pre-miRNA Information
pre-miRNA hsa-mir-4291   
Genomic Coordinates chr9: 93819357 - 93819421
Description Homo sapiens miR-4291 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4291
Sequence 11| UUCAGCAGGAACAGCU |26
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1265713434 9 dbSNP
rs1433969451 12 dbSNP
rs1372852268 16 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MAML1   
Synonyms Mam-1, Mam1
Description mastermind like transcriptional coactivator 1
Transcript NM_014757   
Expression
Putative miRNA Targets on MAML1
3'UTR of MAML1
(miRNA target sites are highlighted)
>MAML1|NM_014757|3'UTR
   1 TGGAAGGATTTGTAGTGTTTTTAGTGTTCATTCATCCTATATTTTTATTCTCAGATTCAAAGAAAGAGCAACTACTTTGG
  81 ACCAAAAGCCCATGGCCTGGGGAGCTGGGCAGGTAGAGCCCAAGCTCCAGGTGAGGCCTGGCCCTGGGCAGGGTCTGTGG
 161 CTGCGCCCCTCAGGCCAGCAGTTGAGGTCCATCGGGCTGGCCCCAGCCCATCTGCTGGCATCAGTACCTGGTGTTGGGAC
 241 AGCAGGATAGGGTTCTAAAGGTGGTTTTCTATCCAAACGACCAAAAAACCAACAGTAACACCAGTGAAACCCCACACTGT
 321 CGGGCTTATAAAAATCTGTGCCATCATGGTGATTTTATCCAAGACTGCTCCACTTACCCCAGTGCTGGGGACAAGTTTCT
 401 GTTGAAACTTTAGATAGCAGAATTATTTGCAATTTGTAGCATAGAAAAGATTTTTAAATTTTTTTACAAAAGGTTTTTAA
 481 ACAGATTAGGGTAGGTGATGGTTTAAATCAATTAAGTGGCATTGGAAACCTAGGGTTTCCTTTTGATTAAGAGCCTTTTT
 561 TGTTTCTGCTCTTTGTCAGCTTTCAGGGGAGAAGGAGGCCACTGGAAAATTATTTCCCTAAGTGCAGGCTGTTGACTGCG
 641 TATGCCAAAAAGGGACAGGAGGCATGGGATAGCAGGTCTGGTGACACAGCTAGGGTCTTCCTAGCAGCTCCTCCTCCTCC
 721 CTCCCAAGGCCCCCAGGAATCCCTTCCTCCCATGTCCTGGCAGCAGGACCCCAGGCTACATATGGAAGGTAGAGATGTGG
 801 GGGTCCTGTATCCTGGAGTATTATGTCTCCCCACCTTCTGCAGTTTTCTCTGAACATGTATGTTGCCCATGGTGGGAGCG
 881 TGGTCACTGTGCAGTTGTGCACAGATGTCTTTCCTTTACCGTTGGCCTTTCTGTCTGCCTCTCCTTCCTCTCTGCAGCCC
 961 AAATGGAAAACAATTATTTACTCCATTGGAGGGAAAGGAAGAGTCTTAGAATTCCTAAGGGAACCTTAGCATAAAGGTTT
1041 TGGGGAAGGAGGCCGTAGGCCGGCCCGGAGGAAGCAATTCCACTTGGTTTGACAACTTCTGCCACTCCCATGTCAGATGA
1121 CTTGCACTTCTTAAAGAGATTGCTTTATAACACTAAGACATCCTTTCTAAAGATTCAAGTGGACTTGACTAAGCTGAGGG
1201 TCCACGAAATAGAATATGACATGTGAGCTGTTTTTGGAAAACGAAGATGGAGAGAGCACTTCCCCGTAACGAAAGCAAAG
1281 TGGTAAGCACAGGGTGAGACCCTTTTACACAGAATGGTGGAGAGAAAAGAGAATGCTGAAAAGTGGCTCAGATGCAGAGT
1361 GTTCTGTGGAGAAACTGCAGCCCCACTTCTGTTTCCCTGGAGTCTCCCAATGGATCATTCAGGAGTGTCCTATGTGAGAA
1441 TTGAGCCAAGGAAAATACTCATGCAACCAGCCTGAGTCGCGGTGAGGGGACGAGAGGTTGTACACACATTGGTAGTTATT
1521 TTGCACCAGCAGTGCCTTTCTCACTGGGGGTACTTGGACCCTCAGATCTTCTTTTCTAATAGCCATTTGCCACCCCAAGT
1601 GGTATGTCGGCCATTTCTCCTTAAAACACCTTCCCTACCTTTCCCATGTACTCAGTTTAGCTCTCAAAGAAGGGGTGAAT
1681 CATAAAGCCAGTGAAAATTTCACCCTCTGAGGGAGTTCCCCAATCTGAAGGGGAAGAGGGTGACCTCAGCGGCTTTTCTC
1761 CCAAAAATCGGCTGAAGGCTGGTTGTGGATCCTTGTTCCTCTCCTGACCCCATCTGGCTGCTGCCCCGTCTCCCACCCCT
1841 GTCCCCGGGGCTCGCTGGCCCTGCACTCCGCCTTAGTCCTGGGGCCGGCGACACAGTGGGGGCTCCTCACTTGCTGCAGT
1921 GTCATAGCAATAAAATGTGATTCTTGGGGTCCCCCCAGGGAGCTGCCCATGGCTTTATTTATGAACCTGGTTTTCGGGAG
2001 TCAGGGGAGGAGATGACTTTGCTTCTGTGCACAGCCCCGTCTTCCAGGAGCCACAACTCAGAAGAAAAGGGTGCTCAGAC
2081 TTTTGTTATACACATTTGCTTTGTGTAAATAAATGTTTACAATTTTATATGAAAGATGGAATAAGCGCTAGAGCTTCCAA
