pre-miRNA Information | |
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pre-miRNA | hsa-mir-2115 |
Genomic Coordinates | chr3: 48316360 - 48316459 |
Description | Homo sapiens miR-2115 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | ||||||||||||||||||||||
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Mature miRNA | hsa-miR-2115-5p | |||||||||||||||||||||
Sequence | 21| AGCUUCCAUGACUCCUGAUGGA |42 | |||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||
Experiments | 454 | |||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | PYGO2 | ||||||||||||||||||||
Synonyms | 1190004M21Rik | ||||||||||||||||||||
Description | pygopus family PHD finger 2 | ||||||||||||||||||||
Transcript | NM_138300 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on PYGO2 | |||||||||||||||||||||
3'UTR of PYGO2 (miRNA target sites are highlighted) |
>PYGO2|NM_138300|3'UTR 1 CGCTGGTGAAGTGGCCCAGGGAAGTGCACATGTCTCTCCCTGCTCTTCCAGGGTGATTTTTTTGATGTTTGGCTCTTGGT 81 CCTTGTTTCCACTGGCTTTCCATCCCCATGGGGCAGAAACAGTGGCTCCTGGGAGCAGAAAAGGAATTGAGGTGGGCAGG 161 CAGAAGAGCCTGGATTGCTCACTGTTTTGGGAAACTTACATGTTGAGATCTACAGAGATCCAGGAAACCAAAGCCCTGCT 241 GAGCAGAGCCATTTTGTGGCTATTTCTGGAGGCCCAGGAGTGTGGCTGCAAGAGAAAAGGGGCTGGAGGAAGATCCGGAG 321 GGCAGGGGTGTTCCCTCTGCTGATGATGGATGCCCCTAACACCTGTGCCTAACACCCCTACTGAACCCCACAGCTCCAGC 401 CTTAGTTTTTGGAGTCAAGTGTTAAAGGTTTCTGGCCAGAGGAATTGGGGTCTTGCCATCCCTGCAATAGCCCTTTTATG 481 GGCTCTGGGAGACAGCTTTAGGGAATAAATGGGGATTTTCCCCTTTTTCTACCCACTCCTTTGCTTCCTCCAAGACTTAC 561 CCAACTCCTTCCCCCTCAGAGAACCAAATAGCCTGAGGAAGCAGGAGAGTTCCTGGTTATGGCAGTTTCTTGGTGATTTG 641 GGGCTTCAAGACAGTAGGTGAGAGATGCTGTCAGGACGTATCTTCTTCATACCAAAGTCACTGGTCCTTTCTCAGCCTCT 721 CTCGTGCTTTTCTCCTAATGACCATATTTTTGCCAAAAATTGGGATATGTTATCTGACAGACCAGAATATTTGAAGTTTG 801 GGCTGTCCTGAAAGTCTGGACTTTGGTGGTACCCTCCTCCCCCAGCCCATCTGTTGCACATTATACTCCGTGTGTTCTTC 881 AACTTTCGGCGCCCTTATTCCCCTGCCTTCCTGGCTTGATTGAAGGAAAGCTTGAAAAGGCGCAGAGCCCTATACCTCAT 961 TTCCTCCATGATAAAAGGATCCAAGTGAGGCCCTGTCACAGCCTGTGGGTAGGGGATGCGGCGGGATCCTCATTGCCATG 1041 GTACTCAAAGGTAGAAGAGCCTGGAGTTTGTTGCTTCTCTTTGCTATTCTTTCATATCCTCTTGGGCCTGGTGATTAATT 1121 AGCAATTCTCATTCCTCTCAGCCAAAGGCCTGCACTGGGCTTTATTTGTCTTTTTTTATTTTTTAAGCACTGCCTGCCAG 1201 AGATGGGCCTGGGGCCTGATGAGGACCTTAGCGCTGCTCGTTCTCCTTTTCTGTTCATGCACACATTCCTCCATGGGGTG 1281 GGGAAGGCAGGCATGGGGTGTGGCCCTCGGAGAAGTTAGGAGTCCCCCAGCTCAAGATACAGTGGCAAAGACCTAGTGGT 1361 CCCCTACCCCCACTTCTCTCAGTTCCTGGCATGAGGAGAGAAGACCCTGCTCTGGTGGAGCTGACAACCTTTGAGGCTGG 1441 GAGGAGAGCAGCCTCTGGGCATCGTTCCCAGTGTCCCTCACACTAAAACGGCGTAGATGGCAACCCCCCACCCCCACCCC 1521 GCTGCTCAACTCTTGTGTTTGTTGTTCTGTTTGCCCCATTTATCTGTTGCTGTTTTTGTGTTGTCTTCCCCTGCTCCGCA 1601 TTTTGTAAAATGGCCCCTGGGGGAGTGTTTTTGCTGGATCTGCTCCCTCTCGCTCTCTCACTCCACTACTTTTTGGAACA 1681 AAGTGATGGCAGAATGCGGTGGTGGTGGGGGTCTTTTGTACTGTTGGATTAATAAAATGATTTTAAAATCCCAAAAAAAA 1761 AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HeLa |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in Chi_124B_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + B
... - Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature. |
Article |
- Chi SW; Zang JB; Mele A; Darnell RB - Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
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CLIP-seq Support 1 for dataset Chi_124B_2A8_130_50 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | HeLa / HeLa cell miR-124 + B |
Location of target site | ENST00000368457.2 | 3UTR | CAAAUAGCCUGAGGAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 19536157 / Chi_HITSCLIP |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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84 hsa-miR-2115-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT155281 | IFNAR2 | interferon alpha and beta receptor subunit 2 | ![]() |
