pre-miRNA Information
pre-miRNA hsa-mir-516b-1   
Genomic Coordinates chr19: 53736845 - 53736934
Synonyms MIRN516-4, MIRN516B-1, MIRN516B1, MIR516B1
Description Homo sapiens miR-516b-1 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-516b-2   
Genomic Coordinates chr19: 53725442 - 53725526
Synonyms MIRN516-3, MIRN516B-2, MIRN516B2, MIR516B2
Description Homo sapiens miR-516b-2 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-516b-3p
Sequence 56| UGCUUCCUUUCAGAGGGU |73
Evidence Experimental
Experiments Array-cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1413434631 1 dbSNP
rs746170707 2 dbSNP
rs1312744198 2 dbSNP
rs752101959 3 dbSNP
rs770077784 4 dbSNP
rs1193425541 6 dbSNP
rs953142850 7 dbSNP
rs1020245150 7 dbSNP
rs775845942 11 dbSNP
rs1402471980 11 dbSNP
rs760158839 15 dbSNP
rs78861479 16 dbSNP
rs765933705 16 dbSNP
Putative Targets

Gene Information
Gene Symbol MPPED1   
Synonyms 239AB, C22orf1, FAM1A
Description metallophosphoesterase domain containing 1
Transcript NM_001044370   
Expression
Putative miRNA Targets on MPPED1
3'UTR of MPPED1
(miRNA target sites are highlighted)
>MPPED1|NM_001044370|3'UTR
   1 CTGCTCCCCACTGCCCCTGCCCTGCCCGCCCGTGTCAGCTCCACAGGCCTGGCCCGGCCACTGTTCCTTCCATGCTGAGT
  81 TGCCTGGACGACCCATCTGGCTGCGGGGACTGGCCTAGCAGGCAGGTCAGGGCCTTGGAACGACTCTTTAGCCTTCTGTC
 161 ACCTGGAGTTGGGACCCTGCGCATCCCCATCAGGGGTTCTGTGCTCATTTACTTTTTCTGCGTGTACATCCTGCGTGTAC
 241 CTCGTTAAAGGACCTACTAAGCTCATGGCCCTGTCATGTTTGGGAAATGACTAAATCTTCATTCTTCTCCCTTGGACGCC
 321 CTCCTGGTTTGGGAAGCTGCTGCTCTTGAATGGGTTTTGGAAGTTACACAAAATCTCCCTCTAACCACGGGTCTGTGTGG
 401 CGGCATGCCCCTGGGTTGGGGTGGGTGGGAGGATTCGTGAGCTGCACACAGACAGTCCCTTTCTCTCCTCCCAAGTGAGG
 481 GAGGAGACAGGCCCAAGGCGGAGGCCCTCCGAGGGAGCATTTAGGGACATCTCAGGAATTCAGACCGCACCTGGCCAGGC
 561 CCACAGCTGTTTGCCTGGCATTGTTCCCCCCTTTTTCTTCCCATAGGCATTTTTGTTTACTTGAACAATGACCTGAGTGT
 641 CCTAGGCATTCACTCGGAGCCTGGATGATGGGGGCTGGTTCTACAGAATGAGCCACTGGCATTCGTGCCCAGGACCAGTG
 721 AGAGCGTTCCCAGTCATGGGGGGATGACCCTTGGTCCCACGGGGAACACACTGCTCTGTAGAATGCGGTAGCCTGGATGG
 801 AGGGTCTGCAGGCTTAGGCTGCAGCAGGCCTGCCATGGGTGTGAACCCATGTCCAGGCACGCACCGACACACATGCACGC
 881 ACGCACCCCTCTTAATTGAACCAAGTGGGTCCTGTGTTTCTCTTTTCTGCCCCGTAGTGAGGTTCTGTTCCTTGGTGCGG
 961 CTTCCCTTGCACCGTTAGGATTCTGTCTGGCATGCCTGCAGCCGAGGAAGCCCAGGACCAGCCGGCCCTGTGAATTGGAG
1041 GGTGGCACAGGGACCGAGCGGGCCCCAGGCTCCAGCAGCCCCACCTTGGACAGCTTCTTTTTCTTCTTTGAATTAGGACT
1121 GGAGGGGGTGGGGCCAGGGCGGTGGTGGGAACCGGTAGGGCCTAGATGAGGGGCAGGCAGTCAGGCAGAAATGGGCAAGT
1201 TCAGGGTCAGATTCTGTCGTTATTTAATATTTTGTTCATCATGGACTTTTTCTGCATTTATTTTGATTTTTAACGTTGCA
1281 TTAAAGTAGTATTATTTGTCCTGAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ugGGA-GAC-UUUCCUUCGu 5'
            ||| | |  :||||||| 
Target 5' tgCCTGCAGCCGAGGAAGCc 3'
993 - 1012 144.00 -11.80
2
miRNA  3' ugGGAGACUUUCCUUCGu 5'
            |||| |  |||:||| 
Target 5' gcCCTCCG--AGGGAGCa 3'
504 - 519 136.00 -20.20
3
miRNA  3' ugGGA-GACU--UUCCUUCGu 5'
            ||| |||:   :|||||| 
Target 5' gcCCTCCTGGTTTGGGAAGCt 3'