2161 CTGTATATTTTTTACTTTTATAGATTTTAAAACTATGATCCTTTATATGTGTGTTTTGGGGGAGCTATGATAAGTTTTAT
2241 GGCAAACGGTTGGTATTGTTAACTTTTTATTGTCATCAAAAGTTCATAAAAGTCCTATTAATCCCCATATTCTTCTACTG
2321 CCCTTAACTCTGGTATACACCAAAAAGAAATCTTTACTTTCCTTGTTTTATCATTATAAAAATAAAGTATTTTGCTAGTA
2401 TGGAAACAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucgaCAAGGACGACUu 5'
              |||:|||:||| 
Target 5' acaaGTTTCTGTTGAa 3'
391 - 406 140.00 -14.60
2
miRNA  3' ucgacaaGGACGACUu 5'
                 :||||||: 
Target 5' cagcccaTCTGCTGGc 3'
204 - 219 125.00 -10.90
3
miRNA  3' ucgacaagGACGACUu 5'
                  |||:||| 
Target 5' agtgcaggCTGTTGAc 3'
621 - 636 124.00 -7.34
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30485003 8 COSMIC
COSN14160767 30 COSMIC
COSN30148827 59 COSMIC
COSN31480818 117 COSMIC
COSN20926019 303 COSMIC
COSN20102282 456 COSMIC
COSN31486294 944 COSMIC
COSN26318333 1090 COSMIC
COSN26566724 1378 COSMIC
COSN8492471 1379 COSMIC
COSN16378762 1688 COSMIC
COSN31486299 1690 COSMIC
COSN8492472 1789 COSMIC
COSN31486302 1845 COSMIC
COSN26585776 1997 COSMIC
COSN20318261 2040 COSMIC
COSN14772443 2056 COSMIC
COSN31529494 2184 COSMIC
COSN31527598 2236 COSMIC
COSN31548625 2260 COSMIC
COSN25341734 2293 COSMIC
COSN15369806 2295 COSMIC
COSN9422806 2331 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs756850315 6 dbSNP
rs75704521 11 dbSNP
rs1040949672 14 dbSNP
rs1039718360 23 dbSNP
rs1356204171 24 dbSNP
rs747440632 26 dbSNP
rs1262587448 34 dbSNP
rs768898576 35 dbSNP
rs781751094 38 dbSNP
rs748544936 40 dbSNP
rs201266834 42 dbSNP
rs1158994167 47 dbSNP
rs1381859922 48 dbSNP
rs1417494698 50 dbSNP
rs1157621466 51 dbSNP
rs997208357 63 dbSNP
rs1188216497 67 dbSNP
rs1443054487 69 dbSNP
rs1372247201 72 dbSNP
rs1258295679 75 dbSNP
rs1203502470 78 dbSNP
rs1028140649 86 dbSNP
rs1269023079 88 dbSNP
rs1292610349 89 dbSNP
rs934280760 90 dbSNP
rs370202415 93 dbSNP
rs1353428889 103 dbSNP
rs1333198094 104 dbSNP
rs1293188181 106 dbSNP
rs1229566294 109 dbSNP
rs539211618 112 dbSNP
rs1315521835 120 dbSNP
rs1381170405 129 dbSNP
rs557551188 131 dbSNP
rs1322215928 132 dbSNP
rs1016303576 133 dbSNP
rs1416961598 134 dbSNP
rs961982742 140 dbSNP
rs892703923 150 dbSNP
rs972028341 154 dbSNP
rs1011100658 160 dbSNP
rs1191043407 161 dbSNP
rs533258024 165 dbSNP
rs1202073950 166 dbSNP
rs1022467218 172 dbSNP
rs1248846969 176 dbSNP
rs1210876103 182 dbSNP
rs549484128 194 dbSNP
rs1262474895 195 dbSNP
rs543141984 203 dbSNP
rs7736199 213 dbSNP
rs573595967 225 dbSNP
rs1034020820 234 dbSNP
rs1226049118 235 dbSNP
rs1365350602 238 dbSNP
rs1299335207 239 dbSNP
rs1438202248 241 dbSNP
rs926782060 244 dbSNP
rs1257473044 246 dbSNP
rs936854255 253 dbSNP
rs1474537696 255 dbSNP
rs1394233452 258 dbSNP
rs1167333163 266 dbSNP
rs1448916610 280 dbSNP
rs1190626865 283 dbSNP
rs146455656 283 dbSNP
rs913662224 294 dbSNP
rs959950329 316 dbSNP
rs1222749327 317 dbSNP
rs541031406 322 dbSNP
rs1040733586 323 dbSNP
rs1026007208 326 dbSNP
rs1205140811 346 dbSNP
rs560579367 356 dbSNP
