pre-miRNA Information
pre-miRNA hsa-mir-4486   
Genomic Coordinates chr11: 19575310 - 19575372
Description Homo sapiens miR-4486 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4486
Sequence 5| GCUGGGCGAGGCUGGCA |21
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs774299284 8 dbSNP
rs902172817 14 dbSNP
rs1222795726 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FSTL3   
Synonyms FLRG, FSRP
Description follistatin like 3
Transcript NM_005860   
Expression
Putative miRNA Targets on FSTL3
3'UTR of FSTL3
(miRNA target sites are highlighted)
>FSTL3|NM_005860|3'UTR
   1 GCCTGCAGGACAGGCCTGGGCCTGGTGCCCGAGGCCCCCCATCATCCCCTGTTATTTATTGCCACAGCAGAGTCTAATTT
  81 ATATGCCACGGACACTCCTTAGAGCCCGGATTCGGACCACTTGGGGATCCCAGAACCTCCCTGACGATATCCTGGAAGGA
 161 CTGAGGAAGGGAGGCCTGGGGGCCGGCTGGTGGGTGGGATAGACCTGCGTTCCGGACACTGAGCGCCTGATTTAGGGCCC
 241 TTCTCTAGGATGCCCCAGCCCCTACCCTAAGACCTATTGCCGGGGAGGATTCCACACTTCCGCTCCTTTGGGGATAAACC
 321 TATTAATTATTGCTACTATCAAGAGGGCTGGGCATTCTCTGCTGGTAATTCCTGAAGAGGCATGACTGCTTTTCTCAGCC
 401 CCAAGCCTCTAGTCTGGGTGTGTACGGAGGGTCTAGCCTGGGTGTGTACGGAGGGTCTAGCCTGGGTGAGTACGGAGGGT
 481 CTAGCCTGGGTGAGTACGGAGGGTCTAGCCTGGGTGAGTACGGAGGGTCTAGCCTGGGTGTGTATGGAGGATCTAGCCTG
 561 GGTGAGTATGGAGGGTCTAGCCTGGGTGAGTATGGAGGGTCTAGCCTGGGTGTGTATGGAGGGTCTAGCCTGGGTGAGTA
 641 TGGAGGGTCTAGCCTGGGTGTGTATGGAGGGTCTAGCCTGGGTGAGTATGGAGGGTCTAGCCTGGGTGTGTACGGAGGGT
 721 CTAGTCTGAGTGCGTGTGGGGACCTCAGAACACTGTGACCTTAGCCCAGCAAGCCAGGCCCTTCATGAAGGCCAAGAAGG
 801 CTGCCACCATTCCCTGCCAGCCCAAGAACTCCAGCTTCCCCACTGCCTCTGTGTGCCCCTTTGCGTCCTGTGAAGGCCAT
 881 TGAGAAATGCCCAGTGTGCCCCCTGGGAAAGGGCACGGCCTGTGCTCCTGACACGGGCTGTGCTTGGCCACAGAACCACC
 961 CAGCGTCTCCCCTGCTGCTGTCCACGTCAGTTCATGAGGCAACGTCGCGTGGTCTCAGACGTGGAGCAGCCAGCGGCAGC
1041 TCAGAGCAGGGCACTGTGTCCGGCGGAGCCAAGTCCACTCTGGGGGAGCTCTGGCGGGGACCACGGGCCACTGCTCACCC
1121 ACTGGCCCCGAGGGGGGTGTAGACGCCAAGACTCACGCATGTGTGACATCCGGAGTCCTGGAGCCGGGTGTCCCAGTGGC
1201 ACCACTAGGTGCCTGCTGCCTCCACAGTGGGGTTCACACCCAGGGCTCCTTGGTCCCCCACAACCTGCCCCGGCCAGGCC
1281 TGCAGACCCAGACTCCAGCCAGACCTGCCTCACCCACCAATGCAGCCGGGGCTGGCGACACCAGCCAGGTGCTGGTCTTG
1361 GGCCAGTTCTCCCACGACGGCTCACCCTCCCCTCCATCTGCGTTGATGCTCAGAATCGCCTACCTGTGCCTGCGTGTAAA
1441 CCACAGCCTCAGACCAGCTATGGGGAGAGGACAACACGGAGGATATCCAGCTTCCCCGGTCTGGGGTGAGGAATGTGGGG
1521 AGCTTGGGCATCCTCCTCCAGCCTCCTCCAGCCCCCAGGCAGTGCCTTACCTGTGGTGCCCAGAAAAGTGCCCCTAGGTT
1601 GGTGGGTCTACAGGAGCCTCAGCCAGGCAGCCCACCCCACCCTGGGGCCCTGCCTCACCAAGGAAATAAAGACTCAAGCC
1681 ATTTAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acGGUCGGAGCGGGUCg 5'
            || |:  :|||||| 
Target 5' taCCTGTGGTGCCCAGa 3'
1568 - 1584 131.00 -18.30
2
miRNA  3' acGGUCGGAGCGGGUCg 5'
            || ||| || |||| 
Target 5' aaCCTGCCCCGGCCAGg 3'
1262 - 1278 127.00 -19.30
3
miRNA  3' acGGUCGGAGCGGGUCg 5'
