pre-miRNA Information
pre-miRNA hsa-mir-2115   
Genomic Coordinates chr3: 48316360 - 48316459
Description Homo sapiens miR-2115 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2115-3p
Sequence 58| CAUCAGAAUUCAUGGAGGCUAG |79
Evidence Experimental
Experiments 454
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31490809 22 COSMIC
COSN31579735 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs543123304 18 dbSNP
rs1450988157 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol INSIG2   
Synonyms INSIG-2
Description insulin induced gene 2
Transcript NM_016133   
Expression
Putative miRNA Targets on INSIG2
3'UTR of INSIG2
(miRNA target sites are highlighted)
>INSIG2|NM_016133|3'UTR
   1 AGAAGGCAAAAAATATCTTTTGTACAGAAAAGCAAGATGAAAAGGATGTGAAATGGTAGATATACCAACAAAACTTCAGA
  81 CTGTAAAATTGCCAGGATGCAGTTTTCCCCTTGATTGGCGTGTGTGTATATATGGATAAATATATATATACACACACACA
 161 TATTACTGCAATCTGTGATTGCTTCATCTGTAAATCAGTTGTAAACCTTTACATATTTGACTTAAATAACTGTAAGATAT
 241 ATATGTACTACATTAAAAAGTGTTGATTAATAGATGAAATTTTTAAATTAATTTTTTAAAACATGCCATACATTGTATCA
 321 CAATGTTAATGTGCCAAGATATTGTTCCTGTCATGCAGAGTATAAGAATGCTTTGAACAATTTGTAGACTTAGTGAAATA
 401 AAATAAGAGGAAAGCCAAAAACAAACAAACAAAAAGCATATGGGGAGCTGGTATTTTCTCTTTAGCTTACTGTTGTGCCT
 481 TTTTATTTTTCTAATCACAGCAGTATGAGTTATGAGTGCCCTAATTTGTGGTTAGTTTCTAATTTAATGTTGTTTCATAG
 561 AGTTTGGAGTGTTTTGATACAGGGTGAAAATGAACTTCTGGTTTCAAACCTGCGTTACTGGAGACAGCCCAAAGAGTAAT
 641 TTTCTGTTTTGACAGGTTTTACTGGAAGTATATGTGATGAGCAGAAGAGGTTATCAGCATTAAATTGTTTTGGTTCTAAA
 721 TTTGGAACAGTATATATAATTAAAAGTAAGGAACATTAGAGGATTTAATTAGAATAAATACATGTTTTGGAAATACAGTG
 801 ACCTCTTGCAGTGTCACAAAAGTGCAAAGTGATATTAGCTGTCATCTGCAATACAGAATCTCATTGCTTTTGCACATGGA
 881 GCATATAGGAAACTCCAAACAGATCACAATGAGGTTTCTAAATCTGTTGGGTTCTGTCTTCTATTGGGTTCTGTGAAGCA
 961 AACCACTGTAGCTTTAGCTGGGTTCAGTCATATGACTCGTTGGTGGAATGCCTAGGTTTTTCATCTTACATGCAGTCTTG
1041 GGGGTGGATGAATACATAATTTCTCATGTATTCGTGTATCCATTAGTGAATAGTTCAAGTCTGTTTAAGAGTGTATTGAG
1121 ATGGCATTCTCTGCATGTTAAAGATCTTAATGGCAACCAGCACCTCTTAAGTATGGTTTAAACATATTCTTAGCTAATTT
1201 TTTCCATTAGTTTTTGAAATTGGTGGCAGTTGTCTGATCCACAAGGGCAAGATCTTCTGAGTACTCTGGGGTGTGAGTAT
1281 GTGTGCACACGTGTGTGTTGGAGTGAGTGAGAGAATGTGTCTGTGCATGTGGCCATGCTTTCCTAGAATGTCAAGTAGAT
1361 ATTTTTACACTTTGAGTTTTAAAGCAATTACTATCAGACTGAGATCTTGTATGCCAAACTTTAATCTGCTTTTATGTTTT
1441 CAGGCTGAAGGTGTGAAAATCCTAAGAGGATTTCATATTGAATATGTGTACACAATCTTAACTATCGTGGTGGAAAACAT
1521 ACTACTATAATTTATTATTATATCTTCCAGATAATGTTATTCATTTAGAACAAATAAGGTATATTTTTTAGAATCAACTT
1601 TGTAAGCACTATAAAATCTTTAATAAGTTATAAGGTCTATGATGTGTTTACTTTAAAAATTGCTGTTAAAAGCAACACGT
1681 ATTAAATATGTAATTATCATCTGGGTTAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaucggaggUACUU-AAGACUAc 5'
                   ||||| |||||:| 
Target 5' agggtgaaaATGAACTTCTGGTt 3'
581 - 603 141.00 -9.70
2
miRNA  3' gaUCGGAGGUACUUAAGACUAc 5'
