miRTarBase - #MIRT713221


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pre-miRNA Information
pre-miRNA hsa-mir-6511b-1   
Genomic Coordinates chr16: 2106669 - 2106753
Description Homo sapiens miR-6511b-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-6511b-2   
Genomic Coordinates chr16: 15134075 - 15134145
Description Homo sapiens miR-6511b-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6511b-3p
Sequence 53| CCUCACCACCCCUUCUGCCUGCA |75
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
993639 5 ClinVar
1196654 15 ClinVar
256998 15 ClinVar
433980 16 ClinVar
586295 18 ClinVar
433979 19 ClinVar
COSM3948368 17 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs769351879 1 dbSNP
rs1001283562 2 dbSNP
rs763611191 3 dbSNP
rs1465530682 4 dbSNP
rs1227492873 4 dbSNP
rs745502224 5 dbSNP
rs551972801 6 dbSNP
rs538162642 6 dbSNP
rs751438298 7 dbSNP
rs1285683081 7 dbSNP
rs1340898267 8 dbSNP
rs4018164 9 dbSNP
rs370568831 9 dbSNP
rs1180919709 10 dbSNP
rs1339482497 10 dbSNP
rs758216756 11 dbSNP
rs1323026290 11 dbSNP
rs1239445091 12 dbSNP
rs1310601001 12 dbSNP
rs1431093969 13 dbSNP
rs752690118 15 dbSNP
rs1371790714 15 dbSNP
rs746463189 16 dbSNP
rs1209415208 17 dbSNP
rs761022804 17 dbSNP
rs1242038386 17 dbSNP
rs370411414 18 dbSNP
rs759723934 19 dbSNP
rs1428318191 19 dbSNP
rs1416441031 20 dbSNP
rs754040914 21 dbSNP
rs776062795 21 dbSNP
rs1273686335 22 dbSNP
rs1182772456 22 dbSNP
rs1472619959 23 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol RCAN2   
Synonyms CSP2, DSCR1L1, MCIP2, RCN2, ZAKI-4, ZAKI4
Description regulator of calcineurin 2
Transcript NM_005822   
Expression
Putative miRNA Targets on RCAN2
3'UTR of RCAN2
(miRNA target sites are highlighted)		 
>RCAN2|NM_005822|3'UTR
   1 GCTGCCTGCTCCTTCTCGATAATAGCCGTCTCCTCTTTATCATGCTTTTTCCCCCTGTTGTTTGTCAAAAAAAATTGCCT
  81 TTAAATTCCTGGGTGTTTGGTTGTTTGAGATTCCTTCCTTGTTATCAAGCCTCTCGGACAAAAGGGCTAGGAAAAGGTGA
 161 TATGTCTCCTGATCATATCATACCCATTAAGTATAACCCATTATTTAGAAGGTTCTAGGGAAAAAAGTAGTATTTTCTTA
 241 TTAAACAATCAGCACAGCCTATATCTTTGTTCTCTCATGTTGATCCAAGCCAGAGACATCAGTAACAAATAGCACCTGTG
 321 TTGTTTGTGAGCTGTTTCAGTCCCAGTCCTGATGTGTGTGCGTTGTTCTCTCCTGGCCACTTAAATAGGACCATATGTAA
 401 ACTTGACTTTGACTGCATGAGATATCCCTATCTGGTCTCACTCAGTCCTCTGCATCCCAACATTCCCAGGACATGCATGA
 481 TCACCAGCATTTATTTTCATTATTTGAGGATATCTTATAACTCACAGATTGTCAGCATCCAGCCATGTCCTATCTAGATT
 561 AGGAAAATGATCAGAATATTCCAGCTCAACAAGTCTGGGTATATTCACTATTGTGAGTCAATACACCATAGCTCTGTTGA
 641 AATTCCTGGAGGCAAAATTGACCTTGGCCCCAAAGATATTCCTCAATAGATTTCAAACACCACTCCCCTGTAGAACTCTC
 721 CCAGCCTCGTTGGGGAGGCTTGTCCAGGGTGATAGAGACTGATTTCAGACAAACCTATTTATTACAAAAGTTTCATGGTG
 801 TCTGAATGATTGTTTTCTCTCTTTGTATATTTGTACAAATGTTTCAGCTGTGCTTTTAAAAAATCTGGATGTTTTTTATT
 881 TAGTGATTGTTCGACAATTAGCTGCTTCAAAACATAATGTGCATTGCTTATGAATGCCTTCATATACTAATACAGATACT
 961 CTGATAATATTACACTCTAATAAGGATAATGCTGAATTTTGAAAGGACACAAAACATCTAATGCCAATATATACATGATT