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2 | 6 | ||||||
MIRT257301 | MYLIP | myosin regulatory light chain interacting protein | ![]() |
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2 | 8 | ||||||
MIRT441907 | SEPN1 | selenoprotein N | ![]() |
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2 | 2 | ||||||
MIRT442300 | ZNF496 | zinc finger protein 496 | ![]() |
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2 | 2 | ||||||
MIRT468235 | SGK1 | serum/glucocorticoid regulated kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT469331 | RGP1 | RGP1 homolog, RAB6A GEF complex partner 1 | ![]() |
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2 | 2 | ||||||
MIRT470203 | PSAT1 | phosphoserine aminotransferase 1 | ![]() |
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2 | 6 | ||||||
MIRT475945 | GXYLT1 | glucoside xylosyltransferase 1 | ![]() |
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2 | 4 | ||||||
MIRT481449 | ARRB2 | arrestin beta 2 | ![]() |
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2 | 2 | ||||||
MIRT497440 | SLC16A10 | solute carrier family 16 member 10 | ![]() |
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2 | 2 | ||||||
MIRT498270 | KIAA1644 | KIAA1644 | ![]() |
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2 | 2 | ||||||
MIRT499225 | VAV3 | vav guanine nucleotide exchange factor 3 | ![]() |
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2 | 4 | ||||||
MIRT501742 | NSD1 | nuclear receptor binding SET domain protein 1 | ![]() |
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2 | 2 | ||||||
MIRT501762 | NRF1 | nuclear respiratory factor 1 | ![]() |
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2 | 6 | ||||||
MIRT527902 | B3GALT5 | beta-1,3-galactosyltransferase 5 | ![]() |
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2 | 4 | ||||||
MIRT528559 | DNAAF3 | dynein axonemal assembly factor 3 | ![]() |
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2 | 2 | ||||||
MIRT531252 | peptide deformylase, mitochondrial | ![]() |
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2 | 2 | |||||||
MIRT539490 | ACTN4 | actinin alpha 4 | ![]() |
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2 | 2 | ||||||
MIRT550683 | YARS | tyrosyl-tRNA synthetase | ![]() |
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2 | 2 | ||||||
MIRT573441 | APOPT1 | apoptogenic 1, mitochondrial | ![]() |
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2 | 2 | ||||||
MIRT616740 | DCTN5 | dynactin subunit 5 | ![]() |
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2 | 2 | ||||||
MIRT617626 | RAB3IP | RAB3A interacting protein | ![]() |
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2 | 2 | ||||||
MIRT620780 | MT1A | metallothionein 1A | ![]() |
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2 | 2 | ||||||
MIRT623174 | NAA50 | N(alpha)-acetyltransferase 50, NatE catalytic subunit | ![]() |
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2 | 2 | ||||||
MIRT624880 | AASDHPPT | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | ![]() |
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2 | 2 | ||||||
MIRT625799 | MDC1 | mediator of DNA damage checkpoint 1 | ![]() |
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2 | 2 | ||||||
MIRT629790 | CHRFAM7A | CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion | ![]() |
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2 | 2 | ||||||
MIRT630535 | AGO3 | argonaute 3, RISC catalytic component | ![]() |
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2 | 2 | ||||||
MIRT630762 | ZNF445 | zinc finger protein 445 | ![]() |
