miRTarBase - #MIRT717866


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pre-miRNA Information
pre-miRNA hsa-mir-4446   
Genomic Coordinates chr3: 113594876 - 113594942
Description Homo sapiens miR-4446 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4446-5p
Sequence 8| AUUUCCCUGCCAUUCCCUUGGC |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1356015605 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CACNA2D1   
Synonyms CACNA2, CACNL2A, CCHL2A, LINC01112, lncRNA-N3
Description calcium voltage-gated channel auxiliary subunit alpha2delta 1
Transcript NM_000722   
Expression
Putative miRNA Targets on CACNA2D1
3'UTR of CACNA2D1
(miRNA target sites are highlighted)		 
>CACNA2D1|NM_000722|3'UTR
   1 CCTTCTAAAAACCAAATCTGCATAGTTAAACTCCAGACCCTGCCAAAACATGAGCCCTGCCCTCAATTACAGTAACGTAG
  81 GGTCAGCTATAAAATCAGACAAACATTAGCTGGGCCTGTTCCATGGCATAACACTAAGGCGCAGACTCCTAAGGCACCCA
 161 CTGGCTGCATGTCAGGGTGTCAGATCCTTAAACGTGTGTGAATGCTGCATCATCTATGTGTAACATCAAAGCAAAATCCT
 241 ATACGTGTCCTCTATTGGAAAATTTGGGAGTTTGTTGTTGCATTGTTGGTGATTACATGTGAAAGGGTTCCCCATACAAT
 321 TGTTAATGAACCATAAGAAATGTCTTGATATTGACCTGGAATTTTGACTTGCTGCAATTTTACTAAGAAAATCTCTAAGG
 401 GGAAAGAAATTATTTTTGCCTTCACTTTTTCTTCTGTGAAAAGTTAATTCCTGCTTTAAGTAGCAATTATTGAAATATAT
 481 AGAGAAAGAGAGAATTAACATTGGTCTAAATTGTTGAAATATAAATAATGGCTAATTTTCTATGAAAAATTTGCCATGAA
 561 TAAAATGCCTTATGAAGAACGGCTTCTTTGCCAAAAATAAAACACAATTGATGACCAATTCAATTTTGATGGGGTAATGA
 641 ATTGATGGTTTGAAAATAGTAACTAAGAAATTATTAAACTAAAGGTGCTTGAGGGAGAAATTAGAATATGTGACATATTT
 721 CCTCATAAATGTAAGCAAGCCCTTAATAAATGCTTTGATGTAATGTTCCTTTTGTTCACAGTACAGTTATGTAGTGCTAG
 801 CCAGATATTTAAAAATGCTCTAAGAAAAGCTTGTCAGGGGGGAGGGGGAAATGTTTTTCTTGTGATAAATGAACTTTGGT
 881 TTACCAAGGGTATTTTGCATGATGCTGCTGCTATTTTAACTTTTCAGTTGTTTTTTCTCTTACTGTAGAGTGTAGTCATT
 961 GAAAAGTTAACTGAGTGATATTGTTATGTAAGAATCTGAACCTTGCAGTGTAAATGCACTTAAGTCATCTTTAAAATGTT
1041 GTTAAACTACTCTGAATATACTGTGCAATGTAAATGCTGAATGATTGGGGTTAGATAAATGGTGAAATGAGAATTAATGA
1121 ATTTTATACAGATTCATGCTTTCGCCTGATAACCTATGTACAGATATTTTAAGTACATAAATCAGATTTGACACATTTAT
1201 TTTTTGAAAAGTACATATATGTTCTCAATGAAGATTCATCCTAGGTTTCCTCTTTGTTCGTTTCAATAGTAGCACATACA
1281 ATCCAAAAGTTCCTGCTACTGCTGCTTTTGCCCTTCCATTTTAAATGGTATGATCGTTTGGCCAAAATTTCCATGCAAGT
1361 TGATAAGGGTTTTACAATAATCTGAACAAATAGGAAACCTTGAATCTCTATGTATGCACATGAATACTTGATTGTGAATA
1441 ATAAAAGTTGTTTTTTATACAGCCTCATTGGTGAAAATGGTTAGTGTAGTAAATCAGATATTTCATTATAGACTAATATG
1521 GTAGCAGATTATTTATGCTTTTAAAAATTATTTTCTGGAGCAAACAGTATTTGAAGAAAAGGTAAAAACTATGAATGTGT
1601 AATTCTAAGAATAGTTAATAATTTTACTGAAGGCTGAACGTATGTAGATATTTTTTATGATAAAATGCAGTTTTTCTTTT
1681 TTTGGAACATGCCAATTACTGGTATGTGTATATGCTGGAAATTTTCTTACATATCCTTTTTAAGTCAAAGTTATTAACAT
1761 TATCCAGCATGCTTTAATATGCTCCACATATCAAAGATATAACCAATAATTTAACGTAGCTTAAAAGATAACATTTGTTT
1841 TGTTTTTAGCTTTGCATACATTTGTAATTCCCTCCCACCACCAATATACCTTAGGTACCATTTGTGTACATTTCAAGATT
1921 TTTTTTTTCAATAAAAAGGTGGGGGGAAATGGAATCACTTTGCCAACTATTGTTCTAAGAGTTGACATCAGTTACCATTT
2001 CTAATGCATTGTTGTGATTTTGTAGTGTCATTCATAACTGGTATTGACATTTTAGAAAACACCAAAGTGATTTAAAATAT
2081 ATGTGGGGAAAAAAACTTCTCACTCTAGTAACAATGTTTTAATCATGTTGTTTGTTAAATATTTAAAAGTTATTGTTCAA
2161 TTTTTGCTAGACTATCTTAAATCATGATAGTGTTGGGAAGGGGGTATCAAAATATAAAATTGTTAGTTTGTGTATATAAA
2241 CAATGCACATTAAAACAATTGAATTGCTTCCAGCATACAACAAACTACCTTAAAATTATGTTCAAAATCTATTAAATATA
2321 TTTTCATGGCTAATGTCGAGTATATGTTTTCATCAATTACATTGTTATTGTATTAATCGCGGTTAAACTTGGCATCTCTT
2401 GGCAGGATCCTATTTAATTTCTGTTGCCATCAAAATATATTTATATGCATGAGTTTTGCTATAAACCTTTATTTTCTGCT
2481 ATAAAGTTATATATTATGACAACCATAAATGCAATTACAAATTGGGTAAGAACAAGCTGAATAAAAGTTGTTCCCATGAC
2561 TAATATTAGTCTTCATGCTTTTAGCATATTTTTTAAGACAGTAACACTCATCCCATCAAATTATTACATTACATTTAGTA
2641 TTTTTCTGAGTTACATTGACAAGAACTTAAATTATAGCCTGTTATTAATATTGATTTCCAACGACTGAACAGTACAACAG
2721 ATCAATAAAAAAGTTTATACACTGCTTTAACTAATTTTTGTTATACTCATGTGGCTTAGTGTAGTTAGTCACTAAAACAG
2801 AGTTCAAGTGAGCTTGGCAATGGTGTTGAGTAACAAGAAAGAATTTTGCATTAATGATTTCTTTTTATTTTCCTCATTTA
2881 AACAACCAGCATTACTGCCAAACACCAACCGTGGTCCATATTTGTAACAGGTTTTTAACATGACATAGTTAGCAAGTTTG
2961 ATTGAAGAGATTTTTAGGTCCTGGGCCTATAAGATTTTAGTATGATCTTTTTTCATGTTTCTAATGCTTGAGGTGTTACT
3041 GCTTAACTTGGGAAAAAAAAAAACAAAAAACAGTGTTCCTGCCATTTGTAAGTTTTCCTATAATATTCCTTTTATTAACT
3121 TTAAAACTGGACTTATCGGGTTCAAATAGGCAGTATCCCTTTTAAGTGACCTTTGCAACCCAAGTGTTACTTGCTTATTT
3201 GATGCTCTCTTGTATTTTAAATCTCATTTAAATCTTTGTCTGTGACCAACAAAGCTTAAGATTTTGTCTTCATTTAAAAC
3281 TCTGAATCTATTCCATTGATCATGTTAGACGTTCAAATGTTTAATGGTATAGTCTGACCTAGTGAAACAAAATGGATGTT
3361 GTTACTTTTTTTAAAGAATAGAATGAAATAACTATTTCACTTGCCCAAAATTTTAAATATTTTTTCATCTAAACTTGTAT
3441 TGTTTCCCATAGCAGAATGTCAATATTCACAGTACATTTCTGTAAAGAGCAAACCAATATAATGTTTTGAGTGTTGAAAA
3521 AAATTCCAGATTTTTGAAGAATTAGACAACTCTTCATCTACCTTATTTCTAGTTCACACAGTTATCTCAAATTCCACTGA
3601 AACTAATGGGATACTGTCTTGTGTAGATGCCAGTTGAGTTTATAATGTGACCTAGTAAAGCTGTCTTTTTTGTTGTGTTG
3681 TATGAGTGTCGGATCATGCTTTTAGGAATACTTTTATTAAAATGGTGTGCATTCATGCAAAAGGCCAACTGGCTTTTGTG
3761 AACAATAGATCTTTTCTCCCCTTTATTTTGTTCTCTTGACACTTTTGTGAAAATTACCTAGCCTGATAAAAACATTTTGT
3841 AAAAATTTGTATAATACTGTTATAAAATATTTATAATCCCAGAAAATGTTGTGTTAAATCTTGTGCAAAAACAGTATATT
3921 CAGAATAAAAGTTTATCATTTAAAGTCAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgGUUCCCUUACCGUCCCUUUa 5'
            ||:|||:: |  :|||||| 
Target 5' gtCAGGGGGGAG--GGGGAAAt 3'
 833 - 852 144.00 -23.50
2 
miRNA  3' cggUUCCCUUACCGUCCCUUUa 5'