1041 AGCCAACATCTTTGCTATCAAGACCACTTGTTTTTAAATAAAGATGCAAGTGTCAGTTGTAGATTATTGGGATGAAGCTA
1121 AATCCCCAGAATGCAGCAGCAGCTGAGCATGTTAAAATGGGGAAGGATGATAGCTACATGTATGCCGGTCCTACTCACGC
1201 GACACCCGTGTGCTCAAAAAAGTTATTTGTTTTTGTTACGTGTGATTTTTCTATTTCTCTAGCCCAAAGTGCATTACAGA
1281 AGATACACCTATAGAACCATTACCTTCTGCTATGTGTGCCAGGCCTCATCTACTCCTGTACATTAATGAATTACTTTAGA
1361 TGCAAACGCAGATTACAATGGAGTGGGGAAGTACTTTCATTACCCAAGCCTCAGAAAAACACACAAGAACAATAACACAG
1441 CAAACAGATTGAGGGATTGTTGTGGTTTTTGACTAAGGTGTATGTTAGTTTCATCAGAAACTTAAAACATAGACTGATCA
1521 CTCAGAAATTAAAGTCCGTTTTACTGTGAATATAGCAATATAGTACTGGACACAGTACTGGTGAAACTGAGGAGAGCATT
1601 GCTTGTAAAATCCTGAGTTTCCATAAGGAAAATGAAAACTCCTTTTAAAAATAAAATCTGAGGAGTGTACAATAAGCATA
1681 TGCTTTGACTTTCCTTTGCTGTGGAGGTTTTTGGTTTTTCATTGATGATAAACGACTACAGACTTAGTAGTGGAGAAATG
1761 GTGTCCTCTAGTGGAAGAAATAGTAGGCTCCGCTATTCAGATGCAGAGCACTGCAGCATCCAGCCTTTCAAAGCTGACTC
1841 TTCTCAATCATCTGTGGGTCATTTGACTTGATTTTTTAAGCTACCCTGAATTTCCAGAATGCAGGTTCTAAAGAAATCTA
1921 GATGAGAGAAAGTATTTGAAAATGATTTTTAAATGTTTTTTAAAAGACACATCTGACATTTTTAACAACTTAGTAAAAGT
2001 TGAAATGACCATTCTGTGTAGTCATAAAAGAAACACAATGAAGTGTATGGCCTCTGGAGTTAGTCTTAGTAAAACTTATT
2081 GCTCTGTGTCAATGTTAACCTGTCTCAGATCAAGTAATTCTTTCACTAGGTTGGGTTTGGGGAGGGGGGAAAAGAGGGGC
2161 TTTTCCTAGGAGAACGATAAGAAATGGAAAGACTCCTTGAAGTGTTGCAAGGGAACCTCCTAGCACTGTGAAAGTCAGAA
2241 TCGCCTCAGCATTTCCATGACGCACATTATGCAAATCTCTTTAGCACTATTTTAAGTTTGAAAACTTTAACAATGAAGGG
2321 GAAGGGGAAGATTTCCACCAACTGAATCATTTGTGCACGTGTATAGCTCAAAGAGCTTAGACTTCAAATATATCTGGTGA
2401 ATGACTCTTTGAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acGUCCGUCUUCCCCACCACUcc 5'
            ::| ||  ||   ||||||  
Target 5' acTGGACA-CAGTACTGGTGAaa 3'
 1565 - 1586 124.00 -9.30
2 
miRNA  3' acGUCCGUCUUCCCCACCACUCc 5'
            :|||: |  ||  ||| ||| 
Target 5' acTAGGTTG--GGTTTGGGGAGg 3'
 2125 - 2145 121.00 -18.00
3 
miRNA  3' acguccgucuuccccACCACUcc 5'
                         ||||||  
Target 5' gacttcaaatatatcTGGTGAat 3'
 2380 - 2402 120.00 -5.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN510361 2 COSMIC
COSN30174841 11 COSMIC
COSN30458124 17 COSMIC
COSN14231203 18 COSMIC
COSN26439751 28 COSMIC
COSN26991839 46 COSMIC
COSN26991840 50 COSMIC
COSN31610127 50 COSMIC
COSN30186407 52 COSMIC
COSN30465842 53 COSMIC
COSN28836079 67 COSMIC
COSN26991841 75 COSMIC
COSN31560219 78 COSMIC
COSN30465890 88 COSMIC
COSN30462104 109 COSMIC
COSN30476989 126 COSMIC
COSN30516804 126 COSMIC
COSN30136599 166 COSMIC
COSN31551724 185 COSMIC
COSN31558753 215 COSMIC
COSN31959993 222 COSMIC
COSN28722004 361 COSMIC
COSN31579759 361 COSMIC
COSN26574000 391 COSMIC
COSN17432771 427 COSMIC
COSN31540682 432 COSMIC
COSN31515898 458 COSMIC
COSN22224014 509 COSMIC
COSN6321884 539 COSMIC
COSN28683818 540 COSMIC
COSN28746769 581 COSMIC
COSN31565336 675 COSMIC
COSN31542691 735 COSMIC
COSN31486941 739 COSMIC
COSN2163466 782 COSMIC
COSN30540872 953 COSMIC
COSN30172951 980 COSMIC
