miRTarBase - #MIRT712247


—
pre-miRNA Information
pre-miRNA hsa-mir-378f   
Genomic Coordinates chr1: 23929070 - 23929147
Description Homo sapiens miR-378f stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-378f
Sequence 52| ACUGGACUUGGAGCCAGAAG |71
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 18 1 + 23929138 29233923 MiREDiBase
A-to-I 19 1 + 23929139 29233923 MiREDiBase
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol RCC2   
Synonyms TD-60
Description regulator of chromosome condensation 2
Transcript NM_001136204   
Other Transcripts NM_018715   
Expression
Putative miRNA Targets on RCC2
3'UTR of RCC2
(miRNA target sites are highlighted)		 
>RCC2|NM_001136204|3'UTR
   1 TGCTCCCGGAGACTCCTCCGACTCCACACCTCTCGCGGCAGCTGTCATTTCCATGTGCACTGGGACGGGAAGTCAAACGA
  81 GGAATTTAAAAAAGCAAAAGTTGACCGAAGGTGCATTTTTGTTTAGACTCCCTGAGGTTCCGTTTTACACATGATCCAAC
 161 GTTAACTACCTTTTTTTCTGTATGCTTTCCAAAGTCCTTTTTTTTCCCTTAATGTTGAATTAAAATACTTGCTCATAGTT
 241 GATTTACCATTCCTACAAAAGAGGCAGAAACTTTGAGCAATCTAGGTTTTTTTTTTTTTTAAGTTTTTTCTTTCTTCCTC
 321 TCCTGAATACACTCCCCAAAACACCCCTTTCCAGTTACAATTAGCATCGTGATCCAAGCAGATGCCACATGGAAGAGGAA
 401 TCGCCATTTACTCAGAAAAAATGTCCCTTACAGGAACCGGCAGCAGCTAGGCAGTCACCGGCCCGCCTCCATCCAAAATC
 481 ACGCTCGCGTGCTTCGGAAGCATCCGGGTCACTCCTTCTCCGCTTTTTCTTGCAGATGGGCCTAGGCCGGTGTCGGTTCT
 561 GTTTCTCCCCTTGGCTGCCTGTACGCCCACAGCCTTCTGGCTGCGACATTATAGAATCGGCCGTGTCCCCCCTGGTGGGG
 641 GATTGGGGATCTGTGTTTAGCCATTTATATCTACTTTAGCTGTTAAAGAGGTCCAAATGAAAATCAGGTGATTGTGGAAC
 721 CATGGGGACTTGGGGGTGGGGCAGAGGTGGGAACATTTGTATCAGTTGAGTCAGCTTGGTGGCTCCCTGTGGAGCCAGGG
 801 CTGAGCCTTGTCACGCGCACTCGCCAATTAAGAGATGGACCAGCCAGCAGTCAAGTGCATTCTCCAGTCCTTGCAAGAAG
 881 GATCAGCCCTTTCTGTGCCAGCCTCGATCGCCTTGTGCTTTGGTCTCTTTTTCTCCCCCCCGCCTGGATCCTGCCTCGCG
 961 CGGGCCGTCCTGTTGCTGAGACTCGGGGTACCGTTCTGCTGACCCAGCTCCCTTTAGTCACGTTTGCTTGGCTCTGGTAC
1041 CAAATAGTTGGGATTACCGAAGAGTCCCCTTCCTTGCGTGTCAGCACGGATGCTGTGACTGCCACCTGCGTCCTCGTCAA
1121 GTGCCCGAGCTCGCCGCCGTGTGTGCTGCGCTGAGTGAGTTATGAGGTGCCTTTCCCGGAACCCTCCTCTCGCCTGGACC
1201 CAAGAGAGGCGACAGCTGTGGCTGGGGCTCTTGGTTTCCAGAGGGTCTGGACTGGTTTGGGTGCTTTAAAATAGATATTT
1281 AGTTCAGTGGTGCTTATGGGGGAGATGGGACTAGAACTTAAGTGTGAGACTTGGGTGGATGGGAAAGTTAAATATTGGTC
1361 TCTTCAAGTTTTTTTTTTCTTTTGCTTTGTTACCACTTGTCACTGTCTCCATGTTAAAATGCCAAAAATGATGTAGTTGT
1441 TGTTGCTTTTTTCCCTATTTTCCACCCCAGTCGCTCCTTACCGTGACTCCTGCCCTTGGAGGGCATGTAGCAGTGTCTGT
1521 CCTGCCAGTCCCAAGGCCCTGTGGGAGGAGACTGGCCTGCATCTCTCTAAGACTTAGTCTGACGCCACGCGCATCTCTTG
1601 TTCTGTGTTCAATCAGTAGTCCAGGGGAGAAGCTTCTGCTACTTCAGAGCTTTGCTAAACTAACCTAATTTGTCCAAATC
1681 ACCCCAAAACCACCATCTCTGACGTAAGCTTCCATGCGACAGCCTGATCCGTTTCCCTGGACAGGTCTCTTTCCTGGAAT
1761 GCAGCCCAGGCACCTGTGCTCCTGGCACCCTTGAGGTCTCTCCTTTGAGCCGTGGTCACCGAGAGGGTTGAGGACGCAGC
1841 ACCCGAGGTCCCAGCCTTTGCAGGAGCCTCCCTGGGCTTAGCTGGACTTAGATCTTCGGTGGCCTCATGTAAACGTGGCA