             ||||   ||| :|||||| 
Target 5' aaaAAGG---TGG-GGGGAAAt 3'
 1933 - 1950 139.00 -14.80
3 
miRNA  3' cgGUUCCCUUACCG--UCCCUUUa 5'
            :|||  |||  |  ||||:|| 
Target 5' acTAAGAAAATCTCTAAGGGGAAa 3'
 382 - 405 138.00 -11.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31547877 5 COSMIC
COSN30504393 15 COSMIC
COSN30134085 20 COSMIC
COSN24294956 38 COSMIC
COSN31497653 40 COSMIC
COSN2376267 45 COSMIC
COSN16643298 48 COSMIC
COSN28885807 60 COSMIC
COSN31510254 66 COSMIC
COSN30189198 76 COSMIC
COSN8517742 80 COSMIC
COSN20335950 95 COSMIC
COSN8517741 109 COSMIC
COSN30467820 110 COSMIC
COSN30189338 117 COSMIC
COSN30131121 183 COSMIC
COSN31485177 245 COSMIC
COSN6893569 305 COSMIC
COSN25441085 324 COSMIC
COSN28734094 438 COSMIC
COSN20590453 518 COSMIC
COSN25243410 667 COSMIC
COSN9772058 711 COSMIC
COSN17393591 813 COSMIC
COSN28201556 841 COSMIC
COSN25486090 968 COSMIC
COSN30045327 983 COSMIC
COSN24554954 1045 COSMIC
COSN23617851 1199 COSMIC
COSN23348144 1209 COSMIC
COSN9511447 1234 COSMIC
COSN17728925 1288 COSMIC
COSN24797317 1464 COSMIC
COSN23530366 1645 COSMIC
COSN28987464 1918 COSMIC
COSN17375213 2301 COSMIC
COSN16362814 2388 COSMIC
COSN28202237 2388 COSMIC
COSN20882656 2467 COSMIC
COSN23605235 2476 COSMIC
COSN29921705 2523 COSMIC
COSN6893568 2693 COSMIC
COSN23081708 2742 COSMIC
COSN20542517 2911 COSMIC
COSN18877387 2956 COSMIC
COSN27216172 3052 COSMIC
COSN23212143 3053 COSMIC
COSN15971200 3064 COSMIC
COSN30029860 3136 COSMIC
COSN22360013 3321 COSMIC
COSN23194026 3334 COSMIC
COSN28202810 3429 COSMIC
COSN17206353 3751 COSMIC
COSN32063682 3760 COSMIC
COSN23033764 3827 COSMIC
COSN27763714 3838 COSMIC
COSN24374605 3923 COSMIC
COSN27763690 3927 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1426970711 2 dbSNP
rs766856402 3 dbSNP
rs1235283401 12 dbSNP
rs751857100 12 dbSNP
rs1488186923 16 dbSNP
rs887563392 20 dbSNP
rs143491535 22 dbSNP
rs1319826745 23 dbSNP
rs1474891251 28 dbSNP
rs1348816440 29 dbSNP
rs1222938106 33 dbSNP
rs1258481463 36 dbSNP
rs773549800 38 dbSNP
rs1305437693 40 dbSNP
rs769366182 42 dbSNP
rs1386892380 43 dbSNP
rs1467159486 44 dbSNP
rs761167589 50 dbSNP
rs776265892 51 dbSNP
rs1468577273 53 dbSNP
rs201437426 55 dbSNP
rs561652573 62 dbSNP
rs148861982 76 dbSNP
rs897712038 77 dbSNP
rs1413199773 79 dbSNP
rs998482426 82 dbSNP
rs901169412 83 dbSNP
rs1163462771 85 dbSNP
rs1393825761 97 dbSNP
rs1042396091 101 dbSNP
rs1325624533 102 dbSNP
rs768405533 104 dbSNP
rs1334156302 114 dbSNP
rs572486752 117 dbSNP
rs1040332443 118 dbSNP
rs78368203 120 dbSNP
rs865966579 122 dbSNP
rs910562402 123 dbSNP
rs1279891412 124 dbSNP
rs1331015327 126 dbSNP
rs1321798329 132 dbSNP
rs1231362696 139 dbSNP
rs986162670 140 dbSNP
rs946779224 141 dbSNP
rs1054264486 145 dbSNP
rs370508103 148 dbSNP
rs1436823493 153 dbSNP
rs545573864 156 dbSNP
rs935833459 157 dbSNP
rs576908848 160 dbSNP
rs1182125409 161 dbSNP
rs1491018801 175 dbSNP
rs1252962052 176 dbSNP
rs555987555 176 dbSNP
rs927185827 177 dbSNP
rs557232938 179 dbSNP
rs988301316 184 dbSNP
rs878992489 185 dbSNP
rs1035241865 187 dbSNP
rs1417703293 189 dbSNP
rs1448055115 193 dbSNP
rs1458886491 193 dbSNP
rs75370027 194 dbSNP
rs1292002585 196 dbSNP
rs1459599544 202 dbSNP
rs916899552 207 dbSNP
rs969647150 210 dbSNP
rs1292458354 213 dbSNP
rs961086786 214 dbSNP
rs1382170482 221 dbSNP
rs1267864381 226 dbSNP
rs1022583971 232 dbSNP
rs1338235505 239 dbSNP
rs575156119 244 dbSNP
rs1276252804 245 dbSNP
rs1432400185 247 dbSNP
rs1484494656 250 dbSNP
rs546875572 253 dbSNP
rs1192590498 255 dbSNP
rs1257297824 257 dbSNP
rs1488630758 261 dbSNP
rs1424878019 263 dbSNP
rs887521771 270 dbSNP
rs1284827373 276 dbSNP
rs1027829408 280 dbSNP
rs555316465 290 dbSNP
rs993320257 297 dbSNP
rs983927463 302 dbSNP
rs1355208372 306 dbSNP
rs1372574382 306 dbSNP
rs954347299 316 dbSNP
rs181262965 319 dbSNP
rs1288795761 327 dbSNP
rs1241420076 331 dbSNP
rs867740907 333 dbSNP
rs897655199 334 dbSNP
rs1325792363 336 dbSNP
rs998826839 340 dbSNP
rs901453927 344 dbSNP
rs1299586666 345 dbSNP
rs1233166549 350 dbSNP
rs146833935 353 dbSNP
rs1202704901 356 dbSNP
rs1009534268 367 dbSNP
rs75040588 370 dbSNP
rs1297820123 371 dbSNP
rs188791666 377 dbSNP
rs1392132374 382 dbSNP
rs1452775327 395 dbSNP
rs893854945 396 dbSNP
rs1362477355 423 dbSNP
rs570146227 426 dbSNP
rs1286916278 434 dbSNP
rs1050406223 443 dbSNP
rs1435764779 446 dbSNP
rs1321935485 448 dbSNP
rs1368215064 460 dbSNP
rs1465450201 462 dbSNP
rs1439697295 470 dbSNP
rs1301628926 477 dbSNP
rs1313591153 478 dbSNP
rs745746368 488 dbSNP
rs183727812 489 dbSNP
rs1329034194 494 dbSNP
rs139202888 494 dbSNP
rs988636324 499 dbSNP
rs771127437 504 dbSNP
rs1249953477 509 dbSNP
rs928130196 510 dbSNP
rs1262093620 528 dbSNP
rs1467243010 530 dbSNP
rs1193237758 532 dbSNP
rs1268248935 533 dbSNP
rs143810802 534 dbSNP
rs561617405 537 dbSNP
rs1488985628 540 dbSNP
rs1363053352 558 dbSNP
rs115295178 568 dbSNP
rs1161359465 569 dbSNP
rs528414477 580 dbSNP
rs558911696 581 dbSNP
rs1439439849 582 dbSNP
rs141394168 608 dbSNP
rs1369219460 615 dbSNP
rs192384152 616 dbSNP
rs563418910 617 dbSNP
rs543618024 618 dbSNP
rs1350305244 621 dbSNP
rs1229533475 632 dbSNP
rs1270648248 633 dbSNP
rs939665300 644 dbSNP
rs1220866282 647 dbSNP
rs1266142231 657 dbSNP
rs993660445 659 dbSNP