COSN9784538 1070 COSMIC
COSN9784537 1145 COSMIC
COSN4859303 1162 COSMIC
COSN6591025 1239 COSMIC
COSN20091394 1304 COSMIC
COSN31778506 1368 COSMIC
COSN26649562 1578 COSMIC
COSN31534120 1627 COSMIC
COSN23516285 1648 COSMIC
COSN9907853 1696 COSMIC
COSN31602585 1703 COSMIC
COSN24901606 1814 COSMIC
COSN2163465 1942 COSMIC
COSN22713825 2040 COSMIC
COSN31556514 2097 COSMIC
COSN19657391 2261 COSMIC
COSN31572089 2343 COSMIC
COSN31531767 2358 COSMIC
COSN23144261 2360 COSMIC
COSN31532945 2361 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs757253329 2 dbSNP
rs1418058763 9 dbSNP
rs1025480080 12 dbSNP
rs567023552 17 dbSNP
rs771622092 18 dbSNP
rs1477719996 19 dbSNP
rs763806340 23 dbSNP
rs368914883 25 dbSNP
rs548900655 27 dbSNP
rs201540536 28 dbSNP
rs1410155431 30 dbSNP
rs1330498068 32 dbSNP
rs1035164734 33 dbSNP
rs773849118 41 dbSNP
rs765792336 42 dbSNP
rs1035593647 43 dbSNP
rs1200571652 46 dbSNP
rs1001225072 49 dbSNP
rs762320278 50 dbSNP
rs1252765918 51 dbSNP
rs752512240 51 dbSNP
rs980518402 51 dbSNP
rs1407722539 52 dbSNP
rs1222295353 57 dbSNP
rs765289032 60 dbSNP
rs1042863223 66 dbSNP
rs17853844 72 dbSNP
rs1271189312 75 dbSNP
rs969125563 75 dbSNP
rs373569682 78 dbSNP
rs1022399267 92 dbSNP
rs1203577551 100 dbSNP
rs1269411238 119 dbSNP
rs1011034184 131 dbSNP
rs891500088 133 dbSNP
rs184708035 135 dbSNP
rs553201047 136 dbSNP
rs1482303797 147 dbSNP
rs922882891 156 dbSNP
rs901194856 166 dbSNP
rs867324322 169 dbSNP
rs976952871 176 dbSNP
rs766659258 179 dbSNP
rs1316486449 182 dbSNP
rs1367891526 183 dbSNP
rs1403612288 184 dbSNP
rs77762642 199 dbSNP
rs1303105422 205 dbSNP
rs761462265 212 dbSNP
rs984491527 222 dbSNP
rs1229709831 230 dbSNP
rs1268580118 233 dbSNP
rs550644414 235 dbSNP
rs774168839 236 dbSNP
rs1229175120 240 dbSNP
rs199559249 242 dbSNP
rs1292193908 246 dbSNP
rs1026123631 247 dbSNP
rs1048885640 249 dbSNP
rs553731575 252 dbSNP
rs1313389944 259 dbSNP
rs192624576 261 dbSNP
rs1035648782 262 dbSNP
rs1001445934 273 dbSNP
rs905743677 274 dbSNP
rs1447016809 277 dbSNP
rs564865518 289 dbSNP
rs1194675134 297 dbSNP
rs1399478830 310 dbSNP
rs1239927775 317 dbSNP
rs1290050953 325 dbSNP
rs866638087 326 dbSNP
rs1454007295 329 dbSNP
rs1474858477 340 dbSNP
rs76165521 342 dbSNP
rs3734655 361 dbSNP
rs150555826 362 dbSNP
rs927622808 366 dbSNP
rs1384482123 376 dbSNP
rs1316310646 388 dbSNP
rs866731504 399 dbSNP
rs575192276 401 dbSNP
rs1453632627 407 dbSNP
rs1317461956 415 dbSNP
rs764413133 429 dbSNP
rs769369249 441 dbSNP
rs935535071 452 dbSNP
rs745374981 453 dbSNP
rs1422538887 454 dbSNP
rs1041313860 462 dbSNP
rs1351303900 473 dbSNP
rs969073185 477 dbSNP
rs761076936 480 dbSNP
rs1205727349 484 dbSNP
rs1445939538 493 dbSNP
rs2799354 501 dbSNP
rs537160651 507 dbSNP
rs544231357 509 dbSNP
rs1206645351 512 dbSNP
rs1183355590 528 dbSNP
rs1364807315 531 dbSNP
rs1455780221 534 dbSNP
rs911452479 542 dbSNP
