pre-miRNA Information | |
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pre-miRNA | hsa-mir-378g |
Genomic Coordinates | chr1: 94745860 - 94745900 |
Description | Homo sapiens miR-378g stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
Mature miRNA Information | |
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Mature miRNA | hsa-miR-378g |
Sequence | 2| ACUGGGCUUGGAGUCAGAAG |21 |
Evidence | Experimental |
Experiments | Illumina |
Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | MPPED1 | ||||||||||||||||||||
Synonyms | 239AB, C22orf1, FAM1A | ||||||||||||||||||||
Description | metallophosphoesterase domain containing 1 | ||||||||||||||||||||
Transcript | NM_001044370 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on MPPED1 | |||||||||||||||||||||
3'UTR of MPPED1 (miRNA target sites are highlighted) |
>MPPED1|NM_001044370|3'UTR 1 CTGCTCCCCACTGCCCCTGCCCTGCCCGCCCGTGTCAGCTCCACAGGCCTGGCCCGGCCACTGTTCCTTCCATGCTGAGT 81 TGCCTGGACGACCCATCTGGCTGCGGGGACTGGCCTAGCAGGCAGGTCAGGGCCTTGGAACGACTCTTTAGCCTTCTGTC 161 ACCTGGAGTTGGGACCCTGCGCATCCCCATCAGGGGTTCTGTGCTCATTTACTTTTTCTGCGTGTACATCCTGCGTGTAC 241 CTCGTTAAAGGACCTACTAAGCTCATGGCCCTGTCATGTTTGGGAAATGACTAAATCTTCATTCTTCTCCCTTGGACGCC 321 CTCCTGGTTTGGGAAGCTGCTGCTCTTGAATGGGTTTTGGAAGTTACACAAAATCTCCCTCTAACCACGGGTCTGTGTGG 401 CGGCATGCCCCTGGGTTGGGGTGGGTGGGAGGATTCGTGAGCTGCACACAGACAGTCCCTTTCTCTCCTCCCAAGTGAGG 481 GAGGAGACAGGCCCAAGGCGGAGGCCCTCCGAGGGAGCATTTAGGGACATCTCAGGAATTCAGACCGCACCTGGCCAGGC 561 CCACAGCTGTTTGCCTGGCATTGTTCCCCCCTTTTTCTTCCCATAGGCATTTTTGTTTACTTGAACAATGACCTGAGTGT 641 CCTAGGCATTCACTCGGAGCCTGGATGATGGGGGCTGGTTCTACAGAATGAGCCACTGGCATTCGTGCCCAGGACCAGTG 721 AGAGCGTTCCCAGTCATGGGGGGATGACCCTTGGTCCCACGGGGAACACACTGCTCTGTAGAATGCGGTAGCCTGGATGG 801 AGGGTCTGCAGGCTTAGGCTGCAGCAGGCCTGCCATGGGTGTGAACCCATGTCCAGGCACGCACCGACACACATGCACGC 881 ACGCACCCCTCTTAATTGAACCAAGTGGGTCCTGTGTTTCTCTTTTCTGCCCCGTAGTGAGGTTCTGTTCCTTGGTGCGG 961 CTTCCCTTGCACCGTTAGGATTCTGTCTGGCATGCCTGCAGCCGAGGAAGCCCAGGACCAGCCGGCCCTGTGAATTGGAG 1041 GGTGGCACAGGGACCGAGCGGGCCCCAGGCTCCAGCAGCCCCACCTTGGACAGCTTCTTTTTCTTCTTTGAATTAGGACT 1121 GGAGGGGGTGGGGCCAGGGCGGTGGTGGGAACCGGTAGGGCCTAGATGAGGGGCAGGCAGTCAGGCAGAAATGGGCAAGT 1201 TCAGGGTCAGATTCTGTCGTTATTTAATATTTTGTTCATCATGGACTTTTTCTGCATTTATTTTGATTTTTAACGTTGCA 1281 TTAAAGTAGTATTATTTGTCCTGAAAAAAAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HeLa | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in Chi_124B_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + B
... - Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Chi SW; Zang JB; Mele A; Darnell RB - Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
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CLIP-seq Support 1 for dataset Chi_124B_2A8_130_50 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | HeLa / HeLa cell miR-124 + B |
Location of target site | ENST00000417669.2 | 3UTR | GGAAGCCCAGGACCAGC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 19536157 / Chi_HITSCLIP |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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68 hsa-miR-378g Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT444739 | SMYD1 | SET and MYND domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT456104 | VAV3 | vav guanine nucleotide exchange factor 3 | ![]() |
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2 | 4 | ||||||
MIRT458683 | MRI1 | methylthioribose-1-phosphate isomerase 1 | ![]() |
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2 | 2 | ||||||
MIRT465802 | TMEM91 | transmembrane protein 91 | ![]() |
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2 | 2 | ||||||
MIRT470843 | PLXND1 | plexin D1 | ![]() |
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2 | 2 | ||||||
MIRT497263 | GRK6 | G protein-coupled receptor kinase 6 | ![]() |
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2 | 2 | ||||||
MIRT497674 | SYNGR1 | synaptogyrin 1 | ![]() |
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2 | 2 | ||||||
MIRT498218 | TLN2 | talin 2 | ![]() |
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2 | 2 | ||||||
