miRTarBase - #MIRT713657


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pre-miRNA Information
pre-miRNA hsa-mir-605   
Genomic Coordinates chr10: 51299573 - 51299655
Synonyms MIRN605, hsa-mir-605, MIR605
Description Homo sapiens miR-605 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-605-3p
Sequence 51| AGAAGGCACUAUGAGAUUUAGA |72
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 10 + 51299626 27587585, 28550310, 26028588, 26449202, 26487287, 29165639 MiREDiBase
A-to-I 14 10 + 51299636 29233923 MiREDiBase
A-to-I 20 10 + 51299642 18684997, 26449202, 27587585, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs759219082 5 dbSNP
rs1491224174 9 dbSNP
rs746611214 10 dbSNP
rs367648737 11 dbSNP
rs1359467239 14 dbSNP
rs1442565019 16 dbSNP
Putative Targets

Gene Information
Gene Symbol PLCE1   
Synonyms NPHS3, PLCE, PPLC
Description phospholipase C epsilon 1
Transcript NM_001165979   
Other Transcripts NM_016341   
Expression
Putative miRNA Targets on PLCE1
3'UTR of PLCE1
(miRNA target sites are highlighted)		 
>PLCE1|NM_001165979|3'UTR
   1 CTAAGGGCAGCATGTTTAACCCAGGTGAAGATCTTTAAGCAAGAAGTTAAAGAGTGAACATGGTGGAAAAAATATAATTA
  81 TTTTCATCAGACTTAAACTGGAAATTGATGATTTCTGAACTGAAGCCTTCACACATGTGAGATCCATGCTGAGGAGAAGC
 161 AAAATGGCACAGGGCTAGTTGCCACCAACCAATTTACTGATGAATGAAGCCCAGGGGACTGCCATTTTATAAATGTCAGC
 241 AGTTGGAAAAATCGTCACGAATTGACTTAGAGCAAGGGTCAGCAAGCTTGTCTGTAAAGGGCCAAACAGTAAATATTTTA
 321 GGGCTGGGGGCCATAAAATATGTTGCAACCACCCAATTCTGCCATTGTAGTGCAAAAGCAGCCATAGACAACACATACAT
 401 GAACGAACGTGGCTGTATTCCAATAAAACTTTATTTATGGACACTGAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agAUUUAGAGUAUCACGGAAGa 5'
            |:|| || | |  |||||| 
Target 5' tcTGAA-CTGA-A--GCCTTCa 3'
 114 - 131 121.00 -9.80
2 
miRNA  3' agAUUUAGAGUAUC---ACGGAAGa 5'
            |:|| | || :|   |||| |: 
Target 5' aaTGAAGCCCAGGGGACTGCCATTt 3'
 203 - 227 108.00 -5.40
3 
miRNA  3' agauuuagaGUAUC-ACGGAAGa 5'
                   |:|:| ||: ||| 
Target 5' atgaacgaaCGTGGCTGTATTCc 3'
 399 - 421 101.00 -6.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
877994 6 ClinVar
1203717 206 ClinVar
301735 2892 ClinVar
301736 2980 ClinVar
301737 3030 ClinVar
879457 3060 ClinVar
301738 3083 ClinVar
301739 3084 ClinVar
879458 3096 ClinVar
301740 3117 ClinVar
301741 3132 ClinVar
301742 3254 ClinVar
COSN30448683 22 COSMIC
COSN30521213 37 COSMIC
COSN30105662 73 COSMIC
COSN30156310 105 COSMIC
COSN16458330 115 COSMIC
COSN30136388 132 COSMIC
COSN1507576 686 COSMIC
COSN1507578 689 COSMIC
COSN22980870 948 COSMIC
COSN1507580 1455 COSMIC
COSN22293998 1623 COSMIC
COSN8726890 1898 COSMIC
COSN32049617 2783 COSMIC
COSM8250874 2891 COSMIC
COSM4446877 2894 COSMIC
COSM9714009 2897 COSMIC
COSN30516639 3015 COSMIC
COSN30590043 3026 COSMIC
rs6583939 541 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1364757088 4 dbSNP
rs1398657166 5 dbSNP
rs149932305 6 dbSNP
rs1345618929 7 dbSNP
rs1224752422 8 dbSNP
rs1471036525 9 dbSNP
rs1276071983 11 dbSNP
rs764937532 12 dbSNP
rs1311237801 17 dbSNP
rs754498112 20 dbSNP
rs750278300 22 dbSNP
rs200616060 23 dbSNP
rs751032226 26 dbSNP
rs754473003 27 dbSNP
rs777144709 27 dbSNP
rs778289709 29 dbSNP
rs749750056 31 dbSNP
rs1359027545 49 dbSNP
rs757837128 49 dbSNP
rs1192984796 52 dbSNP
rs1396479402 59 dbSNP
rs963356089 63 dbSNP
rs1172653193 73 dbSNP
rs1375180700 77 dbSNP
rs1413126492 85 dbSNP
rs1184126970 89 dbSNP
rs766000535 91 dbSNP
rs1265633707 101 dbSNP
rs780890293 105 dbSNP