            ||::|  | | :||:|||| 
Target 5' agAGTTTGGA-GTGTTTTGATa 3'
559 - 579 135.00 -6.00
3
miRNA  3' gaucGGAGGU-ACUUAAGACuac 5'
              |:||:| ||::|||||   
Target 5' ctgtCTTCTATTGGGTTCTGtga 3'
934 - 956 126.00 -18.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM4436511 1 COSMIC
COSN30113990 13 COSMIC
COSN15618788 18 COSMIC
COSN31543267 20 COSMIC
COSN31613699 22 COSMIC
COSN30146951 33 COSMIC
COSN5854636 33 COSMIC
COSN30543640 53 COSMIC
COSN30134151 55 COSMIC
COSN30475624 63 COSMIC
COSN23352169 65 COSMIC
COSN31600636 72 COSMIC
COSN30139158 76 COSMIC
COSN21382140 82 COSMIC
COSN30466400 108 COSMIC
COSN30191218 118 COSMIC
COSN30523401 121 COSMIC
COSN20097083 137 COSMIC
COSN19704981 138 COSMIC
COSN9075178 140 COSMIC
COSN13931008 150 COSMIC
COSN30119438 152 COSMIC
COSN30694375 160 COSMIC
COSN9075179 186 COSMIC
COSN30166529 203 COSMIC
COSN31554688 217 COSMIC
COSN26563732 246 COSMIC
COSN28812073 320 COSMIC
COSN31531969 370 COSMIC
COSN6204353 394 COSMIC
COSN31564655 416 COSMIC
COSN7330581 438 COSMIC
COSN31520620 489 COSMIC
COSN21560752 766 COSMIC
COSN30541129 1237 COSMIC
COSN1781572 1263 COSMIC
COSN26604260 1323 COSMIC
COSN31571027 1327 COSMIC
COSN16129694 1569 COSMIC
COSN21216602 1643 COSMIC
COSN31516395 1698 COSMIC
COSN29244888 1706 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs143040544 2 dbSNP
rs745865214 8 dbSNP
rs771994823 13 dbSNP
rs1285658895 16 dbSNP
rs775437767 17 dbSNP
rs747054304 19 dbSNP
rs1232871129 21 dbSNP
rs1254277592 27 dbSNP
rs1341600076 36 dbSNP
rs1197415815 38 dbSNP
rs768782150 39 dbSNP
rs184785376 42 dbSNP
rs762094148 45 dbSNP
rs377747768 46 dbSNP
rs773696224 48 dbSNP
rs1003849520 49 dbSNP
rs375359197 53 dbSNP
rs766839291 55 dbSNP
rs1208780204 56 dbSNP
rs752174694 57 dbSNP
rs1463077908 66 dbSNP
rs763482826 70 dbSNP
rs898222651 71 dbSNP
rs1363429401 75 dbSNP
rs1428425989 78 dbSNP
rs753541503 83 dbSNP
rs756891234 91 dbSNP
rs189296218 101 dbSNP
rs756695475 102 dbSNP
rs138198712 103 dbSNP
rs530281496 114 dbSNP
rs1022741949 116 dbSNP
rs181008966 119 dbSNP
rs1007075058 120 dbSNP
rs559232105 121 dbSNP
rs1435839141 125 dbSNP
rs1031509885 126 dbSNP
rs963846566 130 dbSNP
rs1156976354 133 dbSNP
rs11407321 136 dbSNP
rs200304846 136 dbSNP
rs140052415 138 dbSNP
rs147649891 139 dbSNP
rs1026522795 140 dbSNP
rs879544679 150 dbSNP
rs1180582592 152 dbSNP
rs955962829 154 dbSNP
rs951002929 156 dbSNP
rs992777555 158 dbSNP
rs988073576 162 dbSNP
rs746332695 165 dbSNP
rs917264290 169 dbSNP
rs1488598293 174 dbSNP
rs970104382 187 dbSNP
rs1290811161 195 dbSNP
rs1243468566 200 dbSNP
rs201455940 203 dbSNP
rs534455876 206 dbSNP
rs1424703375 215 dbSNP
rs1228251175 216 dbSNP
rs1232307997 218 dbSNP
rs1325870355 227 dbSNP
rs1316294949 232 dbSNP
rs1167561846 233 dbSNP
rs980563134 245 dbSNP