1921 GCCAGCCTCTTCTAGAACCCTAGCCCAGGGACTGGAGCAGGAAAGGGACCTTCAAAGTGAAGACTGCCTTGTCCCGCAGC
2001 TCCTTCTGGCTTAGATTGAAAAATGGGCTTCCTAATGGGTTAAATCCTTTAAAACAAGGAGTTGTGGGGGAAGGGTGTCG
2081 TGCACTCCTAGAGAAAGGTACACAGTTGCCCGGTTGGGAATGTGCTTGGCGCTGACCCTGCGGGCATCTGACTGGTCTTC
2161 CAGCTCAGGAAAAAGAATTTGAAAGAGGCTTAGCGTGAAGGGGAATCAAAGAGGAGGTTGTGATTTGGTCGAAGGTGCCT
2241 GGTTTAGTGCTGTAATTGTCTTATTATTTTTTTTATATATATATTTCTTGGAGTAAACATTTTAAATAAACAACAACATT
2321 GTCTACTGTCTTGGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaAGAC-CGAG---GU--UCAGGUCa 5'
            |||| |:||   ||  ||||||| 
Target 5' gtTCTGTGTTCAATCAGTAGTCCAGg 3'
 1600 - 1625 156.00 -18.20
2 
miRNA  3' gaagaccgagguUCAGGUCa 5'
                      |||:||| 
Target 5' aaatagatatttAGTTCAGt 3'
 1269 - 1288 124.00 -8.50
3 
miRNA  3' gaAGAC---CG--AGG-UUCAGGuca 5'
            ||||   ||  ||| ||||||   
Target 5' ttTCTGTATGCTTTCCAAAGTCCttt 3'
 175 - 200 120.00 -13.92
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30477117 24 COSMIC
COSN26991859 36 COSMIC
COSN30450092 52 COSMIC
COSN16131921 66 COSMIC
COSN24404701 67 COSMIC
COSN30184592 79 COSMIC
COSN30509162 91 COSMIC
COSN26586602 95 COSMIC
COSN31577741 109 COSMIC
COSN31561106 110 COSMIC
COSN30160199 134 COSMIC
COSN30505778 142 COSMIC
COSN31592753 160 COSMIC
COSN30113713 164 COSMIC
COSN30136026 205 COSMIC
COSN28644362 366 COSMIC
COSN19058357 717 COSMIC
COSN6009877 761 COSMIC
COSN31532081 1166 COSMIC
COSN31662299 1197 COSMIC
COSN31537878 1210 COSMIC
COSN26571629 1218 COSMIC
COSN31551271 1352 COSMIC
COSN31485620 1379 COSMIC
COSN31551409 1386 COSMIC
COSN26668639 1433 COSMIC
COSN28660037 1590 COSMIC
COSN6430621 2022 COSMIC
COSN22035357 2111 COSMIC
COSN22797771 2266 COSMIC
COSN25117234 2299 COSMIC
COSN20094425 2309 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1431187573 3 dbSNP
rs778746492 4 dbSNP
rs376825493 6 dbSNP
rs748981475 7 dbSNP
rs199651124 8 dbSNP
rs1290825623 9 dbSNP
rs958710872 10 dbSNP
rs755673695 13 dbSNP
rs7531914 14 dbSNP
rs7518375 15 dbSNP
rs1233185711 16 dbSNP
rs1186131292 17 dbSNP
rs1310780635 18 dbSNP
rs759044590 19 dbSNP
rs750956990 20 dbSNP
rs1364804787 24 dbSNP
rs1034778086 25 dbSNP
rs1002858581 26 dbSNP
rs1318793427 29 dbSNP
rs1454613176 33 dbSNP
rs1403035025 34 dbSNP
rs765650298 35 dbSNP
rs184348603 36 dbSNP
rs764171381 37 dbSNP
rs1356060505 42 dbSNP
rs760860242 43 dbSNP
rs1448657388 46 dbSNP
rs772133924 47 dbSNP
rs892303800 52 dbSNP
rs1053684044 53 dbSNP
rs1446217293 62 dbSNP
rs1001202631 66 dbSNP
rs1194347450 70 dbSNP
rs1436723494 78 dbSNP
rs899774454 83 dbSNP
rs1169746669 84 dbSNP
rs1039366329 92 dbSNP
rs1247362544 96 dbSNP
rs181016189 101 dbSNP
rs773137317 107 dbSNP
rs1315041833 112 dbSNP
rs1258197906 114 dbSNP
rs375714392 120 dbSNP
rs1046855122 128 dbSNP
rs371432830 130 dbSNP