rs1175752251 660 dbSNP
rs1324704554 668 dbSNP
rs528064794 671 dbSNP
rs758684529 674 dbSNP
rs752892127 681 dbSNP
rs1205833728 682 dbSNP
rs909583773 685 dbSNP
rs984265891 687 dbSNP
rs1415500753 697 dbSNP
rs1460874183 710 dbSNP
rs1164815444 713 dbSNP
rs747365020 713 dbSNP
rs1460131278 715 dbSNP
rs1297309365 718 dbSNP
rs1342485964 721 dbSNP
rs1370332944 725 dbSNP
rs1298836229 731 dbSNP
rs575070539 740 dbSNP
rs1028887602 741 dbSNP
rs1400062046 746 dbSNP
rs555230472 747 dbSNP
rs1354069700 752 dbSNP
rs867757475 762 dbSNP
rs188943985 765 dbSNP
rs889010033 770 dbSNP
rs779286445 779 dbSNP
rs1422566900 783 dbSNP
rs373720792 786 dbSNP
rs755310397 790 dbSNP
rs1010869732 794 dbSNP
rs1483514740 796 dbSNP
rs1168130433 801 dbSNP
rs185579072 802 dbSNP
rs1021166856 805 dbSNP
rs1472407309 808 dbSNP
rs1423873246 820 dbSNP
rs1415314343 826 dbSNP
rs193034287 829 dbSNP
rs1426287055 833 dbSNP
rs541743601 834 dbSNP
rs1169140544 836 dbSNP
rs1431286841 837 dbSNP
rs559436336 837 dbSNP
rs893809231 838 dbSNP
rs1052480982 839 dbSNP
rs545889971 843 dbSNP
rs776233015 843 dbSNP
rs552485747 847 dbSNP
rs1212825881 848 dbSNP
rs1462050690 849 dbSNP
rs1343083784 850 dbSNP
rs905294058 852 dbSNP
rs935411786 853 dbSNP
rs1257780591 855 dbSNP
rs1441688033 862 dbSNP
rs1044592743 866 dbSNP
rs1197009734 869 dbSNP
rs1484860285 876 dbSNP
rs1187341977 879 dbSNP
rs1390294514 885 dbSNP
rs1320321914 889 dbSNP
rs879928752 890 dbSNP
rs1423503612 891 dbSNP
rs1414200250 899 dbSNP
rs1177270313 909 dbSNP
rs1270984110 913 dbSNP
rs1361360896 913 dbSNP
rs1244227200 917 dbSNP
rs928076290 919 dbSNP
rs1338715272 920 dbSNP
rs949871228 923 dbSNP
rs1301606197 925 dbSNP
rs895696891 927 dbSNP
rs1314772594 934 dbSNP
rs1315024203 934 dbSNP
rs1208083186 937 dbSNP
rs1248094370 940 dbSNP
rs1465917847 941 dbSNP
rs1191215195 953 dbSNP
rs1036942679 955 dbSNP
rs1478167073 956 dbSNP
rs369072139 956 dbSNP
rs1192103010 960 dbSNP
rs1046536970 967 dbSNP
rs1453235602 971 dbSNP
rs1427739814 975 dbSNP
rs866065423 977 dbSNP
rs948236290 978 dbSNP
rs939949113 981 dbSNP
rs916807157 982 dbSNP
rs1399297244 986 dbSNP
rs1329104661 992 dbSNP
rs909522181 1008 dbSNP
rs1458826398 1020 dbSNP
rs984781534 1026 dbSNP
rs1330693603 1030 dbSNP
rs951711083 1039 dbSNP
rs920246189 1055 dbSNP
rs1471533081 1067 dbSNP
rs1370983357 1073 dbSNP
rs971793112 1076 dbSNP
rs1369625759 1081 dbSNP
rs1268614530 1097 dbSNP
rs962080385 1102 dbSNP
rs1190263115 1109 dbSNP
rs1445714752 1123 dbSNP
rs1288571023 1131 dbSNP
rs1451785373 1135 dbSNP
rs1200608131 1137 dbSNP
rs373264632 1141 dbSNP
rs921032454 1143 dbSNP
rs754339169 1144 dbSNP
rs372347069 1146 dbSNP
rs766930293 1154 dbSNP
rs958337559 1156 dbSNP
rs1209392820 1158 dbSNP
rs558639963 1163 dbSNP
rs1406159281 1177 dbSNP
rs1325856157 1181 dbSNP
rs1354366922 1185 dbSNP
rs1368956285 1185 dbSNP
rs761291495 1196 dbSNP
rs1288776555 1205 dbSNP
rs1352218335 1210 dbSNP
rs1267244977 1214 dbSNP
rs1028882193 1217 dbSNP
rs751111746 1219 dbSNP
rs1231424645 1222 dbSNP
rs1032733097 1224 dbSNP
rs1246771800 1233 dbSNP
rs752284638 1234 dbSNP
rs893764064 1245 dbSNP
rs1270363954 1253 dbSNP
rs1376126066 1255 dbSNP
rs1204823749 1257 dbSNP
rs539028362 1260 dbSNP
rs999561795 1266 dbSNP
rs1367962473 1269 dbSNP
rs1473129855 1270 dbSNP
rs1165090240 1276 dbSNP
rs554011995 1281 dbSNP
rs1388503360 1285 dbSNP
rs906597337 1292 dbSNP
rs113128050 1294 dbSNP
rs1336070082 1302 dbSNP
rs969842294 1310 dbSNP
rs878996152 1316 dbSNP
rs1394200629 1317 dbSNP
rs1322480698 1321 dbSNP
rs1403205531 1328 dbSNP
rs948182474 1330 dbSNP
rs916754697 1335 dbSNP
rs1294796402 1336 dbSNP
rs1340971586 1341 dbSNP
rs1048588809 1346 dbSNP
rs1228736402 1348 dbSNP
rs1275780644 1352 dbSNP
rs1036890455 1353 dbSNP
rs931553225 1363 dbSNP
rs1199099697 1367 dbSNP
rs1004109963 1369 dbSNP
rs1189664945 1377 dbSNP
rs1246310975 1382 dbSNP
rs1449070761 1384 dbSNP
rs888384965 1399 dbSNP
rs1391777400 1402 dbSNP
rs1171793905 1410 dbSNP
rs1048503257 1412 dbSNP
rs918867175 1414 dbSNP
rs114394922 1428 dbSNP
rs940358914 1436 dbSNP
rs911606849 1437 dbSNP
rs1363902766 1454 dbSNP
rs536373070 1457 dbSNP
rs746506426 1457 dbSNP
rs150069246 1461 dbSNP
rs1231465651 1464 dbSNP
rs548020002 1466 dbSNP
rs538796012 1469 dbSNP
rs1206181984 1470 dbSNP
rs989353526 1479 dbSNP
rs988285788 1485 dbSNP
rs776041796 1491 dbSNP
rs1464551492 1502 dbSNP
rs188348750 1507 dbSNP
rs1250068796 1509 dbSNP
rs1431681087 1518 dbSNP
rs202103481 1528 dbSNP
rs1450131597 1530 dbSNP
rs1269696440 1537 dbSNP
rs1467502522 1543 dbSNP
rs1156939668 1548 dbSNP
rs1030932257 1550 dbSNP
rs1223413216 1555 dbSNP
rs551858400 1567 dbSNP
rs1322000980 1568 dbSNP
rs1365006442 1569 dbSNP
rs981140484 1570 dbSNP
rs1300997194 1577 dbSNP
rs1332092586 1578 dbSNP
rs139245799 1580 dbSNP
rs1266712798 1582 dbSNP
rs1025009559 1592 dbSNP
rs1209387867 1593 dbSNP
rs906546454 1593 dbSNP
rs563170207 1597 dbSNP
rs1013658675 1601 dbSNP
rs543483666 1611 dbSNP
rs1273980376 1623 dbSNP
rs183058315 1627 dbSNP
rs1267786859 1639 dbSNP
rs762620232 1640 dbSNP
rs1179762783 1651 dbSNP
rs1411076509 1657 dbSNP
rs895272151 1661 dbSNP
rs1303365747 1667 dbSNP
rs1160695631 1668 dbSNP
rs1049019989 1671 dbSNP
rs931525127 1675 dbSNP
rs897379039 1690 dbSNP
rs1037291454 1692 dbSNP
rs1293826013 1693 dbSNP
rs940305524 1702 dbSNP
