pre-miRNA Information
pre-miRNA hsa-mir-4486   
Genomic Coordinates chr11: 19575310 - 19575372
Description Homo sapiens miR-4486 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4486
Sequence 5| GCUGGGCGAGGCUGGCA |21
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs774299284 8 dbSNP
rs902172817 14 dbSNP
rs1222795726 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol HP1BP3   
Synonyms HP1-BP74, HP1BP74
Description heterochromatin protein 1 binding protein 3
Transcript NM_016287   
Expression
Putative miRNA Targets on HP1BP3
3'UTR of HP1BP3
(miRNA target sites are highlighted)
>HP1BP3|NM_016287|3'UTR
   1 ATTTTATAGGAAAAAAGGGTATCATGATGAAATTCAAAATCTTATTTTCTAAGGTCAGTGTGCATTTGTTTAGTTTTGAT
  81 GCTTTTCAAATTACATTATTTTCCTCCCCTATGAACATTGTGGGGAGGGACTCTAAATAAACCAGTTTAGGCATTTGCTA
 161 GCTTTAGGTGCTTTTATTGGTGCCTGCCCTTTTCCTTGTTCATTTTAATTTCTGCAATAATCCTGGACTTTCCTAAACTA
 241 TGTAATGTATACTTGTCCTTTTTCTCTGCCTCCCCCAACCCCCTGTTGTTTTTATGGTCAGCTTTGCCTTTTTTTTTTCT
 321 TCCAATTTTATCTAAACAGTTGCAGAGATTTTTATATTTGTAGAAAGCATCAAGAACGGTATGCCAGTCAGGTCCTGGAA
 401 GTAAAATGGAGGCACAATATAGCACTGACTGAGTTGTAAAGCCTCCTGCCTGGAGACTTCAGTTATAGCTGTAATAATTA
 481 ATCTTATTTATAAAAGCCACTCCACTAACCTTTTCTCTCCAACTGTAAACACAGAGACAGCTTTGGGAATAAGCCAAAAA
 561 CAGGGTGATCTCATTAGATTTTGAAGATATATGACTCCTTTGGGCTACATTTCATATTGATCAATTTCTAGGTATTTTTC
 641 ACTGGCCCAAAGTATTGCATTCCCTTAACAGCAAGCACAAGTTCTCTATATCACTTGTTTTTTGTTGTTGTTGTTGTTGT
 721 CGTCGTTGTTTTGAGACGGAGTCTTGCTCAGGTGCCCCGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCCACCT
 801 CCTGGGTTCAAGCAATTCTCCTGCTTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGTACCACCACGCCTGGCAATTTT
 881 TTTGTATTTTTAGTAGAGATGGGGTTTCGCCGTGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTGC
 961 CTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCACTGTGCCTGGCCTATCCCACTTGGTTTTTGACTGAAGGGGA
1041 AGTGTAGAAATATATTGATTTGTGATTTCTGGTGTCACCTGTGTTACCAAAAATCAAAACAAATCTTTTTTATTTTTTAT
1121 TATTATTATTATTTTTGAGACAGAGTCTCGCTCTGTCGCCCAGTGTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAA
1201 CTCCGCCTCCCAGGTTCAAGCGATTCTCCCACCTCAGCCTCCTGAGTTGGGTCCTACAGGCGCACACGACCACGCCCAGC
1281 TAATTTTTTGTATTTTTAGTAGAGTTGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCAC
1361 TCACCTCAGCCTCCCAAAATCCTGGGGTTACAGATGTGAGCTACCACTCACGGCCCAAATCTTCTTGATCATATGTTTAA
1441 ATATATTTTTTAATATTTGGAGCATGAGTTGTCACTTCTTGTTTGCCTTTTTTATAAGGAAATGTTGGAGAGTTACATCA
1521 TTGCTAATGTAGAAATGTTAAGTGGAAAAATATACAGTTTGGTAAAATAAACTAGATTCTACATTTATTTGTGGGTTTTT
1601 TTCCCCTCCTTTCTTTCCACAGCACTTTTGATATCAAGCAAGTGGCTTCCTTTTTGAGATATTAAAAAAAAAAAGAAAAG
1681 GAAAAAAGTAAATGAAGCCCAACTACCTAACCCTTTCTTATTTGTATTTGTTTTAGTATTGTGAAGTTGTGTTAAATAGT
1761 ACTAGCTAGAAATACAAATTTCTGGTTATCATTTCTCTTCCCTGTGGCACTTGACATTTTAATTGTCTTAAAGTTTTTGA
1841 AGTACATCTTCTGGCCCCTTGAGTACTGCCAGAGGCAAAAGATGTTTGTTTCTTATTCATTCCACTTTTGTCTCCTGGGA
1921 TCCCTTCTGTAGCCTAAAGTATGGCTGGGAAATGGACTTGAGAAGATTGGCTTGAATTAGATCATAATCATGTGTGATCC
2001 CATCATGAATTCATTGGAATTTGTGTTGCATGTAAGGCAATCTTTCCTGTTGTAAATCTTCCTTTTTTAATGTACATATA