rs1009486389 114 dbSNP
rs1336930471 126 dbSNP
rs1350891308 129 dbSNP
rs1021325861 131 dbSNP
rs754221512 140 dbSNP
rs1003290261 141 dbSNP
rs1035746699 142 dbSNP
rs11187865 149 dbSNP
rs1316431946 155 dbSNP
rs958766472 157 dbSNP
rs1235231157 159 dbSNP
rs1302984418 167 dbSNP
rs1363128283 185 dbSNP
rs991554836 187 dbSNP
rs909380597 188 dbSNP
rs186344040 191 dbSNP
rs1383017315 194 dbSNP
rs536641327 201 dbSNP
rs115483893 206 dbSNP
rs992997045 210 dbSNP
rs972306773 211 dbSNP
rs1456261747 213 dbSNP
rs1273627127 214 dbSNP
rs762152956 215 dbSNP
rs570344364 220 dbSNP
rs1446300028 232 dbSNP
rs1245701234 240 dbSNP
rs1191783428 244 dbSNP
rs1447056573 245 dbSNP
rs1263455787 246 dbSNP
rs1207692476 249 dbSNP
rs932978372 251 dbSNP
rs1196189438 253 dbSNP
rs1051880684 254 dbSNP
rs910242493 256 dbSNP
rs943085885 257 dbSNP
rs1454360010 280 dbSNP
rs1192545029 298 dbSNP
rs765892691 301 dbSNP
rs1328273395 333 dbSNP
rs1053566588 337 dbSNP
rs767981756 342 dbSNP
rs967601199 344 dbSNP
rs1386372409 345 dbSNP
rs893640049 346 dbSNP
rs769687072 349 dbSNP
rs1388299833 353 dbSNP
rs1167228535 370 dbSNP
rs1475493256 371 dbSNP
rs1042271780 374 dbSNP
rs1374276726 382 dbSNP
rs1196319049 384 dbSNP
rs906453928 388 dbSNP
rs1490064118 389 dbSNP
rs1170074249 390 dbSNP
rs1003488778 408 dbSNP
rs1036089795 409 dbSNP
rs1225253072 415 dbSNP
rs1397794740 418 dbSNP
rs1409944999 423 dbSNP
rs1329933607 424 dbSNP
rs1482262376 426 dbSNP
rs1396735309 428 dbSNP
rs958735543 436 dbSNP
rs1012952872 460 dbSNP
rs1196875789 462 dbSNP
rs1341580762 464 dbSNP
rs979013786 469 dbSNP
rs539244504 485 dbSNP
rs1223166038 492 dbSNP
rs1325401171 495 dbSNP
rs1016306809 496 dbSNP
rs936343674 497 dbSNP
rs1406586338 498 dbSNP
rs191242737 499 dbSNP
rs1039149798 500 dbSNP
rs1229303886 503 dbSNP
rs1270604072 504 dbSNP
rs1338535693 512 dbSNP
rs750759280 513 dbSNP
rs1410403673 514 dbSNP
rs1170249339 517 dbSNP
rs1201134553 517 dbSNP
rs1232609057 517 dbSNP
rs1398010259 517 dbSNP
rs1429610205 517 dbSNP
rs1471849951 517 dbSNP
rs77268826 518 dbSNP
rs1205841987 526 dbSNP
rs1440022538 526 dbSNP
rs1203167364 531 dbSNP
rs572117368 531 dbSNP
rs921685318 532 dbSNP
rs1265304674 535 dbSNP
rs1274984052 535 dbSNP
rs1468493143 536 dbSNP
rs68014126 536 dbSNP
rs1161397036 537 dbSNP
rs34235039 537 dbSNP
rs1212587661 538 dbSNP
rs1430514977 539 dbSNP
rs34689035 539 dbSNP
rs1264819877 540 dbSNP
rs1368996307 541 dbSNP
rs6583939 541 dbSNP
rs1178089980 543 dbSNP
rs933077734 551 dbSNP
rs1195749511 556 dbSNP
rs1051523349 569 dbSNP
rs142048058 571 dbSNP
rs1244980019 579 dbSNP
rs1026543528 580 dbSNP
rs1169076027 581 dbSNP
rs1316512724 583 dbSNP
rs563262996 587 dbSNP
rs1224173282 593 dbSNP
rs886275358 598 dbSNP
rs955110424 600 dbSNP
rs1037571433 610 dbSNP
rs1325356294 615 dbSNP
rs899114595 620 dbSNP
rs1428242183 621 dbSNP
rs201777555 621 dbSNP
rs987768341 624 dbSNP
rs910210417 633 dbSNP
rs1412057323 637 dbSNP
rs1163519479 645 dbSNP
rs758929979 648 dbSNP
rs989188950 649 dbSNP
rs1387191367 651 dbSNP
rs1319266252 652 dbSNP
rs1325568896 654 dbSNP
rs1485569832 665 dbSNP
rs185975333 679 dbSNP
rs190827686 680 dbSNP
rs545985587 686 dbSNP
rs1448537535 687 dbSNP
rs1289244978 689 dbSNP
rs559234028 714 dbSNP
rs906397937 719 dbSNP
rs939260196 725 dbSNP
rs1245193010 734 dbSNP
rs1360004803 742 dbSNP
rs1034791354 744 dbSNP
rs778018523 751 dbSNP
rs895873009 754 dbSNP
rs756693854 755 dbSNP
rs1263220287 757 dbSNP
rs1014774866 765 dbSNP
rs528288359 769 dbSNP
rs547618693 771 dbSNP