            |||||||| :|||| 
Target 5' ctCCAGCCTCCTCCAGc 3'
1536 - 1552 127.00 -26.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30143265 35 COSMIC
COSN31539558 93 COSMIC
COSN20079613 106 COSMIC
COSN24294783 359 COSMIC
COSN8262871 450 COSMIC
COSN23426868 498 COSMIC
COSN27378284 503 COSMIC
COSN23919966 686 COSMIC
COSN23889489 690 COSMIC
COSN17745300 936 COSMIC
COSN6148359 1044 COSMIC
COSN15237753 1125 COSMIC
COSN6670101 1173 COSMIC
COSN31609667 1338 COSMIC
COSN31601119 1344 COSMIC
COSN26552446 1499 COSMIC
COSN31539541 1537 COSMIC
COSN29512393 1548 COSMIC
COSN29512003 1550 COSMIC
COSN31932784 1603 COSMIC
COSN20115235 1678 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs377149734 6 dbSNP
rs1391071188 7 dbSNP
rs1470243695 8 dbSNP
rs1327019795 10 dbSNP
rs750778881 11 dbSNP
rs1405992565 12 dbSNP
rs1283034528 15 dbSNP
rs200986019 16 dbSNP
rs780465189 17 dbSNP
rs753964131 20 dbSNP
rs1339401741 21 dbSNP
rs923486350 25 dbSNP
rs1249240595 29 dbSNP
rs755167536 31 dbSNP
rs144896081 32 dbSNP
rs760188373 35 dbSNP
rs1241339146 36 dbSNP
rs546075799 38 dbSNP
rs758290122 39 dbSNP
rs373498221 40 dbSNP
rs1203061000 46 dbSNP
rs1373721955 46 dbSNP
rs1274157536 49 dbSNP
rs371259653 49 dbSNP
rs770562121 50 dbSNP
rs1166212766 60 dbSNP
rs754981373 63 dbSNP
rs1425501646 64 dbSNP
rs751583219 65 dbSNP
rs1302951109 68 dbSNP
rs1343986340 73 dbSNP
rs1489123637 86 dbSNP
rs1185486703 87 dbSNP
rs776320752 88 dbSNP
rs1256604440 89 dbSNP
rs147529856 90 dbSNP
rs745536499 91 dbSNP
rs1226144708 94 dbSNP
rs769231007 95 dbSNP
rs139917094 96 dbSNP
rs762335908 99 dbSNP
rs1052216847 101 dbSNP
rs1290798662 105 dbSNP
rs550862342 106 dbSNP
rs1188219411 108 dbSNP
rs1262407473 109 dbSNP
rs1427841421 110 dbSNP
rs749371538 114 dbSNP
rs1022514732 115 dbSNP
rs1445506023 117 dbSNP
rs1163100428 119 dbSNP
rs1348518026 120 dbSNP
rs1455732676 121 dbSNP
rs1012360297 122 dbSNP
rs1246292600 126 dbSNP
rs1384925129 128 dbSNP
rs1381001721 132 dbSNP
rs1294799723 133 dbSNP
rs773597296 138 dbSNP
rs1246261392 144 dbSNP
rs1002508527 146 dbSNP
rs761012383 147 dbSNP
rs1311873461 152 dbSNP
rs1402827887 169 dbSNP
rs1367233050 172 dbSNP
rs1305125399 174 dbSNP
rs1355587731 175 dbSNP
rs1363297997 177 dbSNP
rs1157085831 178 dbSNP
rs1416046891 185 dbSNP
rs1005988944 186 dbSNP
rs1014592498 197 dbSNP
rs1214353450 199 dbSNP
rs35156721 203 dbSNP
rs770965040 203 dbSNP
rs962188043 209 dbSNP
rs976217289 210 dbSNP
rs1209048361 214 dbSNP
rs547858422 215 dbSNP
rs953615379 218 dbSNP
rs1217358294 219 dbSNP
rs142795219 220 dbSNP
rs534115860 224 dbSNP
rs1221626306 225 dbSNP
rs914594383 225 dbSNP
rs947344979 226 dbSNP
rs977543566 243 dbSNP
rs924653622 244 dbSNP
rs1387553433 250 dbSNP
rs1384588771 253 dbSNP
rs1287160075 261 dbSNP
rs935192510 262 dbSNP