318 - 338 134.00 -20.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26548680 4 COSMIC
COSN20042963 21 COSMIC
COSN17722443 28 COSMIC
COSN60362 32 COSMIC
COSN4974647 33 COSMIC
COSN28862361 90 COSMIC
COSN30541829 157 COSMIC
COSN28869138 181 COSMIC
COSN31522548 333 COSMIC
COSN31779368 402 COSMIC
COSN30541811 459 COSMIC
COSN28653339 500 COSMIC
COSN30541824 532 COSMIC
COSN8019612 593 COSMIC
COSN31536655 644 COSMIC
COSN8904966 705 COSMIC
COSN8019613 787 COSMIC
COSN8011053 880 COSMIC
COSN17188991 1178 COSMIC
COSN29512979 1275 COSMIC
COSN1899829 1809 COSMIC
COSN27545463 1988 COSMIC
COSN25997005 1998 COSMIC
COSN5456188 2029 COSMIC
COSN8019614 2082 COSMIC
COSN6563074 2131 COSMIC
COSN25325879 2174 COSMIC
COSN1262625 2194 COSMIC
COSN1262626 2194 COSMIC
rs11555872 2013 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1305363644 2 dbSNP
rs778629615 4 dbSNP
rs749921207 5 dbSNP
rs1360098515 7 dbSNP
rs1354433177 9 dbSNP
rs1228035691 20 dbSNP
rs758409947 26 dbSNP
rs779876890 28 dbSNP
rs377334448 29 dbSNP
rs1159008699 30 dbSNP
rs780954997 32 dbSNP
rs748436302 33 dbSNP
rs773333908 37 dbSNP
rs1235309893 39 dbSNP
rs749353606 40 dbSNP
rs1404834802 41 dbSNP
rs771004758 42 dbSNP
rs1026452528 44 dbSNP
rs1381278327 45 dbSNP
rs1421866972 47 dbSNP
rs370928359 48 dbSNP
rs1360387079 49 dbSNP
rs1261995933 51 dbSNP
rs560536901 56 dbSNP
rs1016680959 57 dbSNP
rs768306360 62 dbSNP
rs1320276123 70 dbSNP
rs962348294 74 dbSNP
rs1276538488 80 dbSNP
rs1433160826 83 dbSNP
rs73887331 90 dbSNP
rs546363024 95 dbSNP
rs763252610 105 dbSNP
rs955337615 106 dbSNP
rs987010980 108 dbSNP
rs1466935992 114 dbSNP
rs1184340959 123 dbSNP
rs1018713038 126 dbSNP
rs1247195735 127 dbSNP
rs1474830103 129 dbSNP
rs1184257271 130 dbSNP
rs1362897361 138 dbSNP
rs1425072354 142 dbSNP
rs1208777165 143 dbSNP
rs1265525658 154 dbSNP
rs1459626809 154 dbSNP
rs766728882 158 dbSNP
rs945216503 160 dbSNP
rs959863404 167 dbSNP
rs1293896914 171 dbSNP
rs975055096 178 dbSNP
rs1043826338 181 dbSNP
rs147675588 182 dbSNP
rs937969574 188 dbSNP
rs182476297 192 dbSNP
rs1403925410 197 dbSNP
rs1385160132 199 dbSNP
rs1338542960 204 dbSNP
rs1470264986 213 dbSNP
rs1399208852 218 dbSNP
rs983255456 222 dbSNP
rs896700652 223 dbSNP
rs1013823350 225 dbSNP
rs548425610 231 dbSNP
rs1442237057 235 dbSNP
rs562051496 236 dbSNP
rs886604132 244 dbSNP
rs1006382403 245 dbSNP
rs1207033799 249 dbSNP
rs1308500009 254 dbSNP
rs1016606762 257 dbSNP
rs774762838 277 dbSNP
rs1219512407 278 dbSNP
rs949744339 281 dbSNP
rs1315843984 304 dbSNP
rs1453233202 310 dbSNP
rs898248770 311 dbSNP
rs1292868883 315 dbSNP
rs996894561 318 dbSNP
rs751153330 319 dbSNP
rs1163553167 322 dbSNP
rs1422378220 326 dbSNP
rs1028003172 327 dbSNP
rs1438586286 328 dbSNP
rs575101825 337 dbSNP
rs75435621 338 dbSNP
rs893168971 341 dbSNP
rs186606193 352 dbSNP
rs1220469431 360 dbSNP
rs1020917000 369 dbSNP
rs1213487151 370 dbSNP
rs1041659668 376 dbSNP
rs139699309 382 dbSNP
rs1008239555 388 dbSNP