rs1409309731 248 dbSNP
rs772476872 253 dbSNP
rs1392608311 255 dbSNP
rs975887905 261 dbSNP
rs935792717 263 dbSNP
rs1052977609 272 dbSNP
rs1370904164 278 dbSNP
rs921390772 280 dbSNP
rs778442462 283 dbSNP
rs559207378 289 dbSNP
rs1451868984 304 dbSNP
rs913143994 307 dbSNP
rs577515567 324 dbSNP
rs1220013097 343 dbSNP
rs1346491721 344 dbSNP
rs544585131 357 dbSNP
rs745519084 363 dbSNP
rs1275280588 368 dbSNP
rs1051274199 385 dbSNP
rs908767822 390 dbSNP
rs1268533218 396 dbSNP
rs1379820310 408 dbSNP
rs889426116 412 dbSNP
rs1416320405 422 dbSNP
rs1286299937 423 dbSNP
rs940276238 427 dbSNP
rs771827956 431 dbSNP
rs1038488043 432 dbSNP
rs898284789 443 dbSNP
rs1409931451 452 dbSNP
rs994959632 471 dbSNP
rs1435727392 479 dbSNP
rs867506962 492 dbSNP
rs78663648 495 dbSNP
rs141434991 506 dbSNP
rs1012620134 507 dbSNP
rs1196761479 518 dbSNP
rs1044536231 536 dbSNP
rs1252354638 548 dbSNP
rs1180786318 550 dbSNP
rs1014437984 558 dbSNP
rs1436061226 559 dbSNP
rs538778221 561 dbSNP
rs541934995 566 dbSNP
rs1280591353 568 dbSNP
rs906963998 572 dbSNP
rs1324291161 582 dbSNP
rs1024571150 584 dbSNP
rs1237348030 585 dbSNP
rs970427406 602 dbSNP
rs114051580 610 dbSNP
rs1033507442 611 dbSNP
rs1441870692 613 dbSNP
rs186254596 614 dbSNP
rs1469879531 615 dbSNP
rs75518380 615 dbSNP
rs1011428002 619 dbSNP
rs1173628035 634 dbSNP
rs1458527484 635 dbSNP
rs1412225202 640 dbSNP
rs1021568505 644 dbSNP
rs1472040561 647 dbSNP
rs776981169 653 dbSNP
rs867761260 671 dbSNP
rs975477391 674 dbSNP
rs115523823 690 dbSNP
rs766591908 691 dbSNP
rs955455707 691 dbSNP
rs986945680 698 dbSNP
rs1460809446 700 dbSNP
rs1174749199 708 dbSNP
rs1242647488 724 dbSNP
rs1201825621 731 dbSNP
rs532336840 734 dbSNP
rs908694233 735 dbSNP
rs191007986 736 dbSNP
rs1223580796 740 dbSNP
rs1039019091 747 dbSNP
rs568779736 761 dbSNP
rs1454045709 763 dbSNP
rs1349608850 769 dbSNP
rs1382653982 773 dbSNP
rs948350720 780 dbSNP
rs1280303427 781 dbSNP
rs1375808680 783 dbSNP
rs181492204 793 dbSNP
rs886582844 795 dbSNP
rs906931499 799 dbSNP
rs1398756458 804 dbSNP
rs1415773656 806 dbSNP
rs1002596439 809 dbSNP
rs1052825207 813 dbSNP
rs1163943857 814 dbSNP
rs548318294 820 dbSNP
rs891615558 822 dbSNP
rs1383246957 833 dbSNP
rs1181854601 835 dbSNP
rs1011440308 850 dbSNP
rs1466256112 851 dbSNP
rs1349207883 869 dbSNP
rs1242927431 874 dbSNP
rs1213697023 876 dbSNP
rs1014380751 877 dbSNP
rs1292518121 880 dbSNP
rs1273139966 882 dbSNP
rs1359383421 884 dbSNP
rs1313510591 885 dbSNP
rs1482903247 886 dbSNP
rs56396683 894 dbSNP
rs1287772296 896 dbSNP
rs765343640 899 dbSNP
rs1001931205 901 dbSNP
rs1303555617 904 dbSNP
rs554999722 910 dbSNP
rs573988053 927 dbSNP
rs534392262 929 dbSNP
rs1425321589 934 dbSNP
rs1429034883 942 dbSNP
rs1420400943 944 dbSNP
rs955384287 949 dbSNP
rs988870458 962 dbSNP
