pre-miRNA Information | |
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pre-miRNA | hsa-mir-6752 |
Genomic Coordinates | chr11: 67490245 - 67490315 |
Description | Homo sapiens miR-6752 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | ||||||||||||||||
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Mature miRNA | hsa-miR-6752-3p | |||||||||||||||
Sequence | 51| UCCCUGCCCCCAUACUCCCAG |71 | |||||||||||||||
Evidence | Experimental | |||||||||||||||
Experiments | Meta-analysis | |||||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | TMEM44 | ||||||||||||||||||||
Synonyms | - | ||||||||||||||||||||
Description | transmembrane protein 44 | ||||||||||||||||||||
Transcript | NM_001166306 | ||||||||||||||||||||
Other Transcripts | NM_001166305 , NM_001011655 , NM_138399 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on TMEM44 | |||||||||||||||||||||
3'UTR of TMEM44 (miRNA target sites are highlighted) |
>TMEM44|NM_001166306|3'UTR 1 ACCTCGAAGGCAGCAAAGAAAATGTGGAGCTACTGGGATCCCAGGTGCACCAGGACTCTGTGAGGACAGCACACCTGAGT 81 GATGATGATTAACACCTTCTGGAGCCAGCTCATCAGCTCAGAGCCCAGGGTCAGGAGTTCGTTCAGTAACGCAGCGGGAA 161 TCAATCTGCACTGACACCGCGGCAGGAACTGAAGCTGCCCTGGCAAGTGAGGAACCAGGAGCCGTCACTGAGTGTGGCTG 241 GGCTACATCATAGCTCATCACGGAGCTACGACTTTGGGTACTGCGGACAGACCTGGATAGGCCCAGCATTCGTTCTGAAG 321 ATCACAGTTCACAGAAGCTTTTGCTTCGTAAAGATAATCCAAAGGATCTCAGACCCGCTCTTCCTTTTCCCTTCATTCCC 401 TTGAGAGTCAGCCATGAACGGAATACCTGCTAGGTTCCAGGAATGAGCTCACCTAACAGATAGCAAATGTGTCTGGTTAG 481 ATCTCAGCAGAGCCCATTCTGCAAGACCTGGCTGAGCCAGATGAGAGGGTGGGCCCTGTGCTGGGGGGCCTTGGGTCACA 561 CACAGGAACCGAGACCTGGCTTCCACCCCCCAGTCACCCACTTGGGTTATCTGCTGGAAGTTATCGATAGGACTGTGTGG 641 CCAACCAAGTGCTTGTGAGATCACTGACACTGCAAAAACAAAGCAAACTGCTCCGGGTACCAGGACTTCCTCCAACCTGG 721 CAAGGGTGTGCGCTGAGGCGGGGCTTGCAGGTGAGGGGGCTGTATGCTTCAGGAACTAACTAAATGCATGCAGAAGGTAA 801 GAGGCATGATGGGAGGTGTTCAAGCACAGCAATCCCATTTGGGAGTTATTTTGATACTGCGATGAGTAAGGGTAAGGGCG 881 CATGGAATGGGGCTAAGGTGGGAGTGAACACTGGGGTGAATAAATTTTAAATCAATTCAAGTATCTCAAAAAAAAAAAAA 961 A Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HeLa |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in Chi_ControlA_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control A
... - Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature. |
Article |
- Chi SW; Zang JB; Mele A; Darnell RB - Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
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CLIP-seq Support 1 for dataset Chi_ControlA_2A8_130_50 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | HeLa / HeLa cell Control A |
Location of target site | ENST00000381975.3 | 3UTR | AGAAAAGAGUGUUCAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 19536157 / Chi_HITSCLIP |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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110 hsa-miR-6752-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT152341 | TNFSF9 | TNF superfamily member 9 | ![]() |
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2 | 2 | ||||||
MIRT273594 | SP1 | Sp1 transcription factor | ![]() |
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2 | 2 | ||||||
MIRT291927 | TPM4 | tropomyosin 4 | ![]() |
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2 | 4 | ||||||
MIRT311186 | ANKRD33B | ankyrin repeat domain 33B | ![]() |
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2 | 4 | ||||||
MIRT378521 | CDKN1A | cyclin dependent kinase inhibitor 1A | ![]() |
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2 | 4 | ||||||
MIRT452467 | SORCS2 | sortilin related VPS10 domain containing receptor 2 | ![]() |
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2 | 2 | ||||||
MIRT478636 | CTDNEP1 | CTD nuclear envelope phosphatase 1 | ![]() |
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2 | 2 | ||||||
MIRT496343 | TMEM81 | transmembrane protein 81 | ![]() |
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2 | 2 | ||||||
MIRT496646 | MFAP3 | microfibril associated protein 3 | ![]() |
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2 | 2 | ||||||
MIRT496711 | DNAJC30 | DnaJ heat shock protein family (Hsp40) member C30 | ![]() |
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2 | 2 | ||||||
MIRT499242 | VAV3 | vav guanine nucleotide exchange factor 3 | ![]() |
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2 | 4 | ||||||
MIRT519777 | ZNF354B | zinc finger protein 354B | ![]() |
