pre-miRNA Information
pre-miRNA hsa-mir-516b-1   
Genomic Coordinates chr19: 53736845 - 53736934
Synonyms MIRN516-4, MIRN516B-1, MIRN516B1, MIR516B1
Description Homo sapiens miR-516b-1 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-516b-2   
Genomic Coordinates chr19: 53725442 - 53725526
Synonyms MIRN516-3, MIRN516B-2, MIRN516B2, MIR516B2
Description Homo sapiens miR-516b-2 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-516b-3p
Sequence 56| UGCUUCCUUUCAGAGGGU |73
Evidence Experimental
Experiments Array-cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1413434631 1 dbSNP
rs746170707 2 dbSNP
rs1312744198 2 dbSNP
rs752101959 3 dbSNP
rs770077784 4 dbSNP
rs1193425541 6 dbSNP
rs953142850 7 dbSNP
rs1020245150 7 dbSNP
rs775845942 11 dbSNP
rs1402471980 11 dbSNP
rs760158839 15 dbSNP
rs78861479 16 dbSNP
rs765933705 16 dbSNP
Putative Targets

Gene Information
Gene Symbol TYRP1   
Synonyms CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN
Description tyrosinase related protein 1
Transcript NM_000550   
Expression
Putative miRNA Targets on TYRP1
3'UTR of TYRP1
(miRNA target sites are highlighted)
>TYRP1|NM_000550|3'UTR
   1 CAAATGCCCTACTCTCTTATGCATTAGTATCACAAAACCACCTGGTTGAATATAATAGATTGAGTTATTAACTGTATTTT
  81 CTTTCACTTTATTACCTTCTTTCTAATACAAGCATATGTTAGCATTAAAGTTCTAGGCATACTTTTCAAAGCTGGGAAGA
 161 CCCTTTCAGAATCTTTTCAATGGGTTTTAATTTTCAGTTCTATTTAAAATGGTGAATGACACTAAACTCCATGATATTTA
 241 AGGATAGTGTGAAGATCTTTGGCATGATTTAAAGGTTGAGTATGTGAAGATATAAGTAAGTGAACTACCATGCTTTGTTT
 321 ACGTGTAAAGGAAAATAATGTTTGATAGTAAATGTCCACTTAAAATACATGAATGGGCATTTCTAAAATGTTAAAACATA
 401 AACACATTTCCATTCATGGATATTTGTCAACAGATTTAAAGAAAACCACAGTTATTAATTAAAGAAAATTAATTATGTGT
 481 AGTTATAAACCAATGAAATTTTGATTAACCTTTTCAAATTAATGTTCCAGTTTGAAGACCAATCAAATATATTATTTAGT
 561 CAACATATACTATTTAGTCTCAGGTTCAAGGCTACAACAAAAATCACCATCTTTGTCAAACTTTGGAGAGGGAAAATCTT
 641 CACTTTCTTAAGCAACAATGGATATTGCCTGTGTTTGCCACTGTGTTTCCCTGCCTCTCAATTCGCTGAAAAAGGAACTA
 721 CCTATCCTTACATTTCACCTACTAATGTCTCTTCTAACATCTTAGAGGTCCATGGAGAAGGCATATGGAGAACATGTTTT
 801 ATACTGCTCTATAAATAGTATTCCAATCACTGTGCTTAATTTAAATAGCATTATCTTATCATTTATCAGCCTTTTATGTA
 881 TTTTCCAAGTAAAATATTAACATATTATTTCATTGGTCTTCTTTTTTATCTGGTTCTATATGAATGCTATTTTTTCCCTT
 961 CTCTTCTAACATGAAATATATTTTCTCTTTTTGATCTTGTGCTATGAAACAATCTTCCAAAGAACTGTATAAGGTGGTCA
1041 TAAGTGAATATTTTAATTAAAATTGGTAAAAATAAATAATAACA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ugGGAGAC--UUUCCUUcgu 5'
            :| |||  |||||||   
Target 5' atTCGCTGAAAAAGGAActa 3'
701 - 720 118.00 -10.20
2
miRNA  3' ugGGAGACUU----UCCUUCgu 5'
            |:|:| ||    :|||||  
Target 5' taCTTTTCAAAGCTGGGAAGac 3'
140 - 161 114.00 -7.90
3
miRNA  3' ugggagAC-UUUCCUUcgu 5'
                || |||||||   
Target 5' tttacgTGTAAAGGAAaat 3'
318 - 336 112.00 -5.02
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
364860 60 ClinVar
914553 66 ClinVar
914554 99 ClinVar
364861 124 ClinVar
914555 196 ClinVar
914556 230 ClinVar
364862 260 ClinVar
364863 293 ClinVar
364864 318 ClinVar
364865 405 ClinVar
364866 459 ClinVar
364867 467 ClinVar
364868 510 ClinVar
912587 519 ClinVar
364869 569 ClinVar
364870 574 ClinVar
364871 592 ClinVar
912588 728 ClinVar
913687 776 ClinVar
