 197 dbSNP
rs889263558 198 dbSNP
rs753988075 199 dbSNP
rs1461242889 200 dbSNP
rs374733617 200 dbSNP
rs1392661856 201 dbSNP
rs972759518 203 dbSNP
rs1461805941 205 dbSNP
rs1350274069 209 dbSNP
rs1165706142 214 dbSNP
rs920844138 218 dbSNP
rs901523629 235 dbSNP
rs997570595 240 dbSNP
rs755182225 244 dbSNP
rs1448811167 245 dbSNP
rs1473202785 247 dbSNP
rs956141653 250 dbSNP
rs766189228 251 dbSNP
rs930654312 252 dbSNP
rs1215152303 255 dbSNP
rs1334609600 258 dbSNP
rs1236468142 262 dbSNP
rs543481442 264 dbSNP
rs1271979212 268 dbSNP
rs1266881419 271 dbSNP
rs1318209876 284 dbSNP
rs1335052376 293 dbSNP
rs1214773229 294 dbSNP
rs563972514 298 dbSNP
rs1390782570 301 dbSNP
rs1368005034 306 dbSNP
rs1443361365 312 dbSNP
rs1392646922 314 dbSNP
rs1164489317 324 dbSNP
rs1454326875 326 dbSNP
rs752762648 333 dbSNP
rs1157515310 334 dbSNP
rs1419051264 338 dbSNP
rs1045777991 344 dbSNP
rs906401555 345 dbSNP
rs935173529 346 dbSNP
rs1198017369 351 dbSNP
rs1486537222 357 dbSNP
rs1052803341 360 dbSNP
rs532247927 361 dbSNP
rs1312760406 362 dbSNP
rs1418540455 363 dbSNP
rs1179715149 365 dbSNP
rs552372347 367 dbSNP
rs758568511 374 dbSNP
rs565883559 375 dbSNP
rs199523847 376 dbSNP
rs1038802093 377 dbSNP
rs140959366 377 dbSNP
rs528354077 377 dbSNP
rs889939842 377 dbSNP
rs901553356 383 dbSNP
rs548544555 384 dbSNP
rs1259041468 385 dbSNP
rs1448422916 385 dbSNP
rs201899016 385 dbSNP
rs28584568 385 dbSNP
rs891738950 386 dbSNP
rs201403453 387 dbSNP
rs1009101585 389 dbSNP
rs1282313661 398 dbSNP
rs1208671485 409 dbSNP
rs1346833797 411 dbSNP
rs1018689287 417 dbSNP
rs1395644622 418 dbSNP
rs1298124582 421 dbSNP
rs568141199 421 dbSNP
rs962551046 421 dbSNP
rs556607164 424 dbSNP
rs1051898 431 dbSNP
rs1355772994 433 dbSNP
rs1232230772 437 dbSNP
rs1293077102 438 dbSNP
rs1333091706 445 dbSNP
rs756968383 460 dbSNP
rs1376165743 463 dbSNP
rs972239753 476 dbSNP
rs1027802663 495 dbSNP
rs868655026 497 dbSNP
rs952287172 501 dbSNP
rs991708061 505 dbSNP
rs1388792864 510 dbSNP
rs552836979 512 dbSNP
rs918565299 519 dbSNP
rs1192047905 521 dbSNP
rs1259620552 528 dbSNP
rs1486127406 531 dbSNP
rs952995758 532 dbSNP
rs915918571 535 dbSNP
rs1275080528 538 dbSNP
rs1197258475 540 dbSNP
rs1337213593 541 dbSNP
rs10156 547 dbSNP
rs911452470 549 dbSNP
rs1356134732 553 dbSNP
rs1170852465 555 dbSNP
rs1413460159 557 dbSNP
rs1355457935 562 dbSNP
rs1330152394 563 dbSNP
rs1411949824 564 dbSNP
rs981969473 565 dbSNP
rs528170211 569 dbSNP
rs745671492 574 dbSNP
rs1041578547 583 dbSNP
rs924699794 590 dbSNP
rs878878016 603 dbSNP
rs934715489 610 dbSNP
rs1460401311 616 dbSNP
rs1304085088 617 dbSNP
rs1474594954 634 dbSNP
rs1233324395 636 dbSNP
rs538772633 637 dbSNP
rs1052287398 639 dbSNP
rs546716916 642 dbSNP
rs1426708122 643 dbSNP
rs1249603980 649 dbSNP
rs1198223666 651 dbSNP
rs1335802640 654 dbSNP
rs769141304 655 dbSNP
rs1231459291 660 dbSNP
rs1050301329 664 dbSNP
rs1310659399 666 dbSNP
rs1011223315 675 dbSNP
rs1042997737 677 dbSNP
rs1333166863 677 dbSNP
rs1341958536 689 dbSNP
rs1334321636 700 dbSNP
rs888815533 701 dbSNP
rs1328664677 710 dbSNP
rs10995 720 dbSNP
rs1001409545 722 dbSNP
rs1035930386 725 dbSNP
rs189567141 726 dbSNP
rs1408115399 728 dbSNP
rs1040550511 735 dbSNP
rs1307427399 742 dbSNP
rs1051907 746 dbSNP