2081 TTTTGAAAAATATGAATAAACATGAAATTTTAAAAGCTGAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acgGUCGGAGCGGGUCg 5'
             |: || ||||||| 
Target 5' acaCGACCACGCCCAGc 3'
1264 - 1280 150.00 -20.90
2
miRNA  3' acGGUCGG---AGCGGGUCg 5'
            |: ||:   |||||||| 
Target 5' gtCTCGCTCTGTCGCCCAGt 3'
1145 - 1164 147.00 -17.30
3
miRNA  3' acggUCGGAGCGGGUCg 5'
              ||:||:||:||| 
Target 5' acggAGTCTTGCTCAGg 3'
736 - 752 129.00 -17.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31602218 3 COSMIC
COSN8407116 8 COSMIC
COSN30144086 10 COSMIC
COSN30681429 11 COSMIC
COSN30137686 17 COSMIC
COSN31519977 35 COSMIC
COSN31487608 78 COSMIC
COSN31570347 108 COSMIC
COSN31559027 136 COSMIC
COSN30168492 186 COSMIC
COSN5737134 208 COSMIC
COSN29608429 308 COSMIC
COSN31515587 351 COSMIC
COSN31588340 378 COSMIC
COSN31480872 409 COSMIC
COSN24297763 537 COSMIC
COSN1429048 573 COSMIC
COSN16528372 622 COSMIC
COSN30542760 664 COSMIC
COSN505807 943 COSMIC
COSN24701822 1158 COSMIC
COSN29932081 1268 COSMIC
COSN1429045 1445 COSMIC
COSN29399247 1462 COSMIC
COSN9058194 1464 COSMIC
COSN1429044 1467 COSMIC
COSN23970113 1603 COSMIC
COSN20094485 1663 COSMIC
COSN31543459 1827 COSMIC
COSN31584676 1922 COSMIC
COSN24362064 1950 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1238476062 2 dbSNP
rs1392116035 6 dbSNP
rs764090149 6 dbSNP
rs1373796451 7 dbSNP
rs1449427820 11 dbSNP
rs932253949 12 dbSNP
rs763762787 17 dbSNP
rs760162752 18 dbSNP
rs752230262 19 dbSNP
rs767319345 21 dbSNP
rs1045038 23 dbSNP
rs1286544930 30 dbSNP
rs774102632 32 dbSNP
rs968771376 36 dbSNP
rs770298021 37 dbSNP
rs1015759143 40 dbSNP
rs1395559354 42 dbSNP
rs762174275 44 dbSNP
rs561050792 45 dbSNP
rs1263240398 48 dbSNP
rs1408182277 54 dbSNP
rs1193671601 58 dbSNP
rs1427779681 62 dbSNP
rs1259588835 64 dbSNP
rs986432064 79 dbSNP
rs917007769 84 dbSNP
rs1167470712 94 dbSNP
rs953667268 97 dbSNP
rs982578755 98 dbSNP
rs1263872757 104 dbSNP
rs534825483 107 dbSNP
rs1203242702 108 dbSNP
rs1244060834 109 dbSNP
rs1030458005 111 dbSNP
rs952346077 119 dbSNP
rs542762565 122 dbSNP
rs764277306 126 dbSNP
rs1490293968 127 dbSNP
rs1326299884 132 dbSNP
rs897547886 137 dbSNP
rs1398377040 142 dbSNP
rs1270108391 150 dbSNP
rs1382848207 151 dbSNP
rs1335559337 157 dbSNP
rs1026667380 158 dbSNP
rs1402027995 162 dbSNP
rs1168222616 164 dbSNP
rs1306336256 165 dbSNP
rs1461282900 168 dbSNP
rs1012798165 170 dbSNP
rs1272904760 186 dbSNP
rs1214658717 192 dbSNP
rs182106479 194 dbSNP
rs780915926 198 dbSNP
rs563517478 202 dbSNP
rs1445212961 203 dbSNP
rs544716035 217 dbSNP
rs138089987 222 dbSNP
rs1252948654 223 dbSNP
rs558978097 225 dbSNP
rs540284125 228 dbSNP
rs896402238 231 dbSNP
rs1304803424 232 dbSNP
rs573454678 240 dbSNP
rs903039271 242 dbSNP
rs111924127 244 dbSNP
rs1042181785 248 dbSNP
rs1449849587 256 dbSNP
rs1378547071 257 dbSNP
rs935169555 258 dbSNP
rs1439740819 266 dbSNP
rs1353876055 268 dbSNP
rs11546452 269 dbSNP
rs1425181255 272 dbSNP
rs924671740 274 dbSNP
rs1384542534 275 dbSNP
rs1162949308 278 dbSNP
rs1442844315 282 dbSNP
rs1050388937 283 dbSNP
rs1437513702 285 dbSNP
rs1248801958 293 dbSNP
