pre-miRNA Information | |
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pre-miRNA | hsa-mir-7161 |
Genomic Coordinates | chr6: 158609707 - 158609790 |
Description | Homo sapiens miR-7161 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||||||||||||||||||||
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Mature miRNA | hsa-miR-7161-5p | ||||||||||||||||||||||||
Sequence | 1| UAAAGACUGUAGAGGCAACUGGU |23 | ||||||||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||||||||
Experiments | Illumina | ||||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | TGFBR2 | ||||||||||||||||||||
Synonyms | AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGFR-2, TGFbeta-RII | ||||||||||||||||||||
Description | transforming growth factor beta receptor 2 | ||||||||||||||||||||
Transcript | NM_001024847 | ||||||||||||||||||||
Other Transcripts | NM_003242 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on TGFBR2 | |||||||||||||||||||||
3'UTR of TGFBR2 (miRNA target sites are highlighted) |
>TGFBR2|NM_001024847|3'UTR 1 CTCTTCTGGGGCAGGCTGGGCCATGTCCAAAGAGGCTGCCCCTCTCACCAAAGAACAGAGGCAGCAGGAAGCTGCCCCTG 81 AACTGATGCTTCCTGGAAAACCAAGGGGGTCACTCCCCTCCCTGTAAGCTGTGGGGATAAGCAGAAACAACAGCAGCAGG 161 GAGTGGGTGACATAGAGCATTCTATGCCTTTGACATTGTCATAGGATAAGCTGTGTTAGCACTTCCTCAGGAAATGAGAT 241 TGATTTTTACAATAGCCAATAACATTTGCACTTTATTAATGCCTGTATATAAATATGAATAGCTATGTTTTATATATATA 321 TATATATATCTATATATGTCTATAGCTCTATATATATAGCCATACCTTGAAAAGAGACAAGGAAAAACATCAAATATTCC 401 CAGGAAATTGGTTTTATTGGAGAACTCCAGAACCAAGCAGAGAAGGAAGGGACCCATGACAGCATTAGCATTTGACAATC 481 ACACATGCAGTGGTTCTCTGACTGTAAAACAGTGAACTTTGCATGAGGAAAGAGGCTCCATGTCTCACAGCCAGCTATGA 561 CCACATTGCACTTGCTTTTGCAAAATAATCATTCCCTGCCTAGCACTTCTCTTCTGGCCATGGAACTAAGTACAGTGGCA 641 CTGTTTGAGGACCAGTGTTCCCGGGGTTCCTGTGTGCCCTTATTTCTCCTGGACTTTTCATTTAAGCTCCAAGCCCCAAA 721 TCTGGGGGGCTAGTTTAGAAACTCTCCCTCAACCTAGTTTAGAAACTCTACCCCATCTTTAATACCTTGAATGTTTTGAA 801 CCCCACTTTTTACCTTCATGGGTTGCAGAAAAATCAGAACAGATGTCCCCATCCATGCGATTGCCCCACCATCTACTAAT 881 GAAAAATTGTTCTTTTTTTCATCTTTCCCCTGCACTTATGTTACTATTCTCTGCTCCCAGCCTTCATCCTTTTCTAAAAA 961 GGAGCAAATTCTCACTCTAGGCTTTATCGTGTTTACTTTTTCATTACACTTGACTTGATTTTCTAGTTTTCTATACAAAC 1041 ACCAATGGGTTCCATCTTTCTGGGCTCCTGATTGCTCAAGCACAGTTTGGCCTGATGAAGAGGATTTCAACTACACAATA 1121 CTATCATTGTCAGGACTATGACCTCAGGCACTCTAAACATATGTTTTGTTTGGTCAGCACAGCGTTTCAAAAAGTGAAGC 1201 CACTTTATAAATATTTGGAGATTTTGCAGGAAAATCTGGATCCCCAGGTAAGGATAGCAGATGGTTTTCAGTTATCTCCA 1281 GTCCACGTTCACAAAATGTGAAGGTGTGGAGACACTTACAAAGCTGCCTCACTTCTCACTGTAAACATTAGCTCTTTCCA 1361 CTGCCTACCTGGACCCCAGTCTAGGAATTAAATCTGCACCTAACCAAGGTCCCTTGTAAGAAATGTCCATTCAAGCAGTC 1441 ATTCTCTGGGTATATAATATGATTTTGACTACCTTATCTGGTGTTAAGATTTGAAGTTGGCCTTTTATTGGACTAAAGGG 1521 GAACTCCTTTAAGGGTCTCAGTTAGCCCAAGTTTCTTTTGCTTATATGTTAATAGTTTTACCCTCTGCATTGGAGAGAGG 1601 AGTGCTTTACTCCAAGAAGCTTTCCTCATGGTTACCGTTCTCTCCATCATGCCAGCCTTCTCAACCTTTGCAGAAATTAC 1681 TAGAGAGGATTTGAATGTGGGACACAAAGGTCCCATTTGCAGTTAGAAAATTTGTGTCCACAAGGACAAGAACAAAGTAT 1761 GAGCTTTAAAACTCCATAGGAAACTTGTTAATCAACAAAGAAGTGTTAATGCTGCAAGTAATCTCTTTTTTAAAACTTTT 1841 TGAAGCTACTTATTTTCAGCCAAATAGGAATATTAGAGAGGGACTGGTAGTGAGAATATCAGCTCTGTTTGGATGGTGGA 1921 AGGTCTCATTTTATTGAGATTTTTAAGATACATGCAAAGGTTTGGAAATAGAACCTCTAGGCACCCTCCTCAGTGTGGGT 2001 GGGCTGAGAGTTAAAGACAGTGTGGCTGCAGTAGCATAGAGGCGCCTAGAAATTCCACTTGCACCGTAGGGCATGCTGAT 2081 ACCATCCCAATAGCTGTTGCCCATTGACCTCTAGTGGTGAGTTTCTAGAATACTGGTCCATTCATGAGATATTCAAGATT 2161 CAAGAGTATTCTCACTTCTGGGTTATCAGCATAAACTGGAATGTAGTGTCAGAGGATACTGTGGCTTGTTTTGTTTATGT 2241 TTTTTTTTCTTATTCAAGAAAAAAGACCAAGGAATAACATTCTGTAGTTCCTAAAAATACTGACTTTTTTCACTACTATA 2321 CATAAAGGGAAAGTTTTATTCTTTTATGGAACACTTCAGCTGTACTCATGTATTAAAATAGGAATGTGAATGCTATATAC 2401 TCTTTTTATATCAAAAGTCTCAAGCACTTATTTTTATTCTATGCATTGTTTGTCTTTTACATAAATAAAATGTTTATTAG 2481 ATTGAATAAAGCAAAATACTCAGGTGAGCATCCTGCCTCCTGTTCCCATTCCTAGTAGCTAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HeLa | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in Chi_ControlB_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control B
... - Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Chi SW; Zang JB; Mele A; Darnell RB - Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
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CLIP-seq Support 1 for dataset Chi_ControlB_2A8_130_50 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | HeLa / HeLa cell Control B |