rs1330275920 132 dbSNP
rs1308920241 137 dbSNP
rs1389350859 141 dbSNP
rs761501463 142 dbSNP
rs920108433 148 dbSNP
rs1426247356 149 dbSNP
rs1383151807 151 dbSNP
rs1162916627 159 dbSNP
rs1417163298 161 dbSNP
rs1297701330 176 dbSNP
rs1440216525 192 dbSNP
rs7531712 198 dbSNP
rs1365651476 201 dbSNP
rs561856866 204 dbSNP
rs541787761 205 dbSNP
rs959200638 206 dbSNP
rs1418303255 209 dbSNP
rs1166745718 226 dbSNP
rs927591742 227 dbSNP
rs981408045 236 dbSNP
rs1268232948 241 dbSNP
rs140308778 246 dbSNP
rs190333256 257 dbSNP
rs1489977485 258 dbSNP
rs1244675752 261 dbSNP
rs1481313327 261 dbSNP
rs1212673662 271 dbSNP
rs1291467824 275 dbSNP
rs1020293056 280 dbSNP
rs1274210974 281 dbSNP
rs1235470042 282 dbSNP
rs1327739803 286 dbSNP
rs540166631 289 dbSNP
rs1241554669 290 dbSNP
rs1375606705 296 dbSNP
rs1356418968 300 dbSNP
rs1032574957 301 dbSNP
rs1159721584 301 dbSNP
rs137860325 301 dbSNP
rs1440453028 301 dbSNP
rs56926341 301 dbSNP
rs879468027 301 dbSNP
rs956536477 301 dbSNP
rs1280805042 302 dbSNP
rs1192395401 303 dbSNP
rs1422447362 303 dbSNP
rs1236181322 304 dbSNP
rs1454461931 305 dbSNP
rs1000727564 306 dbSNP
rs1485191487 310 dbSNP
rs564074300 310 dbSNP
rs774029289 310 dbSNP
rs899744505 312 dbSNP
rs1334809353 314 dbSNP
rs1323883069 317 dbSNP
rs750636 320 dbSNP
rs1301507144 325 dbSNP
rs1233903305 327 dbSNP
rs1371776309 330 dbSNP
rs1007863418 331 dbSNP
rs1384173251 335 dbSNP
rs1289447984 338 dbSNP
rs1455142415 353 dbSNP
rs1302272637 357 dbSNP
rs1357266369 359 dbSNP
rs1402794170 360 dbSNP
rs1420268040 367 dbSNP
rs6672511 381 dbSNP
rs773887376 386 dbSNP
rs890796852 387 dbSNP
rs1186138487 389 dbSNP
rs1427187768 392 dbSNP
rs1261634344 397 dbSNP
rs748776497 398 dbSNP
rs1156896754 399 dbSNP
rs553789867 402 dbSNP
rs1046825250 403 dbSNP
rs1210384426 406 dbSNP
rs929729484 422 dbSNP
rs919716331 423 dbSNP
rs1282486412 426 dbSNP
rs557479197 427 dbSNP
rs1325993101 431 dbSNP
rs775118312 436 dbSNP
rs937566653 438 dbSNP
rs1383896700 439 dbSNP
rs1479560721 442 dbSNP
rs1362208060 446 dbSNP
rs1434888992 449 dbSNP
rs1268663813 450 dbSNP
rs1376899726 459 dbSNP
rs375001934 464 dbSNP
rs927544467 465 dbSNP
rs1373195948 469 dbSNP
rs185752388 476 dbSNP
rs1255786035 479 dbSNP
rs535730027 482 dbSNP
rs535421646 483 dbSNP
rs192050215 486 dbSNP
rs187525387 487 dbSNP
rs1274904638 488 dbSNP
rs1033135195 489 dbSNP
rs533306393 491 dbSNP
rs747585465 492 dbSNP
rs570658746 495 dbSNP
rs1225011463 496 dbSNP
rs184008089 505 dbSNP
rs1018164596 506 dbSNP
rs1463924741 508 dbSNP
rs1400323997 515 dbSNP
rs1164907109 517 dbSNP
rs199763593 520 dbSNP
rs752400081 520 dbSNP
rs768230144 520 dbSNP
rs530634359 521 dbSNP
rs1400016539 522 dbSNP
rs375868980 523 dbSNP
rs1178627045 536 dbSNP
rs1197634935 541 dbSNP
rs993872235 542 dbSNP
rs777935337 545 dbSNP
rs561823665 548 dbSNP
