miRTarBase - #MIRT719727


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pre-miRNA Information
pre-miRNA hsa-mir-4291   
Genomic Coordinates chr9: 93819357 - 93819421
Description Homo sapiens miR-4291 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4291
Sequence 11| UUCAGCAGGAACAGCU |26
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1265713434 9 dbSNP
rs1433969451 12 dbSNP
rs1372852268 16 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SLC39A11   
Synonyms C17orf26, ZIP-11, ZIP11
Description solute carrier family 39 member 11
Transcript NM_001159770   
Other Transcripts NM_139177   
Expression
Putative miRNA Targets on SLC39A11
3'UTR of SLC39A11
(miRNA target sites are highlighted)		 
>SLC39A11|NM_001159770|3'UTR
   1 GGCTGAGACGCTTCGGACCCCGGGAAAGGCCATACGAAGAAACAGCAGTGGTTGGCTTCTATGGGACAACAAGCTTCTTT
  81 CTTCACATTAAAACTTTTTTCCTTCCTCTCTTCTTCATCTCATTATCCTGATTGACTCTGATTATAATAGAACCATTTTT
 161 ACTTTGCTTTGAGGGAGATTTTTGATTTAATGGGGAATTTTAAGGTGTCATGGAAATACAGATTCTTTGTTTTGGCCACT
 241 GAATGGACTCTCTCTTCAGTGGGATTATCAAGGAACTTCAGATCAGGGAAATCTCCACTTCGGGACCTTCTATCTGCCTC
 321 CCAACTCCTCAAGGTCACCTATAGAAGCGAGCTACCAAAAGACGTCTCCTAAGCATTTTGGTGGCCTAGTGACTCAGGGC
 401 AGAGTGGCCAGCACACCTCTCATCCGCCCCTCCTGCTCCATCACTGCTGAGCCTCTCCCCATCTAGAATGTTGGAACTGG
 481 AGCATCATAAAGATAGCAAGCTACCTTCCAAGGCCGAGCCAGCCCAGAGAGGAGCATGTCTTCCTTTACCTCCCCCTAAG
 561 GAGATACTACATGGGAGGGGGACACAGAAAAAGGGAAGGAAATTGGCTAGTCTGGCTTTTTTTTTTTTTTTTTTTAAAGG
 641 CAAAGATTGACATTATTGAAGGAAAGGGGATGAGGACAACTGTGAACTCACAGTGAGCCCTGTGGAAAGAAGAGACAGAC
 721 AGAGTGTGGGTTTGTTCGGAGGCCTCTGCTGTCAATGGATTCCAGGAGCAAGGCCATTTGTCGCGCTTTCCAAATTTCTT
 801 AGGCATTTATTTTGATAAGTTTATAGCCATCATGTTTCTAAGAGACTTGGAGACACCAGCAAACTGCTAGAACTCAAACT
 881 CTTCAATTACTCAAAGAAGGAGCCATTTCAGTTAACTCAAGTGAATGAAAGAGTTTTGGAATCTGCTGTGGGTCCTTCCC
 961 TGTTGACCATTTGGTAACTTATAATCTGACAAAAACTCTTGAGCTGCAACAGGCCTTGCCAGAGGGCTCAGGATGGGAAA
1041 GGAAGAAGGGGATAGGAAAAGAAGAGGTAATTTTACATTTCCCCTTTAAAGTAAATTTTAGCCAACTCATCATTCTGAAA
1121 TGTCCCTATAAAGAATGAGTCGAACTAGACCAGAAGCCAGCCTACTCCTTCTTACATAGCTTCTCCAACAGGGGTAGCAA
1201 TGACCTGTCCACTTCAAACACAGATAAGGCCTGCCATCCTCATTGGTTAAAGGCACACGTGAGACTTTCAGTGGGCTCTG
1281 CTGAGAAGGAAGGCAGCCCAGGAGTCAGGTATGCAGGCATTGCATTGTCAGTGTCTGCTCTCAGAGTTTACACATTCAAT
1361 TGCTTCCAAGGGTGAATCTCCTGCTCTGTGAATGCTATCAGACCCCAAAGGCCAACCTTGGGCTGGGTCTATGTACGTTC
1441 TTCCGAAGCACTGATGATCAAAATTGAAGACACATTCAGAGGTTTGATTGGTTGAGATTAACTGGTGTGGTGGTTGGTGT
1521 ATGTATGTTTTATTTTTATGTCTTTGTATGTAGTTCTACATAATGCAAATTGTGCTTTCTGATGGACAAGACCTCATAAC