rs1271258978 968 dbSNP
rs1223731293 969 dbSNP
rs986870296 979 dbSNP
rs1290238797 990 dbSNP
rs1020393400 993 dbSNP
rs955152738 995 dbSNP
rs372404205 999 dbSNP
rs767338653 1000 dbSNP
rs113649402 1016 dbSNP
rs1283484704 1021 dbSNP
rs1404135166 1022 dbSNP
rs755844747 1029 dbSNP
rs1309588927 1031 dbSNP
rs1253026969 1033 dbSNP
rs942663268 1042 dbSNP
rs974271261 1049 dbSNP
rs765304555 1050 dbSNP
rs1330726137 1064 dbSNP
rs1431759402 1064 dbSNP
rs1486116 1066 dbSNP
rs1267256650 1068 dbSNP
rs919572198 1074 dbSNP
rs542904546 1075 dbSNP
rs1313392075 1077 dbSNP
rs753418976 1097 dbSNP
rs1263196709 1102 dbSNP
rs1371762931 1104 dbSNP
rs1236610380 1108 dbSNP
rs980152500 1114 dbSNP
rs1342076316 1121 dbSNP
rs1196739596 1122 dbSNP
rs928285485 1137 dbSNP
rs1449491664 1138 dbSNP
rs571110137 1144 dbSNP
rs756932052 1148 dbSNP
rs753780482 1157 dbSNP
rs1290689755 1162 dbSNP
rs1046762986 1168 dbSNP
rs1253264878 1170 dbSNP
rs1469539092 1171 dbSNP
rs1427395471 1172 dbSNP
rs896241221 1176 dbSNP
rs1420011166 1187 dbSNP
rs938377554 1196 dbSNP
rs950216065 1210 dbSNP
rs1463024484 1219 dbSNP
rs1243291951 1240 dbSNP
rs1186129766 1242 dbSNP
rs1202470910 1251 dbSNP
rs1320987942 1252 dbSNP
rs1262054545 1255 dbSNP
rs1239540786 1267 dbSNP
rs1316064825 1269 dbSNP
rs1045932001 1270 dbSNP
rs1397752792 1272 dbSNP
rs1052792807 1279 dbSNP
rs1383430084 1286 dbSNP
rs1337533154 1289 dbSNP
rs538184595 1291 dbSNP
rs947166943 1292 dbSNP
rs1001817148 1301 dbSNP
rs1411412808 1301 dbSNP
rs1042910071 1302 dbSNP
rs893112980 1307 dbSNP
rs1404587739 1309 dbSNP
rs1157369796 1317 dbSNP
rs1447040190 1318 dbSNP
rs1386341497 1320 dbSNP
rs756866365 1324 dbSNP
rs1182449019 1328 dbSNP
rs35039067 1335 dbSNP
rs185746544 1339 dbSNP
rs1485321386 1344 dbSNP
rs1258809552 1351 dbSNP
rs1247875686 1354 dbSNP
rs1360083272 1356 dbSNP
rs996091499 1360 dbSNP
rs574500947 1369 dbSNP
rs1008465356 1383 dbSNP
rs541873654 1388 dbSNP
rs1383056378 1389 dbSNP
rs964241669 1392 dbSNP
rs745347077 1394 dbSNP
rs1015648551 1396 dbSNP
rs547234878 1401 dbSNP
rs973991260 1404 dbSNP
rs1272258416 1409 dbSNP
rs1382013547 1412 dbSNP
rs1163450748 1414 dbSNP
rs1443298908 1415 dbSNP
rs1193268262 1421 dbSNP
rs1354629879 1427 dbSNP
rs1259155075 1430 dbSNP
rs1228124163 1433 dbSNP
rs961493208 1435 dbSNP
rs1490439498 1441 dbSNP
rs1273354929 1459 dbSNP
rs1290735248 1461 dbSNP
rs1220219432 1470 dbSNP
rs1469590056 1476 dbSNP
rs76165043 1477 dbSNP
rs1272061824 1479 dbSNP
rs757965809 1488 dbSNP
rs11547750 1492 dbSNP
rs951009455 1493 dbSNP
rs1276495181 1494 dbSNP
rs1246936655 1503 dbSNP
rs1346591811 1505 dbSNP
rs1302891684 1506 dbSNP
rs773367809 1508 dbSNP
rs1195195898 1511 dbSNP
rs970654700 1520 dbSNP
rs1399239990 1526 dbSNP
rs1168002518 1528 dbSNP
rs553222295 1532 dbSNP
rs980366574 1550 dbSNP