rs933683859 265 dbSNP
rs1056304471 268 dbSNP
rs896434269 270 dbSNP
rs947979819 272 dbSNP
rs772370806 274 dbSNP
rs1479747472 275 dbSNP
rs377706967 277 dbSNP
rs1187025183 282 dbSNP
rs374544123 283 dbSNP
rs1014665694 286 dbSNP
rs897570586 292 dbSNP
rs997668028 293 dbSNP
rs1187924367 295 dbSNP
rs558601196 296 dbSNP
rs1261971088 301 dbSNP
rs953647558 302 dbSNP
rs13730 303 dbSNP
rs537654671 310 dbSNP
rs556278157 312 dbSNP
rs1226478243 313 dbSNP
rs1324502514 319 dbSNP
rs1293642603 326 dbSNP
rs1384152985 333 dbSNP
rs574242794 348 dbSNP
rs1365940427 350 dbSNP
rs1043585651 362 dbSNP
rs905049968 363 dbSNP
rs1173702775 366 dbSNP
rs72976224 366 dbSNP
rs1436053109 367 dbSNP
rs1461754563 378 dbSNP
rs553387095 382 dbSNP
rs968753325 385 dbSNP
rs1194793679 387 dbSNP
rs977419112 390 dbSNP
rs1449767490 391 dbSNP
rs924725460 397 dbSNP
rs1034936164 403 dbSNP
rs1181271454 408 dbSNP
rs938736374 410 dbSNP
rs34594434 412 dbSNP
rs1462573457 413 dbSNP
rs1256724734 414 dbSNP
rs1325342300 414 dbSNP
rs1195184158 418 dbSNP
rs1337142240 420 dbSNP
rs992017617 425 dbSNP
rs1430709303 426 dbSNP
rs1229884317 428 dbSNP
rs1343196534 431 dbSNP
rs1314426466 432 dbSNP
rs917774721 434 dbSNP
rs1271256654 435 dbSNP
rs1335375543 435 dbSNP
rs947851799 436 dbSNP
rs1232492467 437 dbSNP
rs1394778907 437 dbSNP
rs112168163 446 dbSNP
rs887688043 450 dbSNP
rs182220058 451 dbSNP
rs993465345 453 dbSNP
rs1035972848 456 dbSNP
rs1446476750 458 dbSNP
rs897601563 460 dbSNP
rs1216457986 462 dbSNP
rs1243736880 466 dbSNP
rs997237100 467 dbSNP
rs1192710410 469 dbSNP
rs2072105 470 dbSNP
rs1455358346 471 dbSNP
rs1156431656 474 dbSNP
rs952146516 475 dbSNP
rs1244071376 479 dbSNP
rs1383671914 479 dbSNP
rs112420088 480 dbSNP
rs1008103700 483 dbSNP
rs1319585271 484 dbSNP
rs1284922906 485 dbSNP
rs1391401200 486 dbSNP
rs1006739497 487 dbSNP
rs1439165167 490 dbSNP
rs1365370533 491 dbSNP
rs879364211 494 dbSNP
rs1372168176 495 dbSNP
rs969371254 498 dbSNP
rs1413887020 499 dbSNP
rs1157549576 502 dbSNP
rs1277970395 502 dbSNP
rs998886947 503 dbSNP
rs62134284 504 dbSNP
rs1224360580 508 dbSNP
rs1479953735 508 dbSNP
rs564637582 515 dbSNP
rs1286273280 518 dbSNP
rs146717515 522 dbSNP
rs1212983764 526 dbSNP
rs2057713 527 dbSNP
rs1253453194 529 dbSNP
rs1017674581 530 dbSNP
rs760954924 536 dbSNP
rs1469627472 542 dbSNP
rs1348672275 543 dbSNP
rs1290702563 545 dbSNP
rs1179266563 546 dbSNP
rs1362813257 551 dbSNP
rs1287057025 552 dbSNP
rs1345201255 552 dbSNP
rs965280083 554 dbSNP
rs1350146939 558 dbSNP
rs992927166 560 dbSNP
rs1398400548 565 dbSNP
rs1386508674 566 dbSNP
rs1470215117 566 dbSNP
rs1159725281 570 dbSNP
rs1469286848 574 dbSNP
rs535149517 575 dbSNP
rs1201380386 576 dbSNP
rs1479112013 578 dbSNP
rs976273374 581 dbSNP
rs1192778352 587 dbSNP
rs543657401 589 dbSNP