rs1012878776 780 dbSNP
rs751597245 781 dbSNP
rs1428058898 785 dbSNP
rs964669982 787 dbSNP
rs1188513414 795 dbSNP
rs1192021323 795 dbSNP
rs1477141047 798 dbSNP
rs1266538688 802 dbSNP
rs1260195925 809 dbSNP
rs974423389 813 dbSNP
rs561354496 814 dbSNP
rs1475850011 816 dbSNP
rs1202340698 823 dbSNP
rs933045426 824 dbSNP
rs1164725342 830 dbSNP
rs1366756981 831 dbSNP
rs987189026 835 dbSNP
rs1343198879 839 dbSNP
rs530147103 839 dbSNP
rs550172987 840 dbSNP
rs570379588 842 dbSNP
rs907664200 844 dbSNP
rs940523095 860 dbSNP
rs200282989 861 dbSNP
rs757427323 870 dbSNP
rs1355222101 871 dbSNP
rs1037519220 881 dbSNP
rs545181885 881 dbSNP
rs899067848 885 dbSNP
rs538924325 909 dbSNP
rs1200406801 913 dbSNP
rs993620224 914 dbSNP
rs368996860 919 dbSNP
rs1360197641 930 dbSNP
rs1175415092 932 dbSNP
rs1417629127 944 dbSNP
rs7901773 951 dbSNP
rs1055776702 954 dbSNP
rs115779357 962 dbSNP
rs1320754885 975 dbSNP
rs1355985021 978 dbSNP
rs1414039192 985 dbSNP
rs756138562 990 dbSNP
rs1310523168 991 dbSNP
rs1305263549 994 dbSNP
rs1391347837 995 dbSNP
rs954934083 996 dbSNP
rs1014316396 997 dbSNP
rs1020375362 1007 dbSNP
rs147763244 1008 dbSNP
rs1379183952 1022 dbSNP
rs535205272 1027 dbSNP
rs1156604890 1030 dbSNP
rs1418262321 1034 dbSNP
rs1017871385 1050 dbSNP
rs964338625 1060 dbSNP
rs749099768 1065 dbSNP
rs534491694 1068 dbSNP
rs1214880068 1080 dbSNP
rs373048535 1089 dbSNP
rs1000347541 1095 dbSNP
rs114292150 1098 dbSNP
rs945109093 1114 dbSNP
rs976072652 1116 dbSNP
rs1028623221 1117 dbSNP
rs1317892953 1119 dbSNP
rs1309859037 1128 dbSNP
rs1451021469 1133 dbSNP
rs1382129510 1139 dbSNP
rs1181720710 1143 dbSNP
rs1454799660 1152 dbSNP
rs11187866 1155 dbSNP
rs778862976 1157 dbSNP
rs987134899 1159 dbSNP
rs1364105496 1166 dbSNP
rs939203328 1169 dbSNP
rs183418042 1174 dbSNP
rs1442661232 1200 dbSNP
rs907610255 1200 dbSNP
rs1183722281 1202 dbSNP
rs754487053 1202 dbSNP
rs895080917 1205 dbSNP
rs1259313109 1210 dbSNP
rs948699402 1216 dbSNP
rs920443799 1219 dbSNP
rs1375795304 1221 dbSNP
rs1037648127 1234 dbSNP
rs10882424 1242 dbSNP
rs993980594 1245 dbSNP
rs1359287111 1247 dbSNP
rs1026437225 1255 dbSNP
rs1056127588 1258 dbSNP
rs1248307319 1261 dbSNP
rs1324755297 1262 dbSNP
rs1398616725 1265 dbSNP
rs1391455302 1266 dbSNP
rs1382928157 1269 dbSNP
rs556497139 1273 dbSNP
rs1299761148 1282 dbSNP
rs117149466 1284 dbSNP
rs1009074091 1286 dbSNP
rs1364927820 1289 dbSNP
rs950029623 1296 dbSNP
rs1473527738 1299 dbSNP
rs1017840170 1306 dbSNP
rs1192028397 1314 dbSNP
rs545823119 1315 dbSNP
rs964974730 1321 dbSNP
rs1011184198 1326 dbSNP
rs1220778552 1329 dbSNP
rs1235996143 1335 dbSNP
rs556285379 1340 dbSNP
rs559591094 1342 dbSNP
rs966443111 1343 dbSNP
rs978208079 1344 dbSNP
rs1337539229 1345 dbSNP
rs1228463625 1361 dbSNP
rs1269633137 1361 dbSNP
rs1054589322 1364 dbSNP
rs1348978039 1370 dbSNP
rs1281580138 1378 dbSNP
rs1402943522 1379 dbSNP
rs927745211 1389 dbSNP
rs1303703935 1403 dbSNP
rs1406950251 1410 dbSNP
rs900005857 1410 dbSNP
rs772613498 1414 dbSNP
rs990632126 1418 dbSNP
rs79592553 1419 dbSNP
rs555303277 1420 dbSNP
rs1038284148 1421 dbSNP
rs1195658653 1424 dbSNP
rs1269974647 1426 dbSNP
rs1395930862 1434 dbSNP
rs1432370185 1439 dbSNP
rs1008502475 1462 dbSNP
rs1436530642 1477 dbSNP
rs1272901510 1479 dbSNP
rs1014554933 1485 dbSNP
rs1173771188 1486 dbSNP
rs1374705807 1488 dbSNP
rs561391323 1490 dbSNP
rs1344641113 1491 dbSNP
rs114444196 1492 dbSNP
rs929324871 1496 dbSNP
rs1438550287 1499 dbSNP
rs973131012 1500 dbSNP