rs568105653 548 dbSNP
rs577132704 554 dbSNP
rs956932238 555 dbSNP
rs931294780 559 dbSNP
rs998474111 570 dbSNP
rs1380836291 579 dbSNP
rs3823240 581 dbSNP
rs1018264448 582 dbSNP
rs973226177 584 dbSNP
rs1297172514 593 dbSNP
rs1241035587 601 dbSNP
rs1327792441 604 dbSNP
rs1203769189 609 dbSNP
rs959896440 610 dbSNP
rs928461492 613 dbSNP
rs1202687258 616 dbSNP
rs979892365 622 dbSNP
rs1382296677 627 dbSNP
rs1363739934 634 dbSNP
rs77828206 642 dbSNP
rs767595578 645 dbSNP
rs1021931307 647 dbSNP
rs1011268412 650 dbSNP
rs1178669330 658 dbSNP
rs539499618 670 dbSNP
rs1404048257 672 dbSNP
rs1031457285 673 dbSNP
rs75265099 681 dbSNP
rs901563672 685 dbSNP
rs141751415 687 dbSNP
rs939262258 690 dbSNP
rs1224119829 699 dbSNP
rs927875555 699 dbSNP
rs1320864279 701 dbSNP
rs569601823 704 dbSNP
rs1232020082 711 dbSNP
rs1251566092 712 dbSNP
rs1044678631 716 dbSNP
rs1456848542 728 dbSNP
rs557673044 729 dbSNP
rs890066782 731 dbSNP
rs1049104509 738 dbSNP
rs1427958257 739 dbSNP
rs1480168935 743 dbSNP
rs1171315543 745 dbSNP
rs1375017465 746 dbSNP
rs914988176 751 dbSNP
rs1296239129 753 dbSNP
rs1369764315 755 dbSNP
rs931369596 755 dbSNP
rs1405462598 756 dbSNP
rs1246216041 760 dbSNP
rs187319556 770 dbSNP
rs753148469 778 dbSNP
rs1469027131 786 dbSNP
rs938749710 792 dbSNP
rs1295741149 794 dbSNP
rs550743471 796 dbSNP
rs1224833178 822 dbSNP
rs1274335399 830 dbSNP
rs763112276 833 dbSNP
rs979944853 836 dbSNP
rs1225318701 850 dbSNP
rs1267383399 859 dbSNP
rs1354243973 864 dbSNP
rs1187171758 868 dbSNP
rs969865501 869 dbSNP
rs1252972474 872 dbSNP
rs749095793 872 dbSNP
rs1227583109 875 dbSNP
rs1170072858 883 dbSNP
rs1389269777 889 dbSNP
rs546381171 892 dbSNP
rs773604424 893 dbSNP
rs528229824 895 dbSNP
rs1288909157 905 dbSNP
rs1006887333 921 dbSNP
rs1294715404 923 dbSNP
rs1380119174 932 dbSNP
rs1296455698 940 dbSNP
rs1442653417 945 dbSNP
rs552072035 946 dbSNP
rs755015273 947 dbSNP
rs1248641091 949 dbSNP
rs1031760478 954 dbSNP
rs1290115117 967 dbSNP
rs1321639462 974 dbSNP
rs1323375919 976 dbSNP
rs1385447509 979 dbSNP
rs1027059964 986 dbSNP
rs994235958 995 dbSNP
rs1188126392 1002 dbSNP
rs768545536 1007 dbSNP
rs897250412 1010 dbSNP
rs746871395 1012 dbSNP
rs567018545 1014 dbSNP
rs1169025579 1016 dbSNP
rs965783072 1031 dbSNP
rs1404672550 1033 dbSNP
rs1388409224 1034 dbSNP
rs1003797053 1035 dbSNP
rs1057100 1038 dbSNP
rs1175538882 1039 dbSNP
rs1017297299 1040 dbSNP
rs906453402 1044 dbSNP
rs1045002283 1058 dbSNP
rs1319400486 1063 dbSNP
rs533131628 1064 dbSNP
rs548792485 1076 dbSNP
rs1454310027 1079 dbSNP
rs113615217 1083 dbSNP
rs1378966990 1083 dbSNP
rs1224780778 1086 dbSNP
rs1252607937 1091 dbSNP
rs191667073 1096 dbSNP
rs1449633868 1100 dbSNP
rs1252342818 1107 dbSNP
rs1196339599 1108 dbSNP
rs996170331 1109 dbSNP
rs115851843 1111 dbSNP
rs1202060273 1116 dbSNP
rs1235828884 1118 dbSNP
rs532402628 1125 dbSNP
rs1235469589 1127 dbSNP
rs1348228436 1132 dbSNP