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2 | 2 | ||||||
MIRT630921 | UNC93A | unc-93 homolog A | ![]() |
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2 | 2 | ||||||
MIRT630949 | PANK1 | pantothenate kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT631688 | NQO2 | N-ribosyldihydronicotinamide:quinone reductase 2 | ![]() |
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2 | 2 | ||||||
MIRT633898 | FGF10 | fibroblast growth factor 10 | ![]() |
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2 | 2 | ||||||
MIRT635935 | PLA2G12A | phospholipase A2 group XIIA | ![]() |
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2 | 2 | ||||||
MIRT636177 | THBD | thrombomodulin | ![]() |
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2 | 2 | ||||||
MIRT636730 | AFAP1 | actin filament associated protein 1 | ![]() |
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2 | 2 | ||||||
MIRT638038 | SHPK | sedoheptulokinase | ![]() |
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2 | 2 | ||||||
MIRT639164 | LAMTOR3 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 | ![]() |
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2 | 2 | ||||||
MIRT639260 | MANEAL | mannosidase endo-alpha like | ![]() |
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2 | 2 | ||||||
MIRT639327 | C9orf41 | carnosine N-methyltransferase 1 | ![]() |
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2 | 2 | ||||||
MIRT639849 | YY1 | YY1 transcription factor | ![]() |
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2 | 2 | ||||||
MIRT641474 | B4GALNT3 | beta-1,4-N-acetyl-galactosaminyltransferase 3 | ![]() |
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2 | 2 | ||||||
MIRT642783 | CHCHD3 | coiled-coil-helix-coiled-coil-helix domain containing 3 | ![]() |
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2 | 2 | ||||||
MIRT643653 | MYOCD | myocardin | ![]() |
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2 | 2 | ||||||
MIRT645717 | PTPRF | protein tyrosine phosphatase, receptor type F | ![]() |
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2 | 2 | ||||||
MIRT648018 | SLCO4C1 | solute carrier organic anion transporter family member 4C1 | ![]() |
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2 | 2 | ||||||
MIRT648236 | C15orf40 | chromosome 15 open reading frame 40 | ![]() |
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2 | 2 | ||||||
MIRT648563 | MEMO1 | mediator of cell motility 1 | ![]() |
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2 | 2 | ||||||
MIRT648731 | HIST1H2BD | histone cluster 1 H2B family member d | ![]() |
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2 | 2 | ||||||
MIRT650179 | LILRA2 | leukocyte immunoglobulin like receptor A2 | ![]() |
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2 | 2 | ||||||
MIRT650721 | TNFSF8 | TNF superfamily member 8 | ![]() |
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2 | 2 | ||||||
MIRT652179 | TRIM44 | tripartite motif containing 44 | ![]() |
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2 | 2 | ||||||
MIRT654272 | RFFL | ring finger and FYVE like domain containing E3 ubiquitin protein ligase | ![]() |
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2 | 2 | ||||||
MIRT654493 | RAD51L3-RFFL | RAD51L3-RFFL readthrough | ![]() |
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2 | 2 | ||||||
MIRT654861 | PPM1F | protein phosphatase, Mg2+/Mn2+ dependent 1F | ![]() |
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2 | 2 | ||||||
MIRT656392 | MCU | mitochondrial calcium uniporter | ![]() |
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2 | 2 | ||||||