MIRT498309 | BCL11B | B-cell CLL/lymphoma 11B | ![]() |
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2 | 2 | ||||||
MIRT504046 | TOMM5 | translocase of outer mitochondrial membrane 5 | ![]() |
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2 | 2 | ||||||
MIRT518196 | CLEC4E | C-type lectin domain family 4 member E | ![]() |
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2 | 2 | ||||||
MIRT533143 | WNT10A | Wnt family member 10A | ![]() |
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2 | 2 | ||||||
MIRT533540 | TPR | translocated promoter region, nuclear basket protein | ![]() |
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2 | 2 | ||||||
MIRT533679 | TMEM86A | transmembrane protein 86A | ![]() |
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2 | 2 | ||||||
MIRT540892 | SRSF9 | serine and arginine rich splicing factor 9 | ![]() |
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2 | 2 | ||||||
MIRT541329 | G3BP1 | G3BP stress granule assembly factor 1 | ![]() |
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2 | 2 | ||||||
MIRT541850 | PLIN5 | perilipin 5 | ![]() |
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2 | 2 | ||||||
MIRT551431 | F2 | coagulation factor II, thrombin | ![]() |
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2 | 2 | ||||||
MIRT552105 | PPP1R1A | protein phosphatase 1 regulatory inhibitor subunit 1A | ![]() |
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2 | 2 | ||||||
MIRT564912 | YTHDF1 | YTH N6-methyladenosine RNA binding protein 1 | ![]() |
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2 | 2 | ||||||
MIRT568605 | ACVR2A | activin A receptor type 2A | ![]() |
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2 | 2 | ||||||
MIRT572604 | PAPLN | papilin, proteoglycan like sulfated glycoprotein | ![]() |
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2 | 2 | ||||||
MIRT574234 | DMRT2 | doublesex and mab-3 related transcription factor 2 | ![]() |
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2 | 2 | ||||||
MIRT575688 | Map1b | microtubule-associated protein 1B | ![]() |
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2 | 2 | ||||||
MIRT576643 | Mill2 | MHC I like leukocyte 2 | ![]() |
1 | 1 | |||||||
MIRT609877 | RAD54L2 | RAD54 like 2 | ![]() |
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2 | 4 | ||||||
MIRT610057 | MYBPC1 | myosin binding protein C, slow type | ![]() |
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2 | 2 | ||||||
MIRT610791 | KLK2 | kallikrein related peptidase 2 | ![]() |
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2 | 2 | ||||||
MIRT617175 | GOSR2 | golgi SNAP receptor complex member 2 | ![]() |
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2 | 2 | ||||||
MIRT617707 | RUSC2 | RUN and SH3 domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT620577 | WBSCR27 | methyltransferase like 27 | ![]() |
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2 | 4 | ||||||
MIRT622657 | POU2F3 | POU class 2 homeobox 3 | ![]() |
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2 | 4 | ||||||
MIRT624561 | BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | ![]() |
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2 | 2 | ||||||
MIRT634255 | TIAL1 | TIA1 cytotoxic granule associated RNA binding protein like 1 | ![]() |
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2 | 2 | ||||||
MIRT634677 | GDE1 | glycerophosphodiester phosphodiesterase 1 | ![]() |
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2 | 2 | ||||||
MIRT635254 | FBXL20 | F-box and leucine rich repeat protein 20 | ![]() |
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2 | 2 | ||||||
MIRT637081 | SELPLG | selectin P ligand | ![]() |
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2 | 2 | ||||||
MIRT639021 | AAK1 | AP2 associated kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT640396 | ZNF785 | zinc finger protein 785 | ![]() |
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2 | 2 | ||||||