rs1273845731 1136 dbSNP
rs148050897 1140 dbSNP
rs1410085577 1141 dbSNP
rs1471602252 1143 dbSNP
rs1337937578 1145 dbSNP
rs188065915 1147 dbSNP
rs935069518 1157 dbSNP
rs1470739654 1163 dbSNP
rs1331819611 1171 dbSNP
rs1409766753 1174 dbSNP
rs938634270 1177 dbSNP
rs760916653 1179 dbSNP
rs1369235656 1186 dbSNP
rs1044478802 1187 dbSNP
rs200464954 1188 dbSNP
rs1435384728 1189 dbSNP
rs923689123 1196 dbSNP
rs1171062115 1198 dbSNP
rs540259831 1200 dbSNP
rs374723737 1201 dbSNP
rs1182185001 1205 dbSNP
rs914380826 1207 dbSNP
rs1204939706 1208 dbSNP
rs989963335 1208 dbSNP
rs529039846 1219 dbSNP
rs1212445996 1222 dbSNP
rs35186088 1223 dbSNP
rs1057101 1226 dbSNP
rs924525154 1227 dbSNP
rs1268919606 1229 dbSNP
rs1481151133 1232 dbSNP
rs1485698591 1233 dbSNP
rs1424050627 1234 dbSNP
rs16874413 1235 dbSNP
rs975752403 1239 dbSNP
rs1172943482 1240 dbSNP
rs1217123434 1241 dbSNP
rs965666768 1244 dbSNP
rs1017347507 1246 dbSNP
rs985835889 1251 dbSNP
rs952954386 1259 dbSNP
rs183034044 1265 dbSNP
rs1347397828 1277 dbSNP
rs1027570756 1282 dbSNP
rs771919593 1286 dbSNP
rs190991029 1298 dbSNP
rs1339833912 1300 dbSNP
rs1204304719 1308 dbSNP
rs906397645 1309 dbSNP
rs575874262 1312 dbSNP
rs1044947474 1317 dbSNP
rs1349227054 1320 dbSNP
rs897411984 1322 dbSNP
rs1803522 1324 dbSNP
rs1475522736 1328 dbSNP
rs1187921745 1331 dbSNP
rs557708139 1331 dbSNP
rs1388663608 1332 dbSNP
rs539274695 1338 dbSNP
rs1295628354 1339 dbSNP
rs1012088747 1341 dbSNP
rs1415886288 1343 dbSNP
rs1015840051 1351 dbSNP
rs1367985908 1357 dbSNP
rs1002898647 1360 dbSNP
rs1053417164 1364 dbSNP
rs907197561 1365 dbSNP
rs1057102 1367 dbSNP
rs948822240 1368 dbSNP
rs893178942 1369 dbSNP
rs1362685088 1377 dbSNP
rs1227414102 1384 dbSNP
rs1054711460 1388 dbSNP
rs1292307164 1395 dbSNP
rs1385928430 1397 dbSNP
rs552977825 1403 dbSNP
rs1159711124 1420 dbSNP
rs1472122470 1425 dbSNP
rs1288461714 1432 dbSNP
rs1409723909 1439 dbSNP
rs1217448721 1443 dbSNP
rs1245842212 1447 dbSNP
rs1190005816 1448 dbSNP
rs1475457743 1450 dbSNP
rs1041231210 1451 dbSNP
rs1387547185 1459 dbSNP
rs1207402659 1460 dbSNP
rs181847456 1466 dbSNP
rs567055802 1471 dbSNP
rs924548427 1475 dbSNP
rs778319768 1479 dbSNP
rs1448443836 1487 dbSNP
rs1284482055 1488 dbSNP
rs1385673703 1498 dbSNP
rs975970769 1500 dbSNP
rs1402555182 1503 dbSNP
rs762853167 1504 dbSNP
rs1318727372 1512 dbSNP
rs531025658 1513 dbSNP
rs910226914 1514 dbSNP
rs985721831 1515 dbSNP
rs769883820 1523 dbSNP
rs1234440888 1527 dbSNP
rs1379006809 1528 dbSNP
rs1242438924 1534 dbSNP
rs758920868 1534 dbSNP
rs1350707173 1535 dbSNP
rs931514724 1537 dbSNP
rs530638031 1538 dbSNP
rs961548123 1542 dbSNP
rs191167507 1545 dbSNP
rs756834361 1562 dbSNP
rs1320111172 1563 dbSNP
rs1441053347 1564 dbSNP
rs1187406155 1574 dbSNP
rs1455794269 1575 dbSNP
rs1471468369 1580 dbSNP
rs1156990213 1589 dbSNP
rs1411409074 1590 dbSNP
rs1015892334 1597 dbSNP
rs1003116499 1599 dbSNP