1601 TGTGATTAATATCAATAAAAAGGGGATGTTGTGGATGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucGACAAG-----GACGACUu 5'
            ||| ||     ||||||| 
Target 5' tcCTGCTCCATCACTGCTGAg 3'
 431 - 451 146.00 -12.80
2 
miRNA  3' ucgacaaGGACGACUu 5'
                 :||||||| 
Target 5' agtgggcTCTGCTGAg 3'
 1270 - 1285 141.00 -13.10
3 
miRNA  3' ucGACAAGGACGACUu 5'
            || | ||||:||| 
Target 5' tcCT-TCCCTGTTGAc 3'
 953 - 967 133.00 -9.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30488637 1 COSMIC
COSN23015232 9 COSMIC
COSN30490219 21 COSMIC
COSN31501941 21 COSMIC
COSN30484127 23 COSMIC
COSN30184124 44 COSMIC
COSN31602087 59 COSMIC
COSN7444897 161 COSMIC
COSN21128999 359 COSMIC
COSN505740 525 COSMIC
COSN30539689 758 COSMIC
COSN31961373 783 COSMIC
COSN24656961 890 COSMIC
COSN31543868 901 COSMIC
COSN20114371 989 COSMIC
COSN30161545 1006 COSMIC
COSN31583073 1014 COSMIC
COSN31519481 1357 COSMIC
COSN26561503 1363 COSMIC
COSN30539466 1366 COSMIC
COSN30539474 1399 COSMIC
COSN31552063 1445 COSMIC
COSN31607929 1569 COSMIC
COSN26565791 1592 COSMIC
rs17780256 800 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs748785671 2 dbSNP
rs777281929 8 dbSNP
rs193153239 9 dbSNP
rs781437408 10 dbSNP
rs372923746 14 dbSNP
rs751867496 15 dbSNP
rs766700697 19 dbSNP
rs945624487 20 dbSNP
rs142468230 21 dbSNP
rs187520331 22 dbSNP
rs369426849 23 dbSNP
rs1207631628 24 dbSNP
rs760559116 27 dbSNP
rs775449496 31 dbSNP
rs1227222380 32 dbSNP
rs758231772 35 dbSNP
rs541463397 36 dbSNP
rs927040400 38 dbSNP
rs774048921 43 dbSNP
rs1321339591 51 dbSNP
rs1176159193 53 dbSNP
rs971028535 54 dbSNP
rs1405978561 55 dbSNP
rs183190153 61 dbSNP
rs949909372 62 dbSNP
rs1012293150 65 dbSNP
rs780362016 71 dbSNP
rs917059344 81 dbSNP
rs1183912596 82 dbSNP
rs1243757526 84 dbSNP
rs973080745 87 dbSNP
rs1431881480 90 dbSNP
rs1186034881 101 dbSNP
rs1391159828 107 dbSNP
rs961281639 107 dbSNP
rs145235675 118 dbSNP
rs984115844 130 dbSNP
rs1479848442 132 dbSNP
rs1386028998 134 dbSNP
rs192608257 135 dbSNP
rs1456319121 140 dbSNP
rs1336832939 147 dbSNP
rs9912126 158 dbSNP
rs1028393508 164 dbSNP
rs149995548 175 dbSNP
rs1048336235 176 dbSNP
rs998394198 184 dbSNP
rs541543722 188 dbSNP
rs750559772 192 dbSNP
rs767588699 196 dbSNP
rs1021081422 200 dbSNP
rs1010241214 205 dbSNP
rs1265962176 217 dbSNP
rs1327352368 224 dbSNP
rs574228658 225 dbSNP
rs1208287085 228 dbSNP
rs1248999449 233 dbSNP
rs1039279141 237 dbSNP
rs894049155 240 dbSNP
rs1199284785 243 dbSNP
rs1054086640 248 dbSNP
rs1256042444 250 dbSNP