364872 854 ClinVar
364873 909 ClinVar
913688 935 ClinVar
913689 945 ClinVar
364874 950 ClinVar
COSN30103655 37 COSMIC
COSN31529544 61 COSMIC
COSN31529832 82 COSMIC
COSN31519907 90 COSMIC
COSN30115280 100 COSMIC
COSN30145298 134 COSMIC
COSN31525043 174 COSMIC
COSN31546698 239 COSMIC
COSN29954541 296 COSMIC
COSN20106035 299 COSMIC
COSN31529000 314 COSMIC
COSN28705382 354 COSMIC
COSN25115924 376 COSMIC
COSN28670615 405 COSMIC
COSN20106041 473 COSMIC
COSN8519945 484 COSMIC
COSN20106046 1083 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs777968853 1 dbSNP
rs747073438 5 dbSNP
rs758721033 7 dbSNP
rs771068323 8 dbSNP
rs1394782853 10 dbSNP
rs1221365168 12 dbSNP
rs41314240 15 dbSNP
rs1451540787 16 dbSNP
rs746354417 21 dbSNP
rs770322083 22 dbSNP
rs1243809846 25 dbSNP
rs775711819 28 dbSNP
rs778207702 29 dbSNP
rs1191635879 30 dbSNP
rs762721980 37 dbSNP
rs371729292 40 dbSNP
rs761340405 41 dbSNP
rs138587103 42 dbSNP
rs1466293850 44 dbSNP
rs1169862233 45 dbSNP
rs1284218689 46 dbSNP
rs1352763732 47 dbSNP
rs184726569 48 dbSNP
rs1446767211 52 dbSNP
rs553363639 56 dbSNP
rs1311538279 58 dbSNP
rs140364108 60 dbSNP
rs1315031819 61 dbSNP
rs41314590 63 dbSNP
rs1230414400 65 dbSNP
rs377228308 65 dbSNP
rs878881586 66 dbSNP
rs1261667997 69 dbSNP
rs890262465 69 dbSNP
rs145547593 73 dbSNP
rs1302919400 74 dbSNP
rs1485694340 75 dbSNP
rs1375433064 78 dbSNP
rs1311417242 81 dbSNP
rs1432059215 83 dbSNP
rs944569843 86 dbSNP
rs1203585115 88 dbSNP
rs1169952934 94 dbSNP
rs1245076143 95 dbSNP
rs777082841 101 dbSNP
rs1415969193 104 dbSNP
rs1485298937 104 dbSNP
rs1255383654 105 dbSNP
rs1182926429 108 dbSNP
rs1052728011 115 dbSNP
rs886811586 117 dbSNP
rs1224701174 119 dbSNP
rs683 124 dbSNP
rs1035854277 128 dbSNP
rs1159636985 128 dbSNP
rs1227289233 130 dbSNP
rs1355346973 133 dbSNP
rs960865254 134 dbSNP
rs1291933040 142 dbSNP
rs1412251285 143 dbSNP
rs990962626 144 dbSNP
rs1023789466 145 dbSNP
rs1351898655 146 dbSNP
rs1362985461 149 dbSNP
rs1010644623 155 dbSNP
rs968255625 159 dbSNP
rs549389872 162 dbSNP
rs555686285 164 dbSNP
rs1184179480 173 dbSNP
rs138153768 181 dbSNP
rs541780478 185 dbSNP
rs1173925125 188 dbSNP
rs566025238 193 dbSNP
rs935337985 196 dbSNP
rs986865300 199 dbSNP
rs1212716305 201 dbSNP
rs1451199891 210 dbSNP
rs1334121501 223 dbSNP
rs116149666 230 dbSNP
rs1230706999 232 dbSNP
rs1393626802 233 dbSNP
rs1308213180 235 dbSNP
rs1306720917 238 dbSNP
rs1390081171 243 dbSNP
rs1369967163 244 dbSNP
rs775351590 247 dbSNP
rs1461145541 249 dbSNP
rs1161543666 256 dbSNP
rs1392292750 256 dbSNP
rs1457688769 257 dbSNP
rs1002845838 258 dbSNP
rs76349729 260 dbSNP
rs1237186348 261 dbSNP
rs961275473 265 dbSNP
rs931215354 269 dbSNP
rs982951365 275 dbSNP
rs1267817537 276 dbSNP
rs1015810635 279 dbSNP
rs962781786 280 dbSNP
rs1047045266 286 dbSNP
rs886741745 288 dbSNP
rs1352004511 291 dbSNP
rs200634606 292 dbSNP
rs1361461170 293 dbSNP
rs71329877 293 dbSNP
rs367769811 296 dbSNP
rs372230399 297 dbSNP
rs113819223 299 dbSNP
rs112654696 300 dbSNP
rs1314262536 301 dbSNP
rs1302414712 308 dbSNP
rs1241342337 310 dbSNP
rs974164436 311 dbSNP
rs1369121366 314 dbSNP
rs1481603401 314 dbSNP
rs1177678984 318 dbSNP
rs886063414 318 dbSNP
rs749839678 322 dbSNP