rs1331799655 590 dbSNP
rs113588713 594 dbSNP
rs113895885 599 dbSNP
rs1323521993 605 dbSNP
rs1460391139 611 dbSNP
rs956268483 612 dbSNP
rs1325801903 613 dbSNP
rs553166668 614 dbSNP
rs1395723735 618 dbSNP
rs1428218753 622 dbSNP
rs1327674158 624 dbSNP
rs1320709697 633 dbSNP
rs987834682 634 dbSNP
rs574789944 635 dbSNP
rs1388846845 638 dbSNP
rs1414775796 642 dbSNP
rs1418546660 647 dbSNP
rs796614275 648 dbSNP
rs913551112 649 dbSNP
rs754136523 653 dbSNP
rs1249969690 654 dbSNP
rs112534095 658 dbSNP
rs1327127676 660 dbSNP
rs1460949612 661 dbSNP
rs867598870 662 dbSNP
rs1239861713 666 dbSNP
rs946378983 668 dbSNP
rs1272826932 670 dbSNP
rs1212425699 678 dbSNP
rs1043878432 679 dbSNP
rs1297655313 686 dbSNP
rs1451225278 687 dbSNP
rs981004803 688 dbSNP
rs1290360693 690 dbSNP
rs1304460196 691 dbSNP
rs184349924 702 dbSNP
rs1326677253 703 dbSNP
rs941932964 705 dbSNP
rs1232650244 709 dbSNP
rs1392306089 710 dbSNP
rs1169486559 714 dbSNP
rs145597354 715 dbSNP
rs1383462273 719 dbSNP
rs1056221427 720 dbSNP
rs138119623 724 dbSNP
rs932952764 727 dbSNP
rs1232641413 729 dbSNP
rs73506019 731 dbSNP
rs1249393156 734 dbSNP
rs140848095 735 dbSNP
rs1212596025 741 dbSNP
rs887789042 744 dbSNP
rs1183518859 753 dbSNP
rs764406871 754 dbSNP
rs1006188807 760 dbSNP
rs1007763610 761 dbSNP
rs764698190 764 dbSNP
rs1043605828 770 dbSNP
rs866853874 777 dbSNP
rs557234006 785 dbSNP
rs999127170 787 dbSNP
rs998127955 790 dbSNP
rs142713124 794 dbSNP
rs937430625 800 dbSNP
rs1167057051 804 dbSNP
rs1031899855 808 dbSNP
rs188330446 814 dbSNP
rs1407831805 819 dbSNP
rs570658815 821 dbSNP
rs989079903 828 dbSNP
rs1473738298 841 dbSNP
rs1014260856 844 dbSNP
rs1489756994 845 dbSNP
rs1166448427 846 dbSNP
rs914797894 847 dbSNP
rs772880548 848 dbSNP
rs1304704046 850 dbSNP
rs968124469 851 dbSNP
rs979080011 855 dbSNP
rs1282476498 856 dbSNP
rs926402986 858 dbSNP
rs538142696 865 dbSNP
rs1295528223 866 dbSNP
rs980652887 890 dbSNP
rs755347302 892 dbSNP
rs917769251 893 dbSNP
rs868466776 895 dbSNP
rs1459336284 896 dbSNP
rs1413152698 899 dbSNP
rs1199192490 901 dbSNP
rs201663550 904 dbSNP
rs1414198593 906 dbSNP
rs909055089 908 dbSNP
rs963150800 910 dbSNP
rs971961296 913 dbSNP
rs376614890 917 dbSNP
rs1006674276 918 dbSNP
rs370540023 920 dbSNP
rs933029539 923 dbSNP
rs1051859851 926 dbSNP
rs1206903282 934 dbSNP
rs1303593634 936 dbSNP
rs910334060 941 dbSNP
rs1387578674 944 dbSNP
rs1361342892 948 dbSNP
rs1030396653 952 dbSNP
rs1437860063 957 dbSNP
rs1390077782 963 dbSNP
rs1277698515 964 dbSNP
rs766221303 965 dbSNP
rs1042789057 966 dbSNP
rs546078084 972 dbSNP
rs1258832781 974 dbSNP
rs1464976712 981 dbSNP
rs1242411909 985 dbSNP
rs904702682 987 dbSNP
rs1346790377 998 dbSNP
rs1256426760 1004 dbSNP
rs549753974 1005 dbSNP
rs1053368209 1007 dbSNP
rs567900736 1008 dbSNP