rs914556237 256 dbSNP
rs1184828488 258 dbSNP
rs1410139242 268 dbSNP
rs1206838004 297 dbSNP
rs1472092763 300 dbSNP
rs561903401 301 dbSNP
rs905647979 302 dbSNP
rs541587407 304 dbSNP
rs1464081974 306 dbSNP
rs79756729 307 dbSNP
rs1271291174 308 dbSNP
rs949808056 312 dbSNP
rs917073791 324 dbSNP
rs917778538 335 dbSNP
rs1228091960 341 dbSNP
rs1346891155 342 dbSNP
rs1284126596 347 dbSNP
rs186553023 348 dbSNP
rs867397409 349 dbSNP
rs1349887816 355 dbSNP
rs570717821 363 dbSNP
rs984145386 364 dbSNP
rs1015926721 380 dbSNP
rs1411897885 384 dbSNP
rs954015779 390 dbSNP
rs762581023 393 dbSNP
rs950406468 399 dbSNP
rs1026070502 400 dbSNP
rs1431051667 401 dbSNP
rs1174747596 408 dbSNP
rs1371450468 411 dbSNP
rs997707499 415 dbSNP
rs12943256 419 dbSNP
rs1175650663 420 dbSNP
rs71354896 420 dbSNP
rs1405305917 425 dbSNP
rs1295021290 426 dbSNP
rs1370043594 427 dbSNP
rs1217624020 429 dbSNP
rs1300744321 434 dbSNP
rs12943232 436 dbSNP
rs1413079979 437 dbSNP
rs1308146535 440 dbSNP
rs776998949 441 dbSNP
rs764345336 446 dbSNP
rs71377865 447 dbSNP
rs769188122 463 dbSNP
rs902006226 469 dbSNP
rs1039632847 473 dbSNP
rs558587116 480 dbSNP
rs1007751678 482 dbSNP
rs1427701629 498 dbSNP
rs1248748833 513 dbSNP
rs763418538 515 dbSNP
rs965456524 516 dbSNP
rs1261906858 522 dbSNP
rs934665607 530 dbSNP
rs775004185 531 dbSNP
rs1021574531 532 dbSNP
rs1173610952 532 dbSNP
rs1009735156 533 dbSNP
rs1472584193 542 dbSNP
rs1425179847 546 dbSNP
rs60081354 555 dbSNP
rs1032541646 556 dbSNP
rs182904319 567 dbSNP
rs1183765421 571 dbSNP
rs1437389746 573 dbSNP
rs1483166425 577 dbSNP
rs1295442296 582 dbSNP
rs905553135 583 dbSNP
rs1236487169 587 dbSNP
rs1207625672 588 dbSNP
rs1292547612 592 dbSNP
rs1044028714 600 dbSNP
rs530193872 601 dbSNP
rs1220430381 607 dbSNP
rs1260929076 608 dbSNP
rs1279085841 611 dbSNP
rs1227700410 612 dbSNP
rs895560514 613 dbSNP
rs1327078383 614 dbSNP
rs1286503706 615 dbSNP
rs1405933654 616 dbSNP
rs1445182512 617 dbSNP
rs984428812 625 dbSNP
rs950401909 626 dbSNP
rs1404525596 629 dbSNP
rs1026424449 631 dbSNP
rs1389695504 632 dbSNP
rs1313375953 636 dbSNP
rs1318634129 636 dbSNP
rs1347851186 636 dbSNP
rs1458953147 636 dbSNP
rs35359576 636 dbSNP
rs386386563 636 dbSNP
rs554496653 636 dbSNP
rs1296559185 637 dbSNP
rs1302409380 637 dbSNP
rs916223908 641 dbSNP
rs1446108493 643 dbSNP
rs1206376797 651 dbSNP
rs1054838048 655 dbSNP
rs1442464626 659 dbSNP
rs975855529 662 dbSNP
rs1235684630 675 dbSNP
rs1361245021 680 dbSNP
rs1037314705 684 dbSNP
rs1457146345 690 dbSNP
rs1387158481 698 dbSNP