rs1225191310 294 dbSNP
rs554967751 294 dbSNP
rs932203140 306 dbSNP
rs977530218 307 dbSNP
rs947365714 318 dbSNP
rs1275775719 319 dbSNP
rs139472957 319 dbSNP
rs976402582 319 dbSNP
rs1237814717 320 dbSNP
rs879244648 320 dbSNP
rs1329384771 322 dbSNP
rs1410631564 323 dbSNP
rs1425802646 326 dbSNP
rs940837973 326 dbSNP
rs908066466 334 dbSNP
rs1174332613 342 dbSNP
rs1480253376 345 dbSNP
rs1430238792 348 dbSNP
rs1421484360 354 dbSNP
rs568921020 369 dbSNP
rs914615834 376 dbSNP
rs982912922 377 dbSNP
rs867350556 385 dbSNP
rs751179243 397 dbSNP
rs1232812347 401 dbSNP
rs1201936185 403 dbSNP
rs1480964900 406 dbSNP
rs986539137 411 dbSNP
rs114114406 412 dbSNP
rs1260753113 414 dbSNP
rs112751008 417 dbSNP
rs1030551680 420 dbSNP
rs958398638 421 dbSNP
rs1348033315 424 dbSNP
rs569340798 425 dbSNP
rs16824579 429 dbSNP
rs1014620455 433 dbSNP
rs1006010419 436 dbSNP
rs902986284 438 dbSNP
rs1432750536 440 dbSNP
rs1221867029 444 dbSNP
rs1318995101 446 dbSNP
rs552143326 448 dbSNP
rs1178811959 458 dbSNP
rs1280086338 463 dbSNP
rs1428966857 465 dbSNP
rs1197749262 468 dbSNP
rs148057005 472 dbSNP
rs1020135541 474 dbSNP
rs1243217416 478 dbSNP
rs1444348150 483 dbSNP
rs1444778347 485 dbSNP
rs1264505030 502 dbSNP
rs1203885684 506 dbSNP
rs1011578393 515 dbSNP
rs565805177 519 dbSNP
rs893231413 522 dbSNP
rs1362465709 535 dbSNP
rs538322782 536 dbSNP
rs1428599559 548 dbSNP
rs1363086845 561 dbSNP
rs1012338958 565 dbSNP
rs931983659 573 dbSNP
rs1469343894 575 dbSNP
rs1405625279 576 dbSNP
rs571042018 578 dbSNP
rs1411990216 588 dbSNP
rs546162510 590 dbSNP
rs999346286 591 dbSNP
rs1417729665 593 dbSNP
rs1244393119 597 dbSNP
rs1407781509 607 dbSNP
rs1460550268 608 dbSNP
rs1178110456 609 dbSNP
rs1240869058 614 dbSNP
rs1206260933 619 dbSNP
rs1442159004 623 dbSNP
rs940968345 624 dbSNP
rs1272084458 634 dbSNP
rs1212680542 640 dbSNP
rs758178932 640 dbSNP
rs528079269 641 dbSNP
rs112490301 647 dbSNP
rs1041820493 652 dbSNP
rs1246818114 654 dbSNP
rs532350149 655 dbSNP
rs1382205581 667 dbSNP
rs947453422 668 dbSNP
rs115051549 670 dbSNP
rs1050418329 677 dbSNP
rs1461326377 678 dbSNP
rs930830898 679 dbSNP
rs527939171 680 dbSNP
rs1387637869 681 dbSNP
rs931991698 686 dbSNP
rs923514274 688 dbSNP
rs1443472973 693 dbSNP
rs549000397 694 dbSNP
rs530882737 697 dbSNP
rs1315935902 701 dbSNP
rs908012065 704 dbSNP
rs1232048700 712 dbSNP
rs773118150 715 dbSNP
rs565143452 718 dbSNP
rs1221749136 721 dbSNP
rs566739861 721 dbSNP
rs776340509 721 dbSNP
rs981741941 721 dbSNP
rs140365716 722 dbSNP
rs1023824233 723 dbSNP
rs1011896327 724 dbSNP
rs545259419 725 dbSNP
rs112262403 727 dbSNP
rs960389323 727 dbSNP
rs1029017068 731 dbSNP
rs1304639135 731 dbSNP
rs1451950017 733 dbSNP
rs1344827402 737 dbSNP
rs996246511 738 dbSNP
rs1421848901 746 dbSNP
rs1383932826 748 dbSNP
rs901815057 754 dbSNP
rs1183478456 755 dbSNP
rs189939691 758 dbSNP
rs565399794 759 dbSNP
rs999481818 760 dbSNP
rs1481294954 762 dbSNP
rs886684465 765 dbSNP
rs112951583 770 dbSNP
rs930779983 775 dbSNP
rs1263717703 779 dbSNP
rs916778451 781 dbSNP
rs774700212 782 dbSNP
