pre-miRNA Information
pre-miRNA hsa-mir-3622b   
Genomic Coordinates chr8: 27701673 - 27701767
Description Homo sapiens miR-3622b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3622b-3p
Sequence 58| UCACCUGAGCUCCCGUGCCUG |78
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1232922758 2 dbSNP
rs530939348 5 dbSNP
rs1439657384 10 dbSNP
rs1157333896 12 dbSNP
rs66683138 14 dbSNP
rs1044808718 15 dbSNP
rs946438979 19 dbSNP
rs551845360 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PDE6B   
Synonyms CSNB3, CSNBAD2, GMP-PDEbeta, PDEB, RP40, rd1
Description phosphodiesterase 6B
Transcript NM_000283   
Other Transcripts NM_001145291 , NM_001145292   
Expression
Putative miRNA Targets on PDE6B
3'UTR of PDE6B
(miRNA target sites are highlighted)
>PDE6B|NM_000283|3'UTR
   1 GCACTGGTCCCATGGGGACCCTATGGCTCCCTCAATCTTCACCCACTAGGATTTGGGTTCTGCCTGTGGCTATTTGCTAC
  81 AAGAGGTTAGGAAGCCCAAGAAAATGACTGAAGATCATTCTGGATATTTTAATTTTTTTTTTTTTTTTTTTTTGAGATGG
 161 AGTCTTGCTCTGTCACCCAGGCTGGAGTGCCGTGGCACGATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGA
 241 TTCTCGTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCACCACCACACATGGCTAATTTTTGTATTTTCAGTAC
 321 AGATGGGGTTTCACCATATTGGGCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCACCCGCCTCAGCTTCCTGAAGTG
 401 CTGGGATTACAGGCATGAGCCACCACGCCCAGCCTGTTTTTATAAACTGAAGCCAACTGTGAATAAACTGTAGCCTACAT
 481 TACTCATCCATTTTTGGATAGTTACCACTGGGAGACCTTTGAAAAGGGTCCATGAACTCTGAAATCACTGAGAACATTTG
 561 CAGCCACACATGTACATATGTGTACACAGGTAGACAGATGGACACAGGCCGTTTCTCATCCAGTTTAGGAAAACACACAT
 641 GCTCAGGAATTCAGAATAAAATAAACAGAAAACTACTTGCCCATTATCTGTGGTAAAATGATAGCGGAAGCCACACTACA
 721 TTTGACCCATCAGAAAATTCTGCCAGAGAGGTCAAGGCCATGAGTAAAGCGGCCATCCAACTTCAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' guccGUGCCCUCGAGUCCACu 5'
              | |  || |||||||| 
Target 5' cgaaCTCCTGACCTCAGGTGa 3'
355 - 375 153.00 -16.90
2
miRNA  3' guCCGUGCCCUCGAGUCCAcu 5'
            |||||  || ||||| |  
Target 5' gtGGCAC--GATCTCAGCTca 3'
192 - 210 115.00 -15.70
3
miRNA  3' guccGUGCCCUCGAGUCCacu 5'
              |||    |||||||   
Target 5' aaaaCACACATGCTCAGGaat 3'
630 - 650 113.00 -14.22
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1061685 1 ClinVar
349400 13 ClinVar
349401 21 ClinVar
349402 22 ClinVar
349403 80 ClinVar
907236 116 ClinVar
349404 133 ClinVar
907237 188 ClinVar
349405 192 ClinVar
903897 216 ClinVar
349406 272 ClinVar
349407 280 ClinVar
349408 310 ClinVar
905779 382 ClinVar
349409 391 ClinVar
349410 415 ClinVar
907297 475 ClinVar
349411 505 ClinVar
349412 546 ClinVar
349413 562 ClinVar
349414 593 ClinVar
976627 612 ClinVar
349415 627 ClinVar
COSN31971991 5 COSMIC
COSN31491986 12 COSMIC
COSN19623065 13 COSMIC
COSN9974425 21 COSMIC
COSN30151895 34 COSMIC
COSN22925431 38 COSMIC
COSN30469752 50 COSMIC
COSN30528542 105 COSMIC
COSN30111308 132 COSMIC
COSN25458588 240 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1172159133 4 dbSNP
rs34380508 6 dbSNP
rs781513249 10 dbSNP
rs1048934516 12 dbSNP
rs28675771 13 dbSNP
rs34749277 14 dbSNP
rs1359812491 15 dbSNP
rs61760239 21 dbSNP
rs371005251 22 dbSNP
rs370166139 24 dbSNP
rs1231917771 25 dbSNP
rs901577789 31 dbSNP
rs995915757 34 dbSNP
rs1275017053 38 dbSNP
rs1349606767 39 dbSNP
rs774213532 41 dbSNP
rs759208165 42 dbSNP
rs1446785872 46 dbSNP
rs1028664959 51 dbSNP
rs1488231696 56 dbSNP
rs1206196396 61 dbSNP
rs767309252 63 dbSNP
rs1011195490 66 dbSNP
rs530216209 69 dbSNP
rs1198251119 73 dbSNP
rs760590199 77 dbSNP
rs763658609 78 dbSNP
rs753277194 80 dbSNP
rs1379502550 83 dbSNP
rs1035168308 84 dbSNP
rs756947084 85 dbSNP
rs778379456 90 dbSNP
rs1463098669 92 dbSNP
rs1418611832 96 dbSNP