rs900864434 361 dbSNP
rs1392191740 367 dbSNP
rs1299133254 369 dbSNP
rs1231447973 371 dbSNP
rs1366396552 373 dbSNP
rs1275135880 377 dbSNP
rs1438342966 378 dbSNP
rs996765181 380 dbSNP
rs77403548 381 dbSNP
rs1430285336 383 dbSNP
rs1312001982 388 dbSNP
rs775955050 394 dbSNP
rs1450185694 402 dbSNP
rs983954518 403 dbSNP
rs143963698 408 dbSNP
rs1005804543 412 dbSNP
rs1212238403 418 dbSNP
rs759950706 423 dbSNP
rs975881357 428 dbSNP
rs1015413344 442 dbSNP
rs922643739 443 dbSNP
rs993565514 446 dbSNP
rs3839291 451 dbSNP
rs398000092 451 dbSNP
rs1342387128 456 dbSNP
rs368742273 457 dbSNP
rs1233075053 459 dbSNP
rs1277413768 459 dbSNP
rs1208084425 461 dbSNP
rs1311174582 476 dbSNP
rs1024918789 491 dbSNP
rs1220546122 494 dbSNP
rs1348135038 495 dbSNP
rs934013117 500 dbSNP
rs182654054 501 dbSNP
rs185358864 506 dbSNP
rs1311061589 512 dbSNP
rs1445870419 517 dbSNP
rs1358708752 523 dbSNP
rs914193363 524 dbSNP
rs1416346053 531 dbSNP
rs550342576 533 dbSNP
rs946941561 538 dbSNP
rs1043925433 539 dbSNP
rs568452394 540 dbSNP
rs905321493 541 dbSNP
rs1254589973 544 dbSNP
rs1186476253 546 dbSNP
rs1001309657 549 dbSNP
rs1237511594 552 dbSNP
rs1211622651 553 dbSNP
rs1055981937 555 dbSNP
rs926872511 556 dbSNP
rs190607251 560 dbSNP
rs1186694925 569 dbSNP
rs1250166802 590 dbSNP
rs973728016 594 dbSNP
rs184153487 596 dbSNP
rs914112144 600 dbSNP
rs1303438069 619 dbSNP
rs1450318638 621 dbSNP
rs565806392 626 dbSNP
rs1386712606 632 dbSNP
rs1320220009 637 dbSNP
rs1025301631 640 dbSNP
rs188628535 641 dbSNP
rs1414718067 659 dbSNP
rs1163264059 662 dbSNP
rs1005387793 663 dbSNP
rs1423671597 664 dbSNP
rs557512926 683 dbSNP
rs1040846937 691 dbSNP
rs1415957052 694 dbSNP
rs922265812 717 dbSNP
rs1016744637 725 dbSNP
rs1176721294 727 dbSNP
rs1344486212 730 dbSNP
rs932310166 751 dbSNP
rs569561720 752 dbSNP
rs963820282 753 dbSNP
rs536740394 754 dbSNP
rs1314838749 755 dbSNP
rs1439785967 761 dbSNP
rs1230098009 779 dbSNP
rs1363168720 780 dbSNP
rs1297115444 782 dbSNP
rs941319092 791 dbSNP
rs922699254 797 dbSNP
rs1292091643 800 dbSNP
rs3797762 811 dbSNP
rs1350967009 824 dbSNP
rs988579317 833 dbSNP
rs913869867 849 dbSNP
rs1406243421 850 dbSNP
rs763531767 851 dbSNP
rs116135791 856 dbSNP
rs761625852 861 dbSNP
rs1025031856 866 dbSNP
rs1043977077 880 dbSNP
rs906496208 881 dbSNP
rs1250771799 891 dbSNP
rs1209010935 906 dbSNP
rs926791407 909 dbSNP
rs1488724037 921 dbSNP
rs1002624832 922 dbSNP
rs938202958 925 dbSNP
rs534296934 932 dbSNP
rs1341396828 940 dbSNP
rs571803640 944 dbSNP
rs1270146927 951 dbSNP
rs1367603611 956 dbSNP
rs895590219 957 dbSNP
rs572637196 966 dbSNP
rs989756391 975 dbSNP
rs750229949 999 dbSNP
rs1046720066 1010 dbSNP
rs886753081 1018 dbSNP
rs1428341481 1021 dbSNP
rs546545979 1028 dbSNP
rs868454123 1031 dbSNP
rs1370495112 1032 dbSNP
rs1168611147 1035 dbSNP
rs1245142298 1036 dbSNP
rs1005440319 1041 dbSNP
rs1375567668 1044 dbSNP
rs564664540 1055 dbSNP
rs1478899956 1056 dbSNP
rs756044829 1057 dbSNP
rs751117462 1058 dbSNP
rs966882565 1062 dbSNP