rs1472308288 1551 dbSNP
rs1165381803 1555 dbSNP
rs1480543947 1559 dbSNP
rs1268000289 1564 dbSNP
rs1197002577 1574 dbSNP
rs1439506422 1579 dbSNP
rs1418839618 1582 dbSNP
rs1196486638 1583 dbSNP
rs928921766 1597 dbSNP
rs938345071 1603 dbSNP
rs1157004939 1604 dbSNP
rs1225623821 1609 dbSNP
rs988437234 1612 dbSNP
rs1283106373 1632 dbSNP
rs1382878516 1633 dbSNP
rs1046299673 1636 dbSNP
rs1338050528 1640 dbSNP
rs1320786293 1642 dbSNP
rs927460581 1646 dbSNP
rs912948827 1647 dbSNP
rs370115667 1652 dbSNP
rs937518213 1653 dbSNP
rs947177677 1663 dbSNP
rs1043224426 1678 dbSNP
rs868334271 1679 dbSNP
rs900323193 1680 dbSNP
rs553845082 1696 dbSNP
rs1294354953 1701 dbSNP
rs1181058266 1702 dbSNP
rs1435974018 1705 dbSNP
rs1051680387 1706 dbSNP
rs1205625955 1713 dbSNP
rs1324549913 1715 dbSNP
rs572967716 1715 dbSNP
rs1353357509 1720 dbSNP
rs1280474911 1732 dbSNP
rs1226236752 1733 dbSNP
rs1375313916 1738 dbSNP
rs1338152029 1752 dbSNP
rs1452646292 1757 dbSNP
rs1018790761 1764 dbSNP
rs1402062235 1766 dbSNP
rs963881157 1768 dbSNP
rs1157778535 1779 dbSNP
rs995746712 1783 dbSNP
rs890381664 1787 dbSNP
rs1185499668 1798 dbSNP
rs1206389426 1799 dbSNP
rs1461792449 1805 dbSNP
rs1242591293 1806 dbSNP
rs1208338303 1811 dbSNP
rs1448955098 1813 dbSNP
rs1285468061 1830 dbSNP
rs951332639 1831 dbSNP
rs1352160835 1832 dbSNP
rs1008199072 1839 dbSNP
rs1015615572 1849 dbSNP
rs1246105993 1849 dbSNP
rs897207706 1851 dbSNP
rs1441833442 1860 dbSNP
rs982399136 1869 dbSNP
rs766697838 1877 dbSNP
rs1345402590 1883 dbSNP
rs866956910 1884 dbSNP
rs1317389056 1897 dbSNP
rs1027513418 1898 dbSNP
rs1367401600 1906 dbSNP
rs1180238050 1919 dbSNP
rs970241622 1948 dbSNP
rs1443902290 1949 dbSNP
rs751990299 1955 dbSNP
rs1001695028 1958 dbSNP
rs1035862886 1966 dbSNP
rs1180182103 1967 dbSNP
rs1476521904 1970 dbSNP
rs1242852036 1979 dbSNP
rs769085247 1983 dbSNP
rs1487485104 1984 dbSNP
rs1370265922 1985 dbSNP
rs1160438146 1989 dbSNP
rs937522476 1997 dbSNP
rs1359340516 1999 dbSNP
rs1400676534 2011 dbSNP
rs1287199677 2015 dbSNP
rs988414410 2017 dbSNP
rs781694729 2027 dbSNP
rs1362227922 2032 dbSNP
rs544857292 2039 dbSNP
rs1269181378 2042 dbSNP
rs1313839366 2046 dbSNP
rs1347210405 2052 dbSNP
rs201268037 2064 dbSNP
rs1303533772 2066 dbSNP
rs1424005429 2067 dbSNP
rs1357718212 2079 dbSNP
rs748343180 2080 dbSNP
rs150819265 2088 dbSNP
rs572245343 2089 dbSNP
rs1287252962 2091 dbSNP
rs540403613 2095 dbSNP
rs1411693785 2102 dbSNP
rs564957723 2103 dbSNP
rs1193278368 2108 dbSNP
rs1240553756 2110 dbSNP
rs138149840 2116 dbSNP
rs556562238 2116 dbSNP
rs66499082 2116 dbSNP
rs745365943 2116 dbSNP
rs756311186 2116 dbSNP
rs1271588136 2117 dbSNP
rs78903265 2119 dbSNP
rs1253795303 2124 dbSNP
rs1200581520 2137 dbSNP
rs35808688 2148 dbSNP
rs1245417314 2149 dbSNP
rs1042008922 2153 dbSNP