rs979261131 389 dbSNP
rs538392547 390 dbSNP
rs1472051568 394 dbSNP
rs552342370 395 dbSNP
rs938121603 398 dbSNP
rs1402676516 399 dbSNP
rs991339824 402 dbSNP
rs192570746 403 dbSNP
rs1361633722 418 dbSNP
rs538043092 422 dbSNP
rs951963454 423 dbSNP
rs28738821 426 dbSNP
rs28406494 427 dbSNP
rs983525232 429 dbSNP
rs917905174 430 dbSNP
rs949452876 432 dbSNP
rs1216246178 435 dbSNP
rs149763845 437 dbSNP
rs886702221 438 dbSNP
rs756195406 439 dbSNP
rs942166546 443 dbSNP
rs375609684 447 dbSNP
rs1312565295 448 dbSNP
rs1221446409 451 dbSNP
rs1338925843 453 dbSNP
rs1283524688 454 dbSNP
rs1381309803 460 dbSNP
rs764423875 476 dbSNP
rs898212162 477 dbSNP
rs996596597 485 dbSNP
rs1349627299 489 dbSNP
rs1453898548 497 dbSNP
rs1405961571 499 dbSNP
rs75641854 500 dbSNP
rs184799697 501 dbSNP
rs551731688 502 dbSNP
rs1007905964 504 dbSNP
rs554242282 511 dbSNP
rs577258643 512 dbSNP
rs1443797642 521 dbSNP
rs1187748498 526 dbSNP
rs1201771987 533 dbSNP
rs891116394 545 dbSNP
rs1325339346 546 dbSNP
rs116273225 547 dbSNP
rs1032161453 548 dbSNP
rs1297331577 555 dbSNP
rs1382284001 556 dbSNP
rs145762729 557 dbSNP
rs1335232051 562 dbSNP
rs1471249345 570 dbSNP
rs1407240318 571 dbSNP
rs996420700 573 dbSNP
rs1460825288 574 dbSNP
rs1177366890 584 dbSNP
rs576519103 585 dbSNP
rs1374982591 586 dbSNP
rs1382685086 587 dbSNP
rs1241369099 590 dbSNP
rs566798855 591 dbSNP
rs1173097195 593 dbSNP
rs1400086753 601 dbSNP
rs562014473 608 dbSNP
rs1416402590 609 dbSNP
rs1337268643 627 dbSNP
rs1252695004 628 dbSNP
rs1004789880 630 dbSNP
rs1358033965 631 dbSNP
rs949382033 634 dbSNP
rs1455013407 636 dbSNP
rs528003816 653 dbSNP
rs117657981 656 dbSNP
rs1377557042 657 dbSNP
rs559935825 660 dbSNP
rs1233395779 662 dbSNP
rs1253759999 668 dbSNP
rs1424283179 669 dbSNP
rs942300971 673 dbSNP
rs1445364258 678 dbSNP
rs1034105976 679 dbSNP
rs1181080348 682 dbSNP
rs148944119 685 dbSNP
rs900651850 705 dbSNP
rs932180979 706 dbSNP
rs68064353 710 dbSNP
rs746539493 715 dbSNP
rs1289195793 719 dbSNP
rs768110021 722 dbSNP
rs1247508168 723 dbSNP
rs1240343752 725 dbSNP
rs1359607106 726 dbSNP
rs1007873319 727 dbSNP
rs1237533320 731 dbSNP
rs946322631 732 dbSNP
rs1330001062 738 dbSNP
rs1404761782 739 dbSNP
rs1363916098 742 dbSNP
rs1305247356 743 dbSNP
rs1407354125 744 dbSNP
rs1425371381 744 dbSNP
rs1157866941 745 dbSNP
rs568943891 748 dbSNP
rs1317708410 750 dbSNP
rs1440861764 754 dbSNP
rs977625968 757 dbSNP
rs1193506462 760 dbSNP
rs902208563 761 dbSNP
rs944035255 762 dbSNP
rs1224345075 764 dbSNP
rs1173429013 767 dbSNP
rs1000764149 771 dbSNP
rs1032710471 772 dbSNP
rs776300309 773 dbSNP
rs959225373 775 dbSNP
rs1280690914 776 dbSNP
rs1012504363 777 dbSNP
rs1025022230 787 dbSNP
rs970806790 788 dbSNP
rs931390976 789 dbSNP
rs1333132397 794 dbSNP
rs1400691108 798 dbSNP
rs1316351275 800 dbSNP
rs1402566672 805 dbSNP
rs983388717 811 dbSNP
rs1387019166 814 dbSNP
rs1440117011 818 dbSNP
rs1159897315 820 dbSNP
rs538006131 821 dbSNP
rs1426951000 823 dbSNP