rs1398862174 1710 dbSNP
rs1407089033 1712 dbSNP
rs1286874144 1713 dbSNP
rs1357994473 1718 dbSNP
rs911554273 1730 dbSNP
rs987175460 1731 dbSNP
rs775022533 1732 dbSNP
rs931702782 1734 dbSNP
rs921731493 1741 dbSNP
rs899492817 1742 dbSNP
rs1320058402 1754 dbSNP
rs554621850 1764 dbSNP
rs1040708649 1765 dbSNP
rs1409323203 1767 dbSNP
rs989690526 1768 dbSNP
rs943764992 1769 dbSNP
rs957915149 1780 dbSNP
rs1250848717 1783 dbSNP
rs1031295886 1792 dbSNP
rs1483327621 1797 dbSNP
rs1052518166 1800 dbSNP
rs892227470 1800 dbSNP
rs561459042 1804 dbSNP
rs1164884252 1813 dbSNP
rs1369793067 1814 dbSNP
rs936856973 1815 dbSNP
rs981033922 1816 dbSNP
rs1410961591 1819 dbSNP
rs1379650168 1824 dbSNP
rs948329395 1831 dbSNP
rs917900886 1833 dbSNP
rs992175022 1842 dbSNP
rs1488008503 1843 dbSNP
rs1313567615 1847 dbSNP
rs1361817098 1854 dbSNP
rs1226524958 1856 dbSNP
rs1273630631 1858 dbSNP
rs1342686113 1860 dbSNP
rs541654850 1865 dbSNP
rs1261072080 1872 dbSNP
rs769570420 1884 dbSNP
rs962089755 1890 dbSNP
rs1181898679 1894 dbSNP
rs1015020365 1902 dbSNP
rs572732525 1920 dbSNP
rs1277794112 1922 dbSNP
rs970652112 1927 dbSNP
rs1173017512 1929 dbSNP
rs34804282 1929 dbSNP
rs397890312 1929 dbSNP
rs533741210 1930 dbSNP
rs1024927108 1931 dbSNP
rs1303475557 1933 dbSNP
rs1385153112 1934 dbSNP
rs1433158075 1938 dbSNP
rs1012224551 1939 dbSNP
rs1297052063 1941 dbSNP
rs559226289 1942 dbSNP
rs759466781 1943 dbSNP
rs1216061270 1944 dbSNP
rs895206520 1946 dbSNP
rs1311506248 1947 dbSNP
rs776692601 1948 dbSNP
rs996041793 1956 dbSNP
rs1027259312 1962 dbSNP
rs1463213100 1967 dbSNP
rs996755497 1970 dbSNP
rs1248205874 1973 dbSNP
rs897331547 1975 dbSNP
rs1337802312 1976 dbSNP
rs1299548032 1981 dbSNP
rs1188619940 1987 dbSNP
rs1019208926 1988 dbSNP
rs754522962 1994 dbSNP
rs1346374854 1995 dbSNP
rs1177868297 1996 dbSNP
rs753896048 1997 dbSNP
rs1408942058 2005 dbSNP
rs1455659601 2008 dbSNP
rs1320005081 2010 dbSNP
rs1334073455 2012 dbSNP
rs1389607575 2022 dbSNP
rs1037642196 2023 dbSNP
rs1007856053 2024 dbSNP
rs1272836745 2030 dbSNP
rs17155680 2036 dbSNP
rs760436597 2041 dbSNP
rs1052187090 2042 dbSNP
rs190038776 2049 dbSNP
rs747051584 2055 dbSNP
rs1268256456 2056 dbSNP
rs1051415624 2060 dbSNP
rs936452429 2063 dbSNP
rs931650396 2064 dbSNP
rs1477590795 2074 dbSNP
rs1245338165 2080 dbSNP
rs904003137 2086 dbSNP
rs1200613540 2088 dbSNP
rs1045658763 2089 dbSNP
rs574838009 2091 dbSNP
rs1158483673 2096 dbSNP
rs1385826903 2096 dbSNP
rs1421727429 2099 dbSNP
rs1321906083 2105 dbSNP
rs1349521257 2106 dbSNP
rs1053542942 2108 dbSNP
rs936467175 2113 dbSNP
rs1227759829 2118 dbSNP
rs1288411257 2126 dbSNP
rs1195987933 2127 dbSNP
rs907912783 2130 dbSNP
rs984881894 2134 dbSNP
rs923789851 2152 dbSNP
rs1271553030 2155 dbSNP
rs977933105 2157 dbSNP
rs1207848403 2158 dbSNP
rs1443959202 2160 dbSNP
rs1364455714 2166 dbSNP
rs750187388 2167 dbSNP
rs374252622 2172 dbSNP
rs970598063 2174 dbSNP
rs1161549916 2178 dbSNP
rs1471162796 2178 dbSNP
rs1413292169 2180 dbSNP
rs1425578972 2184 dbSNP
rs1026793859 2185 dbSNP
rs561218376 2189 dbSNP
rs374425602 2190 dbSNP
rs1329377849 2194 dbSNP
rs1337473417 2200 dbSNP
rs963893766 2201 dbSNP
rs917859050 2202 dbSNP
rs556327522 2203 dbSNP
rs1356579318 2204 dbSNP
rs1247783522 2205 dbSNP
rs990749980 2214 dbSNP
rs1008137990 2224 dbSNP
rs1204900354 2229 dbSNP
rs1251800634 2230 dbSNP
rs1440081057 2234 dbSNP
rs1185469966 2235 dbSNP
rs1377740605 2238 dbSNP
rs1445450556 2239 dbSNP
rs1165774769 2243 dbSNP
rs1284135771 2244 dbSNP
rs764257461 2252 dbSNP
rs111832123 2258 dbSNP
rs1027452832 2273 dbSNP
rs10226282 2275 dbSNP
rs1412731327 2285 dbSNP
rs1000597376 2287 dbSNP
rs961800949 2288 dbSNP
rs1045203136 2292 dbSNP
rs1294864846 2294 dbSNP
rs1364028180 2299 dbSNP
rs150835436 2300 dbSNP
rs1056725230 2307 dbSNP
rs908791354 2307 dbSNP
rs940952924 2308 dbSNP
rs1461389603 2311 dbSNP
rs1413114777 2314 dbSNP
rs1185512935 2315 dbSNP
rs1246363872 2320 dbSNP
rs1449122265 2326 dbSNP
rs1180068302 2329 dbSNP
rs376662830 2332 dbSNP
rs1446418967 2334 dbSNP
rs1243642012 2337 dbSNP
rs1177847218 2338 dbSNP
rs1406740250 2340 dbSNP
rs1456265507 2341 dbSNP
rs537720265 2346 dbSNP
rs1049545987 2353 dbSNP
rs1382482315 2354 dbSNP
rs1296720825 2357 dbSNP
rs1328628874 2360 dbSNP
rs930714329 2362 dbSNP
rs1259611492 2364 dbSNP
rs922016952 2368 dbSNP
rs1204700022 2378 dbSNP
rs1008429583 2379 dbSNP
rs187065686 2380 dbSNP
rs182104359 2381 dbSNP
rs1431169251 2384 dbSNP
rs1197924037 2391 dbSNP
rs1385673483 2394 dbSNP
rs1429851233 2407 dbSNP
rs1481395755 2412 dbSNP
rs995802246 2424 dbSNP
rs1410659628 2441 dbSNP
rs900172622 2445 dbSNP
rs1290196308 2447 dbSNP
rs1453990169 2447 dbSNP
rs748343689 2455 dbSNP
rs1375053673 2456 dbSNP
rs936430669 2458 dbSNP
rs923707429 2471 dbSNP
rs1346657081 2479 dbSNP
rs956641177 2482 dbSNP
rs565800237 2487 dbSNP
rs1030637765 2490 dbSNP
rs1443141272 2496 dbSNP
rs1042187312 2497 dbSNP
rs1349493443 2498 dbSNP
rs1487641368 2498 dbSNP
rs1162813766 2499 dbSNP
rs949234086 2504 dbSNP
rs1426618609 2507 dbSNP
rs967783446 2509 dbSNP
rs917808201 2512 dbSNP
rs377282291 2514 dbSNP
rs1023801468 2526 dbSNP
rs990707173 2530 dbSNP
rs1366307109 2532 dbSNP
rs1012034719 2536 dbSNP
rs959587581 2538 dbSNP
rs1366646169 2541 dbSNP
rs1391861255 2544 dbSNP
rs896640644 2549 dbSNP