rs932687091 323 dbSNP
rs986424724 324 dbSNP
rs1417028901 327 dbSNP
rs1201146073 333 dbSNP
rs1156690792 336 dbSNP
rs1429643424 339 dbSNP
rs543430782 341 dbSNP
rs763782652 341 dbSNP
rs1452170857 342 dbSNP
rs1249561624 344 dbSNP
rs894204835 346 dbSNP
rs911800588 349 dbSNP
rs563254106 356 dbSNP
rs1445881542 358 dbSNP
rs1259085233 362 dbSNP
rs1012646229 369 dbSNP
rs868653868 374 dbSNP
rs1173700804 378 dbSNP
rs1401806749 387 dbSNP
rs1464007897 389 dbSNP
rs1234076160 391 dbSNP
rs1300046241 397 dbSNP
rs1345953385 397 dbSNP
rs1228456140 403 dbSNP
rs1325870146 404 dbSNP
rs1316320607 405 dbSNP
rs2762464 405 dbSNP
rs1312025090 413 dbSNP
rs751236662 413 dbSNP
rs1391821369 416 dbSNP
rs1168789502 419 dbSNP
rs1474887166 422 dbSNP
rs1373071117 426 dbSNP
rs1052210958 429 dbSNP
rs1370835560 433 dbSNP
rs1389962851 450 dbSNP
rs1444609838 451 dbSNP
rs1258871918 452 dbSNP
rs1210835522 454 dbSNP
rs549032453 459 dbSNP
rs946429312 465 dbSNP
rs199676367 466 dbSNP
rs1474074970 467 dbSNP
rs559302797 467 dbSNP
rs71329878 467 dbSNP
rs1223109267 469 dbSNP
rs1247145294 469 dbSNP
rs1268481126 469 dbSNP
rs1355979236 470 dbSNP
rs1292560334 471 dbSNP
rs1261381428 472 dbSNP
rs1043473944 478 dbSNP
rs1308418864 490 dbSNP
rs1408995378 492 dbSNP
rs904836449 494 dbSNP
rs770647391 495 dbSNP
rs776425417 498 dbSNP
rs1205159296 499 dbSNP
rs1056555741 501 dbSNP
rs1250629177 501 dbSNP
rs987218756 502 dbSNP
rs1224526255 504 dbSNP
rs1474514622 506 dbSNP
rs1269309061 509 dbSNP
rs74941076 510 dbSNP
rs551293183 511 dbSNP
rs1271197960 515 dbSNP
rs1196790080 517 dbSNP
rs1335499895 518 dbSNP
rs748262937 519 dbSNP
rs1015738463 523 dbSNP
rs1231311585 524 dbSNP
rs1352318352 525 dbSNP
rs1279895664 526 dbSNP
rs376661181 536 dbSNP
rs962876655 538 dbSNP
rs1428533344 540 dbSNP
rs1171737852 542 dbSNP
rs1354539820 544 dbSNP
rs995570216 545 dbSNP
rs1461651307 548 dbSNP
rs1393009487 550 dbSNP
rs772341145 555 dbSNP
rs1460327538 557 dbSNP
rs1428367309 562 dbSNP
rs975534269 563 dbSNP
rs1305389775 564 dbSNP
rs1178110409 566 dbSNP
rs142323339 569 dbSNP
rs954300080 570 dbSNP
rs1404599327 571 dbSNP
rs986801035 572 dbSNP
rs886063415 574 dbSNP
rs1211950809 577 dbSNP
rs1281556910 577 dbSNP
rs931140427 578 dbSNP
rs1223166767 580 dbSNP
rs1348202958 582 dbSNP
rs1276402416 584 dbSNP
rs912594792 585 dbSNP
rs1369865601 589 dbSNP
rs886063416 592 dbSNP
rs908472034 594 dbSNP
rs113819841 599 dbSNP
rs1345305509 599 dbSNP
rs749668276 599 dbSNP
rs965954145 610 dbSNP
rs1224594410 616 dbSNP
rs1406160789 620 dbSNP
rs894183209 620 dbSNP
rs1454852998 622 dbSNP
rs1012614823 626 dbSNP
rs544701949 633 dbSNP
rs1042796520 637 dbSNP
rs143880580 637 dbSNP
rs779352812 638 dbSNP
rs988021169 638 dbSNP
rs1234814315 647 dbSNP
rs1219815489 651 dbSNP
rs1243422482 653 dbSNP
rs1300757266 655 dbSNP
rs1031225292 657 dbSNP
rs879593763 657 dbSNP
rs1287788801 659 dbSNP
rs879601335 662 dbSNP
rs1430642950 668 dbSNP
rs1344011486 670 dbSNP
rs957163749 671 dbSNP
rs1416743230 672 dbSNP
rs1008502169 674 dbSNP
rs1171943226 678 dbSNP
rs1430524503 685 dbSNP
rs371841317 691 dbSNP
rs946565184 697 dbSNP
rs148209874 698 dbSNP
rs1321830141 700 dbSNP
rs920009112 705 dbSNP
rs569987752 706 dbSNP
rs1206779382 714 dbSNP