rs907869207 824 dbSNP
rs577505920 827 dbSNP
rs963372059 827 dbSNP
rs1190366779 847 dbSNP
rs747807596 848 dbSNP
rs1269314460 851 dbSNP
rs973678934 861 dbSNP
rs548427979 862 dbSNP
rs907083266 866 dbSNP
rs1002541544 867 dbSNP
rs1268690814 876 dbSNP
rs568339995 879 dbSNP
rs528727216 880 dbSNP
rs1260421376 881 dbSNP
rs534122186 883 dbSNP
rs761897311 884 dbSNP
rs1403575597 887 dbSNP
rs943754910 895 dbSNP
rs538023100 897 dbSNP
rs1418328462 900 dbSNP
rs902176129 902 dbSNP
rs1476068944 905 dbSNP
rs1199671412 910 dbSNP
rs1248119252 917 dbSNP
rs1372514711 923 dbSNP
rs1183463825 929 dbSNP
rs1022236641 934 dbSNP
rs570708820 935 dbSNP
rs1307343234 938 dbSNP
rs1053672577 942 dbSNP
rs1271143281 948 dbSNP
rs977679701 952 dbSNP
rs1173040517 955 dbSNP
rs1314490802 959 dbSNP
rs895059505 960 dbSNP
rs965562987 961 dbSNP
rs1012060085 965 dbSNP
rs975403003 967 dbSNP
rs1326376711 974 dbSNP
rs190299863 975 dbSNP
rs1460708752 981 dbSNP
rs931412296 983 dbSNP
rs970565303 986 dbSNP
rs1387615182 990 dbSNP
rs60323442 996 dbSNP
rs1015002574 1003 dbSNP
rs556498263 1004 dbSNP
rs963341299 1005 dbSNP
rs1483525135 1008 dbSNP
rs1317037656 1012 dbSNP
rs1243851244 1016 dbSNP
rs1036156337 1020 dbSNP
rs576501347 1024 dbSNP
rs768143225 1025 dbSNP
rs1055894924 1030 dbSNP
rs1411471937 1033 dbSNP
rs145496908 1037 dbSNP
rs1302211363 1046 dbSNP
rs987768327 1049 dbSNP
rs1244503938 1053 dbSNP
rs1021369034 1056 dbSNP
rs1166036158 1057 dbSNP
rs146484904 1060 dbSNP
rs189233977 1061 dbSNP
rs1042150381 1069 dbSNP
rs1262601622 1070 dbSNP
rs923692049 1071 dbSNP
rs975672745 1077 dbSNP
rs936284564 1078 dbSNP
rs1490843422 1085 dbSNP
rs1487329691 1087 dbSNP
rs753517732 1088 dbSNP
rs1221582602 1095 dbSNP
rs1316236896 1095 dbSNP
rs1028781160 1102 dbSNP
rs1229988690 1106 dbSNP
rs1350952632 1118 dbSNP
rs117277544 1126 dbSNP
rs1293641912 1129 dbSNP
rs370979524 1129 dbSNP
rs908629033 1130 dbSNP
rs1343930655 1132 dbSNP
rs947955138 1141 dbSNP
rs940062003 1142 dbSNP
rs1046334813 1154 dbSNP
rs541374039 1155 dbSNP
rs1185980825 1157 dbSNP
rs971901783 1161 dbSNP
rs1474795275 1165 dbSNP
rs1004706997 1172 dbSNP
rs368459743 1184 dbSNP
rs1329531241 1196 dbSNP
rs899273636 1197 dbSNP
rs1369923318 1205 dbSNP
rs141150893 1206 dbSNP
rs1055715451 1215 dbSNP
rs1301607315 1219 dbSNP
rs894168770 1220 dbSNP
rs1401287146 1227 dbSNP
rs144899355 1234 dbSNP
rs1247243195 1242 dbSNP
rs1436491227 1243 dbSNP
rs760859026 1245 dbSNP
rs1489318596 1252 dbSNP
rs545624849 1266 dbSNP
rs1467944601 1274 dbSNP
rs1354426437 1275 dbSNP
rs1043077308 1276 dbSNP
rs545800167 1279 dbSNP
rs1263964019 1289 dbSNP
rs1190381250 1308 dbSNP
rs998532737 1316 dbSNP
rs764227648 1317 dbSNP
rs1242502968 1323 dbSNP
rs1201517891 1326 dbSNP
rs1246214265 1327 dbSNP
rs1285898044 1331 dbSNP
rs1346936247 1332 dbSNP
rs754045766 1333 dbSNP
rs1218883253 1340 dbSNP
rs1226252075 1351 dbSNP
rs1305204807 1352 dbSNP
rs967503340 1353 dbSNP
rs977587231 1362 dbSNP
rs1483056488 1370 dbSNP
rs796155544 1373 dbSNP