rs751985732 97 dbSNP
rs755338747 99 dbSNP
rs1017402625 101 dbSNP
rs111902957 103 dbSNP
rs781674711 107 dbSNP
rs748723564 110 dbSNP
rs961095150 114 dbSNP
rs1194338211 116 dbSNP
rs1464673356 121 dbSNP
rs1266794989 122 dbSNP
rs770422714 126 dbSNP
rs778007268 128 dbSNP
rs1227438811 130 dbSNP
rs771789776 131 dbSNP
rs1164151133 133 dbSNP
rs1364122614 133 dbSNP
rs1403879236 133 dbSNP
rs1421921497 133 dbSNP
rs374413250 133 dbSNP
rs770336655 133 dbSNP
rs773574159 133 dbSNP
rs775283243 133 dbSNP
rs886059547 133 dbSNP
rs13106957 134 dbSNP
rs771210929 138 dbSNP
rs774473978 139 dbSNP
rs1196100853 147 dbSNP
rs990826775 153 dbSNP
rs1469287795 154 dbSNP
rs1365674321 155 dbSNP
rs1269509347 157 dbSNP
rs1482474168 158 dbSNP
rs1179357275 167 dbSNP
rs1319337201 167 dbSNP
rs1274697457 168 dbSNP
rs1228630416 171 dbSNP
rs916591042 176 dbSNP
rs1253574960 180 dbSNP
rs1470285549 182 dbSNP
rs1014159767 188 dbSNP
rs1236474496 189 dbSNP
rs111449765 192 dbSNP
rs984712038 193 dbSNP
rs780686102 199 dbSNP
rs749756675 200 dbSNP
rs1040628827 216 dbSNP
rs1388760552 223 dbSNP
rs1175903541 230 dbSNP
rs566702336 231 dbSNP
rs1425092253 232 dbSNP
rs1189929787 233 dbSNP
rs1024609341 235 dbSNP
rs1234081636 236 dbSNP
rs534079818 239 dbSNP
rs1272289606 240 dbSNP
rs967073309 245 dbSNP
rs1050165021 246 dbSNP
rs1312497104 247 dbSNP
rs1370462411 259 dbSNP
rs998903805 264 dbSNP
rs1408125314 265 dbSNP
rs1309892593 268 dbSNP
rs1289044408 271 dbSNP
rs552530901 272 dbSNP
rs1368944624 274 dbSNP
rs1314932408 276 dbSNP
rs886059548 280 dbSNP
rs774425841 281 dbSNP
rs1358901460 282 dbSNP
rs1354074775 284 dbSNP
rs373377304 286 dbSNP
rs1421371927 287 dbSNP
rs1413602303 290 dbSNP
rs1247877176 293 dbSNP
rs570771866 295 dbSNP
rs537809822 296 dbSNP
rs556126189 300 dbSNP
rs1249179689 302 dbSNP
rs957135033 307 dbSNP
rs1483471594 309 dbSNP
rs559243245 310 dbSNP
rs1274438195 318 dbSNP
rs1268920836 319 dbSNP
rs574407054 323 dbSNP
rs535576115 324 dbSNP
rs1227870689 325 dbSNP
rs1438053910 326 dbSNP
rs921469569 328 dbSNP
rs1295376557 329 dbSNP
rs1396787237 331 dbSNP
rs1378961192 333 dbSNP
rs955516844 335 dbSNP
rs1455863759 338 dbSNP
rs987078557 351 dbSNP
rs374557720 357 dbSNP
rs1474007239 365 dbSNP
rs960873341 372 dbSNP
rs964499783 379 dbSNP
rs1023673457 382 dbSNP
rs749118636 383 dbSNP
rs886059549 391 dbSNP
rs1170583341 410 dbSNP
rs1248588533 411 dbSNP
rs1207981975 413 dbSNP
rs1327206927 414 dbSNP
rs111404897 415 dbSNP
rs770785727 418 dbSNP
rs984744730 424 dbSNP
rs573129240 425 dbSNP
rs907842169 427 dbSNP
rs540509628 428 dbSNP
rs962271926 430 dbSNP
rs1366317583 433 dbSNP
rs1320509366 437 dbSNP
rs1040666373 442 dbSNP
rs1045670515 444 dbSNP
rs565205055 445 dbSNP
rs1364401486 449 dbSNP
rs1367535191 454 dbSNP
rs1162196055 455 dbSNP
rs903069114 458 dbSNP
rs1390517776 468 dbSNP
rs1226007015 469 dbSNP
rs1187898212 473 dbSNP
rs577140751 475 dbSNP
rs1269640427 479 dbSNP
rs1032699869 492 dbSNP
rs1488163247 493 dbSNP
rs868537239 496 dbSNP
rs1263923415 497 dbSNP
rs1230835120 500 dbSNP
rs544233944 501 dbSNP
rs886059550 505 dbSNP
rs184259528 509 dbSNP
rs745631762 514 dbSNP
rs1226917583 516 dbSNP
rs1373825106 528 dbSNP
rs1324708752 534 dbSNP
rs1386858288 540 dbSNP
rs1389330020 542 dbSNP
rs149186081 546 dbSNP
rs1431223314 547 dbSNP
rs886059551 562 dbSNP
rs1390614815 563 dbSNP
rs914309498 567 dbSNP
rs955526725 571 dbSNP
rs947088823 572 dbSNP
rs1379309069 576 dbSNP
rs1204738974 577 dbSNP
rs1041424393 580 dbSNP
rs1207619481 582 dbSNP
rs1247736992 586 dbSNP
rs902811843 591 dbSNP
rs886059552 593 dbSNP
rs1448205743 600 dbSNP
rs1015750787 601 dbSNP
rs1275990625 604 dbSNP
rs761817528 607 dbSNP
rs961954560 608 dbSNP