rs1328060055 1502 dbSNP
rs1391526657 1515 dbSNP
rs1442481584 1518 dbSNP
rs1326152764 1519 dbSNP
rs1173826373 1523 dbSNP
rs1468932155 1527 dbSNP
rs1366550733 1528 dbSNP
rs1218977674 1534 dbSNP
rs1174733244 1537 dbSNP
rs551346965 1538 dbSNP
rs920407517 1540 dbSNP
rs1048240683 1541 dbSNP
rs890556599 1544 dbSNP
rs550209907 1556 dbSNP
rs991376892 1573 dbSNP
rs917137754 1576 dbSNP
rs1039199623 1578 dbSNP
rs1309654550 1581 dbSNP
rs1041712547 1585 dbSNP
rs1228744097 1586 dbSNP
rs924607965 1593 dbSNP
rs1278942528 1597 dbSNP
rs1240709103 1603 dbSNP
rs1257982184 1604 dbSNP
rs1456452650 1618 dbSNP
rs1334066477 1620 dbSNP
rs74153304 1621 dbSNP
rs1406419211 1622 dbSNP
rs1054938886 1625 dbSNP
rs1399378770 1627 dbSNP
rs1011162886 1629 dbSNP
rs899952047 1631 dbSNP
rs1442044241 1639 dbSNP
rs192520877 1640 dbSNP
rs776324371 1647 dbSNP
rs966747006 1653 dbSNP
rs1461800880 1665 dbSNP
rs147589235 1676 dbSNP
rs1213888037 1682 dbSNP
rs182602963 1684 dbSNP
rs1035159864 1686 dbSNP
rs1283211001 1687 dbSNP
rs1240818477 1690 dbSNP
rs960469527 1691 dbSNP
rs1014505349 1696 dbSNP
rs1312798078 1697 dbSNP
rs1244696136 1700 dbSNP
rs1379248084 1702 dbSNP
rs1285609155 1703 dbSNP
rs961696244 1704 dbSNP
rs1345005913 1705 dbSNP
rs994546626 1713 dbSNP
rs1421882045 1715 dbSNP
rs1027814641 1718 dbSNP
rs1364295252 1718 dbSNP
rs958508554 1718 dbSNP
rs990558421 1727 dbSNP
rs1462557032 1728 dbSNP
rs1242895500 1729 dbSNP
rs917102415 1733 dbSNP
rs1348920029 1734 dbSNP
rs1433790855 1736 dbSNP
rs916406824 1743 dbSNP
rs1299736521 1746 dbSNP
rs373439427 1749 dbSNP
rs1321798436 1753 dbSNP
rs1291355599 1756 dbSNP
rs1364443813 1758 dbSNP
rs1212463349 1763 dbSNP
rs977342773 1766 dbSNP
rs924555523 1769 dbSNP
rs935982242 1773 dbSNP
rs1401004573 1780 dbSNP
rs1054482238 1788 dbSNP
rs1278105918 1789 dbSNP
rs1344007440 1789 dbSNP
rs78898768 1792 dbSNP
rs114371209 1793 dbSNP
rs929268508 1797 dbSNP
rs140548591 1799 dbSNP
rs911903048 1806 dbSNP
rs12221079 1807 dbSNP
rs1424695008 1810 dbSNP
rs567823519 1819 dbSNP
rs536698279 1820 dbSNP
rs940243310 1824 dbSNP
rs900635054 1830 dbSNP
rs1037238719 1832 dbSNP
rs1198644104 1833 dbSNP
rs1244075969 1838 dbSNP
rs1248360954 1844 dbSNP
rs1486064746 1848 dbSNP
rs1011087912 1852 dbSNP
rs541828595 1853 dbSNP
rs902784056 1856 dbSNP
rs1220024934 1857 dbSNP
rs1321855942 1863 dbSNP
rs1282992281 1864 dbSNP
rs1387881233 1867 dbSNP
rs1370415677 1869 dbSNP
rs1000210743 1874 dbSNP
rs1441644368 1875 dbSNP
rs1027354427 1882 dbSNP
rs1173100279 1888 dbSNP
rs1468395309 1892 dbSNP
rs894190112 1902 dbSNP
rs1426970370 1904 dbSNP
rs1188595366 1908 dbSNP
rs377697250 1909 dbSNP
rs1269456244 1917 dbSNP
rs1175398160 1921 dbSNP
rs1012687809 1923 dbSNP
rs1238178680 1923 dbSNP
rs1276152557 1925 dbSNP
rs1200172457 1928 dbSNP
rs1262091963 1931 dbSNP
rs1403100692 1931 dbSNP
rs896190451 1941 dbSNP
rs1345474844 1944 dbSNP
rs1024109390 1950 dbSNP
rs1011948352 1955 dbSNP
rs114817478 1956 dbSNP
rs1339707772 1963 dbSNP
rs962484278 1975 dbSNP
rs572719023 1976 dbSNP
rs1450516899 1978 dbSNP
rs1405677941 1986 dbSNP
rs1303639816 1989 dbSNP
rs775945153 1991 dbSNP
rs951309423 1997 dbSNP
rs541397248 1998 dbSNP
rs911897007 2008 dbSNP
rs944694064 2014 dbSNP
rs867195405 2015 dbSNP
rs1031571457 2016 dbSNP
rs974792530 2021 dbSNP
rs1226744148 2031 dbSNP
rs922026946 2032 dbSNP
rs957338664 2035 dbSNP
rs1484447804 2036 dbSNP
rs990527062 2037 dbSNP
rs1215734210 2039 dbSNP
rs946844818 2040 dbSNP
rs1312061489 2051 dbSNP
rs746770440 2054 dbSNP