rs1386220280 1604 dbSNP
rs376046297 1608 dbSNP
rs907418360 1616 dbSNP
rs1166758293 1623 dbSNP
rs1022973253 1624 dbSNP
rs1012892942 1638 dbSNP
rs893241599 1639 dbSNP
rs779963616 1641 dbSNP
rs1412977894 1642 dbSNP
rs961718765 1644 dbSNP
rs1285895488 1648 dbSNP
rs1327879015 1655 dbSNP
rs770415303 1658 dbSNP
rs186509798 1662 dbSNP
rs981959729 1666 dbSNP
rs970126715 1693 dbSNP
rs1251736514 1698 dbSNP
rs1023400139 1699 dbSNP
rs934531357 1703 dbSNP
rs202110617 1713 dbSNP
rs1251092699 1717 dbSNP
rs745363150 1721 dbSNP
rs1463217398 1730 dbSNP
rs533300618 1732 dbSNP
rs181617665 1733 dbSNP
rs1214691171 1734 dbSNP
rs1465768207 1745 dbSNP
rs1171779965 1751 dbSNP
rs573373426 1758 dbSNP
rs560059029 1771 dbSNP
rs1411522853 1775 dbSNP
rs1216450439 1776 dbSNP
rs944629639 1787 dbSNP
rs3799893 1791 dbSNP
rs1050526100 1798 dbSNP
rs1310040595 1801 dbSNP
rs561384842 1808 dbSNP
rs930312012 1812 dbSNP
rs1433189019 1815 dbSNP
rs943746797 1817 dbSNP
rs920362084 1820 dbSNP
rs889543840 1823 dbSNP
rs1274586034 1829 dbSNP
rs1490671118 1834 dbSNP
rs1049890457 1837 dbSNP
rs971837201 1837 dbSNP
rs753064699 1842 dbSNP
rs3799894 1843 dbSNP
rs1432808487 1844 dbSNP
rs1194185206 1846 dbSNP
rs931504983 1858 dbSNP
rs920190009 1861 dbSNP
rs1369849237 1865 dbSNP
rs1425263945 1871 dbSNP
rs143613673 1876 dbSNP
rs940022255 1878 dbSNP
rs1385814945 1881 dbSNP
rs575913902 1882 dbSNP
rs1295894976 1889 dbSNP
rs928596319 1892 dbSNP
rs981483056 1904 dbSNP
rs970074603 1905 dbSNP
rs908716861 1918 dbSNP
rs1360792076 1926 dbSNP
rs576866633 1928 dbSNP
rs576965915 1931 dbSNP
rs1205900585 1935 dbSNP
rs1167350187 1963 dbSNP
rs76140014 1967 dbSNP
rs1254486902 1971 dbSNP
rs1447942814 1976 dbSNP
rs1192178148 1978 dbSNP
rs1013359128 1991 dbSNP
rs1445150667 1993 dbSNP
rs543096179 1999 dbSNP
rs1347575490 2000 dbSNP
rs578216699 2008 dbSNP
rs957905676 2012 dbSNP
rs1245293305 2013 dbSNP
rs1032241627 2035 dbSNP
rs1390349839 2038 dbSNP
rs1432536781 2039 dbSNP
rs957393675 2043 dbSNP
rs1384005706 2057 dbSNP
rs1033546909 2062 dbSNP
rs113259654 2072 dbSNP
rs371130189 2072 dbSNP
rs1321146543 2077 dbSNP
rs1239832185 2078 dbSNP
rs759982546 2078 dbSNP
rs1463707431 2082 dbSNP
rs1019659969 2084 dbSNP
rs574450246 2092 dbSNP
rs1483455289 2099 dbSNP
rs1007906158 2101 dbSNP
rs1411511289 2110 dbSNP
rs889534079 2124 dbSNP
rs376372747 2137 dbSNP
rs1049545753 2144 dbSNP
rs1040203176 2145 dbSNP
rs1319477481 2149 dbSNP
rs1366684915 2150 dbSNP
rs1407251295 2152 dbSNP
rs1450660393 2154 dbSNP
rs1291508525 2156 dbSNP
rs1444307539 2159 dbSNP
rs1301508187 2173 dbSNP
rs898689786 2175 dbSNP
rs1008657732 2176 dbSNP
rs553375448 2177 dbSNP
rs1227941414 2191 dbSNP
rs889059080 2194 dbSNP
rs940241043 2202 dbSNP
rs1314219339 2219 dbSNP
rs1427227440 2225 dbSNP
rs928904184 2227 dbSNP
rs749795043 2232 dbSNP
rs1211938084 2238 dbSNP
rs775439676 2239 dbSNP
rs1045672416 2242 dbSNP