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2 | 6 | ||||||
MIRT520883 | STX17 | syntaxin 17 | ![]() |
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2 | 2 | ||||||
MIRT522476 | ZAK | mitogen-activated protein kinase kinase kinase 20 | ![]() |
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2 | 2 | ||||||
MIRT523587 | G3BP2 | G3BP stress granule assembly factor 2 | ![]() |
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2 | 6 | ||||||
MIRT525240 | KCNJ12 | potassium voltage-gated channel subfamily J member 12 | ![]() |
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2 | 2 | ||||||
MIRT527025 | PABPN1L | poly(A) binding protein nuclear 1 like, cytoplasmic | ![]() |
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2 | 2 | ||||||
MIRT527709 | IL17REL | interleukin 17 receptor E like | ![]() |
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2 | 2 | ||||||
MIRT530778 | GPD1 | glycerol-3-phosphate dehydrogenase 1 | ![]() |
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2 | 2 | ||||||
MIRT531883 | SCN1B | sodium voltage-gated channel beta subunit 1 | ![]() |
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2 | 2 | ||||||
MIRT533043 | ZBTB46 | zinc finger and BTB domain containing 46 | ![]() |
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2 | 2 | ||||||
MIRT535062 | PPP2R5D | protein phosphatase 2 regulatory subunit B'delta | ![]() |
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2 | 4 | ||||||
MIRT536512 | KCTD15 | potassium channel tetramerization domain containing 15 | ![]() |
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2 | 2 | ||||||
MIRT543793 | RALGAPB | Ral GTPase activating protein non-catalytic beta subunit | ![]() |
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2 | 2 | ||||||
MIRT563977 | HCFC1 | host cell factor C1 | ![]() |
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2 | 2 | ||||||
MIRT569472 | MAN2A2 | mannosidase alpha class 2A member 2 | ![]() |
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2 | 2 | ||||||
MIRT570600 | NFIX | nuclear factor I X | ![]() |
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2 | 2 | ||||||
MIRT571402 | MED4 | mediator complex subunit 4 | ![]() |
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2 | 2 | ||||||
MIRT608418 | PPIC | peptidylprolyl isomerase C | ![]() |
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2 | 6 | ||||||
MIRT608928 | REXO2 | RNA exonuclease 2 | ![]() |
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2 | 4 | ||||||
MIRT609357 | ZNF664 | zinc finger protein 664 | ![]() |
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2 | 2 | ||||||
MIRT611189 | WBSCR17 | polypeptide N-acetylgalactosaminyltransferase 17 | ![]() |
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2 | 4 | ||||||
MIRT615266 | DPF2 | double PHD fingers 2 | ![]() |
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2 | 2 | ||||||
MIRT615408 | VDAC2 | voltage dependent anion channel 2 | ![]() |
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2 | 2 | ||||||
MIRT616323 | AGO3 | argonaute 3, RISC catalytic component | ![]() |
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2 | 2 | ||||||
MIRT616566 | ZNF512B | zinc finger protein 512B | ![]() |
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2 | 2 | ||||||
MIRT616745 | TAZ | tafazzin | ![]() |
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2 | 2 | ||||||
MIRT617316 | MBOAT1 | membrane bound O-acyltransferase domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT620030 | NFAM1 | NFAT activating protein with ITAM motif 1 | ![]() |
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2 | 2 | ||||||
MIRT621166 | RTTN | rotatin | ![]() |
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2 | 2 | ||||||
MIRT623501 | KCNQ3 | potassium voltage-gated channel subfamily Q member 3 | ![]() |
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2 | 2 | ||||||
MIRT623524 | KCNK10 | potassium two pore domain channel subfamily K member 10 | ![]() |
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2 | 2 | ||||||
MIRT629683 | TNFAIP8L1 | TNF alpha induced protein 8 like 1 | ![]() |
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2 | 2 | ||||||
MIRT630795 | TGIF2 | TGFB induced factor homeobox 2 | ![]() |
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2 | 2 | ||||||