rs150466922 2060 dbSNP
rs370202463 2061 dbSNP
rs986912611 2065 dbSNP
rs763565280 2068 dbSNP
rs1057156429 2069 dbSNP
rs1418840943 2075 dbSNP
rs1236848931 2076 dbSNP
rs896115532 2077 dbSNP
rs1178493433 2079 dbSNP
rs1367311782 2081 dbSNP
rs1187859343 2090 dbSNP
rs912680770 2091 dbSNP
rs1408219913 2095 dbSNP
rs1193449974 2104 dbSNP
rs1011874630 2110 dbSNP
rs1023311790 2111 dbSNP
rs1438745891 2116 dbSNP
rs1037184890 2117 dbSNP
rs898267021 2119 dbSNP
rs1247288546 2127 dbSNP
rs995686082 2127 dbSNP
rs564683843 2132 dbSNP
rs898741032 2134 dbSNP
rs573066964 2136 dbSNP
rs1340836731 2150 dbSNP
rs1299969395 2155 dbSNP
rs542062643 2157 dbSNP
rs533616331 2164 dbSNP
rs1163388372 2167 dbSNP
rs1458968706 2190 dbSNP
rs1443962274 2191 dbSNP
rs1436989448 2193 dbSNP
rs1478358873 2197 dbSNP
rs555561366 2199 dbSNP
rs986698463 2208 dbSNP
rs1019959494 2216 dbSNP
rs966008460 2219 dbSNP
rs17438706 2220 dbSNP
rs1268639432 2222 dbSNP
rs9665608 2228 dbSNP
rs1337519067 2230 dbSNP
rs946771076 2232 dbSNP
rs1219410320 2233 dbSNP
rs563787579 2254 dbSNP
rs979958480 2258 dbSNP
rs1279809459 2278 dbSNP
rs998672673 2280 dbSNP
rs924129549 2281 dbSNP
rs138318806 2282 dbSNP
rs750631938 2284 dbSNP
rs1388067573 2287 dbSNP
rs1393616613 2294 dbSNP
rs188161459 2306 dbSNP
rs990085837 2309 dbSNP
rs756288945 2310 dbSNP
rs548985790 2313 dbSNP
rs528717345 2314 dbSNP
rs954065650 2315 dbSNP
rs1044691702 2316 dbSNP
rs1378783776 2319 dbSNP
rs1201575128 2321 dbSNP
rs1436158852 2324 dbSNP
rs1237600502 2325 dbSNP
rs1199532346 2330 dbSNP
rs1440666157 2331 dbSNP
rs1459301602 2333 dbSNP
rs1388409439 2340 dbSNP
rs1205977240 2344 dbSNP
rs1238199143 2348 dbSNP
rs1456936735 2368 dbSNP
rs1176339365 2371 dbSNP
rs565800199 2376 dbSNP
rs1396574776 2381 dbSNP
rs1275379005 2385 dbSNP
rs1455856104 2394 dbSNP
rs898193405 2395 dbSNP
rs1374052005 2396 dbSNP
rs986803098 2401 dbSNP
rs1235924324 2406 dbSNP
rs1446854948 2418 dbSNP
rs1425055579 2420 dbSNP
rs758338478 2423 dbSNP
rs1334278085 2425 dbSNP
rs995256687 2428 dbSNP
rs535890255 2431 dbSNP
rs1403276077 2438 dbSNP
rs940138037 2444 dbSNP
rs116867669 2450 dbSNP
rs370876878 2454 dbSNP
rs1441621844 2455 dbSNP
rs931520254 2456 dbSNP
rs1329544885 2457 dbSNP
rs1279017372 2459 dbSNP
rs1373549458 2463 dbSNP
rs1233659080 2464 dbSNP
rs1274075618 2465 dbSNP
rs1351482430 2466 dbSNP
rs1008493033 2467 dbSNP
rs1308403139 2467 dbSNP
rs1378454487 2467 dbSNP
rs1342637590 2469 dbSNP
rs1019520578 2470 dbSNP
rs1216214446 2470 dbSNP
rs1258649126 2471 dbSNP
rs1282075260 2481 dbSNP
rs71480901 2484 dbSNP
rs1316739778 2495 dbSNP
rs568359223 2510 dbSNP
rs557167609 2514 dbSNP
rs963939675 2530 dbSNP
rs1336612788 2531 dbSNP
rs573691748 2539 dbSNP
rs551414701 2545 dbSNP
rs1254457031 2549 dbSNP
rs1451873356 2550 dbSNP
rs1421610088 2553 dbSNP
rs996795788 2553 dbSNP
rs1383386409 2560 dbSNP
rs1246451533 2572 dbSNP
rs1473218103 2579 dbSNP
rs557046196 2589 dbSNP
rs569344318 2595 dbSNP
rs1189408835 2603 dbSNP
rs948393256 2608 dbSNP
rs1028990156 2616 dbSNP
rs1465164640 2618 dbSNP
rs1217166244 2619 dbSNP
rs1355270031 2627 dbSNP
rs747258504 2631 dbSNP
rs1227225126 2637 dbSNP
rs1379498156 2642 dbSNP
rs906922778 2645 dbSNP
rs1398605099 2653 dbSNP
rs968493721 2654 dbSNP
rs1299345413 2660 dbSNP
rs11187869 2661 dbSNP
rs892977395 2674 dbSNP
rs1323173924 2677 dbSNP
rs1405994380 2683 dbSNP
rs879332055 2683 dbSNP
rs1011859272 2686 dbSNP
rs1028238872 2696 dbSNP
rs1262155046 2705 dbSNP
rs954123006 2708 dbSNP