rs1283819440 791 dbSNP
rs185572643 793 dbSNP
rs893194953 799 dbSNP
rs1050974628 802 dbSNP
rs1404834135 806 dbSNP
rs931996071 813 dbSNP
rs923314808 815 dbSNP
rs1453835307 816 dbSNP
rs1040357705 820 dbSNP
rs1315019177 823 dbSNP
rs561373469 825 dbSNP
rs1429676682 829 dbSNP
rs1198460045 830 dbSNP
rs1361548678 831 dbSNP
rs981139154 833 dbSNP
rs1289602443 835 dbSNP
rs908148576 836 dbSNP
rs967483113 839 dbSNP
rs1207004620 842 dbSNP
rs984953776 845 dbSNP
rs952337169 851 dbSNP
rs916318783 861 dbSNP
rs991011054 863 dbSNP
rs563000307 867 dbSNP
rs575558076 868 dbSNP
rs1425887192 875 dbSNP
rs999197373 876 dbSNP
rs1370693999 884 dbSNP
rs557115592 898 dbSNP
rs1454214646 899 dbSNP
rs538860768 903 dbSNP
rs966587937 904 dbSNP
rs577274884 907 dbSNP
rs1427347839 908 dbSNP
rs555366410 909 dbSNP
rs1022649724 911 dbSNP
rs1010719315 912 dbSNP
rs867936393 918 dbSNP
rs889654006 931 dbSNP
rs534759748 932 dbSNP
rs865869186 939 dbSNP
rs1186757156 942 dbSNP
rs770561675 943 dbSNP
rs1267970085 945 dbSNP
rs376673419 954 dbSNP
rs546515750 955 dbSNP
rs901945003 959 dbSNP
rs1482464817 961 dbSNP
rs567150147 963 dbSNP
rs548991760 964 dbSNP
rs536931193 966 dbSNP
rs940713946 969 dbSNP
rs1004880822 972 dbSNP
rs1382960666 974 dbSNP
rs769154872 988 dbSNP
rs749597300 990 dbSNP
rs1225345312 994 dbSNP
rs1398299460 998 dbSNP
rs886461312 1000 dbSNP
rs569983233 1004 dbSNP
rs756234129 1005 dbSNP
rs1049327993 1006 dbSNP
rs181415925 1024 dbSNP
rs1385980763 1036 dbSNP
rs995100259 1040 dbSNP
rs1422309811 1045 dbSNP
rs17408061 1052 dbSNP
rs1196754499 1053 dbSNP
rs777831403 1053 dbSNP
rs1482982382 1054 dbSNP
rs916773933 1055 dbSNP
rs991005539 1069 dbSNP
rs937053001 1076 dbSNP
rs1343837276 1077 dbSNP
rs939046918 1079 dbSNP
rs906943693 1085 dbSNP
rs927709006 1087 dbSNP
rs945715862 1099 dbSNP
rs190165748 1108 dbSNP
rs966388177 1116 dbSNP
rs1304842212 1119 dbSNP
rs771922445 1119 dbSNP
rs921732049 1121 dbSNP
rs747855936 1123 dbSNP
rs746360986 1126 dbSNP
rs1365775098 1128 dbSNP
rs966309821 1129 dbSNP
rs1373102806 1131 dbSNP
rs1019008800 1134 dbSNP
rs1250117550 1134 dbSNP
rs1490665010 1134 dbSNP
rs1172156056 1137 dbSNP
rs989844901 1143 dbSNP
rs372284597 1149 dbSNP
rs1027674816 1150 dbSNP
rs953993165 1155 dbSNP
rs143212903 1157 dbSNP
rs1434624666 1158 dbSNP
rs528631281 1158 dbSNP
rs1344812925 1163 dbSNP
rs1322914486 1164 dbSNP
rs544331479 1168 dbSNP
rs1248372592 1173 dbSNP
rs1195110749 1188 dbSNP
rs756230962 1204 dbSNP
rs997987239 1205 dbSNP
rs901912173 1207 dbSNP
rs561101883 1212 dbSNP
rs530610313 1223 dbSNP
rs1321739877 1228 dbSNP
rs1282817361 1233 dbSNP
rs1246620244 1234 dbSNP
rs1197450932 1235 dbSNP
rs1004827915 1236 dbSNP
rs1261877999 1238 dbSNP
rs886472759 1240 dbSNP
rs1003712691 1246 dbSNP
rs1326679646 1254 dbSNP
rs1049314123 1255 dbSNP
rs1223912579 1256 dbSNP
rs1344109745 1261 dbSNP
rs1273000363 1262 dbSNP
rs1289678080 1264 dbSNP
rs1045472878 1267 dbSNP
rs575497190 1268 dbSNP
rs1434559702 1270 dbSNP
rs186979323 1273 dbSNP
rs1391371855 1274 dbSNP
rs1470502440 1282 dbSNP
rs1397831876 1285 dbSNP
rs563644175 1288 dbSNP