MIRT634638 | HIP1 | huntingtin interacting protein 1 | ![]() |
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2 | 4 | ||||||
MIRT636788 | RAB40B | RAB40B, member RAS oncogene family | ![]() |
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2 | 2 | ||||||
MIRT640332 | DAAM2 | dishevelled associated activator of morphogenesis 2 | ![]() |
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2 | 2 | ||||||
MIRT640557 | SMCR8 | Smith-Magenis syndrome chromosome region, candidate 8 | ![]() |
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2 | 2 | ||||||
MIRT643319 | TMEM151B | transmembrane protein 151B | ![]() |
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2 | 2 | ||||||
MIRT643991 | DUSP28 | dual specificity phosphatase 28 | ![]() |
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2 | 2 | ||||||
MIRT644618 | CD300E | CD300e molecule | ![]() |
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2 | 2 | ||||||
MIRT646445 | XRCC2 | X-ray repair cross complementing 2 | ![]() |
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2 | 2 | ||||||
MIRT648020 | SLCO4C1 | solute carrier organic anion transporter family member 4C1 | ![]() |
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2 | 2 | ||||||
MIRT648077 | ZMIZ2 | zinc finger MIZ-type containing 2 | ![]() |
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2 | 2 | ||||||
MIRT649618 | ITPKC | inositol-trisphosphate 3-kinase C | ![]() |
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2 | 2 | ||||||
MIRT650414 | ZNF442 | zinc finger protein 442 | ![]() |
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2 | 2 | ||||||
MIRT650850 | SEMA4G | semaphorin 4G | ![]() |
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2 | 2 | ||||||
MIRT654694 | PSMB5 | proteasome subunit beta 5 | ![]() |
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2 | 2 | ||||||
MIRT655512 | PAIP2B | poly(A) binding protein interacting protein 2B | ![]() |
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2 | 2 | ||||||
MIRT657620 | GRAP2 | GRB2-related adaptor protein 2 | ![]() |
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2 | 2 | ||||||
MIRT658009 | GALNT10 | polypeptide N-acetylgalactosaminyltransferase 10 | ![]() |
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2 | 2 | ||||||
MIRT658329 | FAM83F | family with sequence similarity 83 member F | ![]() |
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2 | 2 | ||||||
MIRT658832 | SRCAP | Snf2 related CREBBP activator protein | ![]() |
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2 | 2 | ||||||
MIRT658920 | DPY19L4 | dpy-19 like 4 | ![]() |
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2 | 2 | ||||||
MIRT661058 | RPL18A | ribosomal protein L18a | ![]() |
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2 | 2 | ||||||
MIRT662342 | MYLK3 | myosin light chain kinase 3 | ![]() |
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2 | 2 | ||||||
MIRT663451 | FBXO2 | F-box protein 2 | ![]() |
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2 | 2 | ||||||
MIRT676752 | SGTB | small glutamine rich tetratricopeptide repeat containing beta | ![]() |
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2 | 4 | ||||||
MIRT684705 | LRRD1 | leucine rich repeats and death domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT687247 | PDHB | pyruvate dehydrogenase E1 beta subunit | ![]() |
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2 | 2 | ||||||
MIRT693881 | NT5C2 | 5'-nucleotidase, cytosolic II | ![]() |
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2 | 2 | ||||||
MIRT693922 | HNRNPA1L2 | heterogeneous nuclear ribonucleoprotein A1-like 2 | ![]() |
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2 | 2 | ||||||
MIRT695921 | ZNF174 | zinc finger protein 174 | ![]() |
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2 | 2 | ||||||
MIRT702867 | HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | ![]() |
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2 | 2 | ||||||
MIRT708863 | TMSB4X | thymosin beta 4, X-linked | ![]() |
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2 | 2 | ||||||
MIRT708936 | CRY2 | cryptochrome circadian clock 2 | ![]() |
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2 | 2 | ||||||
MIRT709476 | FAXC | failed axon connections homolog | ![]() |
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2 | 2 | ||||||