Location of target site | ENST00000359013.4 | 3UTR | UGGAGAAUAUAACAGUCU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 19536157 / Chi_HITSCLIP |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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94 hsa-miR-7161-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT131193 | INCENP | inner centromere protein | ![]() |
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2 | 4 | ||||||
MIRT318016 | CENPQ | centromere protein Q | ![]() |
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2 | 2 | ||||||
MIRT405275 | ZNF678 | zinc finger protein 678 | ![]() |
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2 | 2 | ||||||
MIRT442570 | CCDC59 | coiled-coil domain containing 59 | ![]() |
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2 | 2 | ||||||
MIRT442611 | CRIPT | CXXC repeat containing interactor of PDZ3 domain | ![]() |
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2 | 2 | ||||||
MIRT444013 | GOLGA8H | golgin A8 family member H | ![]() |
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2 | 2 | ||||||
MIRT444024 | GOLGA8M | golgin A8 family member M | ![]() |
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2 | 2 | ||||||
MIRT444339 | GOLGA6L4 | golgin A6 family-like 4 | ![]() |
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2 | 2 | ||||||
MIRT444611 | GOLGA6L10 | golgin A6 family-like 10 | ![]() |
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2 | 2 | ||||||
MIRT446342 | MAN1A2 | mannosidase alpha class 1A member 2 | ![]() |
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2 | 2 | ||||||
MIRT446558 | GOLGA8J | golgin A8 family member J | ![]() |
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2 | 2 | ||||||
MIRT447671 | PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | ![]() |
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2 | 2 | ||||||
MIRT447975 | MSH6 | mutS homolog 6 | ![]() |
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2 | 2 | ||||||
MIRT448895 | CNNM3 | cyclin and CBS domain divalent metal cation transport mediator 3 | ![]() |
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2 | 2 | ||||||
MIRT448936 | CHD7 | chromodomain helicase DNA binding protein 7 | ![]() |
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2 | 2 | ||||||
MIRT449414 | TRIM5 | tripartite motif containing 5 | ![]() |
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2 | 2 | ||||||
MIRT450291 | ADH5 | alcohol dehydrogenase 5 (class III), chi polypeptide | ![]() |
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2 | 2 | ||||||
MIRT454877 | PCNA | proliferating cell nuclear antigen | ![]() |
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2 | 4 | ||||||
MIRT456615 | SFMBT2 | Scm like with four mbt domains 2 | ![]() |
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2 | 2 | ||||||
MIRT462108 | TMEM214 | transmembrane protein 214 | ![]() |
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2 | 2 | ||||||
MIRT471923 | NRAS | NRAS proto-oncogene, GTPase | ![]() |
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2 | 4 | ||||||
MIRT474437 | KLHL21 | kelch like family member 21 | ![]() |
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2 | 2 | ||||||
MIRT476600 | G3BP1 | G3BP stress granule assembly factor 1 | ![]() |
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2 | 2 | ||||||
MIRT480573 | BZW1 | basic leucine zipper and W2 domains 1 | ![]() |
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2 | 2 | ||||||
MIRT483890 | IL20RB | interleukin 20 receptor subunit beta | ![]() |
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2 | 6 | ||||||
MIRT493363 | KIF5B | kinesin family member 5B | ![]() |
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2 | 2 | ||||||
MIRT494934 | TMEM167A | transmembrane protein 167A | ![]() |
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2 | 2 | ||||||
MIRT495915 | CLDN1 | claudin 1 | ![]() |
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2 | 2 | ||||||
MIRT501574 | PLEKHF2 | pleckstrin homology and FYVE domain containing 2 | ![]() |
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2 | 4 | ||||||
MIRT502193 | IGF1R | insulin like growth factor 1 receptor | ![]() |