rs562106000 1009 dbSNP
rs557962524 1010 dbSNP
rs1462785649 1014 dbSNP
rs1170743836 1017 dbSNP
rs1014291909 1021 dbSNP
rs772618778 1022 dbSNP
rs959276851 1027 dbSNP
rs1023369414 1032 dbSNP
rs991885783 1035 dbSNP
rs917633443 1036 dbSNP
rs1313637431 1040 dbSNP
rs905840101 1044 dbSNP
rs1381411891 1048 dbSNP
rs571772157 1054 dbSNP
rs1479547307 1062 dbSNP
rs929146070 1063 dbSNP
rs1207560278 1064 dbSNP
rs1342951280 1065 dbSNP
rs539069763 1066 dbSNP
rs1326839171 1070 dbSNP
rs909156009 1078 dbSNP
rs1230277800 1082 dbSNP
rs1016983351 1083 dbSNP
rs963184292 1087 dbSNP
rs1342837787 1089 dbSNP
rs1211153428 1096 dbSNP
rs370737835 1097 dbSNP
rs1369101741 1104 dbSNP
rs754876312 1105 dbSNP
rs954616613 1106 dbSNP
rs987180059 1108 dbSNP
rs767538118 1112 dbSNP
rs1450498374 1115 dbSNP
rs1473723232 1120 dbSNP
rs576710343 1129 dbSNP
rs575826926 1131 dbSNP
rs1471446883 1132 dbSNP
rs1051856123 1135 dbSNP
rs1174474798 1137 dbSNP
rs1289218051 1138 dbSNP
rs891845100 1140 dbSNP
rs73506022 1145 dbSNP
rs934849186 1146 dbSNP
rs1385506180 1150 dbSNP
rs904799317 1152 dbSNP
rs1053266282 1153 dbSNP
rs1323724534 1156 dbSNP
rs115890931 1158 dbSNP
rs541604339 1161 dbSNP
rs959040892 1171 dbSNP
rs1044621322 1172 dbSNP
rs35799448 1173 dbSNP
rs370642630 1175 dbSNP
rs746041465 1182 dbSNP
rs983277314 1184 dbSNP
rs758620145 1186 dbSNP
rs1413869448 1187 dbSNP
rs1260658182 1189 dbSNP
rs1182699358 1196 dbSNP
rs909027675 1197 dbSNP
rs1246306158 1198 dbSNP
rs1197032935 1208 dbSNP
rs1453343211 1213 dbSNP
rs1017472519 1214 dbSNP
rs1208644269 1221 dbSNP
rs1327749864 1226 dbSNP
rs1270386733 1228 dbSNP
rs1465800691 1238 dbSNP
rs941834988 1246 dbSNP
rs180801604 1249 dbSNP
rs11666961 1255 dbSNP
rs921809498 1264 dbSNP
rs1331161714 1265 dbSNP
rs993321543 1269 dbSNP
rs1026088261 1272 dbSNP
rs1390687213 1273 dbSNP
rs954524543 1276 dbSNP
rs1159861183 1283 dbSNP
rs987807823 1284 dbSNP
rs1469041516 1294 dbSNP
rs1422815922 1295 dbSNP
rs1468296976 1299 dbSNP
rs1192028857 1300 dbSNP
rs1017487067 1303 dbSNP
rs917278567 1304 dbSNP
rs933309639 1305 dbSNP
rs1051761851 1321 dbSNP
rs964736500 1328 dbSNP
rs528884635 1329 dbSNP
rs1158390803 1331 dbSNP
rs978449820 1337 dbSNP
rs1250400249 1338 dbSNP
rs1209908498 1340 dbSNP
rs1442141406 1345 dbSNP
rs1364449035 1348 dbSNP
rs1220569309 1354 dbSNP
rs1345345195 1357 dbSNP
rs1458804721 1358 dbSNP
rs925720491 1372 dbSNP
rs551531635 1376 dbSNP
rs988536277 1377 dbSNP
rs904705435 1378 dbSNP
rs374577132 1379 dbSNP
rs950210150 1380 dbSNP
rs531544129 1384 dbSNP
rs1056055129 1387 dbSNP
rs550029802 1394 dbSNP
rs80087121 1396 dbSNP
rs1168230225 1401 dbSNP
rs1390457707 1402 dbSNP
rs529066927 1403 dbSNP
rs769061060 1404 dbSNP
rs1230818843 1410 dbSNP
rs1189756428 1415 dbSNP
rs1271783052 1418 dbSNP
