pre-miRNA Information
pre-miRNA hsa-mir-497   
Genomic Coordinates chr17: 7017911 - 7018022
Synonyms MIRN497, hsa-mir-497, MIR497
Description Homo sapiens miR-497 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-497-3p
Sequence 64| CAAACCACACUGUGGUGUUAGA |85
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 17 - 7017957 29233923 MiREDiBase
A-to-I 4 17 - 7017956 29233923 MiREDiBase
A-to-I 20 17 - 7017940 24964909, 25521855, 27229138, 29165639, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1413601274 5 dbSNP
rs1028648384 6 dbSNP
rs1479092960 9 dbSNP
rs1261056598 10 dbSNP
rs997278260 11 dbSNP
rs1324708562 13 dbSNP
rs755634302 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol KNSTRN   
Synonyms C15orf23, HSD11, SKAP, TRAF4AF1
Description kinetochore localized astrin/SPAG5 binding protein
Transcript NM_001142761   
Other Transcripts NM_001142762 , NM_033286   
Expression
Putative miRNA Targets on KNSTRN
3'UTR of KNSTRN
(miRNA target sites are highlighted)
>KNSTRN|NM_001142761|3'UTR
   1 AGGATTTCATCGTTCCAGTTTAGATACAGGAGTCTAGTCCCTCTCTACTACTAGAGGGACAATTCCTAAAACCAGTGCAT
  81 AGAAATAAAATCTAAAATAGAAGATACAGTCTGTTGATACTCCAGTGGTCTTCCTTAGTGGAATAGGAGCATAATGTTCT
 161 GATGTGGGAATTGTGTTTCCTGTTAGTCAAGAGTTTTGTGTATGTGTTGTTTTCTTTTGGAATGTCTTTCCATGCAGGCC
 241 TTAAAGGTAAAGCTGGAGATGAAAGAGGAAAGAGTCCGATTCCTAGAACAGCAAACCTTATGTAACAATCAAGTAAATGA
 321 TTTAACAACAGCCCTTAAGGAAATGGAGCAGCTATTAGAAATGTAAGAAGAAGCAAGTGGCCAGATGGCTCCCTCTTGGG
 401 CATAAAATCTCAGAGGAAGCTACTTAGGACATCATCTTGGCCATGATCTTCTGGGACTCACCATCTCCAGAATGAAAACA
 481 ATTTCTACAGTAGACTTAAGGACAGTTTATGCTGAAATGGCAATTCCTCATTTAAGCAAGTTTTCCCAACCTTCAGGTTG
 561 GTCAGCCCTCCTGAGCCTCACAGGTGGATAATTGAGGCCTACAAGAGAGGGGAGCCTAGGAGCTTGGATTGACCTTCTAG
 641 TCAACCACCTGACTTCAGCACACCATTACAATCGGGAGACTAAACCAACAACCAGAGGATCTAAAATGTCACATTCAGAT
 721 TTTCAGGAAGAAAATCTTCATTACAGTGGAGCACAAATGTTCCATACAAGACATCATTGAGGAGCCATGCTGTCCCCTTC
 801 TAACCTGAAACACATTCTTTCCCATCCTGGTTGGGCTTCTGTACCTCCTTATTAATTTATGAACCTGAAGTTGCTTGAAG
 881 TGTTTTGGGCTTAATAAATGGGGTGAAAGTATAGGTAGCAGTAACACCTACATGAAACAATACACCTTGGATCTTTTAAT
 961 CTAAATTACTTTTCTTTTTTAAGTCTACTTTTAAAATAAATACTTCTGTAAATATTCTGACTGTAACATTGAGGAATGAA
1041 AATAGCCTTTTAACCTAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agAUUGUGGUGUCACACCAAAc 5'
            |:|:||: ||  ||||| | 
Target 5' gtTGATACTCCA--GTGGTCTt 3'
113 - 132 128.00 -12.30
2
miRNA  3' agaUUGUGGUGUCACACCAAac 5'
             |:| :||||| |||| |  
Target 5' ctgAGCCTCACAG-GTGGATaa 3'
571 - 591 114.00 -15.46
3
miRNA  3' agaUUGUGGUGUCA--------CACCAAAc 5'
             ||| |:: |||        ||| ||| 
Target 5' atgAAC-CTGAAGTTGCTTGAAGTGTTTTg 3'
859 - 887 112.00 -7.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
786753 366 ClinVar
COSN30449409 9 COSMIC
COSN18325575 69 COSMIC
COSN13618052 83 COSMIC
COSN25762928 106 COSMIC
COSN30511453 107 COSMIC
COSN30473649 134 COSMIC
COSN30151120 142 COSMIC
COSN30151051 157 COSMIC
COSN31511494 184 COSMIC
COSN26563589 201 COSMIC
COSN30515896 224 COSMIC
COSN31567331 227 COSMIC
COSM5097163 234 COSMIC
COSM5082548 239 COSMIC
COSM274217 253 COSMIC
COSM9529328 262 COSMIC
COSM4054354 278 COSMIC
COSM9086081 279 COSMIC
COSM9748753 286 COSMIC
COSM4572849 300 COSMIC
COSM256445 317 COSMIC