rs1373266023 2554 dbSNP
rs558560632 2556 dbSNP
rs1252360936 2563 dbSNP
rs1005116992 2580 dbSNP
rs974505718 2584 dbSNP
rs1177452375 2591 dbSNP
rs1292222358 2595 dbSNP
rs886706528 2599 dbSNP
rs1202778140 2601 dbSNP
rs1232180032 2603 dbSNP
rs1049025566 2607 dbSNP
rs1480934243 2607 dbSNP
rs930643501 2609 dbSNP
rs961471900 2610 dbSNP
rs1244591081 2615 dbSNP
rs1183894044 2619 dbSNP
rs201881099 2636 dbSNP
rs374734857 2636 dbSNP
rs1426885991 2646 dbSNP
rs1359521633 2648 dbSNP
rs1167124952 2650 dbSNP
rs116219848 2653 dbSNP
rs1462982743 2654 dbSNP
rs796992460 2655 dbSNP
rs1377153061 2656 dbSNP
rs955528334 2658 dbSNP
rs1315927937 2663 dbSNP
rs569631060 2675 dbSNP
rs912377528 2682 dbSNP
rs1240004550 2683 dbSNP
rs1351990284 2684 dbSNP
rs371194605 2684 dbSNP
rs1272070753 2685 dbSNP
rs1309666953 2688 dbSNP
rs1307980887 2691 dbSNP
rs1206613384 2693 dbSNP
rs1253739688 2695 dbSNP
rs1460433970 2698 dbSNP
rs1028545352 2701 dbSNP
rs867883022 2702 dbSNP
rs1291985956 2704 dbSNP
rs1447318164 2707 dbSNP
rs1185112892 2708 dbSNP
rs1419313082 2709 dbSNP
rs1406856782 2715 dbSNP
rs1429623418 2722 dbSNP
rs576347776 2725 dbSNP
rs754251361 2726 dbSNP
rs1173079652 2727 dbSNP
rs1357941357 2733 dbSNP
rs1469310863 2733 dbSNP
rs1337502064 2738 dbSNP
rs1366203148 2738 dbSNP
rs1408528189 2739 dbSNP
rs1297542490 2740 dbSNP
rs1417737803 2742 dbSNP
rs956614719 2747 dbSNP
rs1365446616 2748 dbSNP
rs1159615115 2752 dbSNP
rs1216116996 2757 dbSNP
rs1000966272 2770 dbSNP
rs1432381777 2774 dbSNP
rs1422696625 2776 dbSNP
rs372822709 2780 dbSNP
rs1203704183 2786 dbSNP
rs1264503605 2788 dbSNP
rs1490379186 2790 dbSNP
rs1261774098 2791 dbSNP
rs1242341519 2796 dbSNP
rs902241163 2799 dbSNP
rs1042136966 2800 dbSNP
rs1213797878 2803 dbSNP
rs1427766496 2803 dbSNP
rs1480417043 2807 dbSNP
rs1177211944 2820 dbSNP
rs923856895 2838 dbSNP
rs1485201291 2840 dbSNP
rs1317819914 2857 dbSNP
rs979410455 2861 dbSNP
rs968109453 2865 dbSNP
rs1023327310 2868 dbSNP
rs949180718 2876 dbSNP
rs1344770068 2879 dbSNP
rs1224101353 2886 dbSNP
rs1284631391 2887 dbSNP
rs1011982355 2890 dbSNP
rs1311914202 2897 dbSNP
rs1318386127 2904 dbSNP
rs896317664 2910 dbSNP
rs556291182 2911 dbSNP
rs1346259554 2924 dbSNP
rs759605245 2928 dbSNP
rs937926593 2930 dbSNP
rs1271693186 2939 dbSNP
rs1277706739 2943 dbSNP
rs1158096385 2948 dbSNP
rs529774812 2949 dbSNP
rs777158227 2952 dbSNP
rs1402702438 2956 dbSNP
rs1028320976 2964 dbSNP
rs369054952 2966 dbSNP
rs376681675 2966 dbSNP
rs995135430 2966 dbSNP
rs1405480819 2968 dbSNP
rs900489218 2976 dbSNP
rs1474529920 2983 dbSNP
rs919866561 2984 dbSNP
rs1289363417 2999 dbSNP
rs1465372540 3003 dbSNP
rs1333929294 3004 dbSNP
rs1440781415 3011 dbSNP
rs117235395 3012 dbSNP
rs944763962 3013 dbSNP
rs1480586852 3015 dbSNP
rs1226312081 3017 dbSNP
rs1290035347 3024 dbSNP
rs750953763 3028 dbSNP
rs1223710303 3035 dbSNP
rs1190954367 3041 dbSNP
rs890547718 3044 dbSNP
rs1436615280 3045 dbSNP
rs1429757388 3052 dbSNP
rs1233574055 3053 dbSNP
rs541612465 3053 dbSNP
rs1206166910 3054 dbSNP
rs527904063 3057 dbSNP
rs762377920 3058 dbSNP
rs879066671 3059 dbSNP
rs946677101 3060 dbSNP
rs916224488 3063 dbSNP
rs1328929565 3064 dbSNP
rs1449838128 3064 dbSNP
rs1466260030 3064 dbSNP
rs76529619 3064 dbSNP
rs1313849887 3065 dbSNP
rs1383105419 3065 dbSNP
rs1247127418 3067 dbSNP
rs1225411959 3068 dbSNP
rs1317663752 3068 dbSNP
rs778130955 3069 dbSNP
rs1296218066 3071 dbSNP
rs891018901 3072 dbSNP
rs1251236004 3077 dbSNP
rs1395333872 3080 dbSNP
rs565375895 3088 dbSNP
rs1242716387 3094 dbSNP
rs190782522 3106 dbSNP
rs960412665 3115 dbSNP
rs1399162976 3118 dbSNP
rs1371181769 3122 dbSNP
rs1475039180 3125 dbSNP
rs957629336 3131 dbSNP
rs1168356431 3135 dbSNP
rs1033690636 3136 dbSNP
rs576702226 3137 dbSNP
rs950941513 3138 dbSNP
rs1000512118 3139 dbSNP
rs58012667 3147 dbSNP
rs187219851 3150 dbSNP
rs540132289 3151 dbSNP
rs1227159914 3157 dbSNP
rs1271232998 3158 dbSNP
rs1320660910 3159 dbSNP
rs1017524900 3160 dbSNP
rs1262641476 3173 dbSNP
rs1241807467 3175 dbSNP
rs1205883720 3178 dbSNP
rs866061946 3179 dbSNP
rs1259917645 3181 dbSNP
rs370648118 3190 dbSNP
rs896265977 3194 dbSNP
rs890495257 3202 dbSNP
rs1175064980 3205 dbSNP
rs1054956491 3212 dbSNP
rs1185882759 3222 dbSNP
rs1462036696 3223 dbSNP
rs1053122487 3238 dbSNP
rs934788528 3241 dbSNP
rs902324054 3244 dbSNP
rs1043582403 3247 dbSNP
rs1341587282 3255 dbSNP
rs1258193854 3258 dbSNP
rs937856494 3260 dbSNP
rs1252014419 3261 dbSNP
rs1282716456 3262 dbSNP
rs1324283381 3266 dbSNP
rs1235525487 3268 dbSNP
rs1244116521 3269 dbSNP
rs1259137274 3284 dbSNP
rs1357276554 3304 dbSNP
rs946599131 3308 dbSNP
rs142342709 3310 dbSNP
rs573767318 3311 dbSNP
rs1489835686 3313 dbSNP
rs1198690106 3319 dbSNP
rs1375785763 3326 dbSNP
rs759380564 3331 dbSNP
rs1156351707 3332 dbSNP
rs1392725903 3336 dbSNP
rs1396746288 3349 dbSNP
rs7786072 3363 dbSNP
rs1454035262 3372 dbSNP
rs1159492131 3373 dbSNP
rs1423133367 3373 dbSNP
rs1455934396 3373 dbSNP
rs927649923 3379 dbSNP
rs1346719143 3392 dbSNP
rs571187683 3400 dbSNP
rs1165959847 3409 dbSNP
rs983593644 3410 dbSNP
rs986837603 3420 dbSNP
rs1240101686 3421 dbSNP
rs766311254 3422 dbSNP
rs1356927520 3424 dbSNP
rs760642438 3427 dbSNP
rs921377963 3433 dbSNP
rs975576325 3436 dbSNP
rs964891771 3440 dbSNP
rs1174947156 3449 dbSNP