rs759474221 1376 dbSNP
rs1335387210 1381 dbSNP
rs35881890 1383 dbSNP
rs936433141 1389 dbSNP
rs1177997258 1390 dbSNP
rs989274725 1397 dbSNP
rs764995383 1398 dbSNP
rs531462133 1405 dbSNP
rs757882719 1417 dbSNP
rs1421064356 1424 dbSNP
rs916215808 1429 dbSNP
rs947786460 1436 dbSNP
rs1384467537 1440 dbSNP
rs1185331214 1446 dbSNP
rs1046290875 1448 dbSNP
rs548395398 1449 dbSNP
rs1256660165 1452 dbSNP
rs1194847479 1458 dbSNP
rs1479432679 1467 dbSNP
rs906468076 1473 dbSNP
rs1464256366 1476 dbSNP
rs1304187205 1477 dbSNP
rs572833810 1480 dbSNP
rs940504820 1482 dbSNP
rs1313550059 1483 dbSNP
rs1247699055 1484 dbSNP
rs1341424016 1490 dbSNP
rs1396958976 1492 dbSNP
rs865894733 1496 dbSNP
rs750224202 1498 dbSNP
rs1015573185 1511 dbSNP
rs148265901 1513 dbSNP
rs1036166697 1518 dbSNP
rs1372585556 1524 dbSNP
rs899031197 1526 dbSNP
rs995311523 1527 dbSNP
rs568308399 1539 dbSNP
rs193188933 1540 dbSNP
rs991699402 1543 dbSNP
rs1180766615 1559 dbSNP
rs1310109155 1573 dbSNP
rs889106031 1581 dbSNP
rs1311640716 1589 dbSNP
rs1208332486 1592 dbSNP
rs915834326 1593 dbSNP
rs1205513095 1595 dbSNP
rs1490039872 1596 dbSNP
rs547332661 1605 dbSNP
rs1212119016 1610 dbSNP
rs141152721 1614 dbSNP
rs1260674053 1618 dbSNP
rs902844323 1620 dbSNP
rs758135987 1623 dbSNP
rs1236065155 1625 dbSNP
rs934450024 1627 dbSNP
rs1404623881 1628 dbSNP
rs1343689100 1632 dbSNP
rs1325566504 1635 dbSNP
rs539421105 1642 dbSNP
rs900896631 1643 dbSNP
rs372405422 1646 dbSNP
rs150287037 1662 dbSNP
rs185143202 1663 dbSNP
rs1413983032 1692 dbSNP
rs957586652 1694 dbSNP
rs1179131611 1703 dbSNP
rs535597243 1706 dbSNP
rs1028884202 1711 dbSNP
rs1200310152 1713 dbSNP
rs1451687553 1714 dbSNP
rs1284098412 1717 dbSNP
rs1423901638 1725 dbSNP
rs989633233 1726 dbSNP
rs916367833 1727 dbSNP
rs1331642668 1728 dbSNP
rs1269209263 1758 dbSNP
rs969426956 1759 dbSNP
rs981745725 1761 dbSNP
rs1177860910 1764 dbSNP
rs779992235 1769 dbSNP
rs961367706 1770 dbSNP
rs1331113424 1774 dbSNP
rs1398494011 1783 dbSNP
rs1390525684 1784 dbSNP
rs555541087 1785 dbSNP
rs1159573132 1786 dbSNP
rs1003664852 1788 dbSNP
rs940598395 1800 dbSNP
rs751461457 1807 dbSNP
rs959684455 1809 dbSNP
rs751257643 1811 dbSNP
rs572261580 1812 dbSNP
rs915700727 1819 dbSNP
rs756812858 1830 dbSNP
rs978631279 1831 dbSNP
rs924313485 1832 dbSNP
rs934334486 1833 dbSNP
rs754525748 1834 dbSNP
rs541623878 1837 dbSNP
rs1050905777 1840 dbSNP
rs1218189325 1843 dbSNP
rs889206846 1844 dbSNP
rs1268532028 1847 dbSNP
rs1009288037 1850 dbSNP
rs1230742259 1855 dbSNP
rs1040413803 1856 dbSNP
rs903216301 1859 dbSNP
rs574029044 1860 dbSNP
rs1335762104 1864 dbSNP
rs1414727296 1874 dbSNP
rs1418393070 1879 dbSNP
rs1166122823 1881 dbSNP
rs558134656 1890 dbSNP
rs1033302730 1894 dbSNP
rs957765550 1896 dbSNP
rs1391255928 1897 dbSNP
rs1487256821 1905 dbSNP
rs1192433822 1907 dbSNP
rs1211047787 1917 dbSNP
rs190041480 1920 dbSNP
rs1023767031 1921 dbSNP
rs1298233936 1922 dbSNP
rs1168046971 1925 dbSNP
rs1376667576 1927 dbSNP