COSM3987926 364 COSMIC
COSN31510306 416 COSMIC
COSN30163000 456 COSMIC
COSN28878502 459 COSMIC
COSN31601629 544 COSMIC
COSN6272639 988 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs776493263 6 dbSNP
rs748097193 12 dbSNP
rs769517906 13 dbSNP
rs376425558 16 dbSNP
rs766641415 19 dbSNP
rs1221563886 22 dbSNP
rs1477077545 23 dbSNP
rs774708387 25 dbSNP
rs1490403917 26 dbSNP
rs1255927781 27 dbSNP
rs759592377 28 dbSNP
rs1255183512 31 dbSNP
rs1266442830 31 dbSNP
rs1439501853 34 dbSNP
rs767611992 37 dbSNP
rs1266650470 43 dbSNP
rs753180572 45 dbSNP
rs756600383 46 dbSNP
rs1165521182 47 dbSNP
rs563646616 49 dbSNP
rs754141045 51 dbSNP
rs1318056919 57 dbSNP
rs1006120600 59 dbSNP
rs879065223 60 dbSNP
rs1278534385 61 dbSNP
rs1218193064 65 dbSNP
rs8037941 77 dbSNP
rs758266561 88 dbSNP
rs1363942733 92 dbSNP
rs181989004 106 dbSNP
rs1455090605 107 dbSNP
rs1345783679 112 dbSNP
rs994229109 118 dbSNP
rs917683022 126 dbSNP
rs955390235 132 dbSNP
rs1194287493 137 dbSNP
rs1449105410 140 dbSNP
rs1246350760 142 dbSNP
rs1467384596 146 dbSNP
rs970343600 147 dbSNP
rs1171766508 151 dbSNP
rs980454084 160 dbSNP
rs1440600935 162 dbSNP
rs1281866949 166 dbSNP
rs1018646586 171 dbSNP
rs56317498 182 dbSNP
rs1292990647 186 dbSNP
rs775993148 187 dbSNP
rs758054217 189 dbSNP
rs1362361000 198 dbSNP
rs1399002944 199 dbSNP
rs779750968 201 dbSNP
rs1328849903 203 dbSNP
rs1412882647 203 dbSNP
rs913768148 204 dbSNP
rs1171489993 205 dbSNP
rs751216309 207 dbSNP
rs200872015 210 dbSNP
rs748068908 213 dbSNP
rs1359744330 218 dbSNP
rs769806376 221 dbSNP
rs1289324769 222 dbSNP
rs1444336176 223 dbSNP
rs1429186788 225 dbSNP
rs777713107 230 dbSNP
rs201042301 233 dbSNP
rs201289104 235 dbSNP
rs774761615 236 dbSNP
rs1185531562 237 dbSNP
rs1243764094 239 dbSNP
rs565554379 240 dbSNP
rs1161975612 259 dbSNP
rs201814444 263 dbSNP
rs1462862636 264 dbSNP
rs1180428241 270 dbSNP
rs1255937036 270 dbSNP
rs775588585 275 dbSNP
rs761096365 277 dbSNP
rs369930942 278 dbSNP
rs200025938 279 dbSNP
rs186157950 283 dbSNP
rs765884043 286 dbSNP
rs1249306919 289 dbSNP
rs1310207988 290 dbSNP
rs749911100 293 dbSNP
rs927580566 293 dbSNP
rs748267102 296 dbSNP
rs1307669959 299 dbSNP
rs1327807283 300 dbSNP
rs375197641 302 dbSNP
rs770205245 303 dbSNP
rs751211021 308 dbSNP
rs1337393292 309 dbSNP
rs1205413472 318 dbSNP
rs1231156437 320 dbSNP
rs754619508 323 dbSNP
rs1460975827 324 dbSNP
rs752195768 329 dbSNP
rs755678785 331 dbSNP
rs777913445 332 dbSNP
rs749214550 334 dbSNP
rs1038308234 335 dbSNP
rs1217575509 338 dbSNP
rs1371644864 341 dbSNP
rs770890334 343 dbSNP
rs897172783 344 dbSNP
rs778725206 352 dbSNP
rs746096458 353 dbSNP
rs569657077 355 dbSNP
rs1363676460 357 dbSNP
rs139286584 366 dbSNP
rs369469587 372 dbSNP
rs768711798 374 dbSNP
rs1225104902 375 dbSNP
rs777174472 378 dbSNP
rs1163225303 379 dbSNP
rs189861256 381 dbSNP
rs1051616770 390 dbSNP
rs200552828 392 dbSNP
rs1262523057 394 dbSNP
rs1486326327 396 dbSNP
rs1204702302 400 dbSNP
rs376622940 401 dbSNP
rs369417225 404 dbSNP
rs1200570619 408 dbSNP
rs1429249173 411 dbSNP
rs1196973508 412 dbSNP
rs373391184 416 dbSNP
rs11541643 419 dbSNP
rs1336651191 430 dbSNP
rs1424595945 432 dbSNP
rs1293876886 442 dbSNP
rs115872791 446 dbSNP
rs766983922 447 dbSNP