rs1922075 3450 dbSNP
rs1017808818 3455 dbSNP
rs1009136769 3475 dbSNP
rs957788411 3477 dbSNP
rs954695614 3482 dbSNP
rs1251510321 3484 dbSNP
rs1383017767 3484 dbSNP
rs1209377201 3487 dbSNP
rs1423075221 3495 dbSNP
rs773038203 3496 dbSNP
rs1033224830 3497 dbSNP
rs1031655385 3503 dbSNP
rs1459943139 3504 dbSNP
rs1296509713 3508 dbSNP
rs1395952766 3510 dbSNP
rs1293858069 3512 dbSNP
rs534062163 3524 dbSNP
rs1311669278 3525 dbSNP
rs1246568251 3530 dbSNP
rs747355503 3545 dbSNP
rs1323415078 3549 dbSNP
rs140826521 3551 dbSNP
rs1202430838 3552 dbSNP
rs1250696331 3559 dbSNP
rs1480640166 3561 dbSNP
rs978083731 3570 dbSNP
rs547205070 3581 dbSNP
rs558518398 3590 dbSNP
rs1020561403 3598 dbSNP
rs200817079 3599 dbSNP
rs1168875367 3601 dbSNP
rs1322458259 3608 dbSNP
rs1462520663 3609 dbSNP
rs1402574817 3628 dbSNP
rs1366822726 3640 dbSNP
rs778159159 3642 dbSNP
rs896211879 3646 dbSNP
rs1452260384 3648 dbSNP
rs895021369 3649 dbSNP
rs1033865574 3660 dbSNP
rs1380979924 3662 dbSNP
rs569862151 3665 dbSNP
rs549751631 3666 dbSNP
rs1055041275 3672 dbSNP
rs1308037576 3675 dbSNP
rs1219898766 3677 dbSNP
rs1425900521 3678 dbSNP
rs939279361 3682 dbSNP
rs771625596 3690 dbSNP
rs772124475 3691 dbSNP
rs898331636 3692 dbSNP
rs1364609504 3693 dbSNP
rs1185169175 3696 dbSNP
rs1419379342 3705 dbSNP
rs868451298 3706 dbSNP
rs1038239227 3707 dbSNP
rs1198339464 3717 dbSNP
rs1047409932 3723 dbSNP
rs1427364378 3724 dbSNP
rs929020039 3728 dbSNP
rs76348287 3744 dbSNP
rs1361137218 3748 dbSNP
rs1288109932 3752 dbSNP
rs887047672 3760 dbSNP
rs1051080747 3762 dbSNP
rs567887796 3765 dbSNP
rs1280804377 3771 dbSNP
rs964840736 3776 dbSNP
rs571608045 3777 dbSNP
rs921333282 3779 dbSNP
rs1280243681 3790 dbSNP
rs1040193071 3799 dbSNP
rs1214054002 3814 dbSNP
rs778705281 3816 dbSNP
rs1241954351 3817 dbSNP
rs1223294007 3820 dbSNP
rs1488899482 3821 dbSNP
rs1196383851 3824 dbSNP
rs987662708 3835 dbSNP
rs936147923 3836 dbSNP
rs1480122638 3839 dbSNP
rs926114142 3846 dbSNP
rs1191876978 3849 dbSNP
rs547502401 3851 dbSNP
rs1282064742 3862 dbSNP
rs866468090 3883 dbSNP
rs1351055376 3889 dbSNP
rs1421292993 3891 dbSNP
rs917515273 3891 dbSNP
rs1273887567 3893 dbSNP
rs774609256 3893 dbSNP
rs1301158091 3906 dbSNP
rs1344833475 3914 dbSNP
rs1404989425 3915 dbSNP
rs768905662 3916 dbSNP
rs1346875167 3925 dbSNP
rs1370704962 3927 dbSNP
rs1222916500 3931 dbSNP
rs749540711 3934 dbSNP
rs960365871 3939 dbSNP
rs551310023 3946 dbSNP
rs969169508 3946 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124B_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgguucccuuaccguCCCUUUa 5'
                         |||||| 
Target 5' -------------uuGGGAAAa 3'
 		1 - 9
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_124B_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + B
Location of target site ENST00000356860.3 | 3UTR | UUGGGAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078060 PCTP phosphatidylcholine transfer protein 2 2
MIRT099072 FOXC1 forkhead box C1 2 2
MIRT130186 TXNIP thioredoxin interacting protein 2 2
MIRT148786 NARS asparaginyl-tRNA synthetase 2 2
MIRT261965 SEPHS1 selenophosphate synthetase 1 2 2
MIRT345867 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT409087 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT451883 SOD2 superoxide dismutase 2 2 4
MIRT469236 RHOB ras homolog family member B 2 2
MIRT469435 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT483055 FOXB1 forkhead box B1 2 8
MIRT484640 TBC1D5 TBC1 domain family member 5 2 6
MIRT493106 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT497307 TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 2 2
MIRT497798 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT501273 SCARB2 scavenger receptor class B member 2 2 4
MIRT506756 KMT2D lysine methyltransferase 2D 2 2
MIRT511986 EEF2 eukaryotic translation elongation factor 2 2 4
MIRT513126 ZNF431 zinc finger protein 431 2 2
MIRT519733 ZNF394 zinc finger protein 394 2 4
MIRT520351 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520542 TPPP tubulin polymerization promoting protein 2 8
MIRT530782 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 2
MIRT531112 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT532144 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT533208 WAPAL WAPL cohesin release factor 2 2
MIRT533419 TWF1 twinfilin actin binding protein 1 2 2
MIRT534063 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT534288 SLAIN2 SLAIN motif family member 2 2 2
MIRT537796 EFNB2 ephrin B2 2 2
MIRT538017 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT538058 DMD dystrophin 2 2
MIRT538132 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT538680 CCDC80 coiled-coil domain containing 80 2 2
MIRT538788 C3orf52 chromosome 3 open reading frame 52 2 2
MIRT542762 PPAP2B phospholipid phosphatase 3 2 2
MIRT546861 RAB10 RAB10, member RAS oncogene family 2 4
MIRT547418 MED4 mediator complex subunit 4 2 4
MIRT551633 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT552329 ZNF704 zinc finger protein 704 2 2
MIRT556124 MFSD9 major facilitator superfamily domain containing 9 2 4
MIRT559290 ATXN1 ataxin 1 2 2
MIRT562125 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563777 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2 2