rs939852424 705 dbSNP
rs566224194 710 dbSNP
rs769631584 712 dbSNP
rs1388051612 714 dbSNP
rs1017693821 720 dbSNP
rs764327338 725 dbSNP
rs1357963753 726 dbSNP
rs1447861997 728 dbSNP
rs547800349 737 dbSNP
rs921273633 738 dbSNP
rs976770765 747 dbSNP
rs1287295758 755 dbSNP
rs1345221461 758 dbSNP
rs1220478945 760 dbSNP
rs1275812277 762 dbSNP
rs191009479 764 dbSNP
rs944158994 772 dbSNP
rs1205767293 773 dbSNP
rs558687324 782 dbSNP
rs545120371 783 dbSNP
rs958210736 784 dbSNP
rs111544969 785 dbSNP
rs1478458842 792 dbSNP
rs1174398176 796 dbSNP
rs17780256 800 dbSNP
rs1414461495 805 dbSNP
rs866441810 814 dbSNP
rs1372844226 816 dbSNP
rs1312171120 818 dbSNP
rs1408405888 823 dbSNP
rs1307762462 824 dbSNP
rs1331331831 828 dbSNP
rs17780250 829 dbSNP
rs1381669917 832 dbSNP
rs1229107782 833 dbSNP
rs1316144130 846 dbSNP
rs1339917971 848 dbSNP
rs929255266 854 dbSNP
rs1023089729 862 dbSNP
rs3803828 866 dbSNP
rs976162215 872 dbSNP
rs1453843753 873 dbSNP
rs1169244517 879 dbSNP
rs965784179 890 dbSNP
rs1323062984 892 dbSNP
rs1454778489 899 dbSNP
rs895578782 905 dbSNP
rs746035976 908 dbSNP
rs1162172376 909 dbSNP
rs1003936465 911 dbSNP
rs1406713998 912 dbSNP
rs561311795 913 dbSNP
rs888300246 925 dbSNP
rs1048223258 927 dbSNP
rs1406800905 932 dbSNP
rs1126965 933 dbSNP
rs1321137945 933 dbSNP
rs986233444 936 dbSNP
rs1447361483 941 dbSNP
rs1299129367 945 dbSNP
rs1126966 947 dbSNP
rs1227505839 951 dbSNP
rs552691939 952 dbSNP
rs1189119724 969 dbSNP
rs1211905632 973 dbSNP
rs1288016175 975 dbSNP
rs151012180 978 dbSNP
rs1126967 981 dbSNP
rs1249915694 987 dbSNP
rs71354897 990 dbSNP
rs201790507 991 dbSNP
rs3840060 991 dbSNP
rs397857377 991 dbSNP
rs1369446155 1008 dbSNP
rs903465092 1018 dbSNP
rs1323604074 1019 dbSNP
rs1161776266 1021 dbSNP
rs1457383730 1029 dbSNP
rs558788261 1034 dbSNP
rs1292727318 1040 dbSNP
rs1321993346 1042 dbSNP
rs536930973 1045 dbSNP
rs1434372353 1048 dbSNP
rs913861035 1051 dbSNP
rs1014691519 1061 dbSNP
rs1363399721 1065 dbSNP
rs186565134 1068 dbSNP
rs1350009058 1075 dbSNP
rs1383267777 1081 dbSNP
rs548744021 1082 dbSNP
rs1005664798 1083 dbSNP
rs756270564 1085 dbSNP
rs1257514513 1092 dbSNP
rs565889151 1094 dbSNP
rs552300700 1100 dbSNP
rs1365660220 1102 dbSNP
rs1472749580 1111 dbSNP
rs371330228 1119 dbSNP
rs1167505522 1120 dbSNP
rs1025209901 1121 dbSNP
rs1302874363 1125 dbSNP
rs992932639 1127 dbSNP
rs73343560 1128 dbSNP
rs1333331564 1133 dbSNP
rs1015652998 1134 dbSNP
rs1170931869 1137 dbSNP
rs1290420387 1139 dbSNP
rs751982282 1141 dbSNP
rs1265120710 1142 dbSNP