rs1969829 549 dbSNP
rs1237814829 554 dbSNP
rs1335991329 555 dbSNP
rs3752352 556 dbSNP
rs1438064958 561 dbSNP
rs1240706989 567 dbSNP
rs1393163622 571 dbSNP
rs1325788795 573 dbSNP
rs1038159524 574 dbSNP
rs1462458534 577 dbSNP
rs1157205185 583 dbSNP
rs528457858 584 dbSNP
rs755084478 585 dbSNP
rs906045054 585 dbSNP
rs1045931616 592 dbSNP
rs191745357 604 dbSNP
rs1204968406 605 dbSNP
rs950288883 607 dbSNP
rs913507374 608 dbSNP
rs1281807240 611 dbSNP
rs1399968736 618 dbSNP
rs545878271 619 dbSNP
rs1351210796 621 dbSNP
rs1320992347 622 dbSNP
rs188451636 623 dbSNP
rs936049731 626 dbSNP
rs974856196 627 dbSNP
rs557384710 631 dbSNP
rs1363870814 632 dbSNP
rs1018135068 633 dbSNP
rs1386192945 633 dbSNP
rs1394503259 634 dbSNP
rs1433125482 634 dbSNP
rs1429973045 638 dbSNP
rs986661553 640 dbSNP
rs1455478400 643 dbSNP
rs955257408 649 dbSNP
rs149679206 653 dbSNP
rs1338796395 657 dbSNP
rs1447336107 662 dbSNP
rs1450455028 663 dbSNP
rs994233528 672 dbSNP
rs1346722658 677 dbSNP
rs1280333227 695 dbSNP
rs1156838531 706 dbSNP
rs898170352 708 dbSNP
rs3752353 716 dbSNP
rs1479035391 734 dbSNP
rs1268912434 736 dbSNP
rs1430690622 747 dbSNP
rs1327348511 759 dbSNP
rs1017057526 765 dbSNP
rs748566947 768 dbSNP
rs1001311550 774 dbSNP
rs1416223932 785 dbSNP
rs555488093 797 dbSNP
rs1475715073 798 dbSNP
rs1264991728 801 dbSNP
rs1185539661 811 dbSNP
rs139598727 814 dbSNP
rs566343885 815 dbSNP
rs1053380606 816 dbSNP
rs1271714411 817 dbSNP
rs935960606 820 dbSNP
rs1340694961 822 dbSNP
rs925993538 823 dbSNP
rs1204823165 827 dbSNP
rs975203274 845 dbSNP
rs943421307 847 dbSNP
rs912005015 848 dbSNP
rs1450504916 849 dbSNP
rs986630145 859 dbSNP
rs1328289033 866 dbSNP
rs1213712381 874 dbSNP
rs1410399274 900 dbSNP
rs1425684314 902 dbSNP
rs955226352 905 dbSNP
rs552887516 909 dbSNP
rs1317156464 911 dbSNP
rs1183196804 912 dbSNP
rs1243666334 919 dbSNP
rs368435686 922 dbSNP
rs112090321 929 dbSNP
rs1231758115 929 dbSNP
rs1332091474 933 dbSNP
rs1439110632 934 dbSNP
rs1016584833 935 dbSNP
rs1334575301 937 dbSNP
rs114031304 939 dbSNP
rs1014341388 940 dbSNP
rs753892639 941 dbSNP
rs1000465446 942 dbSNP
rs1039018211 942 dbSNP
rs1053754791 942 dbSNP
rs1387453518 954 dbSNP
rs530602907 957 dbSNP
rs943390112 958 dbSNP
rs182475614 959 dbSNP
rs1051859355 960 dbSNP
rs548273270 961 dbSNP
rs1283800974 962 dbSNP
rs1224581753 966 dbSNP
rs151013604 967 dbSNP
rs11587520 968 dbSNP
rs1230751431 969 dbSNP
rs1440002758 980 dbSNP
rs973034744 984 dbSNP
rs1490469019 985 dbSNP
rs1293645436 990 dbSNP
rs551501639 992 dbSNP
rs962638345 993 dbSNP
rs1421167167 998 dbSNP
rs1358595677 1003 dbSNP
rs909828298 1004 dbSNP
rs1454388246 1006 dbSNP
rs979728434 1021 dbSNP
rs758952761 1022 dbSNP
rs868069642 1027 dbSNP
rs1260535142 1028 dbSNP
rs1217554605 1035 dbSNP
rs1356139224 1036 dbSNP
rs1278200308 1037 dbSNP