rs941391898 1419 dbSNP
rs1038322912 1420 dbSNP
rs1248673588 1422 dbSNP
rs1479817266 1429 dbSNP
rs185604599 1435 dbSNP
rs1004653510 1436 dbSNP
rs1252689956 1437 dbSNP
rs1297778282 1445 dbSNP
rs994233908 1451 dbSNP
rs1051099547 1453 dbSNP
rs1227642332 1455 dbSNP
rs1376947068 1461 dbSNP
rs890295657 1466 dbSNP
rs1448429703 1468 dbSNP
rs565438325 1473 dbSNP
rs1428121973 1475 dbSNP
rs1008693389 1478 dbSNP
rs963250260 1479 dbSNP
rs1017979025 1483 dbSNP
rs964644193 1494 dbSNP
rs1184119816 1496 dbSNP
rs539516218 1498 dbSNP
rs1046245 1502 dbSNP
rs1251622685 1503 dbSNP
rs1179566193 1506 dbSNP
rs1483855910 1509 dbSNP
rs557507281 1512 dbSNP
rs1046253 1514 dbSNP
rs1220120606 1519 dbSNP
rs537372081 1524 dbSNP
rs1352532218 1528 dbSNP
rs1291855368 1529 dbSNP
rs1349632654 1532 dbSNP
rs1461215167 1532 dbSNP
rs1286296800 1534 dbSNP
rs987496211 1537 dbSNP
rs71335266 1539 dbSNP
rs15490 1542 dbSNP
rs1352512017 1547 dbSNP
rs190017883 1559 dbSNP
rs988565701 1564 dbSNP
rs868316643 1566 dbSNP
rs574343984 1568 dbSNP
rs1351834761 1572 dbSNP
rs1412330859 1578 dbSNP
rs946005002 1586 dbSNP
rs916961249 1608 dbSNP
rs1411650891 1612 dbSNP
rs1355304573 1613 dbSNP
rs1473788185 1632 dbSNP
rs1252037655 1633 dbSNP
rs887331832 1635 dbSNP
rs1487183960 1638 dbSNP
rs1005695370 1640 dbSNP
rs765810356 1640 dbSNP
rs972010873 1643 dbSNP
rs1222209548 1647 dbSNP
rs1038527914 1648 dbSNP
rs1229386733 1653 dbSNP
rs937565221 1668 dbSNP
rs1056361790 1672 dbSNP
rs200850780 1674 dbSNP
rs143269437 1675 dbSNP
rs112808207 1676 dbSNP
rs33916887 1676 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_ControlB_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acGGUCGGAGCGGGUCg 5'
            || |:  :|||||| 
Target 5' uaCCUGUGGUGCCCAGa 3'
7 - 23
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_ControlB_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control B
Location of target site ENST00000166139.4 | 3UTR | GUGCCUUACCUGUGGUGCCCAGAAAAGUGCCCCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-4486 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT254654 NF2 neurofibromin 2 2 2
MIRT458684 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT470845 PLXND1 plexin D1 2 2
MIRT493011 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT497264 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT497675 SYNGR1 synaptogyrin 1 2 2
MIRT498219 TLN2 talin 2 2 2
MIRT498310 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT504048 TOMM5 translocase of outer mitochondrial membrane 5 2 2
MIRT519959 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT531521 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT533144 WNT10A Wnt family member 10A 2 2
MIRT533541 TPR translocated promoter region, nuclear basket protein 2 2