rs1333856165 463 dbSNP
rs142745139 468 dbSNP
rs1391966517 470 dbSNP
rs61298638 482 dbSNP
rs1270459091 505 dbSNP
rs12595509 509 dbSNP
rs536862947 515 dbSNP
rs970480931 521 dbSNP
rs991921109 522 dbSNP
rs1469066544 530 dbSNP
rs1025180379 546 dbSNP
rs980413186 548 dbSNP
rs1212659934 551 dbSNP
rs531911239 555 dbSNP
rs1419145048 556 dbSNP
rs1033387747 562 dbSNP
rs971577281 569 dbSNP
rs1191329521 576 dbSNP
rs1291768392 577 dbSNP
rs1273601485 579 dbSNP
rs1207813774 580 dbSNP
rs764242371 581 dbSNP
rs775192611 588 dbSNP
rs1262413944 596 dbSNP
rs1322195348 608 dbSNP
rs980703867 618 dbSNP
rs557070430 621 dbSNP
rs1330571245 623 dbSNP
rs150753348 630 dbSNP
rs1443411249 638 dbSNP
rs1371929830 640 dbSNP
rs941585374 646 dbSNP
rs913810370 654 dbSNP
rs11541641 656 dbSNP
rs1453906957 657 dbSNP
rs976567482 658 dbSNP
rs1171142760 662 dbSNP
rs918546499 663 dbSNP
rs922675422 671 dbSNP
rs932763204 674 dbSNP
rs1051179169 675 dbSNP
rs1263828659 677 dbSNP
rs1049715039 702 dbSNP
rs1205612908 706 dbSNP
rs137878630 711 dbSNP
rs1241810341 712 dbSNP
rs1236503855 720 dbSNP
rs941367526 721 dbSNP
rs1037248831 728 dbSNP
rs942530558 735 dbSNP
rs573300179 740 dbSNP
rs897420061 747 dbSNP
rs1395984722 749 dbSNP
rs1374112244 756 dbSNP
rs1171202112 758 dbSNP
rs903696566 761 dbSNP
rs78181034 762 dbSNP
rs1395362320 763 dbSNP
rs571726708 775 dbSNP
rs1014404823 778 dbSNP
rs1024508810 780 dbSNP
rs906277033 786 dbSNP
rs545390461 790 dbSNP
rs1193563798 791 dbSNP
rs565588986 791 dbSNP
rs753552809 798 dbSNP
rs1000746002 801 dbSNP
rs1033852784 806 dbSNP
rs1421053247 815 dbSNP
rs531185176 835 dbSNP
rs892124684 848 dbSNP
rs1213065084 853 dbSNP
rs989569368 855 dbSNP
rs1344169158 860 dbSNP
rs544578212 862 dbSNP
rs1428232393 868 dbSNP
rs966626726 882 dbSNP
rs1375488059 889 dbSNP
rs1327553388 896 dbSNP
rs139964319 897 dbSNP
rs1407881761 897 dbSNP
rs561572320 903 dbSNP
rs530219538 904 dbSNP
rs976536150 906 dbSNP
rs922479466 916 dbSNP
rs1168353605 924 dbSNP
rs954120725 928 dbSNP
rs985529697 936 dbSNP
rs765021335 939 dbSNP
rs1312901463 941 dbSNP
rs1355939694 942 dbSNP
rs941348502 943 dbSNP
rs980557897 951 dbSNP
rs1034443860 956 dbSNP
rs962851959 957 dbSNP
rs1273967457 962 dbSNP
rs974291795 965 dbSNP
rs918872603 966 dbSNP
rs929979632 966 dbSNP
rs1234474014 978 dbSNP
rs1445442918 984 dbSNP
rs1212548316 985 dbSNP
rs987228866 992 dbSNP
rs1278451167 1000 dbSNP
rs1238380169 1002 dbSNP
rs1037455767 1007 dbSNP
rs1329094302 1016 dbSNP
rs1461182545 1022 dbSNP
rs1460767759 1025 dbSNP
rs1392066256 1028 dbSNP
rs912582307 1029 dbSNP
rs1182270786 1030 dbSNP
rs1407071698 1041 dbSNP
rs1175621099 1046 dbSNP
rs1382774458 1047 dbSNP
rs918834634 1051 dbSNP
rs950317160 1056 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_ControlA_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control A ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agauuguggugucaCACCAAAc 5'
                        ||||||| 
Target 5' -------------cGUGGUUUc 3'
1 - 9
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_ControlA_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control A
Location of target site ENST00000608100.1 | 3UTR | CGUGGUUUCACCAUGUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