rs921717356 2154 dbSNP
rs1271650186 2159 dbSNP
rs931795048 2161 dbSNP
rs1282422178 2164 dbSNP
rs891097405 2170 dbSNP
rs1051605483 2171 dbSNP
rs1325232539 2174 dbSNP
rs911784813 2183 dbSNP
rs1404036159 2186 dbSNP
rs1365444831 2205 dbSNP
rs1299767277 2211 dbSNP
rs940605617 2212 dbSNP
rs530516117 2233 dbSNP
rs544192025 2236 dbSNP
rs897140809 2248 dbSNP
rs1431646331 2254 dbSNP
rs1177602086 2255 dbSNP
rs376429722 2256 dbSNP
rs1179510752 2259 dbSNP
rs1481245471 2267 dbSNP
rs1237099213 2270 dbSNP
rs191580372 2273 dbSNP
rs1026806349 2289 dbSNP
rs1222696229 2292 dbSNP
rs887009725 2297 dbSNP
rs1004063200 2304 dbSNP
rs183087080 2305 dbSNP
rs1224335610 2308 dbSNP
rs1372507396 2315 dbSNP
rs548256100 2317 dbSNP
rs1330779200 2325 dbSNP
rs139239474 2333 dbSNP
rs1001622886 2337 dbSNP
rs980848081 2343 dbSNP
rs1033426899 2344 dbSNP
rs114333409 2347 dbSNP
rs960222103 2352 dbSNP
rs796196868 2357 dbSNP
rs1176275908 2360 dbSNP
rs149592890 2361 dbSNP
rs538407678 2361 dbSNP
rs570978774 2371 dbSNP
rs1396756879 2373 dbSNP
rs1482068020 2399 dbSNP
rs188138752 2401 dbSNP
rs191014337 2407 dbSNP
rs568460772 2409 dbSNP
rs1238081955 2411 dbSNP
rs1385142526 2422 dbSNP
rs753653538 2424 dbSNP
rs946208235 2427 dbSNP
rs1395729005 2436 dbSNP
rs1400268619 2442 dbSNP
rs978837631 2443 dbSNP
rs1454598438 2450 dbSNP
rs1329963947 2452 dbSNP
rs921668163 2462 dbSNP
rs763125109 2463 dbSNP
rs1446944139 2466 dbSNP
rs977634770 2474 dbSNP
rs535447604 2480 dbSNP
rs1305448656 2485 dbSNP
rs150045288 2492 dbSNP
rs1421700306 2494 dbSNP
rs1263319036 2497 dbSNP
rs953122579 2500 dbSNP
rs1487809136 2513 dbSNP
rs1283588067 2514 dbSNP
rs1251721112 2516 dbSNP
rs987278534 2518 dbSNP
rs1481062927 2521 dbSNP
rs911708227 2525 dbSNP
rs1360059883 2527 dbSNP
rs1266127049 2528 dbSNP
rs1244075441 2533 dbSNP
rs940533607 2543 dbSNP
rs1036273371 2551 dbSNP
rs1265557316 2552 dbSNP
rs756773932 2570 dbSNP
rs1382968395 2572 dbSNP
rs1340345148 2574 dbSNP
rs1296734619 2577 dbSNP
rs1273272342 2578 dbSNP
rs920545274 2581 dbSNP
rs931289180 2589 dbSNP
rs1366668784 2592 dbSNP
rs1048881728 2594 dbSNP
rs1040145546 2595 dbSNP
rs1374454378 2603 dbSNP
rs1170763647 2604 dbSNP
rs899903162 2605 dbSNP
rs1397429481 2610 dbSNP
rs931422712 2613 dbSNP
rs1048481130 2619 dbSNP
rs1170165643 2625 dbSNP
rs553781951 2629 dbSNP
rs370855265 2630 dbSNP
rs572183654 2635 dbSNP
rs1374036032 2641 dbSNP
rs905916664 2652 dbSNP
rs144265492 2676 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_ControlB_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaUC-GGAGGUAC-UUAAGacuac 5'
            || :| ||| | :||||     
Target 5' -aAGUUCCCCAGGUGAUUC----- 3'
1 - 18
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_ControlB_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control B