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2 | 4 | ||||||
MIRT502928 | CDC42SE1 | CDC42 small effector 1 | ![]() |
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2 | 4 | ||||||
MIRT506393 | NUCKS1 | nuclear casein kinase and cyclin dependent kinase substrate 1 | ![]() |
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2 | 4 | ||||||
MIRT506570 | MNX1 | motor neuron and pancreas homeobox 1 | ![]() |
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2 | 4 | ||||||
MIRT509478 | GNL3L | G protein nucleolar 3 like | ![]() |
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2 | 6 | ||||||
MIRT518537 | FLCN | folliculin | ![]() |
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2 | 6 | ||||||
MIRT519577 | ZNFX1 | zinc finger NFX1-type containing 1 | ![]() |
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2 | 4 | ||||||
MIRT524088 | DNAJC10 | DnaJ heat shock protein family (Hsp40) member C10 | ![]() |
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2 | 4 | ||||||
MIRT524146 | LDHD | lactate dehydrogenase D | ![]() |
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2 | 4 | ||||||
MIRT524659 | C1orf50 | chromosome 1 open reading frame 50 | ![]() |
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2 | 10 | ||||||
MIRT526324 | UGT2A1 | UDP glucuronosyltransferase family 2 member A1 complex locus | ![]() |
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2 | 2 | ||||||
MIRT526566 | UGT2A2 | UDP glucuronosyltransferase family 2 member A2 | ![]() |
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2 | 2 | ||||||
MIRT526612 | ZNF780A | zinc finger protein 780A | ![]() |
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2 | 4 | ||||||
MIRT526889 | PLEKHG2 | pleckstrin homology and RhoGEF domain containing G2 | ![]() |
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2 | 2 | ||||||
MIRT527115 | ARHGAP15 | Rho GTPase activating protein 15 | ![]() |
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2 | 2 | ||||||
MIRT528023 | ACOT9 | acyl-CoA thioesterase 9 | ![]() |
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2 | 2 | ||||||
MIRT529589 | TMEM220 | transmembrane protein 220 | ![]() |
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2 | 2 | ||||||
MIRT532797 | STYK1 | serine/threonine/tyrosine kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT537099 | GPC6 | glypican 6 | ![]() |
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2 | 2 | ||||||
MIRT539070 | ATP6V1C1 | ATPase H+ transporting V1 subunit C1 | ![]() |
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2 | 2 | ||||||
MIRT545495 | DAPK2 | death associated protein kinase 2 | ![]() |
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2 | 2 | ||||||
MIRT545814 | ZNF608 | zinc finger protein 608 | ![]() |
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2 | 4 | ||||||
MIRT553533 | TMEM185B | transmembrane protein 185B | ![]() |
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2 | 4 | ||||||
MIRT557285 | HIST2H2BE | histone cluster 2 H2B family member e | ![]() |
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2 | 2 | ||||||
MIRT559552 | ARGLU1 | arginine and glutamate rich 1 | ![]() |
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2 | 4 | ||||||
MIRT561069 | EIF4A3 | eukaryotic translation initiation factor 4A3 | ![]() |
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2 | 2 | ||||||
MIRT561710 | PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | ![]() |
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2 | 2 | ||||||
MIRT561995 | LRRC58 | leucine rich repeat containing 58 | ![]() |
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2 | 2 | ||||||
MIRT565896 | NHS | NHS actin remodeling regulator | ![]() |
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2 | 2 | ||||||
MIRT567333 | HMGB1 | high mobility group box 1 | ![]() |
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2 | 2 | ||||||
MIRT568042 | CLDN12 | claudin 12 | ![]() |
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2 | 2 | ||||||
MIRT568315 | BAG4 | BCL2 associated athanogene 4 | ![]() |
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2 | 2 | ||||||
MIRT570677 | GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | ![]() |
