pre-miRNA Information
pre-miRNA hsa-mir-6751   
Genomic Coordinates chr11: 65129916 - 65129978
Description Homo sapiens miR-6751 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6751-3p
Sequence 43| ACUGAGCCUCUCUCUCUCCAG |63
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM6795708 8 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs749989972 2 dbSNP
rs1266150108 3 dbSNP
rs1488089412 6 dbSNP
rs1259846893 8 dbSNP
rs3802937 10 dbSNP
rs371083440 12 dbSNP
rs1264909843 13 dbSNP
rs751042478 14 dbSNP
rs757551063 19 dbSNP
Putative Targets

Gene Information
Gene Symbol ANKRD18A   
Synonyms -
Description ankyrin repeat domain 18A
Transcript NM_147195   
Expression
Putative miRNA Targets on ANKRD18A
3'UTR of ANKRD18A
(miRNA target sites are highlighted)
>ANKRD18A|NM_147195|3'UTR
   1 GCACTTGCTCCCGTCTACTTTCTTTTGTAGAATCCACTGGTAAGCCACATCTAATGAAGAGATTAACCATAAAATCTTAA
  81 GGAAAAGTTGTATGATTTAAAAGATCATAAAACTTTATTACTGGGCTATTTACATGAAATTTTAATTGTTTCTCATATAA
 161 TATAAAACATCATAATCTTTACTAAAGTAGAATATTTTCATGTCACATATGGTGTATATTTATATGTTATTTTAAATGAT
 241 GTTTTTTAGCCTCCTTAAGTTTTAAGTGGATCTTGCAAATGAACACCAGCGTTATTGAGTTTGGCCTACTCAAATTGCCT
 321 GAATGTCAGCTGTTTAAACAGCCAAACAACCAAGTCATCATTGATACTTTAGTAAAGGTCATCGAGGGCTTCTTTGCATT
 401 TTACAGTTTTTATTACCATATGTAGTAGGAGACTTAAAGAGTATCTGCCAGGTTTGTCCATACTAGTGTTACGGTTTTCT
 481 TCTTGTAGCTCAATAGTATTTTGTGTGGAGATACTTTGAAGCTCTGTAAATATCTGGTTACTCCTCAAAACCCACTAGAT
 561 TTAGCATTTCATGGATGACTTGTGTTTGAACAAGTATTACTGTGATGGTTGCCAGATGATTGTTTTTCTTATTTTCTTCT
 641 TTGTTCTACATGGAGAAATAAAACCAATAAATAAAGGAGAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaCCUCUCU--CUCUCCGAGUCa 5'
            ||||| |    || |||| | 
Target 5' gtGGAGATACTTTGAAGCTCTGt 3'
505 - 527 97.00 -14.20
2
miRNA  3' gaCCUCUCUCUCUCCGAGuca 5'
            ||  |  ||| ||||:   
Target 5' aaGGTCATCGAG-GGCTTctt 3'
375 - 394 94.00 -9.32
3
miRNA  3' gaccucucuCUCU-CCGA--GUCa 5'
                   | || ||:|  ||| 
Target 5' agtattactGTGATGGTTGCCAGa 3'
593 - 616 88.00 -7.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM6600448 8 COSMIC
COSM7940861 10 COSMIC
COSM6861801 13 COSMIC
COSM1598333 22 COSMIC
COSM8876640 22 COSMIC
COSN19623946 56 COSMIC
COSN30447108 61 COSMIC
COSN26560348 74 COSMIC
COSN30510128 74 COSMIC
COSN30485213 82 COSMIC
COSN30534676 87 COSMIC
COSN2529185 106 COSMIC
COSN30134061 118 COSMIC
COSN30469013 123 COSMIC
COSN14393249 136 COSMIC
COSN31554763 141 COSMIC
COSN30540753 177 COSMIC
COSN16495631 233 COSMIC
COSN28664626 240 COSMIC
COSN14730917 315 COSMIC
COSN20499451 386 COSMIC
COSN20495967 388 COSMIC
COSN20497156 390 COSMIC
COSN26802869 511 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs578175423 12 dbSNP
rs556466572 13 dbSNP
rs1304033882 16 dbSNP
rs1324973679 21 dbSNP
rs1384340150 24 dbSNP
rs755874180 26 dbSNP
rs1442066668 27 dbSNP
rs908269525 29 dbSNP
rs1183549363 37 dbSNP
rs1443091872 38 dbSNP
rs1256617866 39 dbSNP
rs184227277 40 dbSNP
rs1210375456 44 dbSNP
rs1446138142 45 dbSNP
rs567562545 49 dbSNP
rs7023650 50 dbSNP
rs765972007 51 dbSNP
rs55960030 56 dbSNP
rs773015190 61 dbSNP
rs58957943 63 dbSNP
rs1284633746 64 dbSNP
rs1448989851 65 dbSNP
rs140529454 66 dbSNP
rs1467316230 67 dbSNP
rs764897266 68 dbSNP
rs1296608808 69 dbSNP
rs760979902 70 dbSNP
rs775897263 74 dbSNP
rs772505198 75 dbSNP
rs964299504 82 dbSNP
rs1404160995 85 dbSNP
rs774482050 87 dbSNP
rs1335447947 94 dbSNP
rs1017631948 98 dbSNP
rs1346673795 103 dbSNP
rs1391382829 108 dbSNP
rs1399958954 115 dbSNP
rs566861497 118 dbSNP
rs1320455353 128 dbSNP
rs979821281 129 dbSNP
rs1273260514 133 dbSNP
rs1465786314 144 dbSNP
rs573666169 145 dbSNP
rs1416749848 146 dbSNP
rs1320783658 147 dbSNP
rs968120417 148 dbSNP
rs1020964040 168 dbSNP
rs1368893849 172 dbSNP