Location of target site ENST00000245787.4 | 3UTR | AAGUUCCCCAGGUGAUUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
UCEC -0.995 0.03 -1.000 0.5 3 Click to see details
BLCA 0.622 0.09 0.314 0.27 6 Click to see details
HNSC 0.255 0.19 0.204 0.24 14 Click to see details
STAD 0.347 0.39 0.500 0.33 3 Click to see details
LUSC 0.072 0.4 0.014 0.48 15 Click to see details
BRCA 0.027 0.44 0.117 0.27 31 Click to see details
LIHC -0.088 0.46 0.000 0.5 4 Click to see details
LIHC -0.088 0.46 0.000 0.5 4 Click to see details
LIHC -0.088 0.46 0.000 0.5 4 Click to see details
LIHC -0.088 0.46 0.000 0.5 4 Click to see details
LIHC -0.088 0.46 0.000 0.5 4 Click to see details
LIHC -0.088 0.46 0.000 0.5 4 Click to see details
LIHC -0.088 0.46 0.000 0.5 4 Click to see details
80 hsa-miR-2115-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057089 DDIT4 DNA damage inducible transcript 4 2 2
MIRT071216 FCF1 FCF1, rRNA-processing protein 2 2
MIRT226901 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT235961 BACH1 BTB domain and CNC homolog 1 2 2
MIRT294569 ZNF460 zinc finger protein 460 2 4
MIRT321046 RAC1 Rac family small GTPase 1 2 4
MIRT359666 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT366451 KLHL15 kelch like family member 15 2 2
MIRT405375 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT441794 TCEAL5 transcription elongation factor A like 5 2 2
MIRT443295 TCEAL3 transcription elongation factor A like 3 2 2
MIRT455275 DDX39B DExD-box helicase 39B 2 2
MIRT458523 C5orf22 chromosome 5 open reading frame 22 2 2
MIRT464960 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT466848 STX6 syntaxin 6 2 2
MIRT469252 RHOB ras homolog family member B 2 2
MIRT469825 RAB14 RAB14, member RAS oncogene family 2 4
MIRT470047 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT471420 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT472024 NPM1 nucleophosmin 1 2 2
MIRT484156 CENPN centromere protein N 2 2
MIRT485490 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT490462 PROSER2 proline and serine rich 2 2 2
MIRT493069 MTCH1 mitochondrial carrier 1 2 2
MIRT493573 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 8
MIRT494919 NDUFC2-KCTD14 NDUFC2-KCTD14 readthrough 2 2
MIRT500439 ZMAT3 zinc finger matrin-type 3 2 2
MIRT500931 SRPR SRP receptor alpha subunit 2 4
MIRT501551 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT501809 NEURL1B neuralized E3 ubiquitin protein ligase 1B 2 2
MIRT502415 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT506504 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT507861 CCNE2 cyclin E2 2 2
MIRT510511 YOD1 YOD1 deubiquitinase 2 6
MIRT516073 RAB42 RAB42, member RAS oncogene family 2 2
MIRT519030 KYNU kynureninase 2 6
MIRT521762 PPIL1 peptidylprolyl isomerase like 1 2 4