rs1278763589 2709 dbSNP
rs1489258697 2709 dbSNP
rs1008170625 2711 dbSNP
rs1321784413 2711 dbSNP
rs924028539 2713 dbSNP
rs1019588489 2714 dbSNP
rs961420726 2725 dbSNP
rs1220821602 2727 dbSNP
rs1317267125 2738 dbSNP
rs1293453983 2741 dbSNP
rs1437350906 2741 dbSNP
rs972796404 2746 dbSNP
rs570509242 2753 dbSNP
rs920056129 2769 dbSNP
rs1356477486 2772 dbSNP
rs1208804788 2778 dbSNP
rs539085954 2781 dbSNP
rs552901819 2786 dbSNP
rs1190497362 2789 dbSNP
rs1450222370 2790 dbSNP
rs1196377217 2794 dbSNP
rs992754564 2804 dbSNP
rs991417025 2809 dbSNP
rs1196391483 2810 dbSNP
rs566663831 2811 dbSNP
rs949626869 2820 dbSNP
rs1220920021 2824 dbSNP
rs1192152452 2825 dbSNP
rs535701895 2827 dbSNP
rs1307239553 2828 dbSNP
rs948292708 2828 dbSNP
rs113301723 2832 dbSNP
rs892917263 2832 dbSNP
rs1333606604 2836 dbSNP
rs149647941 2846 dbSNP
rs746272652 2848 dbSNP
rs145174290 2856 dbSNP
rs1347347625 2859 dbSNP
rs759751018 2860 dbSNP
rs1298136356 2861 dbSNP
rs1267576679 2863 dbSNP
rs866256878 2864 dbSNP
rs1176279516 2868 dbSNP
rs1406305724 2871 dbSNP
rs745533827 2874 dbSNP
rs765627678 2876 dbSNP
rs1224025853 2880 dbSNP
rs768622758 2881 dbSNP
rs776838414 2884 dbSNP
rs1215544947 2886 dbSNP
rs761643951 2887 dbSNP
rs1490815454 2888 dbSNP
rs3203713 2892 dbSNP
rs775922374 2895 dbSNP
rs772961752 2898 dbSNP
rs1178018416 2899 dbSNP
rs1382337452 2900 dbSNP
rs191878411 2907 dbSNP
rs763496536 2912 dbSNP
rs1464907685 2919 dbSNP
rs1189961208 2920 dbSNP
rs765970558 2920 dbSNP
rs1008001465 2923 dbSNP
rs1019536556 2925 dbSNP
rs1322104106 2927 dbSNP
rs751230289 2929 dbSNP
rs764202676 2930 dbSNP
rs751602724 2932 dbSNP
rs759024887 2933 dbSNP
rs757493640 2934 dbSNP
rs576903960 2937 dbSNP
rs1376726345 2938 dbSNP
rs1361550737 2941 dbSNP
rs1302094952 2945 dbSNP
rs1466330009 2948 dbSNP
rs752297646 2952 dbSNP
rs1362411807 2953 dbSNP
rs767668379 2954 dbSNP
rs1157860783 2956 dbSNP
rs757671049 2956 dbSNP
rs1288994593 2957 dbSNP
rs779591551 2963 dbSNP
rs750765503 2964 dbSNP
rs750225258 2967 dbSNP
rs1421740084 2969 dbSNP
rs758845393 2969 dbSNP
rs775998675 2974 dbSNP
rs886047506 2980 dbSNP
rs1027051042 2990 dbSNP
rs899701528 2992 dbSNP
rs952933826 2995 dbSNP
rs1424471445 2998 dbSNP
rs1186983519 3011 dbSNP
rs1216446005 3015 dbSNP
rs996764468 3021 dbSNP
rs11187870 3030 dbSNP
rs764568175 3031 dbSNP
rs1441728722 3048 dbSNP
rs970929348 3049 dbSNP
rs1001286005 3056 dbSNP
rs1396445104 3057 dbSNP
rs754510047 3065 dbSNP
rs1031060752 3067 dbSNP
rs1159511346 3078 dbSNP
rs1359590580 3080 dbSNP
rs376587612 3083 dbSNP
rs184484950 3084 dbSNP
rs553328712 3089 dbSNP
rs796811868 3094 dbSNP
rs918075400 3095 dbSNP
rs1367591988 3096 dbSNP
rs542154992 3102 dbSNP
rs1402904459 3104 dbSNP
rs1476395464 3112 dbSNP
rs79412094 3117 dbSNP
rs138795090 3118 dbSNP
rs934312433 3122 dbSNP
rs920194264 3123 dbSNP
rs141966806 3126 dbSNP
rs1308082830 3128 dbSNP
rs982839227 3129 dbSNP
rs146319051 3132 dbSNP
rs533005572 3134 dbSNP
rs943778663 3136 dbSNP
rs1247176553 3137 dbSNP
rs1336715939 3149 dbSNP
rs1276014778 3157 dbSNP
rs1040856592 3158 dbSNP
rs1049559770 3159 dbSNP
rs1341129147 3166 dbSNP
rs899629411 3168 dbSNP
rs546283067 3178 dbSNP
rs1200412838 3180 dbSNP
rs1254127496 3194 dbSNP
rs566520124 3199 dbSNP
rs1042966285 3205 dbSNP
rs1459149862 3209 dbSNP
rs1389307207 3220 dbSNP
rs889621726 3226 dbSNP
rs1179432863 3229 dbSNP
rs535434087 3235 dbSNP
rs201122307 3237 dbSNP
rs1284873710 3242 dbSNP
rs555726388 3249 dbSNP
rs1170458815 3253 dbSNP