rs897378542 1929 dbSNP
rs969178236 1935 dbSNP
rs1467490554 1936 dbSNP
rs1305806676 1939 dbSNP
rs545459879 1940 dbSNP
rs981855193 1949 dbSNP
rs1431101923 1952 dbSNP
rs34178784 1955 dbSNP
rs780732162 1957 dbSNP
rs1163481486 1960 dbSNP
rs961724828 1966 dbSNP
rs971944980 1975 dbSNP
rs562539760 1978 dbSNP
rs920530052 1983 dbSNP
rs1434860487 1985 dbSNP
rs1469958166 1993 dbSNP
rs959497633 1997 dbSNP
rs531431119 1998 dbSNP
rs769484665 2004 dbSNP
rs1012733918 2005 dbSNP
rs1368338860 2006 dbSNP
rs1319808052 2012 dbSNP
rs11555872 2013 dbSNP
rs181044351 2014 dbSNP
rs1349716805 2016 dbSNP
rs1286058332 2017 dbSNP
rs1411331289 2021 dbSNP
rs1350536137 2027 dbSNP
rs944762595 2029 dbSNP
rs527446740 2040 dbSNP
rs1455953859 2043 dbSNP
rs978531140 2056 dbSNP
rs1352063878 2071 dbSNP
rs1166114723 2074 dbSNP
rs746248145 2076 dbSNP
rs924533854 2077 dbSNP
rs1319797546 2078 dbSNP
rs1161613175 2086 dbSNP
rs772515974 2086 dbSNP
rs1288798592 2087 dbSNP
rs1268478944 2088 dbSNP
rs1189496334 2102 dbSNP
rs1489510123 2103 dbSNP
rs955933171 2110 dbSNP
rs1328202003 2115 dbSNP
rs1266055354 2116 dbSNP
rs746171703 2119 dbSNP
rs903183713 2121 dbSNP
rs776170410 2125 dbSNP
rs1384496955 2126 dbSNP
rs547588745 2128 dbSNP
rs893391338 2131 dbSNP
rs185122977 2132 dbSNP
rs1161773328 2134 dbSNP
rs879398311 2135 dbSNP
rs1428781735 2143 dbSNP
rs971996305 2145 dbSNP
rs188007280 2154 dbSNP
rs1426024203 2155 dbSNP
rs1003243176 2171 dbSNP
rs149764547 2172 dbSNP
rs1464356766 2174 dbSNP
rs549895287 2174 dbSNP
rs62232046 2175 dbSNP
rs1037166386 2176 dbSNP
rs1227066392 2176 dbSNP
rs1246138548 2176 dbSNP
rs1273500001 2176 dbSNP
rs531608043 2176 dbSNP
rs575838430 2176 dbSNP
rs59503737 2176 dbSNP
rs71941708 2176 dbSNP
rs75184258 2178 dbSNP
rs76188214 2179 dbSNP
rs1363574548 2180 dbSNP
rs897432297 2187 dbSNP
rs1034765542 2190 dbSNP
rs1479047377 2192 dbSNP
rs77415102 2192 dbSNP
rs1003769445 2193 dbSNP
rs1168860465 2193 dbSNP
rs75782702 2194 dbSNP
rs1404123251 2195 dbSNP
rs1167485586 2196 dbSNP
rs1366321938 2197 dbSNP
rs1167986490 2199 dbSNP
rs1447744693 2200 dbSNP
rs961653598 2210 dbSNP
rs535463353 2211 dbSNP
rs971705926 2213 dbSNP
rs1190505811 2219 dbSNP
rs1449830612 2224 dbSNP
rs1255270375 2229 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124B_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ugggagacuuuCCUUCGu 5'
                     |||||| 
Target 5' -----------GGAAGCc 3'
1 - 7
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_124B_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + B
Location of target site ENST00000417669.2 | 3UTR | GGAAGCCCAGGACCAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE32688 Pancreatic cancer 0.456 4.4e-3 0.158 1.9e-1 32 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.323 5.8e-2 0.243 1.2e-1 25 Click to see details
GSE17306 Multiple myeloma -0.145 1.6e-1 0.255 3.9e-2 49 Click to see details
GSE27834 Pluripotent stem cells -0.085 3.8e-1 -0.141 3.0e-1 16 Click to see details