rs1468580682 752 dbSNP
rs960175605 757 dbSNP
rs748736827 764 dbSNP
rs1469654903 766 dbSNP
rs1255059553 771 dbSNP
rs1212084884 774 dbSNP
rs897592540 780 dbSNP
rs865901443 782 dbSNP
rs1210213286 791 dbSNP
rs1285100254 803 dbSNP
rs1225955404 804 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124A_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + A HITS-CLIP data was present in Chi_124B_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + B HITS-CLIP data was present in Chi_ControlB_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_124A_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + A
Location of target site ENST00000245932.6 | 3UTR | GGCUGGGGAGGCCCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset Chi_124B_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + B
Location of target site ENST00000245932.6 | 3UTR | GGCUGGGGAGGCCCCCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset Chi_ControlB_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control B
Location of target site ENST00000245932.6 | 3UTR | GGCUGGGGAGGCCCCCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
90 hsa-miR-6787-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT449091 XPO6 exportin 6 2 2
MIRT449991 PSMG1 proteasome assembly chaperone 1 2 2
MIRT454608 MYADM myeloid associated differentiation marker 2 2
MIRT456116 VAV3 vav guanine nucleotide exchange factor 3 2 6
MIRT457064 TOR4A torsin family 4 member A 2 2
MIRT461023 SDF4 stromal cell derived factor 4 2 2
MIRT467197 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT471711 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT472566 NACC1 nucleus accumbens associated 1 2 2
MIRT476079 GRB2 growth factor receptor bound protein 2 2 2
MIRT480150 CALR calreticulin 2 2
MIRT483027 KHSRP KH-type splicing regulatory protein 2 4
MIRT483498 STMN3 stathmin 3 2 4
MIRT483728 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT484550 BARHL1 BarH like homeobox 1 2 6
MIRT484684 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT486059 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT486116 INO80E INO80 complex subunit E 2 2
MIRT486313 SIPA1 signal-induced proliferation-associated 1 2 2
MIRT486525 CLCN7 chloride voltage-gated channel 7 2 2
MIRT486857 DPF1 double PHD fingers 1 2 2
MIRT487352 PHF15 jade family PHD finger 2 1 1
MIRT487582 FAM83H family with sequence similarity 83 member H 2 4
MIRT487792 GPR20 G protein-coupled receptor 20 2 4
MIRT488104 POU3F1 POU class 3 homeobox 1 2 2
MIRT488786 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT489361 SYNGR1 synaptogyrin 1 2 4
MIRT489387 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT489680 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT489731 GNAI2 G protein subunit alpha i2 2 4
MIRT489750 TACC3 transforming acidic coiled-coil containing protein 3 2 2
MIRT490029 PCSK4 proprotein convertase subtilisin/kexin type 4 2 2
MIRT490379 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT490580 SLC47A1 solute carrier family 47 member 1 2 2
MIRT490753 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT491187 JUND JunD proto-oncogene, AP-1 transcription factor subunit 2 4
MIRT491301 VGF VGF nerve growth factor inducible 2 2