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2 | 2 | ||||||
MIRT571047 | YRDC | yrdC N6-threonylcarbamoyltransferase domain containing | ![]() |
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2 | 2 | ||||||
MIRT571359 | SFT2D2 | SFT2 domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT571935 | LCOR | ligand dependent nuclear receptor corepressor | ![]() |
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2 | 2 | ||||||
MIRT572786 | ZNF277 | zinc finger protein 277 | ![]() |
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2 | 2 | ||||||
MIRT573936 | CNTNAP2 | contactin associated protein like 2 | ![]() |
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2 | 2 | ||||||
MIRT576962 | Anxa4 | annexin A4 | ![]() |
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2 | 3 | ||||||
MIRT608297 | KATNAL1 | katanin catalytic subunit A1 like 1 | ![]() |
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2 | 2 | ||||||
MIRT613342 | AFF1 | AF4/FMR2 family member 1 | ![]() |
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2 | 2 | ||||||
MIRT613529 | ANAPC7 | anaphase promoting complex subunit 7 | ![]() |
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2 | 2 | ||||||
MIRT614705 | TOR1AIP2 | torsin 1A interacting protein 2 | ![]() |
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2 | 2 | ||||||
MIRT616658 | ORAI1 | ORAI calcium release-activated calcium modulator 1 | ![]() |
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2 | 2 | ||||||
MIRT624731 | ANXA4 | annexin A4 | ![]() |
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2 | 3 | ||||||
MIRT626525 | TSC1 | TSC complex subunit 1 | ![]() |
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2 | 2 | ||||||
MIRT627647 | SCN1A | sodium voltage-gated channel alpha subunit 1 | ![]() |
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2 | 2 | ||||||
MIRT637423 | EPB41L3 | erythrocyte membrane protein band 4.1 like 3 | ![]() |
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2 | 2 | ||||||
MIRT641059 | TCP11L1 | t-complex 11 like 1 | ![]() |
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2 | 4 | ||||||
MIRT645591 | SAR1A | secretion associated Ras related GTPase 1A | ![]() |
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2 | 2 | ||||||
MIRT646455 | ZNF705A | zinc finger protein 705A | ![]() |
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2 | 2 | ||||||
MIRT656454 | MAPK6 | mitogen-activated protein kinase 6 | ![]() |
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2 | 2 | ||||||
MIRT676551 | TMPPE | transmembrane protein with metallophosphoesterase domain | ![]() |
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2 | 4 | ||||||
MIRT682720 | KIAA1456 | KIAA1456 | ![]() |
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2 | 2 | ||||||
MIRT698307 | TMEM2 | transmembrane protein 2 | ![]() |
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2 | 2 | ||||||
MIRT701906 | MMGT1 | membrane magnesium transporter 1 | ![]() |
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2 | 2 | ||||||
MIRT702228 | LONRF3 | LON peptidase N-terminal domain and ring finger 3 | ![]() |
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2 | 2 | ||||||
MIRT708642 | UBE2W | ubiquitin conjugating enzyme E2 W | ![]() |
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2 | 2 | ||||||
MIRT709326 | HMBOX1 | homeobox containing 1 | ![]() |
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2 | 2 | ||||||
MIRT711400 | RANBP2 | RAN binding protein 2 | ![]() |
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2 | 2 | ||||||
MIRT712130 | TGFBR2 | transforming growth factor beta receptor 2 | ![]() |
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2 | 2 | ||||||
MIRT714226 | ARMC10 | armadillo repeat containing 10 | ![]() |
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2 | 2 | ||||||
MIRT716914 | CACNB2 | calcium voltage-gated channel auxiliary subunit beta 2 | ![]() |
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2 | 2 | ||||||
MIRT723060 | FGD6 | FYVE, RhoGEF and PH domain containing 6 | ![]() |
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2 | 2 | ||||||
MIRT723846 | MN1 | MN1 proto-oncogene, transcriptional regulator | ![]() |
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2 | 2 |