MIRT564430 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT566102 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT567126 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 2
MIRT571213 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT571939 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT571967 KIF21A kinesin family member 21A 2 2
MIRT606792 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 8
MIRT607351 TNS1 tensin 1 2 4
MIRT609416 GJB7 gap junction protein beta 7 2 4
MIRT609522 AZI2 5-azacytidine induced 2 2 4
MIRT611218 FAM174B family with sequence similarity 174 member B 2 2
MIRT611385 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT612053 KLB klotho beta 2 4
MIRT612102 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT612146 SIX1 SIX homeobox 1 2 4
MIRT612488 SIX3 SIX homeobox 3 2 4
MIRT613685 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613763 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT613876 FGD1 FYVE, RhoGEF and PH domain containing 1 2 2
MIRT613965 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 4
MIRT614894 PAPOLG poly(A) polymerase gamma 2 2
MIRT614912 NFIA nuclear factor I A 2 2
MIRT615013 ERGIC2 ERGIC and golgi 2 2 2
MIRT615106 BCL7A BCL tumor suppressor 7A 2 2
MIRT615242 FAM227A family with sequence similarity 227 member A 2 4
MIRT615695 NEGR1 neuronal growth regulator 1 2 2
MIRT615956 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT615979 FSTL4 follistatin like 4 2 2
MIRT616053 PTPRE protein tyrosine phosphatase, receptor type E 2 4
MIRT616073 TBX2 T-box 2 2 4
MIRT616234 NPAS3 neuronal PAS domain protein 3 2 2
MIRT616306 CELF2 CUGBP Elav-like family member 2 2 2
MIRT616474 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT616662 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT616887 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT616902 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT617025 SYT6 synaptotagmin 6 2 2
MIRT617162 SLC16A5 solute carrier family 16 member 5 2 2
MIRT617318 DPF3 double PHD fingers 3 2 2
MIRT617792 CHRM2 cholinergic receptor muscarinic 2 2 2
MIRT618418 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT618663 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT620212 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620413 TFDP3 transcription factor Dp family member 3 2 2
MIRT620667 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620709 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT620956 SFT2D2 SFT2 domain containing 2 2 2
MIRT621225 LMAN1 lectin, mannose binding 1 2 2
MIRT621333 SLC11A1 solute carrier family 11 member 1 2 2
MIRT621696 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT623484 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623777 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT624215 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624675 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT627369 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT628252 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT630790 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT635631 PRR15L proline rich 15 like 2 2
MIRT636425 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT637295 ACTN2 actinin alpha 2 2 2
MIRT637345 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637842 SLC2A9 solute carrier family 2 member 9 2 2
MIRT638327 RCAN1 regulator of calcineurin 1 2 2
MIRT638375 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638751 EPHA4 EPH receptor A4 2 2
MIRT638965 ARHGAP6 Rho GTPase activating protein 6 2 2
MIRT639094 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT639172 CEP70 centrosomal protein 70 2 2
MIRT639254 SLC38A1 solute carrier family 38 member 1 2 4
MIRT639368 ZCCHC24 zinc finger CCHC-type containing 24 2 4
MIRT639504 CACNA1G calcium voltage-gated channel subunit alpha1 G 2 2
MIRT639644 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT640486 EXOC5 exocyst complex component 5 2 2
MIRT641424 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT641550 LIPG lipase G, endothelial type 2 2
MIRT642180 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT642656 RGS6 regulator of G protein signaling 6 2 2
MIRT642873 SAMD1 sterile alpha motif domain containing 1 2 2
MIRT643355 TRIM10 tripartite motif containing 10 2 2
MIRT643531 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT643998 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644105 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2 2
MIRT644421 VDR vitamin D receptor 2 2
MIRT644481 SLFN12 schlafen family member 12 2 2
MIRT644573 SPOP speckle type BTB/POZ protein 2 2
MIRT645354 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT645383 FBLIM1 filamin binding LIM protein 1 2 2
MIRT645758 SURF6 surfeit 6 2 2
MIRT646060 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT646194 DUSP10 dual specificity phosphatase 10 2 2
MIRT647915 RGS5 regulator of G protein signaling 5 2 2
MIRT649216 AMMECR1L AMMECR1 like 2 2
MIRT649265 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT649522 GTF3C3 general transcription factor IIIC subunit 3 2 2