95 hsa-miR-497-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT092955 CYP2U1 cytochrome P450 family 2 subfamily U member 1 2 4
MIRT124568 PRRC2B proline rich coiled-coil 2B 2 2
MIRT125196 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 4
MIRT147296 KPNA2 karyopherin subunit alpha 2 2 8
MIRT163999 KIAA1109 KIAA1109 2 4
MIRT252495 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT357969 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT443007 TRIOBP TRIO and F-actin binding protein 2 2
MIRT443524 NETO1 neuropilin and tolloid like 1 2 2
MIRT443573 EVX2 even-skipped homeobox 2 2 2
MIRT443656 BACH1 BTB domain and CNC homolog 1 2 2
MIRT460670 KRT10 keratin 10 2 8
MIRT464761 UBE2N ubiquitin conjugating enzyme E2 N 2 2
MIRT465032 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT465040 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT468667 SEC62 SEC62 homolog, preprotein translocation factor 2 2
MIRT473694 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT477618 EFNA3 ephrin A3 2 2
MIRT480506 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT480592 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT486915 ZNF398 zinc finger protein 398 2 6
MIRT487770 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 16
MIRT493265 MDFIC MyoD family inhibitor domain containing 2 2
MIRT495271 SLC1A2 solute carrier family 1 member 2 2 4
MIRT495309 CHST12 carbohydrate sulfotransferase 12 2 2
MIRT496681 DPP6 dipeptidyl peptidase like 6 2 4
MIRT496891 FOXP1 forkhead box P1 2 2
MIRT497330 IRF4 interferon regulatory factor 4 2 2
MIRT498272 KIAA1644 KIAA1644 2 2
MIRT498634 CHD4 chromodomain helicase DNA binding protein 4 2 10
MIRT500581 USP53 ubiquitin specific peptidase 53 2 2
MIRT500751 TMPPE transmembrane protein with metallophosphoesterase domain 2 6
MIRT509668 ZNF354B zinc finger protein 354B 2 10
MIRT510919 PSMA2 proteasome subunit alpha 2 2 4
MIRT519118 CEP76 centrosomal protein 76 2 2
MIRT526193 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 2 2
MIRT526746 HLA-DOB major histocompatibility complex, class II, DO beta 2 2
MIRT527270 FBLN2 fibulin 2 2 2
MIRT528198 PLEKHM2 pleckstrin homology and RUN domain containing M2 2 2
MIRT528330 TBC1D22B TBC1 domain family member 22B 2 2
MIRT530346 GABRB3 gamma-aminobutyric acid type A receptor beta3 subunit 2 2
MIRT533627 TMX3 thioredoxin related transmembrane protein 3 2 2
MIRT533738 TMEM200C transmembrane protein 200C 2 2
MIRT533779 TMEM133 transmembrane protein 133 2 2
MIRT534317 SKIDA1 SKI/DACH domain containing 1 2 2
MIRT538438 COG5 component of oligomeric golgi complex 5 2 2
MIRT539156 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT539474 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT539620 SHISA9 shisa family member 9 2 2
MIRT539650 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540346 OPHN1 oligophrenin 1 2 2
MIRT540412 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2 2
MIRT541200 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 2
MIRT541395 CDC27 cell division cycle 27 2 2
MIRT546443 SNX5 sorting nexin 5 2 2
MIRT547369 MSI2 musashi RNA binding protein 2 2 2
MIRT553288 TSPAN3 tetraspanin 3 2 2