MIRT656623 | LRRC15 | leucine rich repeat containing 15 | ![]() |
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2 | 2 | ||||||
MIRT657085 | JMY | junction mediating and regulatory protein, p53 cofactor | ![]() |
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2 | 2 | ||||||
MIRT659793 | CBLB | Cbl proto-oncogene B | ![]() |
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2 | 2 | ||||||
MIRT660155 | BRCC3 | BRCA1/BRCA2-containing complex subunit 3 | ![]() |
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2 | 2 | ||||||
MIRT662444 | SERPINB5 | serpin family B member 5 | ![]() |
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2 | 2 | ||||||
MIRT663116 | SPTA1 | spectrin alpha, erythrocytic 1 | ![]() |
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2 | 2 | ||||||
MIRT665759 | TMEM43 | transmembrane protein 43 | ![]() |
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2 | 2 | ||||||
MIRT666357 | SIKE1 | suppressor of IKBKE 1 | ![]() |
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2 | 2 | ||||||
MIRT668521 | ESRRG | estrogen related receptor gamma | ![]() |
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2 | 2 | ||||||
MIRT677776 | FKTN | fukutin | ![]() |
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2 | 2 | ||||||
MIRT678900 | TTLL12 | tubulin tyrosine ligase like 12 | ![]() |
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2 | 2 | ||||||
MIRT702825 | HOOK3 | hook microtubule tethering protein 3 | ![]() |
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2 | 2 | ||||||
MIRT704424 | CTNNBIP1 | catenin beta interacting protein 1 | ![]() |
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2 | 2 | ||||||
MIRT709470 | KRTAP19-1 | keratin associated protein 19-1 | ![]() |
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2 | 2 | ||||||
MIRT710939 | MRPL45 | mitochondrial ribosomal protein L45 | ![]() |
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2 | 2 | ||||||
MIRT713306 | TYRP1 | tyrosinase related protein 1 | ![]() |
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2 | 2 | ||||||
MIRT716932 | FAM13A | family with sequence similarity 13 member A | ![]() |
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2 | 2 | ||||||
MIRT717539 | PYGO2 | pygopus family PHD finger 2 | ![]() |
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2 | 2 | ||||||
MIRT718060 | CYP3A5 | cytochrome P450 family 3 subfamily A member 5 | ![]() |
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2 | 2 | ||||||
MIRT718934 | TRIM66 | tripartite motif containing 66 | ![]() |
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2 | 2 | ||||||
MIRT719770 | ZNF236 | zinc finger protein 236 | ![]() |
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2 | 2 | ||||||
MIRT720164 | PNPO | pyridoxamine 5'-phosphate oxidase | ![]() |
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2 | 2 | ||||||
MIRT721280 | RAD54L2 | RAD54 like 2 | ![]() |
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2 | 2 | ||||||
MIRT721359 | ENTHD1 | ENTH domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT721506 | CARHSP1 | calcium regulated heat stable protein 1 | ![]() |
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2 | 2 | ||||||
MIRT721920 | LINGO2 | leucine rich repeat and Ig domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT722791 | FUT4 | fucosyltransferase 4 | ![]() |
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2 | 2 | ||||||
MIRT723933 | SVOP | SV2 related protein | ![]() |
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2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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