MIRT642441 | CLUAP1 | clusterin associated protein 1 | ![]() |
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2 | 2 | ||||||
MIRT645666 | ADK | adenosine kinase | ![]() |
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2 | 2 | ||||||
MIRT646083 | MGST3 | microsomal glutathione S-transferase 3 | ![]() |
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2 | 2 | ||||||
MIRT650513 | UFM1 | ubiquitin fold modifier 1 | ![]() |
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2 | 2 | ||||||
MIRT652474 | TMEM181 | transmembrane protein 181 | ![]() |
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2 | 2 | ||||||
MIRT652584 | TIMM8A | translocase of inner mitochondrial membrane 8A | ![]() |
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2 | 2 | ||||||
MIRT654763 | PRKAR2A | protein kinase cAMP-dependent type II regulatory subunit alpha | ![]() |
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2 | 2 | ||||||
MIRT655200 | PHAX | phosphorylated adaptor for RNA export | ![]() |
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2 | 2 | ||||||
MIRT658353 | FAM65B | RHO family interacting cell polarization regulator 2 | ![]() |
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2 | 2 | ||||||
MIRT661820 | PRPSAP1 | phosphoribosyl pyrophosphate synthetase associated protein 1 | ![]() |
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2 | 2 | ||||||
MIRT662190 | MEI1 | meiotic double-stranded break formation protein 1 | ![]() |
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2 | 2 | ||||||
MIRT664375 | CYB5A | cytochrome b5 type A | ![]() |
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2 | 2 | ||||||
MIRT665025 | ELK1 | ELK1, ETS transcription factor | ![]() |
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2 | 2 | ||||||
MIRT666492 | SBNO1 | strawberry notch homolog 1 | ![]() |
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2 | 2 | ||||||
MIRT668480 | EXOSC2 | exosome component 2 | ![]() |
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2 | 2 | ||||||
MIRT682768 | TMEM120B | transmembrane protein 120B | ![]() |
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2 | 2 | ||||||
MIRT689628 | NAA30 | N(alpha)-acetyltransferase 30, NatC catalytic subunit | ![]() |
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2 | 2 | ||||||
MIRT691846 | OSCAR | osteoclast associated, immunoglobulin-like receptor | ![]() |
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2 | 2 | ||||||
MIRT696490 | COX6B1 | cytochrome c oxidase subunit 6B1 | ![]() |
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2 | 2 | ||||||
MIRT712480 | FSTL3 | follistatin like 3 | ![]() |
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2 | 2 | ||||||
MIRT712780 | ZNF154 | zinc finger protein 154 | ![]() |
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2 | 2 | ||||||
MIRT716607 | MPPED1 | metallophosphoesterase domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT719357 | ITPKB | inositol-trisphosphate 3-kinase B | ![]() |
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2 | 2 | ||||||
MIRT719739 | SLC39A11 | solute carrier family 39 member 11 | ![]() |
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2 | 2 | ||||||
MIRT722569 | C1orf95 | stum, mechanosensory transduction mediator homolog | ![]() |
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2 | 2 | ||||||
MIRT722838 | C17orf102 | chromosome 17 open reading frame 102 | ![]() |
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2 | 2 | ||||||
MIRT733138 | LINC00963 | long intergenic non-protein coding RNA 963 | ![]() |
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3 | 0 | |||||
MIRT733139 | CHI3L1 | chitinase 3 like 1 | ![]() |
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3 | 0 | |||||
MIRT736944 | TARBP2 | TARBP2, RISC loading complex RNA binding subunit | ![]() |
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2 | 0 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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