rs886047507 3254 dbSNP
rs1375343118 3260 dbSNP
rs994114853 3262 dbSNP
rs1451113970 3263 dbSNP
rs888512818 3264 dbSNP
rs892500911 3264 dbSNP
rs1012747218 3265 dbSNP
rs569145509 3267 dbSNP
rs1013618747 3269 dbSNP
rs1197845455 3272 dbSNP
rs767671259 3273 dbSNP
rs969502125 3279 dbSNP
rs116808240 3285 dbSNP
rs750458075 3292 dbSNP
rs1230927854 3293 dbSNP
rs1401757374 3293 dbSNP
rs760903244 3295 dbSNP
rs1330263837 3302 dbSNP
rs983090349 3303 dbSNP
rs908202595 3311 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124B_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + B HITS-CLIP data was present in Chi_ControlA_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control A ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_124B_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + B
Location of target site ENST00000371380.3 | 3UTR | UGAUUUCUGAACUGAAGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset Chi_ControlA_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control A
Location of target site ENST00000371380.3 | 3UTR | UGAUUUCUGAACUGAAGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
100 hsa-miR-605-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061339 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT061584 BTG2 BTG anti-proliferation factor 2 2 6
MIRT076140 WDR81 WD repeat domain 81 2 2
MIRT079361 CCDC137 coiled-coil domain containing 137 2 2
MIRT079547 VAMP3 vesicle associated membrane protein 3 2 2
MIRT096242 CANX calnexin 2 2
MIRT243877 G3BP1 G3BP stress granule assembly factor 1 2 4
MIRT249186 AKIRIN1 akirin 1 2 8
MIRT273604 SP1 Sp1 transcription factor 2 2
MIRT316766 FOXC1 forkhead box C1 2 4
MIRT322410 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT370117 TRIB3 tribbles pseudokinase 3 2 2
MIRT392725 UBN2 ubinuclein 2 2 2
MIRT406910 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT407440 CTDSP1 CTD small phosphatase 1 2 2
MIRT441887 RD3 retinal degeneration 3 2 4
MIRT444979 C15orf52 chromosome 15 open reading frame 52 2 2
MIRT445241 FOXD4 forkhead box D4 2 2
MIRT445500 FOXD4L5 forkhead box D4 like 5 2 2
MIRT445503 FOXD4L4 forkhead box D4 like 4 2 2
MIRT447025 FOXD4L1 forkhead box D4 like 1 2 2
MIRT447743 TMCC3 transmembrane and coiled-coil domain family 3 2 2
MIRT448761 HDX highly divergent homeobox 2 2
MIRT450003 HAX1 HCLS1 associated protein X-1 2 2
MIRT452830 FAM131B family with sequence similarity 131 member B 2 2
MIRT452872 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT453506 ARRB1 arrestin beta 1 2 2
MIRT454169 HIST1H2BK histone cluster 1 H2B family member k 2 2
MIRT458742 CES2 carboxylesterase 2 2 2
MIRT459166 HSPA6 heat shock protein family A (Hsp70) member 6 2 21
MIRT460246 IL17RB interleukin 17 receptor B 2 4
MIRT460514 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT460698 RNF157 ring finger protein 157 2 2
MIRT461481 METTL1 methyltransferase like 1 2 2
MIRT462617 C20orf27 chromosome 20 open reading frame 27 2 4
MIRT463233 ZNF131 zinc finger protein 131 2 2
MIRT465699 TNPO2 transportin 2 2 8
MIRT466304 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT468957 RPS14 ribosomal protein S14 2 6
MIRT469571 RARA retinoic acid receptor alpha 2 2
MIRT469685 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT470800 PMP22 peripheral myelin protein 22 2 2
MIRT471649 PANK2 pantothenate kinase 2 2 4
MIRT471722 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT472281 NFIB nuclear factor I B 2 4