rs1029488258 1063 dbSNP
rs976476471 1064 dbSNP
rs146518257 1066 dbSNP
rs932451272 1067 dbSNP
rs544038068 1068 dbSNP
rs985525247 1076 dbSNP
rs909570848 1078 dbSNP
rs941268473 1082 dbSNP
rs1408403940 1094 dbSNP
rs1350400481 1095 dbSNP
rs576455006 1096 dbSNP
rs750158319 1096 dbSNP
rs529409197 1104 dbSNP
rs1036921998 1111 dbSNP
rs1020983990 1112 dbSNP
rs66685266 1119 dbSNP
rs1379016967 1125 dbSNP
rs979409818 1132 dbSNP
rs559730997 1137 dbSNP
rs1252408960 1140 dbSNP
rs1184314657 1153 dbSNP
rs1270571028 1161 dbSNP
rs1329937039 1163 dbSNP
rs1254121306 1164 dbSNP
rs1046442286 1188 dbSNP
rs1288031274 1194 dbSNP
rs758458698 1197 dbSNP
rs1453582033 1199 dbSNP
rs906604439 1200 dbSNP
rs938270504 1206 dbSNP
rs533074560 1207 dbSNP
rs1289501123 1212 dbSNP
rs1230724007 1220 dbSNP
rs1339260463 1221 dbSNP
rs918054565 1224 dbSNP
rs767812952 1230 dbSNP
rs1332864913 1234 dbSNP
rs1396164181 1244 dbSNP
rs1403899605 1245 dbSNP
rs1318179004 1249 dbSNP
rs1456485300 1254 dbSNP
rs1222559140 1266 dbSNP
rs1412369093 1271 dbSNP
rs777681252 1272 dbSNP
rs1471730252 1289 dbSNP
rs1471486962 1291 dbSNP
rs1367835833 1295 dbSNP
rs1184272033 1297 dbSNP
rs1046773311 1301 dbSNP
rs1186919528 1311 dbSNP
rs1412542671 1327 dbSNP
rs1245170142 1330 dbSNP
rs1034078568 1334 dbSNP
rs893842971 1337 dbSNP
rs1474605339 1340 dbSNP
rs886847974 1344 dbSNP
rs1207266876 1354 dbSNP
rs1011136762 1359 dbSNP
rs1160905869 1367 dbSNP
rs1284195570 1383 dbSNP
rs55967209 1387 dbSNP
rs966832055 1408 dbSNP
rs1405641447 1411 dbSNP
rs1037995822 1428 dbSNP
rs1029867740 1433 dbSNP
rs534837227 1433 dbSNP
rs996740767 1434 dbSNP
rs953908948 1435 dbSNP
rs1403456910 1442 dbSNP
rs985256322 1443 dbSNP
rs1196961272 1447 dbSNP
rs1163816740 1467 dbSNP
rs1029912254 1471 dbSNP
rs1458455278 1473 dbSNP
rs1354386671 1477 dbSNP
rs890937528 1479 dbSNP
rs558124638 1480 dbSNP
rs1009667804 1481 dbSNP
rs781710917 1482 dbSNP
rs79276061 1492 dbSNP
rs1289764848 1495 dbSNP
rs746163522 1504 dbSNP
rs1033647220 1506 dbSNP
rs918512306 1513 dbSNP
rs1351599215 1518 dbSNP
rs1233179069 1520 dbSNP
rs111774800 1524 dbSNP
rs1227043190 1528 dbSNP
rs959894334 1531 dbSNP
rs950005693 1544 dbSNP
rs1299454811 1547 dbSNP
rs1433993736 1554 dbSNP
rs193235726 1562 dbSNP
rs918094143 1566 dbSNP
rs927172918 1567 dbSNP
rs929522761 1577 dbSNP
rs1429263263 1583 dbSNP
rs1390984450 1586 dbSNP
rs573953612 1590 dbSNP
rs1272479651 1594 dbSNP
rs908338157 1595 dbSNP
rs13176869 1602 dbSNP
rs775072791 1605 dbSNP
rs899457535 1609 dbSNP
rs1010916004 1610 dbSNP
rs1042444882 1611 dbSNP
rs540945072 1614 dbSNP
rs73347986 1614 dbSNP
rs1252487127 1620 dbSNP
rs1274650771 1628 dbSNP
rs983252549 1631 dbSNP
rs534753606 1636 dbSNP
rs1050993978 1646 dbSNP
rs1275156975 1649 dbSNP
rs891023436 1656 dbSNP
rs1009443776 1664 dbSNP
rs867838469 1684 dbSNP
rs1472839235 1686 dbSNP
rs1409256986 1699 dbSNP
rs1371185692 1706 dbSNP
rs1020792519 1707 dbSNP
rs1331012559 1709 dbSNP
rs1166968002 1715 dbSNP
rs1412915591 1724 dbSNP
rs1424738399 1731 dbSNP