rs1054054094 1293 dbSNP
rs777351336 1303 dbSNP
rs1476686070 1306 dbSNP
rs1373114906 1309 dbSNP
rs1187399646 1315 dbSNP
rs758197463 1317 dbSNP
rs746074703 1318 dbSNP
rs935700104 1319 dbSNP
rs1203984637 1328 dbSNP
rs939516239 1332 dbSNP
rs1276307114 1337 dbSNP
rs182365779 1338 dbSNP
rs977863666 1344 dbSNP
rs1176660875 1348 dbSNP
rs1467415574 1351 dbSNP
rs372516127 1352 dbSNP
rs577809651 1352 dbSNP
rs945023491 1359 dbSNP
rs914854742 1362 dbSNP
rs1180781684 1365 dbSNP
rs1419666379 1366 dbSNP
rs989171526 1368 dbSNP
rs1180597808 1371 dbSNP
rs954071886 1375 dbSNP
rs1262785087 1387 dbSNP
rs911726434 1393 dbSNP
rs1028259846 1399 dbSNP
rs976536308 1400 dbSNP
rs368101985 1403 dbSNP
rs965213632 1404 dbSNP
rs1168577505 1411 dbSNP
rs1447129525 1422 dbSNP
rs1347368729 1427 dbSNP
rs1386604294 1427 dbSNP
rs1018979663 1430 dbSNP
rs1004961980 1435 dbSNP
rs950780019 1441 dbSNP
rs1206374407 1442 dbSNP
rs1027622539 1445 dbSNP
rs141214434 1447 dbSNP
rs1028034594 1455 dbSNP
rs573714962 1463 dbSNP
rs1449877004 1466 dbSNP
rs1381344236 1474 dbSNP
rs79013483 1475 dbSNP
rs994859677 1481 dbSNP
rs1334226994 1487 dbSNP
rs895360941 1488 dbSNP
rs1378726588 1496 dbSNP
rs1282730431 1508 dbSNP
rs1055406589 1513 dbSNP
rs544965148 1521 dbSNP
rs555030682 1524 dbSNP
rs906674591 1526 dbSNP
rs1415864950 1528 dbSNP
rs1366844561 1529 dbSNP
rs1164904621 1542 dbSNP
rs1404330087 1551 dbSNP
rs189175907 1552 dbSNP
rs569917449 1553 dbSNP
rs1157835950 1554 dbSNP
rs1470372125 1556 dbSNP
rs1454067169 1557 dbSNP
rs551708764 1559 dbSNP
rs1042583139 1573 dbSNP
rs945087926 1580 dbSNP
rs1490828689 1591 dbSNP
rs1161553639 1592 dbSNP
rs184771586 1596 dbSNP
rs1442878577 1599 dbSNP
rs577501382 1601 dbSNP
rs891558083 1602 dbSNP
rs1054159334 1603 dbSNP
rs1188295701 1603 dbSNP
rs1351466799 1605 dbSNP
rs1444406157 1612 dbSNP
rs1288145621 1617 dbSNP
rs1259844522 1618 dbSNP
rs866103683 1619 dbSNP
rs757750020 1620 dbSNP
rs1294686767 1624 dbSNP
rs1354816582 1631 dbSNP
rs1347648655 1646 dbSNP
rs1160814927 1649 dbSNP
rs35945612 1656 dbSNP
rs1288813926 1658 dbSNP
rs1457461885 1659 dbSNP
rs1244486977 1660 dbSNP
rs1410900157 1661 dbSNP
rs76730149 1662 dbSNP
rs1284343228 1663 dbSNP
rs79530366 1664 dbSNP
rs1038919156 1671 dbSNP
rs932359549 1672 dbSNP
rs1218158047 1675 dbSNP
rs1245111289 1675 dbSNP
rs1330122256 1675 dbSNP
rs199883670 1675 dbSNP
rs35433329 1675 dbSNP
rs921167926 1675 dbSNP
rs944624394 1676 dbSNP
rs1449561073 1679 dbSNP
rs911705811 1680 dbSNP
rs575955175 1681 dbSNP
rs976672066 1682 dbSNP
rs1435278373 1683 dbSNP
rs965180695 1696 dbSNP
rs1318203622 1705 dbSNP
rs1470831273 1708 dbSNP
rs373195540 1711 dbSNP
rs1400416996 1712 dbSNP
rs1378030691 1729 dbSNP
rs1175250647 1742 dbSNP
rs1431394519 1751 dbSNP
rs1423105618 1756 dbSNP
rs929152130 1759 dbSNP
rs982587279 1766 dbSNP
rs973522786 1782 dbSNP
rs1207100333 1786 dbSNP
rs1423981998 1794 dbSNP
rs959351695 1795 dbSNP
rs1233109632 1796 dbSNP
rs1310960432 1797 dbSNP
rs950832616 1802 dbSNP
rs926623706 1807 dbSNP
rs1163922970 1811 dbSNP
rs1473781161 1815 dbSNP