rs1307788237 719 dbSNP
rs1288408491 720 dbSNP
rs1332948886 722 dbSNP
rs1359909837 725 dbSNP
rs535597991 728 dbSNP
rs753070665 731 dbSNP
rs908397025 735 dbSNP
rs1248113125 739 dbSNP
rs938597288 750 dbSNP
rs555814718 763 dbSNP
rs1375148752 767 dbSNP
rs1056126504 770 dbSNP
rs556784472 774 dbSNP
rs189509118 779 dbSNP
rs896149497 783 dbSNP
rs1004431294 785 dbSNP
rs1169789504 795 dbSNP
rs1355385844 795 dbSNP
rs1426771667 805 dbSNP
rs1420146662 809 dbSNP
rs1037307206 810 dbSNP
rs1358471766 812 dbSNP
rs1474844416 812 dbSNP
rs778090143 814 dbSNP
rs1178793656 817 dbSNP
rs915544315 818 dbSNP
rs898636732 819 dbSNP
rs1250370580 821 dbSNP
rs995661848 824 dbSNP
rs1243584946 832 dbSNP
rs1234433274 835 dbSNP
rs1286070040 841 dbSNP
rs1355444878 845 dbSNP
rs1028519464 847 dbSNP
rs954153754 848 dbSNP
rs1214591722 851 dbSNP
rs1393542233 851 dbSNP
rs910 854 dbSNP
rs1297775994 857 dbSNP
rs1460672376 860 dbSNP
rs1165835792 862 dbSNP
rs1396702964 862 dbSNP
rs1460850320 864 dbSNP
rs934455289 870 dbSNP
rs1161237551 871 dbSNP
rs1419397464 875 dbSNP
rs1175047726 881 dbSNP
rs1249569509 881 dbSNP
rs558528035 883 dbSNP
rs1462227101 886 dbSNP
rs757338871 895 dbSNP
rs1212576129 899 dbSNP
rs1334731488 902 dbSNP
rs1053013912 903 dbSNP
rs1317839899 903 dbSNP
rs1306742945 908 dbSNP
rs1063380 909 dbSNP
rs1444553405 910 dbSNP
rs868571708 914 dbSNP
rs181805510 916 dbSNP
rs1019870543 917 dbSNP
rs1440319551 917 dbSNP
rs41303677 921 dbSNP
rs987988820 926 dbSNP
rs1020811882 938 dbSNP
rs1290496803 939 dbSNP
rs899793058 940 dbSNP
rs1410584324 941 dbSNP
rs1401536569 942 dbSNP
rs967959444 945 dbSNP
rs996867422 946 dbSNP
rs1386563637 947 dbSNP
rs781409342 948 dbSNP
rs763340664 950 dbSNP
rs886063417 950 dbSNP
rs771179000 967 dbSNP
rs1382017688 971 dbSNP
rs952756426 974 dbSNP
rs1486519325 978 dbSNP
rs1445704329 979 dbSNP
rs1238495684 981 dbSNP
rs368570019 981 dbSNP
rs979230916 981 dbSNP
rs1281109361 982 dbSNP
rs1350291625 984 dbSNP
rs1304374146 985 dbSNP
rs769741325 986 dbSNP
rs1233858488 994 dbSNP
rs926481733 1000 dbSNP
rs982928528 1001 dbSNP
rs1320444477 1013 dbSNP
rs937743238 1020 dbSNP
rs1351078870 1022 dbSNP
rs992321829 1034 dbSNP
rs959910320 1041 dbSNP
rs566527702 1045 dbSNP
rs41303679 1050 dbSNP
rs939680593 1053 dbSNP
rs186925501 1058 dbSNP
rs1452193540 1063 dbSNP
rs1374289901 1064 dbSNP
rs1193354259 1066 dbSNP
rs1261947738 1068 dbSNP
rs561383131 1071 dbSNP
rs1186000866 1074 dbSNP
rs1313186488 1075 dbSNP
rs3079540 1075 dbSNP
rs5896525 1075 dbSNP
rs1234988369 1080 dbSNP
rs978385818 1081 dbSNP
rs1036729649 1082 dbSNP
rs1176843398 1084 dbSNP
rs193004734 1084 dbSNP
rs1343205939 1085 dbSNP
rs1342084749 1086 dbSNP
rs41303675 1086 dbSNP
rs1271978102 1087 dbSNP
rs1228292821 1090 dbSNP
rs925643725 1093 dbSNP
rs934402394 1100 dbSNP
rs898733239 1103 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_ControlA_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control A ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ugggagacUUUCCUUCGu 5'
                  |:||||||| 
Target 5' --------AGAGGAAGCa 3'
1 - 10
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_ControlA_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control A