rs541782469 611 dbSNP
rs1374125665 612 dbSNP
rs1370788500 613 dbSNP
rs896686048 618 dbSNP
rs919961965 619 dbSNP
rs937981500 624 dbSNP
rs886059553 627 dbSNP
rs1465463486 628 dbSNP
rs1376050463 630 dbSNP
rs1184434188 632 dbSNP
rs1477767236 636 dbSNP
rs764015595 642 dbSNP
rs560711337 644 dbSNP
rs113646387 645 dbSNP
rs1180226841 650 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124A_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + A HITS-CLIP data was present in Chi_124B_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' guccgugcccucgagUCCACu 5'
                         ||||| 
Target 5' ---------------AGGUGa 3'
1 - 6
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_124A_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + A
Location of target site ENST00000255622.6 | 3UTR | AGGUGAUCACCCGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset Chi_124B_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + B
Location of target site ENST00000255622.6 | 3UTR | AGGUGAUCACCCGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA 0.165 0.36 0.286 0.27 7 Click to see details
THCA 0.165 0.36 0.286 0.27 7 Click to see details
THCA 0.165 0.36 0.286 0.27 7 Click to see details
THCA 0.165 0.36 0.286 0.27 7 Click to see details
THCA 0.165 0.36 0.286 0.27 7 Click to see details
THCA 0.165 0.36 0.286 0.27 7 Click to see details
102 hsa-miR-3622b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT076713 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT080212 PRKACB protein kinase cAMP-activated catalytic subunit beta 2 2
MIRT081398 GTPBP3 GTP binding protein 3, mitochondrial 2 2
MIRT107158 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT254071 BACH1 BTB domain and CNC homolog 1 2 2
MIRT409790 FOXO3 forkhead box O3 2 2
MIRT448679 MAPK9 mitogen-activated protein kinase 9 2 2
MIRT450206 ABHD15 abhydrolase domain containing 15 2 2
MIRT486621 PDK3 pyruvate dehydrogenase kinase 3 2 2
MIRT489267 TTLL1 tubulin tyrosine ligase like 1 2 2
MIRT493117 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 4
MIRT494570 BAK1 BCL2 antagonist/killer 1 2 2
MIRT497395 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT504900 CCDC86 coiled-coil domain containing 86 2 2
MIRT505192 USP46 ubiquitin specific peptidase 46 2 4
MIRT506522 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 6
MIRT508162 ABCC5 ATP binding cassette subfamily C member 5 2 8
MIRT508545 PARVG parvin gamma 2 4
MIRT509850 BIRC5 baculoviral IAP repeat containing 5 2 6
MIRT510088 PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2 8
MIRT512094 CRK CRK proto-oncogene, adaptor protein 2 4
MIRT515381 RPL7 ribosomal protein L7 2 2
MIRT519176 SCO1 SCO1, cytochrome c oxidase assembly protein 2 2
MIRT519964 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT522292 NKAP NFKB activating protein 2 2
MIRT523160 HMGB2 high mobility group box 2 2 4
MIRT525314 FANCA Fanconi anemia complementation group A 2 2
MIRT528194 PLEKHM2 pleckstrin homology and RUN domain containing M2 2 2
MIRT532885 ZNF451 zinc finger protein 451 2 2
MIRT538209 CYR61 cysteine rich angiogenic inducer 61 2 2
MIRT539497 ACTN4 actinin alpha 4 2 2
MIRT554600 RRAGC Ras related GTP binding C 2 2
MIRT562444 DCTN6 dynactin subunit 6 2 2
MIRT562748 AOC3 amine oxidase, copper containing 3 2 2
MIRT565798 SEC14L5 SEC14 like lipid binding 5 2 2
MIRT565838 SCML2 Scm polycomb group protein like 2 2 2
MIRT566072 RCC2 regulator of chromosome condensation 2 2 2
MIRT566104 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT572407 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT576198 Vsig2 V-set and immunoglobulin domain containing 2 2 2