rs768334550 1820 dbSNP
rs971403899 1825 dbSNP
rs1192687538 1851 dbSNP
rs1402588044 1861 dbSNP
rs1302084359 1865 dbSNP
rs1021091136 1869 dbSNP
rs1265850145 1876 dbSNP
rs1356224049 1878 dbSNP
rs1220719154 1880 dbSNP
rs1490345393 1882 dbSNP
rs879236696 1888 dbSNP
rs1389681186 1889 dbSNP
rs958241558 1899 dbSNP
rs1032716639 1909 dbSNP
rs1027755353 1917 dbSNP
rs1291140427 1917 dbSNP
rs1200251823 1921 dbSNP
rs1426222563 1927 dbSNP
rs757292020 1940 dbSNP
rs202165734 1950 dbSNP
rs565732772 1968 dbSNP
rs547594839 1977 dbSNP
rs900128401 1990 dbSNP
rs1269251075 1991 dbSNP
rs959428826 1999 dbSNP
rs1271893190 2005 dbSNP
rs1008786722 2006 dbSNP
rs890355883 2009 dbSNP
rs1033922156 2012 dbSNP
rs540541364 2013 dbSNP
rs1394062316 2014 dbSNP
rs1375306803 2023 dbSNP
rs561447089 2031 dbSNP
rs1042553435 2040 dbSNP
rs1369980975 2046 dbSNP
rs574694984 2055 dbSNP
rs1009758085 2058 dbSNP
rs926618740 2069 dbSNP
rs1187189345 2071 dbSNP
rs767549219 2071 dbSNP
rs1053569399 2072 dbSNP
rs932302118 2074 dbSNP
rs3210951 2091 dbSNP
rs1254478372 2093 dbSNP
rs1325401835 2102 dbSNP
rs1407178377 2104 dbSNP
rs549077670 2112 dbSNP
rs920969244 2113 dbSNP
rs1394486596 2116 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_ControlA_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control A ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acggucggagCGGGUCg 5'
                    |: ||| 
Target 5' -caguguggaGUGCAGu 3'
1 - 16
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_016287 | 3UTR | AACUCCGCCUCCCAGGUUCAAGCGAUUCUCCCACCUCAGCCUCCUGAGUUGGGUCCUACAGGCGCACACGACCACGCCCAGCUAAUUUUUUGUAUUUUUAGUAGAGUUGGGGUUUCACCAUGUUAGCCAGGAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_016287 | 3UTR | CUUGGCUCACUGCAAACUCCGCCUCCCAGGUUCAAGCGAUUCUCCCACCUCAGCCUCCUGAGUUGGGUCCUACAGGCGCACACGACCACGCCCAGCUAAUUUUUUGUAUUUUUAGUAGAGUUGGGGUUUCACCAUGUUAGCCAGGAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_016287 | 3UTR | CUCCGCCUCCCAGGUUCAAGCGAUUCUCCCACCUCAGCCUCCUGAGUUGGGUCCUACAGGCGCACACGACCACGCCCAGCUAAUUUUUUGUAUUUUUAGUAGAGUUGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_016287 | 3UTR | GCAAACUCCGCCUCCCAGGUUCAAGCGAUUCUCCCACCUCAGCCUCCUGAGUUGGGUCCUACAGGCGCACACGACCACGCCCAGCUAAUUUUUUGUAUUUUUAGUAGAGUUGGGGUUUCACCAUGUUAGCCAGGAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_016287 | 3UTR | CUCCGCCUCCCAGGUUCAAGCGAUUCUCCCACCUCAGCCUCCUGAGUUGGGUCCUACAGGCGCACACGACCACGCCCAGCUAAUUUUUUGUAUUUUUAGUAGAGUUGGGGUUUCACCAUGUUAGCCAGGAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_016287 | 3UTR | ACUCCGCCUCCCAGGUUCAAGCGAUUCUCCCACCUCAGCCUCCUGAGUUGGGUCCUACAGGCGCACACGACCACGCCCAGCUAAUUUUUUGUAUUUUUAGUAGAGUUGGGGUUUCACCAUGUUAGCCAGGAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset Chi_ControlA_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control A
Location of target site ENST00000312239.5 | 3UTR | CAGUGUGGAGUGCAGUGGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-4486 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT254654 NF2 neurofibromin 2 2 2
MIRT458684 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT470845 PLXND1 plexin D1 2 2