MIRT491462 HOXB8 homeobox B8 2 2
MIRT491702 PDZD4 PDZ domain containing 4 2 2
MIRT491724 RTN4R reticulon 4 receptor 2 2
MIRT491737 SEMA3F semaphorin 3F 2 2
MIRT491984 UNK unkempt family zinc finger 2 2
MIRT492844 NRGN neurogranin 2 2
MIRT492936 NEUROD2 neuronal differentiation 2 2 4
MIRT493713 H2AFX H2A histone family member X 2 2
MIRT494623 ASB6 ankyrin repeat and SOCS box containing 6 2 4
MIRT494703 ARHGAP31 Rho GTPase activating protein 31 2 2
MIRT495602 NKX2-5 NK2 homeobox 5 2 2
MIRT495750 PDE4C phosphodiesterase 4C 2 4
MIRT500367 ZNF385A zinc finger protein 385A 2 2
MIRT501161 SLC10A7 solute carrier family 10 member 7 2 6
MIRT501702 PCGF3 polycomb group ring finger 3 2 6
MIRT504922 PDRG1 p53 and DNA damage regulated 1 2 2
MIRT517945 TRIM59 tripartite motif containing 59 2 2
MIRT524212 DDI2 DNA damage inducible 1 homolog 2 2 6
MIRT531186 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT531972 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT558055 EVI5L ecotropic viral integration site 5 like 2 2
MIRT560482 LACE1 AFG1 like ATPase 2 2
MIRT563217 FXN frataxin 2 2
MIRT569095 FSCN1 fascin actin-bundling protein 1 2 2
MIRT569522 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 2
MIRT569531 CTTN cortactin 2 2
MIRT569848 RGS5 regulator of G protein signaling 5 2 2
MIRT570738 ANKRD52 ankyrin repeat domain 52 2 2
MIRT574140 MARVELD1 MARVEL domain containing 1 2 2
MIRT615994 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT628493 ZNF556 zinc finger protein 556 2 2
MIRT633451 KLLN killin, p53-regulated DNA replication inhibitor 2 2
MIRT649054 SLC1A2 solute carrier family 1 member 2 2 2
MIRT649340 HEXA hexosaminidase subunit alpha 2 2
MIRT670226 PTCHD1 patched domain containing 1 2 2
MIRT670666 KIAA1551 KIAA1551 2 2
MIRT671452 CDH7 cadherin 7 2 2
MIRT671729 ZNF451 zinc finger protein 451 2 2
MIRT690285 ZNF154 zinc finger protein 154 2 2
MIRT700575 PRSS22 protease, serine 22 2 2
MIRT701411 NKRF NFKB repressing factor 2 2
MIRT711877 VASP vasodilator stimulated phosphoprotein 2 2
MIRT712082 UNC13A unc-13 homolog A 2 2
MIRT712523 CYTH2 cytohesin 2 2 2
MIRT712751 GMDS GDP-mannose 4,6-dehydratase 2 2
MIRT714681 PRX periaxin 2 2
MIRT714718 VPS8 VPS8, CORVET complex subunit 2 2
MIRT717508 HRNR hornerin 2 2
MIRT717650 THBS2 thrombospondin 2 2 2
MIRT719592 PIAS4 protein inhibitor of activated STAT 4 2 2
MIRT720521 PTGR2 prostaglandin reductase 2 2 2
MIRT721295 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT724922 VPS18 VPS18, CORVET/HOPS core subunit 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6787 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6787-5p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6787-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6787-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-6787-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6787-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-6787-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-6787-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-6787-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-6787-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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