MIRT709752 | UBD | ubiquitin D | ![]() |
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2 | 2 | ||||||
MIRT710128 | VANGL2 | VANGL planar cell polarity protein 2 | ![]() |
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2 | 2 | ||||||
MIRT710274 | FAM107A | family with sequence similarity 107 member A | ![]() |
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2 | 2 | ||||||
MIRT711146 | TMEM174 | transmembrane protein 174 | ![]() |
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2 | 2 | ||||||
MIRT712582 | ATP2B4 | ATPase plasma membrane Ca2+ transporting 4 | ![]() |
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2 | 2 | ||||||
MIRT712648 | TXNL4A | thioredoxin like 4A | ![]() |
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2 | 2 | ||||||
MIRT713325 | TMEM44 | transmembrane protein 44 | ![]() |
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2 | 2 | ||||||
MIRT713413 | PEX16 | peroxisomal biogenesis factor 16 | ![]() |
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2 | 2 | ||||||
MIRT713891 | RNF19B | ring finger protein 19B | ![]() |
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2 | 2 | ||||||
MIRT714549 | COL14A1 | collagen type XIV alpha 1 chain | ![]() |
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2 | 2 | ||||||
MIRT714809 | ARHGEF19 | Rho guanine nucleotide exchange factor 19 | ![]() |
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2 | 2 | ||||||
MIRT714840 | SCAMP2 | secretory carrier membrane protein 2 | ![]() |
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2 | 2 | ||||||
MIRT715779 | DDX42 | DEAD-box helicase 42 | ![]() |
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2 | 2 | ||||||
MIRT715795 | TBL3 | transducin beta like 3 | ![]() |
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2 | 2 | ||||||
MIRT716088 | RNF150 | ring finger protein 150 | ![]() |
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2 | 2 | ||||||
MIRT716712 | IMP4 | IMP4, U3 small nucleolar ribonucleoprotein | ![]() |
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2 | 2 | ||||||
MIRT716737 | APOL6 | apolipoprotein L6 | ![]() |
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2 | 2 | ||||||
MIRT717069 | MTMR6 | myotubularin related protein 6 | ![]() |
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2 | 2 | ||||||
MIRT718185 | HLCS | holocarboxylase synthetase | ![]() |
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2 | 2 | ||||||
MIRT719386 | SECTM1 | secreted and transmembrane 1 | ![]() |
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2 | 2 | ||||||
MIRT720679 | SLC39A13 | solute carrier family 39 member 13 | ![]() |
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2 | 2 | ||||||
MIRT721315 | FAM58A | cyclin Q | ![]() |
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2 | 2 | ||||||
MIRT721396 | LDLRAD4 | low density lipoprotein receptor class A domain containing 4 | ![]() |
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2 | 2 | ||||||
MIRT721896 | ITPR2 | inositol 1,4,5-trisphosphate receptor type 2 | ![]() |
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2 | 2 | ||||||
MIRT722442 | ZBTB7B | zinc finger and BTB domain containing 7B | ![]() |
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2 | 2 | ||||||
MIRT723009 | FADS1 | fatty acid desaturase 1 | ![]() |
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2 | 2 | ||||||
MIRT723675 | CTC1 | CST telomere replication complex component 1 | ![]() |
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2 | 2 | ||||||
MIRT723774 | ROBO4 | roundabout guidance receptor 4 | ![]() |
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2 | 2 | ||||||
MIRT723814 | OR1L8 | olfactory receptor family 1 subfamily L member 8 | ![]() |
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2 | 2 | ||||||
MIRT723959 | TMEM184A | transmembrane protein 184A | ![]() |
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2 | 2 | ||||||
MIRT724449 | OPA3 | OPA3, outer mitochondrial membrane lipid metabolism regulator | ![]() |
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2 | 2 | ||||||
MIRT724798 | C1D | C1D nuclear receptor corepressor | ![]() |
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2 | 2 | ||||||
MIRT725626 | CAMKV | CaM kinase like vesicle associated | ![]() |
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2 | 2 |