Location of target site ENST00000388918.5 | 3UTR | AGAGGAAGCAUUAAAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE32688 Pancreatic cancer -0.235 9.8e-2 -0.139 2.2e-1 32 Click to see details
GSE17306 Multiple myeloma -0.126 1.9e-1 0.314 1.4e-2 49 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.131 2.7e-1 0.065 3.8e-1 25 Click to see details
GSE27834 Pluripotent stem cells -0.147 2.9e-1 -0.132 3.1e-1 16 Click to see details
GSE27834 Pluripotent stem cells -0.147 2.9e-1 -0.132 3.1e-1 16 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
85 hsa-miR-516b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT077049 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT155261 IFNAR2 interferon alpha and beta receptor subunit 2 2 4
MIRT446119 ASTN1 astrotactin 1 2 2
MIRT447355 STOM stomatin 2 2
MIRT469329 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT470201 PSAT1 phosphoserine aminotransferase 1 2 6
MIRT475944 GXYLT1 glucoside xylosyltransferase 1 2 4
MIRT498268 KIAA1644 KIAA1644 2 2
MIRT501725 OVOL1 ovo like transcriptional repressor 1 2 2
MIRT522860 KIAA1551 KIAA1551 2 2
MIRT527900 B3GALT5 beta-1,3-galactosyltransferase 5 2 4
MIRT528557 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT531250 PDF peptide deformylase, mitochondrial 2 2
MIRT534410 SENP1 SUMO1/sentrin specific peptidase 1 2 2
MIRT544656 MED19 mediator complex subunit 19 2 2
MIRT550681 YARS tyrosyl-tRNA synthetase 2 2
MIRT557208 HNRNPF heterogeneous nuclear ribonucleoprotein F 2 4
MIRT611532 DDB1 damage specific DNA binding protein 1 2 2
MIRT612087 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT616535 PARD6B par-6 family cell polarity regulator beta 2 4
MIRT616738 DCTN5 dynactin subunit 5 2 2
MIRT616754 SVOP SV2 related protein 2 4
MIRT617380 FAM227A family with sequence similarity 227 member A 2 2
MIRT617624 RAB3IP RAB3A interacting protein 2 2
MIRT620778 MT1A metallothionein 1A 2 2
MIRT623172 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT626034 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT627376 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT630533 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT631686 NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 2 2
MIRT633896 FGF10 fibroblast growth factor 10 2 2
MIRT635933 PLA2G12A phospholipase A2 group XIIA 2 2
MIRT636275 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT636285 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT636502 GDAP1L1 ganglioside induced differentiation associated protein 1 like 1 2 2
MIRT638037 SHPK sedoheptulokinase 2 2
MIRT639162 LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 2 2
MIRT639571 GORASP1 golgi reassembly stacking protein 1 2 2
MIRT641248 CENPN centromere protein N 2 2
MIRT643650 MYOCD myocardin 2 2
MIRT645490 TRIM63 tripartite motif containing 63 2 2
MIRT648016 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT648102 LRRFIP1 LRR binding FLII interacting protein 1 2 2
MIRT648729 HIST1H2BD histone cluster 1 H2B family member d 2 2
MIRT650177 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT652787 TCEANC2 transcription elongation factor A N-terminal and central domain containing 2 2 2