rs1233647493 1040 dbSNP
rs11540750 1041 dbSNP
rs113783183 1043 dbSNP
rs1380493883 1048 dbSNP
rs1360956630 1053 dbSNP
rs1371466587 1058 dbSNP
rs1289249090 1059 dbSNP
rs956373008 1062 dbSNP
rs1373235979 1069 dbSNP
rs1279263702 1074 dbSNP
rs546142941 1078 dbSNP
rs1378901185 1086 dbSNP
rs1367889717 1088 dbSNP
rs1427280972 1090 dbSNP
rs1261400866 1093 dbSNP
rs1000797082 1095 dbSNP
rs780204468 1099 dbSNP
rs1039727284 1100 dbSNP
rs1424607640 1109 dbSNP
rs1361667558 1110 dbSNP
rs1225080575 1112 dbSNP
rs1052580 1115 dbSNP
rs6669495 1116 dbSNP
rs1353382934 1121 dbSNP
rs544163844 1125 dbSNP
rs1415053360 1130 dbSNP
rs1176316896 1132 dbSNP
rs750377345 1133 dbSNP
rs575079081 1135 dbSNP
rs1270822116 1136 dbSNP
rs1460857458 1137 dbSNP
rs1373003722 1138 dbSNP
rs555251115 1139 dbSNP
rs1478992237 1145 dbSNP
rs1416193371 1146 dbSNP
rs541648494 1148 dbSNP
rs765390236 1149 dbSNP
rs1490170935 1150 dbSNP
rs1480382321 1163 dbSNP
rs572855365 1166 dbSNP
rs1258608628 1170 dbSNP
rs1036862855 1176 dbSNP
rs1261175313 1177 dbSNP
rs1292470780 1182 dbSNP
rs1244990554 1187 dbSNP
rs1217863316 1190 dbSNP
rs941223408 1191 dbSNP
rs1390295336 1192 dbSNP
rs139637787 1197 dbSNP
rs1224384216 1198 dbSNP
rs539392127 1199 dbSNP
rs909763846 1200 dbSNP
rs1392669219 1202 dbSNP
rs1446881146 1202 dbSNP
rs1281785254 1208 dbSNP
rs979989995 1210 dbSNP
rs1363086161 1211 dbSNP
rs969671696 1215 dbSNP
rs916926406 1227 dbSNP
rs992481722 1231 dbSNP
rs1452235728 1244 dbSNP
rs1180382002 1272 dbSNP
rs1272237431 1278 dbSNP
rs955798040 1278 dbSNP
rs1210209520 1279 dbSNP
rs1358272228 1282 dbSNP
rs1258556597 1289 dbSNP
rs1237923743 1298 dbSNP
rs1342967419 1298 dbSNP
rs1376939504 1309 dbSNP
rs1310839616 1333 dbSNP
rs1449569897 1334 dbSNP
rs1369428166 1338 dbSNP
rs1031878808 1340 dbSNP
rs1406297867 1344 dbSNP
rs978944587 1346 dbSNP
rs1157006939 1354 dbSNP
rs969300548 1355 dbSNP
rs1380933518 1360 dbSNP
rs1017833623 1362 dbSNP
rs1157686973 1363 dbSNP
rs754964648 1368 dbSNP
rs1470017264 1370 dbSNP
rs570386706 1371 dbSNP
rs1007835635 1372 dbSNP
rs890434005 1376 dbSNP
rs1030326163 1379 dbSNP
rs1259435045 1379 dbSNP
rs1287802948 1379 dbSNP
rs1353983231 1379 dbSNP
rs1231428292 1382 dbSNP
rs1430904364 1384 dbSNP
rs1346593086 1392 dbSNP
rs1274745053 1400 dbSNP
rs556827253 1410 dbSNP
rs897900260 1412 dbSNP
rs1316702682 1418 dbSNP
rs1480027740 1429 dbSNP
rs1262157082 1432 dbSNP
rs1188245689 1433 dbSNP
rs1432920140 1438 dbSNP
rs1484827606 1439 dbSNP
rs1424594026 1441 dbSNP
rs1038196411 1446 dbSNP
rs1173045446 1446 dbSNP
rs1371068124 1447 dbSNP
rs1204316835 1452 dbSNP
rs1192199224 1453 dbSNP
rs1488529947 1455 dbSNP
rs536994742 1459 dbSNP
rs941161872 1463 dbSNP
rs1223119478 1469 dbSNP
rs1278740732 1473 dbSNP
rs1220262665 1476 dbSNP
rs888295592 1481 dbSNP
rs1044263274 1482 dbSNP