rs1009698010 173 dbSNP
rs1192859000 176 dbSNP
rs896618406 186 dbSNP
rs1035595082 187 dbSNP
rs1180922475 187 dbSNP
rs1168351951 204 dbSNP
rs1002492971 207 dbSNP
rs905425758 212 dbSNP
rs191531032 214 dbSNP
rs1366309822 216 dbSNP
rs1399866975 218 dbSNP
rs753520905 222 dbSNP
rs533196788 224 dbSNP
rs1458311459 226 dbSNP
rs1284021218 234 dbSNP
rs200409646 240 dbSNP
rs566063973 248 dbSNP
rs886866185 248 dbSNP
rs933726708 258 dbSNP
rs1285173291 275 dbSNP
rs562752254 277 dbSNP
rs1283793230 287 dbSNP
rs199619821 290 dbSNP
rs550931326 291 dbSNP
rs1471911802 295 dbSNP
rs1185664249 298 dbSNP
rs1375374545 299 dbSNP
rs1419163868 303 dbSNP
rs1310753393 304 dbSNP
rs942655016 305 dbSNP
rs1348857526 308 dbSNP
rs529095757 309 dbSNP
rs1401816918 314 dbSNP
rs1333873297 321 dbSNP
rs1321158844 329 dbSNP
rs1445280857 331 dbSNP
rs561815037 339 dbSNP
rs1383124529 343 dbSNP
rs1238783986 346 dbSNP
rs1306526765 351 dbSNP
rs925836737 353 dbSNP
rs979469091 360 dbSNP
rs556919095 361 dbSNP
rs1437694068 363 dbSNP
rs77696195 369 dbSNP
rs1020996660 377 dbSNP
rs572859814 383 dbSNP
rs960770323 384 dbSNP
rs76370208 386 dbSNP
rs115382662 387 dbSNP
rs74372039 388 dbSNP
rs79915426 390 dbSNP
rs1002760414 394 dbSNP
rs545761091 395 dbSNP
rs370382355 398 dbSNP
rs78161171 406 dbSNP
rs145739264 417 dbSNP
rs1471142926 421 dbSNP
rs77208148 422 dbSNP
rs1337878285 433 dbSNP
rs1017570667 439 dbSNP
rs1406339057 439 dbSNP
rs1352031911 443 dbSNP
rs745631932 448 dbSNP
rs778889009 461 dbSNP
rs112835728 462 dbSNP
rs1366214469 464 dbSNP
rs1225106359 466 dbSNP
rs374018536 472 dbSNP
rs1457432367 473 dbSNP
rs75866423 482 dbSNP
rs1197021995 488 dbSNP
rs77527111 489 dbSNP
rs78963810 511 dbSNP
rs573997667 516 dbSNP
rs918961236 526 dbSNP
rs971773216 527 dbSNP
rs1438116525 532 dbSNP
rs1331347843 535 dbSNP
rs188499434 543 dbSNP
rs1297249584 544 dbSNP
rs997966449 551 dbSNP
rs112666212 559 dbSNP
rs1481738619 561 dbSNP
rs1362297193 590 dbSNP
rs534146945 599 dbSNP
rs1301913195 608 dbSNP
rs1424469056 618 dbSNP
rs1039555282 622 dbSNP
rs1479103363 626 dbSNP
rs1398240640 628 dbSNP
rs1247491275 643 dbSNP
rs753884138 646 dbSNP
rs1343505473 648 dbSNP
rs942498360 650 dbSNP
rs1317093658 660 dbSNP
rs941665292 664 dbSNP
rs1225032321 665 dbSNP
rs547698016 670 dbSNP
rs1340402101 672 dbSNP
rs1209304337 676 dbSNP
rs1339934976 676 dbSNP
rs1042914435 681 dbSNP
rs183438807 682 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124B_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaccUCUCUCUCUCCGAGUCa 5'
              |||| |:|||||  || 
Target 5' ---cAGAGUGGGAGGCAGAGa 3'
1 - 18
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_124B_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + B
Location of target site ENST00000313339.3 | 3UTR | CAGAGUGGGAGGCAGAGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
77 hsa-miR-6751-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT130738 GATAD2B GATA zinc finger domain containing 2B 2 4
MIRT134924 CCND2 cyclin D2 2 2
MIRT273034 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT276645 KPNA3 karyopherin subunit alpha 3 2 6
MIRT446531 OAS2 2'-5'-oligoadenylate synthetase 2 2 2
MIRT456268 TDRKH tudor and KH domain containing 2 12
MIRT494454 BTG2 BTG anti-proliferation factor 2 2 2
MIRT494965 USP46 ubiquitin specific peptidase 46 2 2
MIRT496689 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT496697 RGS11 regulator of G protein signaling 11 2 2
MIRT504376 IRF4 interferon regulatory factor 4 2 6
MIRT510980 PFN2 profilin 2 2 6
MIRT512548 MFN2 mitofusin 2 2 6
MIRT513639 TP53INP2 tumor protein p53 inducible nuclear protein 2 2 2
MIRT514016 CAMSAP1 calmodulin regulated spectrin associated protein 1 2 4