MIRT473680 MAPKBP1 mitogen-activated protein kinase binding protein 1 2 2
MIRT475859 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT477326 EPHA2 EPH receptor A2 2 2
MIRT477831 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478572 CTNND1 catenin delta 1 2 4
MIRT479634 CD81 CD81 molecule 2 2
MIRT481950 ANKRD11 ankyrin repeat domain 11 2 2
MIRT483696 ZNF74 zinc finger protein 74 2 6
MIRT488798 MALT1 MALT1 paracaspase 2 2
MIRT489066 STARD3 StAR related lipid transfer domain containing 3 2 2
MIRT492533 PSMD11 proteasome 26S subunit, non-ATPase 11 2 2
MIRT492857 NRARP NOTCH regulated ankyrin repeat protein 2 2
MIRT496793 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2 2
MIRT500122 ZNF106 zinc finger protein 106 2 4
MIRT505359 TMEM167A transmembrane protein 167A 2 2
MIRT506786 KLHL15 kelch like family member 15 2 6
MIRT510692 SRM spermidine synthase 2 6
MIRT515841 CEP104 centrosomal protein 104 2 4
MIRT516448 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 4
MIRT528855 PKP1 plakophilin 1 2 2
MIRT533848 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT539025 ATXN7L1 ataxin 7 like 1 2 4
MIRT542872 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT546543 SATB2 SATB homeobox 2 2 2
MIRT554114 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT560569 ZNF460 zinc finger protein 460 2 2
MIRT560796 EPM2AIP1 EPM2A interacting protein 1 2 2
MIRT562836 GCFC2 GC-rich sequence DNA-binding factor 2 2 2
MIRT563109 IFRD2 interferon related developmental regulator 2 2 2
MIRT564177 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT564283 ASB1 ankyrin repeat and SOCS box containing 1 2 2
MIRT564350 USP22 ubiquitin specific peptidase 22 2 2
MIRT565279 TNFRSF21 TNF receptor superfamily member 21 2 2
MIRT565338 TMEM104 transmembrane protein 104 2 2
MIRT565905 SCAMP2 secretory carrier membrane protein 2 2 2
MIRT567108 ITGB1 integrin subunit beta 1 2 2
MIRT567601 FANCF Fanconi anemia complementation group F 2 2
MIRT567779 DGAT2 diacylglycerol O-acyltransferase 2 2 2
MIRT568075 CENPQ centromere protein Q 2 2
MIRT624304 COL12A1 collagen type XII alpha 1 chain 2 2
MIRT644395 CDKL1 cyclin dependent kinase like 1 2 2
MIRT661547 ZNF674 zinc finger protein 674 2 4
MIRT670949 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT672951 AKAP5 A-kinase anchoring protein 5 2 2
MIRT697426 ZFP36 ZFP36 ring finger protein 2 2
MIRT700793 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT702657 ITGA3 integrin subunit alpha 3 2 2
MIRT708945 FZR1 fizzy and cell division cycle 20 related 1 2 2
MIRT713657 PLCE1 phospholipase C epsilon 1 2 2
MIRT719239 CYSLTR2 cysteinyl leukotriene receptor 2 2 2
MIRT719951 BLOC1S6 biogenesis of lysosomal organelles complex 1 subunit 6 2 2
MIRT722048 HLA-E major histocompatibility complex, class I, E 2 2
MIRT722201 URM1 ubiquitin related modifier 1 2 2
MIRT724790 C1D C1D nuclear receptor corepressor 2 2
MIRT734347 CYP2B6 cytochrome P450 family 2 subfamily B member 6 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-605 Anthranilamide-pyrazolo[1,5-a]pyrimidine NULL NULL Quantitative real-time PCR neuroblastoma cells 23992861 2013 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-605 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-605 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-605-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)

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