MIRT493011 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT497264 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT497675 SYNGR1 synaptogyrin 1 2 2
MIRT498219 TLN2 talin 2 2 2
MIRT498310 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT504048 TOMM5 translocase of outer mitochondrial membrane 5 2 2
MIRT519959 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT531521 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT533144 WNT10A Wnt family member 10A 2 2
MIRT533541 TPR translocated promoter region, nuclear basket protein 2 2
MIRT533681 TMEM86A transmembrane protein 86A 2 2
MIRT540321 PIGR polymeric immunoglobulin receptor 2 2
MIRT540719 GUF1 GUF1 homolog, GTPase 2 2
MIRT541566 ZNF43 zinc finger protein 43 2 4
MIRT541787 TBCCD1 TBCC domain containing 1 2 2
MIRT541925 ORC1 origin recognition complex subunit 1 2 4
MIRT542232 FUT9 fucosyltransferase 9 2 2
MIRT542285 POLR3K RNA polymerase III subunit K 2 2
MIRT542299 QTRTD1 queuine tRNA-ribosyltransferase accessory subunit 2 2 4
MIRT542368 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT542441 C3 complement C3 2 4
MIRT542475 APOC3 apolipoprotein C3 2 2
MIRT542535 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542640 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT542788 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT552104 PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 2 2
MIRT564913 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT568606 ACVR2A activin A receptor type 2A 2 2
MIRT607389 LANCL3 LanC like 3 2 2
MIRT607451 ZNF543 zinc finger protein 543 2 2
MIRT610058 MYBPC1 myosin binding protein C, slow type 2 2
MIRT610793 KLK2 kallikrein related peptidase 2 2 2
MIRT617176 GOSR2 golgi SNAP receptor complex member 2 2 2
MIRT620579 WBSCR27 methyltransferase like 27 2 4
MIRT622085 SRPX2 sushi repeat containing protein, X-linked 2 2 2
MIRT622542 PXMP4 peroxisomal membrane protein 4 2 2
MIRT630009 PDE6B phosphodiesterase 6B 2 2
MIRT631813 PTDSS2 phosphatidylserine synthase 2 2 2
MIRT632721 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT632757 MED28 mediator complex subunit 28 2 2
MIRT634821 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT635255 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT637082 SELPLG selectin P ligand 2 2
MIRT637357 ZNF460 zinc finger protein 460 2 2
MIRT637472 DEFB105B defensin beta 105B 2 4
MIRT637504 DEFB105A defensin beta 105A 2 4
MIRT639022 AAK1 AP2 associated kinase 1 2 2
MIRT641012 ANKFY1 ankyrin repeat and FYVE domain containing 1 2 2
MIRT642170 HEBP2 heme binding protein 2 2 2
MIRT648977 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT650515 UFM1 ubiquitin fold modifier 1 2 2
MIRT650949 INMT indolethylamine N-methyltransferase 2 2
MIRT658354 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT660736 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT662191 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT663045 SLC16A4 solute carrier family 16 member 4 2 2