rs796290753 1733 dbSNP
rs113736712 1750 dbSNP
rs768397250 1751 dbSNP
rs1428255825 1759 dbSNP
rs1182154781 1763 dbSNP
rs1410359784 1763 dbSNP
rs1223193389 1765 dbSNP
rs1483681358 1770 dbSNP
rs1007027580 1771 dbSNP
rs1310282078 1775 dbSNP
rs1016684593 1782 dbSNP
rs868564751 1801 dbSNP
rs962318857 1802 dbSNP
rs1803458 1803 dbSNP
rs1225083053 1807 dbSNP
rs1326871099 1809 dbSNP
rs1287510710 1825 dbSNP
rs1462741622 1827 dbSNP
rs1228886436 1828 dbSNP
rs115034831 1829 dbSNP
rs1299903301 1835 dbSNP
rs1445983023 1837 dbSNP
rs1332763090 1840 dbSNP
rs959373925 1847 dbSNP
rs1337686937 1850 dbSNP
rs1471148666 1854 dbSNP
rs1013993660 1855 dbSNP
rs1158938266 1867 dbSNP
rs540124102 1870 dbSNP
rs761445153 1871 dbSNP
rs1340257927 1879 dbSNP
rs1472199878 1885 dbSNP
rs950963824 1887 dbSNP
rs1230849435 1888 dbSNP
rs983615963 1890 dbSNP
rs1463290452 1891 dbSNP
rs1267186054 1894 dbSNP
rs1209135204 1896 dbSNP
rs937211523 1897 dbSNP
rs141085395 1898 dbSNP
rs962437825 1899 dbSNP
rs973768555 1902 dbSNP
rs920941876 1903 dbSNP
rs902542759 1906 dbSNP
rs576810506 1907 dbSNP
rs932363191 1909 dbSNP
rs1320244452 1924 dbSNP
rs1258102394 1940 dbSNP
rs767352713 1944 dbSNP
rs912515027 1946 dbSNP
rs576422414 1952 dbSNP
rs889911317 1953 dbSNP
rs945241307 1955 dbSNP
rs1413829401 1965 dbSNP
rs1191795113 1974 dbSNP
rs1007066331 1977 dbSNP
rs1017092205 1978 dbSNP
rs1247091845 1980 dbSNP
rs1188962431 1984 dbSNP
rs1486747162 1995 dbSNP
rs544002958 1996 dbSNP
rs1263589649 2003 dbSNP
rs1245633214 2013 dbSNP
rs1450995545 2015 dbSNP
rs1292511401 2018 dbSNP
rs1248283093 2021 dbSNP
rs1363274815 2026 dbSNP
rs962434791 2029 dbSNP
rs1042247963 2036 dbSNP
rs1391236350 2037 dbSNP
rs777757452 2039 dbSNP
rs1025252118 2040 dbSNP
rs6627 2056 dbSNP
rs1000965415 2057 dbSNP
rs1396713043 2066 dbSNP
rs1320025304 2074 dbSNP
rs1389132541 2082 dbSNP
rs1170772002 2084 dbSNP
rs573009457 2086 dbSNP
rs1803459 2087 dbSNP
rs1264954302 2089 dbSNP
rs1190413867 2093 dbSNP
rs1488735751 2095 dbSNP
rs1437621998 2114 dbSNP
rs540779000 2130 dbSNP
rs1224814832 2134 dbSNP
rs1055246227 2138 dbSNP
rs895205006 2147 dbSNP
rs574035202 2148 dbSNP
rs1309485604 2150 dbSNP
rs1025385742 2154 dbSNP
rs1346691798 2155 dbSNP
rs950973355 2161 dbSNP
rs1305528887 2163 dbSNP
rs1005050903 2174 dbSNP
rs1257712251 2179 dbSNP
rs1298284932 2182 dbSNP
rs1463138429 2187 dbSNP
rs1034274092 2195 dbSNP
rs1345682363 2196 dbSNP
rs541541516 2223 dbSNP
rs1480680742 2225 dbSNP
rs1265757415 2230 dbSNP
rs1179859782 2231 dbSNP
rs1016403833 2243 dbSNP
rs1465857255 2248 dbSNP
rs559478722 2259 dbSNP
rs958751342 2271 dbSNP
rs963484602 2280 dbSNP
rs1481732363 2288 dbSNP
rs1254554965 2289 dbSNP
rs975302544 2294 dbSNP
rs533115762 2298 dbSNP
rs1285609733 2302 dbSNP
rs1227055863 2319 dbSNP
rs1350416061 2325 dbSNP
rs1307014739 2327 dbSNP
rs946767960 2333 dbSNP
rs1432986605 2334 dbSNP
rs1470107552 2337 dbSNP
rs551366661 2348 dbSNP
rs953925642 2353 dbSNP
rs1407972608 2360 dbSNP
rs978182511 2366 dbSNP
rs1472188564 2370 dbSNP