rs141167633 2243 dbSNP
rs915992663 2252 dbSNP
rs990217601 2254 dbSNP
rs1423506993 2255 dbSNP
rs1415859037 2256 dbSNP
rs371735300 2260 dbSNP
rs957882697 2261 dbSNP
rs796884606 2262 dbSNP
rs925084956 2266 dbSNP
rs1348662993 2271 dbSNP
rs190025688 2301 dbSNP
rs1369999386 2307 dbSNP
rs1217752329 2308 dbSNP
rs1251691738 2308 dbSNP
rs1162303021 2311 dbSNP
rs1203175457 2315 dbSNP
rs1205735285 2319 dbSNP
rs1276717542 2324 dbSNP
rs1486710232 2332 dbSNP
rs1475920125 2347 dbSNP
rs1482060908 2351 dbSNP
rs920266633 2358 dbSNP
rs184852116 2359 dbSNP
rs1478797840 2362 dbSNP
rs1036401551 2374 dbSNP
rs1019564336 2379 dbSNP
rs940422411 2387 dbSNP
rs1256627839 2388 dbSNP
rs1170932509 2390 dbSNP
rs138222249 2391 dbSNP
rs981636588 2393 dbSNP
rs953718958 2396 dbSNP
rs1351701972 2400 dbSNP
rs1434499228 2403 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_ControlA_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control A ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acguccgucuuccccACCACUCc 5'
                         ||||||| 
Target 5' ---------------UGGUGAGu 3'
 		1 - 8
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_ControlA_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control A
Location of target site ENST00000394885.3 | 3UTR | UGGUGAGUGGAAUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
69 hsa-miR-6511b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059269 CELF1 CUGBP Elav-like family member 1 2 2
MIRT061287 IPO7 importin 7 2 2
MIRT115533 MAZ MYC associated zinc finger protein 2 2
MIRT345986 BIRC5 baculoviral IAP repeat containing 5 2 8
MIRT379536 HNRNPK heterogeneous nuclear ribonucleoprotein K 2 2
MIRT442491 RBBP5 RB binding protein 5, histone lysine methyltransferase complex subunit 2 8
MIRT443701 HUNK hormonally up-regulated Neu-associated kinase 2 4
MIRT459167 HSPA6 heat shock protein family A (Hsp70) member 6 2 21
MIRT497179 ZBTB40 zinc finger and BTB domain containing 40 2 2
MIRT497846 GATA6 GATA binding protein 6 2 4
MIRT519625 ZNF781 zinc finger protein 781 2 2
MIRT519838 ZFP69B ZFP69 zinc finger protein B 2 4
MIRT528560 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT530718 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT530810 GPR182 G protein-coupled receptor 182 2 2
MIRT533265 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT533726 TMEM246 transmembrane protein 246 2 2
MIRT535547 P2RY2 purinergic receptor P2Y2 2 2
MIRT536019 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT539494 ACTN4 actinin alpha 4 2 2
MIRT541793 MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 2 8
MIRT554509 RUNX1T1 RUNX1 translocation partner 1 2 2
MIRT558784 CEP55 centrosomal protein 55 2 2
MIRT560013 ZNF525 zinc finger protein 525 2 2
MIRT560078 ZNF195 zinc finger protein 195 2 2
MIRT570135 IL1RL2 interleukin 1 receptor like 2 2 2
MIRT570890 ZNF780A zinc finger protein 780A 2 2