MIRT533681 TMEM86A transmembrane protein 86A 2 2
MIRT540321 PIGR polymeric immunoglobulin receptor 2 2
MIRT540719 GUF1 GUF1 homolog, GTPase 2 2
MIRT541566 ZNF43 zinc finger protein 43 2 4
MIRT541787 TBCCD1 TBCC domain containing 1 2 2
MIRT541925 ORC1 origin recognition complex subunit 1 2 4
MIRT542232 FUT9 fucosyltransferase 9 2 2
MIRT542285 POLR3K RNA polymerase III subunit K 2 2
MIRT542299 QTRTD1 queuine tRNA-ribosyltransferase accessory subunit 2 2 4
MIRT542368 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT542441 C3 complement C3 2 4
MIRT542475 APOC3 apolipoprotein C3 2 2
MIRT542535 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542640 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT542788 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT552104 PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 2 2
MIRT564913 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT568606 ACVR2A activin A receptor type 2A 2 2
MIRT607389 LANCL3 LanC like 3 2 2
MIRT607451 ZNF543 zinc finger protein 543 2 2
MIRT610058 MYBPC1 myosin binding protein C, slow type 2 2
MIRT610793 KLK2 kallikrein related peptidase 2 2 2
MIRT617176 GOSR2 golgi SNAP receptor complex member 2 2 2
MIRT620579 WBSCR27 methyltransferase like 27 2 4
MIRT622085 SRPX2 sushi repeat containing protein, X-linked 2 2 2
MIRT622542 PXMP4 peroxisomal membrane protein 4 2 2
MIRT630009 PDE6B phosphodiesterase 6B 2 2
MIRT631813 PTDSS2 phosphatidylserine synthase 2 2 2
MIRT632721 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT632757 MED28 mediator complex subunit 28 2 2
MIRT634821 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT635255 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT637082 SELPLG selectin P ligand 2 2
MIRT637357 ZNF460 zinc finger protein 460 2 2
MIRT637472 DEFB105B defensin beta 105B 2 4
MIRT637504 DEFB105A defensin beta 105A 2 4
MIRT639022 AAK1 AP2 associated kinase 1 2 2
MIRT641012 ANKFY1 ankyrin repeat and FYVE domain containing 1 2 2
MIRT642170 HEBP2 heme binding protein 2 2 2
MIRT648977 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT650515 UFM1 ubiquitin fold modifier 1 2 2
MIRT650949 INMT indolethylamine N-methyltransferase 2 2
MIRT658354 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT660736 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT662191 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT663045 SLC16A4 solute carrier family 16 member 4 2 2
MIRT664811 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT665161 SF3A1 splicing factor 3a subunit 1 2 4
MIRT665346 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT666493 SBNO1 strawberry notch homolog 1 2 2
MIRT666545 RNF115 ring finger protein 115 2 2
MIRT669351 BMP3 bone morphogenetic protein 3 2 2