rs188630676 1483 dbSNP
rs1381055740 1486 dbSNP
rs547938586 1489 dbSNP
rs1413198111 1492 dbSNP
rs1358596425 1493 dbSNP
rs1334940271 1494 dbSNP
rs1319321171 1504 dbSNP
rs1416312240 1505 dbSNP
rs1417284361 1506 dbSNP
rs531124042 1514 dbSNP
rs773306392 1516 dbSNP
rs992452342 1526 dbSNP
rs3737768 1531 dbSNP
rs35771044 1537 dbSNP
rs1425547717 1538 dbSNP
rs1185285369 1550 dbSNP
rs566135758 1561 dbSNP
rs183352167 1562 dbSNP
rs754104507 1565 dbSNP
rs374550948 1583 dbSNP
rs1465201902 1584 dbSNP
rs563715290 1585 dbSNP
rs1271475424 1586 dbSNP
rs978921257 1588 dbSNP
rs1373459693 1589 dbSNP
rs3193024 1590 dbSNP
rs1017801050 1591 dbSNP
rs1260873076 1600 dbSNP
rs1285068948 1605 dbSNP
rs986329282 1606 dbSNP
rs1450273174 1610 dbSNP
rs541057473 1612 dbSNP
rs1462757171 1614 dbSNP
rs1466098401 1621 dbSNP
rs1402130776 1629 dbSNP
rs1162536125 1633 dbSNP
rs1030620626 1636 dbSNP
rs530372678 1638 dbSNP
rs1414051467 1642 dbSNP
rs1183287025 1644 dbSNP
rs1203320075 1645 dbSNP
rs993477813 1649 dbSNP
rs1178510265 1650 dbSNP
rs1253473268 1664 dbSNP
rs1225629220 1667 dbSNP
rs1212200118 1676 dbSNP
rs897821955 1677 dbSNP
rs190304239 1678 dbSNP
rs1371212908 1682 dbSNP
rs1248792609 1683 dbSNP
rs1447341240 1684 dbSNP
rs1379022559 1685 dbSNP
rs1323872379 1694 dbSNP
rs185893412 1697 dbSNP
rs572575088 1703 dbSNP
rs905315647 1704 dbSNP
rs1395111501 1705 dbSNP
rs1396696235 1706 dbSNP
rs1299671185 1707 dbSNP
rs1460333741 1708 dbSNP
rs1389304458 1709 dbSNP
rs1164185612 1712 dbSNP
rs559379163 1713 dbSNP
rs1488338605 1717 dbSNP
rs545620517 1718 dbSNP
rs1223978204 1723 dbSNP
rs1351789913 1728 dbSNP
rs948595139 1729 dbSNP
rs576768707 1730 dbSNP
rs762721142 1731 dbSNP
rs1056986183 1734 dbSNP
rs934305435 1735 dbSNP
rs1295081069 1741 dbSNP
rs1252847877 1749 dbSNP
rs556493027 1752 dbSNP
rs1359490501 1753 dbSNP
rs536656820 1757 dbSNP
rs1392757859 1767 dbSNP
rs1174516540 1769 dbSNP
rs1480546162 1770 dbSNP
rs1426236953 1776 dbSNP
rs1193285234 1781 dbSNP
rs1292937942 1785 dbSNP
rs112380887 1788 dbSNP
rs1262714042 1791 dbSNP
rs1357856586 1796 dbSNP
rs1312291594 1797 dbSNP
rs947114463 1800 dbSNP
rs910329685 1801 dbSNP
rs2526826 1802 dbSNP
rs954864817 1811 dbSNP
rs574353749 1813 dbSNP
rs190032649 1820 dbSNP
rs1339641121 1821 dbSNP
rs769353983 1824 dbSNP
rs923476294 1825 dbSNP
rs1303489591 1826 dbSNP
rs1401487980 1826 dbSNP
rs1426500111 1827 dbSNP
rs972743024 1833 dbSNP
rs962041296 1836 dbSNP
rs1016664040 1840 dbSNP
rs534792634 1843 dbSNP
rs1162745849 1845 dbSNP
rs1470593356 1846 dbSNP
rs1006244455 1857 dbSNP
rs761026901 1858 dbSNP
rs1179994385 1859 dbSNP
rs969442079 1860 dbSNP
rs1472371687 1864 dbSNP
rs1478932697 1866 dbSNP
rs1270073744 1867 dbSNP
rs1199936508 1876 dbSNP
rs1483652385 1877 dbSNP
rs1023709426 1888 dbSNP
rs199587369 1897 dbSNP
rs772631308 1898 dbSNP