MIRT514074 MTRNR2L6 MT-RNR2-like 6 2 2
MIRT515300 C15orf38-AP3S2 C15orf38-AP3S2 readthrough 2 4
MIRT517285 AP3S2 adaptor related protein complex 3 sigma 2 subunit 2 4
MIRT519075 KCNK6 potassium two pore domain channel subfamily K member 6 2 2
MIRT520779 TCF23 transcription factor 23 2 2
MIRT522485 MFSD9 major facilitator superfamily domain containing 9 2 2
MIRT528856 PKP1 plakophilin 1 2 2
MIRT529081 PATE2 prostate and testis expressed 2 2 2
MIRT531209 PLA2G4D phospholipase A2 group IVD 2 2
MIRT533988 TAB3 TGF-beta activated kinase 1 and MAP3K7 binding protein 3 2 2
MIRT537024 GRIN2B glutamate ionotropic receptor NMDA type subunit 2B 2 2
MIRT537498 FAM168B family with sequence similarity 168 member B 2 2
MIRT553125 UBE2Z ubiquitin conjugating enzyme E2 Z 2 2
MIRT555591 PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma 2 2
MIRT556370 LUZP1 leucine zipper protein 1 2 2
MIRT569745 C2orf71 chromosome 2 open reading frame 71 2 2
MIRT570149 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT571243 FADS6 fatty acid desaturase 6 2 2
MIRT573065 TRIB1 tribbles pseudokinase 1 2 2
MIRT575533 Map4 microtubule-associated protein 4 2 2
MIRT575777 Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b 2 2
MIRT616558 ZNF512B zinc finger protein 512B 2 2
MIRT624851 ABI2 abl interactor 2 2 2
MIRT630078 GRWD1 glutamate rich WD repeat containing 1 2 2
MIRT631479 KLHL21 kelch like family member 21 2 2
MIRT632173 CCL22 C-C motif chemokine ligand 22 2 2
MIRT638397 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT641192 ISG20L2 interferon stimulated exonuclease gene 20 like 2 2 2
MIRT642562 TEX9 testis expressed 9 2 2
MIRT642935 KRTAP5-9 keratin associated protein 5-9 2 2
MIRT649703 ZNF175 zinc finger protein 175 2 2
MIRT650437 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT652113 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT652273 TOMM20 translocase of outer mitochondrial membrane 20 2 2
MIRT655215 PFKM phosphofructokinase, muscle 2 2
MIRT682778 ZNF852 zinc finger protein 852 2 2
MIRT683001 MUC20 mucin 20, cell surface associated 2 2
MIRT684320 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT689435 CYB561 cytochrome b561 2 2
MIRT693847 ZNF107 zinc finger protein 107 2 2
MIRT696715 TAX1BP3 Tax1 binding protein 3 2 2
MIRT698597 TEX261 testis expressed 261 2 2
MIRT699973 RREB1 ras responsive element binding protein 1 2 2
MIRT703310 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT706796 RAI1 retinoic acid induced 1 2 2
MIRT709004 CD109 CD109 molecule 2 2
MIRT709181 TBC1D10B TBC1 domain family member 10B 2 2
MIRT709835 PAQR7 progestin and adipoQ receptor family member 7 2 2
MIRT711627 CORO1C coronin 1C 2 2
MIRT712634 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 2
MIRT713694 CYB5R4 cytochrome b5 reductase 4 2 2
MIRT713752 SLC9A8 solute carrier family 9 member A8 2 2
MIRT714908 CHMP3 charged multivesicular body protein 3 2 2
MIRT716371 CBLL1 Cbl proto-oncogene like 1 2 2
MIRT718303 XPOT exportin for tRNA 2 2
MIRT718713 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT718740 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT719441 NPTX2 neuronal pentraxin 2 2 2
MIRT720896 OTUD4 OTU deubiquitinase 4 2 2
MIRT722448 RXFP4 relaxin/insulin like family peptide receptor 4 2 2
MIRT723882 VKORC1 vitamin K epoxide reductase complex subunit 1 2 2
MIRT724586 SYNJ2BP synaptojanin 2 binding protein 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6751 Cisplatin 5460033 NSC119875 approved sensitive Low Ovarian Cancer cell line (A2780)
hsa-mir-6751 Triptolide 107985 NSC163062 sensitive Low Ovarian Cancer cell line (A2780)

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