rs919171400 1143 dbSNP
rs1040016239 1144 dbSNP
rs888188748 1145 dbSNP
rs1269716231 1147 dbSNP
rs944384150 1161 dbSNP
rs1257344143 1167 dbSNP
rs1483570271 1171 dbSNP
rs1340389702 1174 dbSNP
rs1409346590 1174 dbSNP
rs1418078500 1180 dbSNP
rs1026859086 1181 dbSNP
rs1277178865 1188 dbSNP
rs1464539964 1193 dbSNP
rs910245259 1194 dbSNP
rs1312003557 1195 dbSNP
rs985824857 1200 dbSNP
rs996664602 1212 dbSNP
rs1299731638 1220 dbSNP
rs1389046107 1229 dbSNP
rs1305911778 1242 dbSNP
rs899773920 1243 dbSNP
rs536490660 1255 dbSNP
rs1371464681 1256 dbSNP
rs566136331 1257 dbSNP
rs139321890 1258 dbSNP
rs532506386 1259 dbSNP
rs1052353383 1267 dbSNP
rs936794084 1270 dbSNP
rs571564573 1273 dbSNP
rs925369691 1311 dbSNP
rs1207744156 1319 dbSNP
rs1372075708 1331 dbSNP
rs967613634 1350 dbSNP
rs1465326321 1353 dbSNP
rs1375726687 1355 dbSNP
rs1045234465 1359 dbSNP
rs1268894123 1360 dbSNP
rs550185146 1362 dbSNP
rs1430926809 1364 dbSNP
rs1024993657 1372 dbSNP
rs531893030 1387 dbSNP
rs561295244 1397 dbSNP
rs549156975 1403 dbSNP
rs1390745732 1405 dbSNP
rs948210188 1408 dbSNP
rs1166498965 1418 dbSNP
rs918050140 1421 dbSNP
rs1181606900 1423 dbSNP
rs1482186520 1425 dbSNP
rs958679502 1431 dbSNP
rs992442211 1433 dbSNP
rs962569219 1436 dbSNP
rs367570397 1437 dbSNP
rs1034390642 1444 dbSNP
rs982440980 1445 dbSNP
rs952463728 1463 dbSNP
rs373700548 1471 dbSNP
rs1324930918 1484 dbSNP
rs1266864200 1485 dbSNP
rs866985749 1488 dbSNP
rs763217748 1490 dbSNP
rs79794830 1495 dbSNP
rs1451316897 1502 dbSNP
rs558977067 1505 dbSNP
rs1418581754 1507 dbSNP
rs1424156794 1514 dbSNP
rs540750133 1518 dbSNP
rs1166592268 1522 dbSNP
rs1351830148 1525 dbSNP
rs993755225 1527 dbSNP
rs768470166 1529 dbSNP
rs1008151972 1532 dbSNP
rs753052058 1534 dbSNP
rs1389459417 1546 dbSNP
rs1307182963 1548 dbSNP
rs897712112 1551 dbSNP
rs765696825 1554 dbSNP
rs1399782770 1557 dbSNP
rs1361810203 1568 dbSNP
rs1229280517 1578 dbSNP
rs1052428022 1581 dbSNP
rs944661768 1582 dbSNP
rs1304442933 1586 dbSNP
rs1332242548 1596 dbSNP
rs116203989 1600 dbSNP
rs1050084123 1605 dbSNP
rs1387884432 1612 dbSNP
rs935716331 1624 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124B_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset GSM4903829
Method / RBP HITS-CLIP / AGO
Cell line / Condition Human neurons / CTLTD_shCTL_a
Location of target site NM_139177 | 3UTR | GUGGGCUCUGCUGAGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161238