rs1311642568 1906 dbSNP
rs552632351 1907 dbSNP
rs1396086771 1910 dbSNP
rs1380756671 1913 dbSNP
rs538805727 1915 dbSNP
rs1399943623 1917 dbSNP
rs570168329 1919 dbSNP
rs1467573876 1920 dbSNP
rs1206223251 1921 dbSNP
rs903130876 1923 dbSNP
rs1043099691 1926 dbSNP
rs1424432857 1927 dbSNP
rs1350815372 1932 dbSNP
rs1258381845 1938 dbSNP
rs947077327 1939 dbSNP
rs910267500 1944 dbSNP
rs1258711495 1950 dbSNP
rs1261950423 1966 dbSNP
rs1200294915 1969 dbSNP
rs1354057972 1973 dbSNP
rs1236457771 1981 dbSNP
rs1050173151 1983 dbSNP
rs933450446 1986 dbSNP
rs1221248800 1991 dbSNP
rs1283688393 1994 dbSNP
rs748477076 1995 dbSNP
rs143098265 2006 dbSNP
rs1322883906 2007 dbSNP
rs1445125914 2010 dbSNP
rs1376804553 2017 dbSNP
rs962590093 2020 dbSNP
rs7191 2022 dbSNP
rs985189680 2023 dbSNP
rs1162841632 2024 dbSNP
rs1458617505 2032 dbSNP
rs1156857532 2033 dbSNP
rs1456923350 2035 dbSNP
rs561537955 2039 dbSNP
rs1439231903 2040 dbSNP
rs1238694334 2052 dbSNP
rs7512044 2055 dbSNP
rs774112069 2058 dbSNP
rs1479700822 2062 dbSNP
rs1266431270 2064 dbSNP
rs1210000057 2068 dbSNP
rs527875441 2074 dbSNP
rs565384203 2079 dbSNP
rs1013643211 2080 dbSNP
rs967325064 2083 dbSNP
rs959839421 2084 dbSNP
rs1194582863 2089 dbSNP
rs1449188812 2090 dbSNP
rs1241837927 2098 dbSNP
rs1263260632 2101 dbSNP
rs1323317517 2108 dbSNP
rs1202784567 2109 dbSNP
rs186711072 2111 dbSNP
rs1035920688 2112 dbSNP
rs1296641487 2130 dbSNP
rs1419140475 2130 dbSNP
rs998724618 2131 dbSNP
rs1477005527 2132 dbSNP
rs1376785434 2135 dbSNP
rs1199298929 2141 dbSNP
rs1453169614 2151 dbSNP
rs1260560322 2153 dbSNP
rs564352771 2154 dbSNP
rs1488304530 2161 dbSNP
rs1042985076 2164 dbSNP
rs1224959495 2170 dbSNP
rs1207341781 2171 dbSNP
rs576823263 2175 dbSNP
rs888801872 2180 dbSNP
rs1234400544 2182 dbSNP
rs1050140682 2193 dbSNP
rs779930023 2194 dbSNP
rs1431417562 2195 dbSNP
rs1052791 2211 dbSNP
rs1320369988 2211 dbSNP
rs1412902379 2221 dbSNP
rs933043281 2223 dbSNP
rs1173138447 2228 dbSNP
rs563057067 2231 dbSNP
rs1421246817 2232 dbSNP
rs1328065287 2244 dbSNP
rs1316336030 2247 dbSNP
rs1434544407 2254 dbSNP
rs901616691 2263 dbSNP
rs1207399398 2264 dbSNP
rs1278503946 2266 dbSNP
rs1406919957 2266 dbSNP
rs1178905026 2267 dbSNP
rs1256572859 2269 dbSNP
rs1326034863 2269 dbSNP
rs545883330 2273 dbSNP
rs1341351904 2274 dbSNP
rs74910956 2274 dbSNP
rs1424932951 2275 dbSNP
rs77450018 2275 dbSNP
rs940902924 2275 dbSNP
rs1339985549 2277 dbSNP
rs1334692063 2281 dbSNP
rs1470924789 2285 dbSNP
rs879207964 2290 dbSNP
rs1397769208 2294 dbSNP
rs1169690070 2310 dbSNP
rs1168813325 2311 dbSNP
rs1466000419 2311 dbSNP
rs1179799736 2313 dbSNP
rs909421052 2314 dbSNP
rs1237576510 2315 dbSNP
rs376837231 2316 dbSNP
rs948035017 2317 dbSNP
rs985010858 2317 dbSNP
rs1198391953 2319 dbSNP
rs3838948 2319 dbSNP
rs573668764 2319 dbSNP