MIRT522898 KCNJ3 potassium voltage-gated channel subfamily J member 3 2 4
MIRT527370 MGARP mitochondria localized glutamic acid rich protein 2 2
MIRT530691 C8orf46 chromosome 8 open reading frame 46 2 2
MIRT530867 TRUB1 TruB pseudouridine synthase family member 1 2 2
MIRT531832 MTPAP mitochondrial poly(A) polymerase 2 4
MIRT533035 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT533165 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT533464 TRIM71 tripartite motif containing 71 2 2
MIRT534331 SHCBP1 SHC binding and spindle associated 1 2 2
MIRT539372 ADSS adenylosuccinate synthase 2 6
MIRT545951 ZBTB10 zinc finger and BTB domain containing 10 2 2
MIRT553283 TSR1 TSR1, ribosome maturation factor 2 2
MIRT553532 TMEM185B transmembrane protein 185B 2 4
MIRT556480 LIPA lipase A, lysosomal acid type 2 2
MIRT556975 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT557697 GATA6 GATA binding protein 6 2 2
MIRT558901 CCDC58 coiled-coil domain containing 58 2 2
MIRT559224 BLMH bleomycin hydrolase 2 2
MIRT559827 SLPI secretory leukocyte peptidase inhibitor 2 2
MIRT563435 SLC3A2 solute carrier family 3 member 2 2 2
MIRT569270 PCDH11X protocadherin 11 X-linked 2 2
MIRT571386 JKAMP JNK1/MAPK8-associated membrane protein 2 2
MIRT572567 AFF1 AF4/FMR2 family member 1 2 2
MIRT610400 AR androgen receptor 2 2
MIRT611058 ZNF621 zinc finger protein 621 2 2
MIRT635118 TMEM233 transmembrane protein 233 2 2
MIRT641617 DEFB118 defensin beta 118 2 2
MIRT642146 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT647295 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT648155 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT652780 TENM3 teneurin transmembrane protein 3 2 2
MIRT657356 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT658718 ELN elastin 2 2
MIRT662441 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT665302 ZBTB38 zinc finger and BTB domain containing 38 2 2
MIRT699898 RUNX1 runt related transcription factor 1 2 2
MIRT700921 PDS5A PDS5 cohesin associated factor A 2 2
MIRT700992 PDE3A phosphodiesterase 3A 2 2
MIRT707397 DCAF4L1 DDB1 and CUL4 associated factor 4 like 1 2 2
MIRT711895 INSIG2 insulin induced gene 2 2 2
MIRT712072 XRCC5 X-ray repair cross complementing 5 2 2
MIRT716121 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT724470 SMAD2 SMAD family member 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2115 Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-mir-2115 Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-2115-3p Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-2115-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-2115-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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