MIRT576313 Acbd7 acyl-Coenzyme A binding domain containing 7 2 2
MIRT576651 Mill2 MHC I like leukocyte 2 1 1
MIRT576859 Socs6 suppressor of cytokine signaling 6 2 2
MIRT606819 BICD2 BICD cargo adaptor 2 2 2
MIRT610738 NUDT16 nudix hydrolase 16 2 4
MIRT614798 RORA RAR related orphan receptor A 2 2
MIRT619006 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 2 2
MIRT619420 NOS1AP nitric oxide synthase 1 adaptor protein 2 2
MIRT620405 MYO1H myosin IH 2 2
MIRT624869 ABHD13 abhydrolase domain containing 13 2 2
MIRT633527 ZFP30 ZFP30 zinc finger protein 2 2
MIRT633927 DNAH9 dynein axonemal heavy chain 9 2 2
MIRT636611 CLIC5 chloride intracellular channel 5 2 2
MIRT640616 MIOX myo-inositol oxygenase 2 2
MIRT642605 C14orf180 chromosome 14 open reading frame 180 2 2
MIRT644624 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT655113 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT658976 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT661495 CHMP1B charged multivesicular body protein 1B 2 2
MIRT662996 TMEM59 transmembrane protein 59 2 2
MIRT663075 SFR1 SWI5 dependent homologous recombination repair protein 1 2 2
MIRT665405 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT666106 SSR1 signal sequence receptor subunit 1 2 2
MIRT669562 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT670070 ZNF783 zinc finger family member 783 2 2
MIRT671192 ZNF891 zinc finger protein 891 2 2
MIRT675361 KLHL26 kelch like family member 26 2 2
MIRT678857 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT679443 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT684163 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT684543 ZNF460 zinc finger protein 460 2 2
MIRT684674 SLC2A11 solute carrier family 2 member 11 2 2
MIRT684971 MINOS1 mitochondrial inner membrane organizing system 1 2 2
MIRT686006 NEK4 NIMA related kinase 4 2 2
MIRT687758 KIAA1328 KIAA1328 2 2
MIRT688961 ATXN3 ataxin 3 2 2
MIRT689409 UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 2 2
MIRT690001 MMP17 matrix metallopeptidase 17 2 2
MIRT690165 ELP3 elongator acetyltransferase complex subunit 3 2 2
MIRT690202 C5orf45 MRN complex interacting protein 2 2
MIRT690477 ZNF33A zinc finger protein 33A 2 2
MIRT690566 MICA MHC class I polypeptide-related sequence A 2 2
MIRT692160 C10orf111 chromosome 10 open reading frame 111 2 2
MIRT693430 PLGLB2 plasminogen-like B2 2 2
MIRT693547 ZNF708 zinc finger protein 708 2 2
MIRT693697 PLGLB1 plasminogen-like B1 2 2
MIRT695006 HSPA6 heat shock protein family A (Hsp70) member 6 2 2
MIRT698525 TFRC transferrin receptor 2 2
MIRT699574 SIKE1 suppressor of IKBKE 1 2 2
MIRT703446 FYTTD1 forty-two-three domain containing 1 2 2
MIRT704397 CTSS cathepsin S 2 2
MIRT704485 CPT1A carnitine palmitoyltransferase 1A 2 2
MIRT709822 STPG1 sperm tail PG-rich repeat containing 1 2 2
MIRT710859 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT711893 INSIG2 insulin induced gene 2 2 2
MIRT713796 CPLX2 complexin 2 2 2
MIRT718800 C1GALT1C1 C1GALT1 specific chaperone 1 2 2
MIRT719501 SEC24B SEC24 homolog B, COPII coat complex component 2 2
MIRT719722 PDE6B phosphodiesterase 6B 2 2
MIRT722204 URM1 ubiquitin related modifier 1 2 2
MIRT723523 CLPTM1L CLPTM1 like 2 2
MIRT725471 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3622b-3p Platinum 23939 sensitive tissue
hsa-miR-3622b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3622b-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-3622b-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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