MIRT664811 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT665161 SF3A1 splicing factor 3a subunit 1 2 4
MIRT665346 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT666493 SBNO1 strawberry notch homolog 1 2 2
MIRT666545 RNF115 ring finger protein 115 2 2
MIRT669351 BMP3 bone morphogenetic protein 3 2 2
MIRT669904 KIAA0754 KIAA0754 2 4
MIRT670323 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT670430 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT670672 KIAA1551 KIAA1551 2 2
MIRT670746 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670998 PTGIS prostaglandin I2 synthase 2 2
MIRT671290 RPL37A ribosomal protein L37a 2 2
MIRT671469 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT671833 STIL STIL, centriolar assembly protein 2 2
MIRT673006 TAF1 TATA-box binding protein associated factor 1 2 2
MIRT675881 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT678625 OLFML2A olfactomedin like 2A 2 2
MIRT678790 NUPL2 nucleoporin like 2 2 2
MIRT679560 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT681032 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682480 LIX1L limb and CNS expressed 1 like 2 2
MIRT682758 MDM2 MDM2 proto-oncogene 2 2
MIRT682810 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT682867 C9orf156 tRNA methyltransferase O 2 2
MIRT689233 RPS19 ribosomal protein S19 2 2
MIRT689305 C5AR2 complement component 5a receptor 2 2 2
MIRT689363 ZNF101 zinc finger protein 101 2 2
MIRT689629 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT689654 RBM23 RNA binding motif protein 23 2 2
MIRT690148 PPIL6 peptidylprolyl isomerase like 6 2 2
MIRT691407 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT691847 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT692234 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT694320 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT694365 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT696215 LYZ lysozyme 2 2
MIRT697230 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT700487 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT700612 PRKCA protein kinase C alpha 2 2
MIRT702456 KIAA1467 family with sequence similarity 234 member B 2 2
MIRT702990 HERPUD2 HERPUD family member 2 2 2
MIRT703998 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT704701 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT712481 FSTL3 follistatin like 3 2 2
MIRT712781 ZNF154 zinc finger protein 154 2 2
MIRT714369 HP1BP3 heterochromatin protein 1 binding protein 3 2 2
MIRT722570 C1orf95 stum, mechanosensory transduction mediator homolog 2 2
MIRT722839 C17orf102 chromosome 17 open reading frame 102 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4486 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4486 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive Low Gastric Cancer cell line (SGC-7901)
hsa-mir-4486 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4486 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

Error report submission