MIRT669904 KIAA0754 KIAA0754 2 4
MIRT670323 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT670430 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT670672 KIAA1551 KIAA1551 2 2
MIRT670746 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670998 PTGIS prostaglandin I2 synthase 2 2
MIRT671290 RPL37A ribosomal protein L37a 2 2
MIRT671469 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT671833 STIL STIL, centriolar assembly protein 2 2
MIRT673006 TAF1 TATA-box binding protein associated factor 1 2 2
MIRT675881 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT678625 OLFML2A olfactomedin like 2A 2 2
MIRT678790 NUPL2 nucleoporin like 2 2 2
MIRT679560 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT681032 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682480 LIX1L limb and CNS expressed 1 like 2 2
MIRT682758 MDM2 MDM2 proto-oncogene 2 2
MIRT682810 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT682867 C9orf156 tRNA methyltransferase O 2 2
MIRT689233 RPS19 ribosomal protein S19 2 2
MIRT689305 C5AR2 complement component 5a receptor 2 2 2
MIRT689363 ZNF101 zinc finger protein 101 2 2
MIRT689629 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT689654 RBM23 RNA binding motif protein 23 2 2
MIRT690148 PPIL6 peptidylprolyl isomerase like 6 2 2
MIRT691407 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT691847 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT692234 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT694320 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT694365 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT696215 LYZ lysozyme 2 2
MIRT697230 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT700487 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT700612 PRKCA protein kinase C alpha 2 2
MIRT702456 KIAA1467 family with sequence similarity 234 member B 2 2
MIRT702990 HERPUD2 HERPUD family member 2 2 2
MIRT703998 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT704701 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT712481 FSTL3 follistatin like 3 2 2
MIRT712781 ZNF154 zinc finger protein 154 2 2
MIRT714369 HP1BP3 heterochromatin protein 1 binding protein 3 2 2
MIRT722570 C1orf95 stum, mechanosensory transduction mediator homolog 2 2
MIRT722839 C17orf102 chromosome 17 open reading frame 102 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4486 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4486 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive Low Gastric Cancer cell line (SGC-7901)
hsa-mir-4486 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4486 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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