GSE21849 B cell lymphoma -0.018 4.6e-1 0.195 1.6e-1 29 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
85 hsa-miR-516b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT077049 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT155261 IFNAR2 interferon alpha and beta receptor subunit 2 2 4
MIRT446119 ASTN1 astrotactin 1 2 2
MIRT447355 STOM stomatin 2 2
MIRT469329 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT470201 PSAT1 phosphoserine aminotransferase 1 2 6
MIRT475944 GXYLT1 glucoside xylosyltransferase 1 2 4
MIRT498268 KIAA1644 KIAA1644 2 2
MIRT501725 OVOL1 ovo like transcriptional repressor 1 2 2
MIRT522860 KIAA1551 KIAA1551 2 2
MIRT527900 B3GALT5 beta-1,3-galactosyltransferase 5 2 4
MIRT528557 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT531250 PDF peptide deformylase, mitochondrial 2 2
MIRT534410 SENP1 SUMO1/sentrin specific peptidase 1 2 2
MIRT544656 MED19 mediator complex subunit 19 2 2
MIRT550681 YARS tyrosyl-tRNA synthetase 2 2
MIRT557208 HNRNPF heterogeneous nuclear ribonucleoprotein F 2 4
MIRT611532 DDB1 damage specific DNA binding protein 1 2 2
MIRT612087 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT616535 PARD6B par-6 family cell polarity regulator beta 2 4
MIRT616738 DCTN5 dynactin subunit 5 2 2
MIRT616754 SVOP SV2 related protein 2 4
MIRT617380 FAM227A family with sequence similarity 227 member A 2 2
MIRT617624 RAB3IP RAB3A interacting protein 2 2
MIRT620778 MT1A metallothionein 1A 2 2
MIRT623172 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT626034 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT627376 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT630533 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT631686 NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 2 2
MIRT633896 FGF10 fibroblast growth factor 10 2 2
MIRT635933 PLA2G12A phospholipase A2 group XIIA 2 2
MIRT636275 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT636285 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT636502 GDAP1L1 ganglioside induced differentiation associated protein 1 like 1 2 2
MIRT638037 SHPK sedoheptulokinase 2 2
MIRT639162 LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 2 2
MIRT639571 GORASP1 golgi reassembly stacking protein 1 2 2
MIRT641248 CENPN centromere protein N 2 2
MIRT643650 MYOCD myocardin 2 2
MIRT645490 TRIM63 tripartite motif containing 63 2 2
MIRT648016 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT648102 LRRFIP1 LRR binding FLII interacting protein 1 2 2
MIRT648729 HIST1H2BD histone cluster 1 H2B family member d 2 2
MIRT650177 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT652787 TCEANC2 transcription elongation factor A N-terminal and central domain containing 2 2 2
MIRT653248 SORD sorbitol dehydrogenase 2 2
MIRT654859 PPM1F protein phosphatase, Mg2+/Mn2+ dependent 1F 2 2
MIRT655533 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT656390 MCU mitochondrial calcium uniporter 2 2