rs1188732353 2377 dbSNP
rs923914538 2391 dbSNP
rs1423518075 2393 dbSNP
rs1182613161 2400 dbSNP
rs1420999691 2401 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124B_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ucgacaaggACGACUu 5'
                   |||||| 
Target 5' --aagagaaUGCUGAa 3'
1 - 14
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_124B_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + B
Location of target site ENST00000292599.3 | 3UTR | AAGAGAAUGCUGAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-4291 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT102445 CALU calumenin 2 4
MIRT108677 ZBTB33 zinc finger and BTB domain containing 33 2 4
MIRT125969 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT179018 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT379033 CDK6 cyclin dependent kinase 6 2 6
MIRT442473 CPEB4 cytoplasmic polyadenylation element binding protein 4 2 2
MIRT442910 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 2 2
MIRT442979 ZNF736 zinc finger protein 736 2 2
MIRT445663 TNFSF15 TNF superfamily member 15 2 2
MIRT446237 FZD6 frizzled class receptor 6 2 2
MIRT448860 FAM49B family with sequence similarity 49 member B 2 2
MIRT455559 TRAF1 TNF receptor associated factor 1 2 2
MIRT459704 ZNF641 zinc finger protein 641 2 2
MIRT460608 FEM1A fem-1 homolog A 2 2
MIRT462251 LAMA4 laminin subunit alpha 4 2 2
MIRT462469 FIZ1 FLT3 interacting zinc finger 1 2 2
MIRT466656 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 6
MIRT466841 STX6 syntaxin 6 2 2
MIRT471403 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT471517 PCGF3 polycomb group ring finger 3 2 2
MIRT471681 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT472858 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT474813 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 2 2
MIRT474931 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT475814 HDGF heparin binding growth factor 2 2
MIRT480434 C17orf49 chromosome 17 open reading frame 49 2 2
MIRT480903 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT481478 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT484982 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 8
MIRT485019 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 8
MIRT485036 TMEM189 transmembrane protein 189 2 8
MIRT495074 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT496004 CD180 CD180 molecule 2 2
MIRT500675 TRIM37 tripartite motif containing 37 2 2
MIRT504544 ZNF417 zinc finger protein 417 2 6
MIRT506782 KLHL15 kelch like family member 15 2 6
MIRT507256 FGF2 fibroblast growth factor 2 2 6
MIRT507386 EN2 engrailed homeobox 2 2 2
MIRT512505 BTBD19 BTB domain containing 19 2 2
MIRT516903 CTSB cathepsin B 2 2
MIRT528124 PPP1R10 protein phosphatase 1 regulatory subunit 10 2 2
MIRT528874 ATF3 activating transcription factor 3 2 2
MIRT536091 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT541079 RLIM ring finger protein, LIM domain interacting 2 2