MIRT554402 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT557822 FOXN2 forkhead box N2 2 2
MIRT568530 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT569508 THYN1 thymocyte nuclear protein 1 2 2
MIRT570707 FAM69A family with sequence similarity 69 member A 2 2
MIRT608376 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT608483 NKTR natural killer cell triggering receptor 2 6
MIRT613533 TRA2B transformer 2 beta homolog 2 2
MIRT616601 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT618166 DUSP18 dual specificity phosphatase 18 2 2
MIRT632059 CEP135 centrosomal protein 135 2 2
MIRT647379 ZDHHC23 zinc finger DHHC-type containing 23 2 2
MIRT648366 POTED POTE ankyrin domain family member D 2 2
MIRT651075 ZNF518B zinc finger protein 518B 2 4
MIRT653618 SLC30A4 solute carrier family 30 member 4 2 2
MIRT653636 SLC30A1 solute carrier family 30 member 1 2 2
MIRT654895 POU2F1 POU class 2 homeobox 1 2 2
MIRT656232 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT659880 CAPRIN1 cell cycle associated protein 1 2 2
MIRT660526 ARL4C ADP ribosylation factor like GTPase 4C 2 2
MIRT666286 SLC30A3 solute carrier family 30 member 3 2 2
MIRT686808 SNX2 sorting nexin 2 2 4
MIRT695302 TK1 thymidine kinase 1 2 2
MIRT699737 SERINC3 serine incorporator 3 2 2
MIRT700794 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT712270 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT712617 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT714264 RPL10A ribosomal protein L10a 2 2
MIRT715072 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715386 TADA3 transcriptional adaptor 3 2 2
MIRT716397 NPAS1 neuronal PAS domain protein 1 2 2
MIRT725328 NFASC neurofascin 2 2
MIRT725503 GANAB glucosidase II alpha subunit 2 2
MIRT732913 IRAK2 interleukin 1 receptor associated kinase 2 3 0
MIRT734890 SMAD3 SMAD family member 3 3 0
MIRT737328 LINC02476 long intergenic non-protein coding RNA 2476 3 0
MIRT737544 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 4 0
MIRT755545 PAK1 p21 (RAC1) activated kinase 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-497 Bufalin NULL 9547215 Quantitative real-time PCR colorectal cancer HCT116 cells 24375248 2014 up-regulated
miR-497 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-497 Ethanol NULL 702 Quantitative real-time PCR CIE10 22141737 2012 up-regulated
miR-497 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-497 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive Low Breast Cancer cell line (MCF-7, T47D)
hsa-mir-497 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-497 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-497 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-497-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-497-3p Docetaxel 148124 NSC628503 approved resistant High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549, PC-9)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-497-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-497-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant tissue
hsa-miR-497-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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