MIRT656881 KIF1C kinesin family member 1C 2 2
MIRT657083 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT657629 GPX8 glutathione peroxidase 8 (putative) 2 2
MIRT658295 FAM83F family with sequence similarity 83 member F 2 2
MIRT659432 COL1A1 collagen type I alpha 1 chain 2 2
MIRT659791 CBLB Cbl proto-oncogene B 2 2
MIRT660153 BRCC3 BRCA1/BRCA2-containing complex subunit 3 2 2
MIRT660490 ARRDC3 arrestin domain containing 3 2 2
MIRT660503 ARPC2 actin related protein 2/3 complex subunit 2 2 2
MIRT666356 SIKE1 suppressor of IKBKE 1 2 2
MIRT677774 FKTN fukutin 2 2
MIRT688556 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT697415 ZFP91 ZFP91 zinc finger protein 2 2
MIRT709468 KRTAP19-1 keratin associated protein 19-1 2 2
MIRT711154 WDR82P1 WD repeat domain 82 pseudogene 1 2 2
MIRT711467 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT712515 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT712661 PCTP phosphatidylcholine transfer protein 2 2
MIRT713304 TYRP1 tyrosinase related protein 1 2 2
MIRT714597 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT716603 MPPED1 metallophosphoesterase domain containing 1 2 2
MIRT717537 PYGO2 pygopus family PHD finger 2 2 2
MIRT718058 CYP3A5 cytochrome P450 family 3 subfamily A member 5 2 2
MIRT718539 PIGQ phosphatidylinositol glycan anchor biosynthesis class Q 2 2
MIRT719768 ZNF236 zinc finger protein 236 2 2
MIRT720162 PNPO pyridoxamine 5'-phosphate oxidase 2 2
MIRT720360 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT721182 HOPX HOP homeobox 2 2
MIRT721278 RAD54L2 RAD54 like 2 2 2
MIRT721357 ENTHD1 ENTH domain containing 1 2 2
MIRT721504 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT721918 LINGO2 leucine rich repeat and Ig domain containing 2 2 2
MIRT722278 LURAP1 leucine rich adaptor protein 1 2 2
MIRT722789 FUT4 fucosyltransferase 4 2 2
MIRT724390 ABAT 4-aminobutyrate aminotransferase 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-516b Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-516b Bromocriptine approved 31101 Microarray Prolactinoma 22366961 2012 up-regulated
miR-516b Bromocriptine approved 31101 Quantitative real-time PCR Prolactinoma 22366961 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-516b-3p Paclitaxel 36314 NSC125973 approved sensitive High Pan-Cancer cell line (NCI-H460, NCI-H522, NCI-H322M, HOP62, A549, EKVX, MALME-3M, NCI-H226, HT-29, HCT-116, SE-620, HCT-15, HCC2998, COLO205, HS-578T, NCI/ADR-RES, OVCAR8, OVCAR4, ACHN, SN-12C, 786-O, CAKI-1, UO-31, TK-10, A498, SK-MEL-28, UACC-257, M14, UACC-62, SK
hsa-miR-516b-3p Ribavirin+Pegylated IFNa-2b sensitive tissue (chronic hepatitis C)
hsa-miR-516b-3p Testosterone+Exemestane sensitive cell line (MCF-7)
hsa-miR-516b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-516b-3p Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)

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