MIRT653248 SORD sorbitol dehydrogenase 2 2
MIRT654859 PPM1F protein phosphatase, Mg2+/Mn2+ dependent 1F 2 2
MIRT655533 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT656390 MCU mitochondrial calcium uniporter 2 2
MIRT656881 KIF1C kinesin family member 1C 2 2
MIRT657083 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT657629 GPX8 glutathione peroxidase 8 (putative) 2 2
MIRT658295 FAM83F family with sequence similarity 83 member F 2 2
MIRT659432 COL1A1 collagen type I alpha 1 chain 2 2
MIRT659791 CBLB Cbl proto-oncogene B 2 2
MIRT660153 BRCC3 BRCA1/BRCA2-containing complex subunit 3 2 2
MIRT660490 ARRDC3 arrestin domain containing 3 2 2
MIRT660503 ARPC2 actin related protein 2/3 complex subunit 2 2 2
MIRT666356 SIKE1 suppressor of IKBKE 1 2 2
MIRT677774 FKTN fukutin 2 2
MIRT688556 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT697415 ZFP91 ZFP91 zinc finger protein 2 2
MIRT709468 KRTAP19-1 keratin associated protein 19-1 2 2
MIRT711154 WDR82P1 WD repeat domain 82 pseudogene 1 2 2
MIRT711467 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT712515 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT712661 PCTP phosphatidylcholine transfer protein 2 2
MIRT713304 TYRP1 tyrosinase related protein 1 2 2
MIRT714597 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT716603 MPPED1 metallophosphoesterase domain containing 1 2 2
MIRT717537 PYGO2 pygopus family PHD finger 2 2 2
MIRT718058 CYP3A5 cytochrome P450 family 3 subfamily A member 5 2 2
MIRT718539 PIGQ phosphatidylinositol glycan anchor biosynthesis class Q 2 2
MIRT719768 ZNF236 zinc finger protein 236 2 2
MIRT720162 PNPO pyridoxamine 5'-phosphate oxidase 2 2
MIRT720360 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT721182 HOPX HOP homeobox 2 2
MIRT721278 RAD54L2 RAD54 like 2 2 2
MIRT721357 ENTHD1 ENTH domain containing 1 2 2
MIRT721504 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT721918 LINGO2 leucine rich repeat and Ig domain containing 2 2 2
MIRT722278 LURAP1 leucine rich adaptor protein 1 2 2
MIRT722789 FUT4 fucosyltransferase 4 2 2
MIRT724390 ABAT 4-aminobutyrate aminotransferase 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-516b Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-516b Bromocriptine approved 31101 Microarray Prolactinoma 22366961 2012 up-regulated
miR-516b Bromocriptine approved 31101 Quantitative real-time PCR Prolactinoma 22366961 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-516b-3p Paclitaxel 36314 NSC125973 approved sensitive High Pan-Cancer cell line (NCI-H460, NCI-H522, NCI-H322M, HOP62, A549, EKVX, MALME-3M, NCI-H226, HT-29, HCT-116, SE-620, HCT-15, HCC2998, COLO205, HS-578T, NCI/ADR-RES, OVCAR8, OVCAR4, ACHN, SN-12C, 786-O, CAKI-1, UO-31, TK-10, A498, SK-MEL-28, UACC-257, M14, UACC-62, SK
hsa-miR-516b-3p Ribavirin+Pegylated IFNa-2b sensitive tissue (chronic hepatitis C)
hsa-miR-516b-3p Testosterone+Exemestane sensitive cell line (MCF-7)
hsa-miR-516b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-516b-3p Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)

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