MIRT649605 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650392 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT650835 SEMA4G semaphorin 4G 2 2
MIRT651273 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT651674 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT651763 VASP vasodilator stimulated phosphoprotein 2 2
MIRT652250 TPD52L3 tumor protein D52 like 3 2 2
MIRT652277 TOM1L2 target of myb1 like 2 membrane trafficking protein 2 2
MIRT652316 TNFSF15 TNF superfamily member 15 2 2
MIRT652342 TMOD3 tropomodulin 3 2 2
MIRT652373 TMEM57 transmembrane protein 57 2 2
MIRT652438 TMEM236 transmembrane protein 236 2 2
MIRT652723 TGFB2 transforming growth factor beta 2 2 2
MIRT652752 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653310 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT653327 SMIM18 small integral membrane protein 18 2 2
MIRT653406 SLC7A2 solute carrier family 7 member 2 2 2
MIRT653512 SLC41A1 solute carrier family 41 member 1 2 2
MIRT653912 SERPINC1 serpin family C member 1 2 2
MIRT654111 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654153 RORB RAR related orphan receptor B 2 2
MIRT654548 RAB14 RAB14, member RAS oncogene family 2 2
MIRT654920 POLR3D RNA polymerase III subunit D 2 2
MIRT655169 PHF19 PHD finger protein 19 2 2
MIRT655412 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655784 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT655836 NGDN neuroguidin 2 2
MIRT656079 MTA3 metastasis associated 1 family member 3 2 2
MIRT656404 MCTP1 multiple C2 and transmembrane domain containing 1 2 2
MIRT656720 LMLN leishmanolysin like peptidase 2 2
MIRT656774 LARP1 La ribonucleoprotein domain family member 1 2 2
MIRT656922 KIAA1462 junctional cadherin 5 associated 2 2
MIRT657004 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT657477 HCAR2 hydroxycarboxylic acid receptor 2 2 2
MIRT657539 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657911 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658478 EXOC8 exocyst complex component 8 2 2
MIRT658612 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT658823 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658965 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT659706 CCDC93 coiled-coil domain containing 93 2 2
MIRT660034 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660108 BTBD3 BTB domain containing 3 2 2
MIRT660697 AMOTL2 angiomotin like 2 2 2
MIRT660763 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660884 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT660956 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661217 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT661596 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661624 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662430 EID2 EP300 interacting inhibitor of differentiation 2 2 2
MIRT664816 NOX5 NADPH oxidase 5 2 2
MIRT665548 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT665815 TMEM161B transmembrane protein 161B 2 2
MIRT666668 RBM23 RNA binding motif protein 23 2 2
MIRT667995 HCFC2 host cell factor C2 2 2
MIRT668064 GPR180 G protein-coupled receptor 180 2 2
MIRT669056 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT669637 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT699368 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699882 RUNX1 runt related transcription factor 1 2 2
MIRT703834 ETV3 ETS variant 3 2 2
MIRT708528 ZNF177 zinc finger protein 177 2 2
MIRT709696 DMWD DM1 locus, WD repeat containing 2 2
MIRT710381 PARD6G par-6 family cell polarity regulator gamma 2 2
MIRT710639 GLUL glutamate-ammonia ligase 2 2
MIRT711584 SETD1A SET domain containing 1A 2 2
MIRT713208 FAM13A family with sequence similarity 13 member A 2 2
MIRT714129 IL20RB interleukin 20 receptor subunit beta 2 2
MIRT714204 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT714733 CCNO cyclin O 2 2
MIRT714761 ZNF462 zinc finger protein 462 2 2
MIRT715624 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715755 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT716075 RNF150 ring finger protein 150 2 2
MIRT716179 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT717450 RWDD2A RWD domain containing 2A 2 2
MIRT717866 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT720964 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT721564 SLC5A12 solute carrier family 5 member 12 2 2
MIRT722348 BAG2 BCL2 associated athanogene 2 2 2
MIRT723235 BTLA B and T lymphocyte associated 2 2
MIRT724018 LMBRD2 LMBR1 domain containing 2 2 2
MIRT724507 KLHL5 kelch like family member 5 2 2
MIRT725478 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4446 Aed Therapy sensitive High Epilepsy tissue
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4446 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4446 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4446 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4446-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4446-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4446-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4446-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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