MIRT541099 RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2 2
MIRT545360 LIN7C lin-7 homolog C, crumbs cell polarity complex component 2 2
MIRT545831 ZNF367 zinc finger protein 367 2 4
MIRT547115 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 2
MIRT547312 NPTN neuroplastin 2 2
MIRT547959 HIGD1A HIG1 hypoxia inducible domain family member 1A 2 4
MIRT549943 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT550749 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT565145 TUBB2A tubulin beta 2A class IIa 2 2
MIRT571050 POLQ DNA polymerase theta 2 2
MIRT571361 ZNF45 zinc finger protein 45 2 2
MIRT610133 FOXI2 forkhead box I2 2 2
MIRT613145 DSE dermatan sulfate epimerase 2 2
MIRT613379 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT615752 C6 complement C6 2 2
MIRT616460 ADRA2B adrenoceptor alpha 2B 2 2
MIRT616719 FEM1B fem-1 homolog B 2 2
MIRT618312 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT631491 RASSF4 Ras association domain family member 4 2 2
MIRT643134 PLCXD2 phosphatidylinositol specific phospholipase C X domain containing 2 2 2
MIRT643482 DISC1 disrupted in schizophrenia 1 2 2
MIRT649715 TWSG1 twisted gastrulation BMP signaling modulator 1 2 2
MIRT653542 SLC38A7 solute carrier family 38 member 7 2 2
MIRT666307 SLC22A3 solute carrier family 22 member 3 2 2
MIRT692005 NAP1L4 nucleosome assembly protein 1 like 4 2 2
MIRT696838 ARL2BP ADP ribosylation factor like GTPase 2 binding protein 2 2
MIRT698204 TMEM248 transmembrane protein 248 2 2
MIRT703316 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2 2
MIRT709376 FAM13A family with sequence similarity 13 member A 2 2
MIRT710112 MED23 mediator complex subunit 23 2 2
MIRT711975 HOMER2 homer scaffolding protein 2 2 2
MIRT712275 PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2 2
MIRT714108 TMED9 transmembrane p24 trafficking protein 9 2 2
MIRT719113 MAML1 mastermind like transcriptional coactivator 1 2 2
MIRT719727 SLC39A11 solute carrier family 39 member 11 2 2
MIRT720018 TFAP2C transcription factor AP-2 gamma 2 2
MIRT720358 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT720372 NUDT3 nudix hydrolase 3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4291 Platinum-based doublet chemotherapy resistant High Lung Adenocarcinoma tissue
hsa-miR-4291 Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-4291 Paclitaxel 36314 NSC125973 approved resistant High Prostate Cancer cell line (DU-145, PC-3)
hsa-miR-4291 Doxorubicin 31703 NSC123127 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-4291 Radioactivity Iodine resistant High Papillary Thyroid Cancer tissue
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-4291 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4291 Platinum-based doublet chemotherapy resistant tissue (lung adenocarcinoma)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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