rs1275341324 2321 dbSNP
rs1464101347 2326 dbSNP
rs1355669084 2328 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_ControlB_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaagaccgaggUUC-AGGUCa 5'
                     ||| |:| | 
Target 5' ---caggggagAAGCUUCUG- 3'
 		1 - 17
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_ControlB_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control B
Location of target site ENST00000375436.4 | 3UTR | CAGGGGAGAAGCUUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
27 hsa-miR-378f Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT463100 ZNF609 zinc finger protein 609 2 2
MIRT469371 REST RE1 silencing transcription factor 2 6
MIRT495441 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 2
MIRT513606 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT520414 TXNL1 thioredoxin like 1 2 4
MIRT525111 PRKD2 protein kinase D2 2 2
MIRT525979 SPA17 sperm autoantigenic protein 17 2 2
MIRT527002 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT529215 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT529835 ARGFX arginine-fifty homeobox 2 2
MIRT532300 HAUS3 HAUS augmin like complex subunit 3 2 2
MIRT537577 ESYT2 extended synaptotagmin 2 2 2
MIRT543140 AKT1 AKT serine/threonine kinase 1 2 2
MIRT554924 RAP1B RAP1B, member of RAS oncogene family 2 2
MIRT564970 WTAP WT1 associated protein 2 2
MIRT570115 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT652734 TGFB2 transforming growth factor beta 2 2 2
MIRT655948 NDST1 N-deacetylase and N-sulfotransferase 1 2 2
MIRT655997 MYRF myelin regulatory factor 2 2
MIRT684875 P4HB prolyl 4-hydroxylase subunit beta 2 2
MIRT692969 LGSN lengsin, lens protein with glutamine synthetase domain 2 2
MIRT693737 ACACA acetyl-CoA carboxylase alpha 2 2
MIRT710991 PPARGC1B PPARG coactivator 1 beta 2 2
MIRT712247 RCC2 regulator of chromosome condensation 2 2 2
MIRT718602 DCTPP1 dCTP pyrophosphatase 1 2 2
MIRT723499 WDR33 WD repeat domain 33 2 2
MIRT725448 HIPK3 homeodomain interacting protein kinase 3 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378f Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378f Doxorubicin 31703 NSC123127 approved sensitive High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-miR-378f Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (SW480, HCT-116)
hsa-miR-378f Erlotinib 176870 NSC718781 approved resistant High Head And Neck Squamous Cell Carcinoma cell line (HN6)
hsa-mir-378f Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-miR-378f Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-378f Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-378f Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)

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