MIRT607972 SNX22 sorting nexin 22 2 2
MIRT608104 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT610471 ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif 13 2 4
MIRT611134 GGT7 gamma-glutamyltransferase 7 2 2
MIRT611448 NRIP3 nuclear receptor interacting protein 3 2 2
MIRT613019 GABPB1 GA binding protein transcription factor beta subunit 1 2 4
MIRT615753 C6 complement C6 2 2
MIRT620464 CERS6 ceramide synthase 6 2 2
MIRT632248 VPS41 VPS41, HOPS complex subunit 2 2
MIRT636099 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT637452 ZNF324B zinc finger protein 324B 2 2
MIRT638927 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT646768 WDR3 WD repeat domain 3 2 2
MIRT652610 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT652868 TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 2 2
MIRT653655 SLC27A4 solute carrier family 27 member 4 2 2
MIRT657089 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT657884 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT662919 MED18 mediator complex subunit 18 2 2
MIRT685622 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT687427 NRIP1 nuclear receptor interacting protein 1 2 2
MIRT692304 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT695127 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695144 PRY PTPN13-like, Y-linked 2 2
MIRT696286 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT699350 SLC35E1 solute carrier family 35 member E1 2 2
MIRT709901 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT710877 SLC25A42 solute carrier family 25 member 42 2 2
MIRT711365 MED7 mediator complex subunit 7 2 2
MIRT711444 FRMPD3 FERM and PDZ domain containing 3 2 2
MIRT713221 RCAN2 regulator of calcineurin 2 2 2
MIRT713281 LAIR1 leukocyte associated immunoglobulin like receptor 1 2 2
MIRT714195 TRAF7 TNF receptor associated factor 7 2 2
MIRT715152 IL12B interleukin 12B 2 2
MIRT719197 CASP10 caspase 10 2 2
MIRT719469 SRF serum response factor 2 2
MIRT720197 MPP6 membrane palmitoylated protein 6 2 2
MIRT720449 SLC16A5 solute carrier family 16 member 5 2 2
MIRT720461 RAB31 RAB31, member RAS oncogene family 2 2
MIRT721646 ZNF207 zinc finger protein 207 2 2
MIRT722001 CLLU1OS chronic lymphocytic leukemia up-regulated 1 opposite strand 2 2
MIRT725521 FAM229B family with sequence similarity 229 member B 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6511b-3p Imatinib 5291 NSC743414 approved sensitive High Chronic Myelogenous Leukemia tissue
hsa-miR-6511b-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-6511b-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-6511b-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6511b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-6511b-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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