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_139177 | 3UTR | UAUAAAGAAUGAGUCGAACUAGACCAGAAGCCAGCCUACUCCUUCUUACAUAGCUUCUCCAACAGGGGUAGCAAUGACCUGUCCACUUCAAACACAGAUAAGGCCUGCCAUCCUCAUUGGUUAAAGGCACACGUGAGACUUUCAGUGGGCUCUGCUGAGAAGGAAGGCAGCCCAGGAGUCAGGUAUGCAGGCAUUGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_139177 | 3UTR | AGAAUGAGUCGAACUAGACCAGAAGCCAGCCUACUCCUUCUUACAUAGCUUCUCCAACAGGGGUAGCAAUGACCUGUCCACUUCAAACACAGAUAAGGCCUGCCAUCCUCAUUGGUUAAAGGCACACGUGAGACUUUCAGUGGGCUCUGCUGAGAAGGAAGGCAGCCCAGGAGUCAGGUAUGCAGGCAUUGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_139177 | 3UTR | CGAACUAGACCAGAAGCCAGCCUACUCCUUCUUACAUAGCUUCUCCAACAGGGGUAGCAAUGACCUGUCCACUUCAAACACAGAUAAGGCCUGCCAUCCUCAUUGGUUAAAGGCACACGUGAGACUUUCAGUGGGCUCUGCUGAGAAGGAAGGCAGCCCAGGAGUCAGGUAUGCAGGCAUUGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_139177 | 3UTR | AUAAAGAAUGAGUCGAACUAGACCAGAAGCCAGCCUACUCCUUCUUACAUAGCUUCUCCAACAGGGGUAGCAAUGACCUGUCCACUUCAAACACAGAUAAGGCCUGCCAUCCUCAUUGGUUAAAGGCACACGUGAGACUUUCAGUGGGCUCUGCUGAGAAGGAAGGCAGCCCAGGAGUCAGGUAUGCAGGCAUUGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_139177 | 3UTR | CUAUAAAGAAUGAGUCGAACUAGACCAGAAGCCAGCCUACUCCUUCUUACAUAGCUUCUCCAACAGGGGUAGCAAUGACCUGUCCACUUCAAACACAGAUAAGGCCUGCCAUCCUCAUUGGUUAAAGGCACACGUGAGACUUUCAGUGGGCUCUGCUGAGAAGGAAGGCAGCCCAGGAGUCAGGUAUGCAGGCAUUGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_001159770 | 3UTR | AAAUGUCCCUAUAAAGAAUGAGUCGAACUAGACCAGAAGCCAGCCUACUCCUUCUUACAUAGCUUCUCCAACAGGGGUAGCAAUGACCUGUCCACUUCAAACACAGAUAAGGCCUGCCAUCCUCAUUGGUUAAAGGCACACGUGAGACUUUCAGUGGGCUCUGCUGAGAAGGAAGGCAGCCCAGGAGUCAGGUAUGCAGGCAUUGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset Chi_124B_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + B
Location of target site ENST00000255559.3 | 3UTR | CUGAGAAGGAAGGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-4291 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT102445 CALU calumenin 2 4
MIRT108677 ZBTB33 zinc finger and BTB domain containing 33 2 4
MIRT125969 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT179018 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT379033 CDK6 cyclin dependent kinase 6 2 6
MIRT442473 CPEB4 cytoplasmic polyadenylation element binding protein 4 2 2
MIRT442910 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 2 2
MIRT442979 ZNF736 zinc finger protein 736 2 2
MIRT445663 TNFSF15 TNF superfamily member 15 2 2
MIRT446237 FZD6 frizzled class receptor 6 2 2
MIRT448860 FAM49B family with sequence similarity 49 member B 2 2
MIRT455559 TRAF1 TNF receptor associated factor 1 2 2
MIRT459704 ZNF641 zinc finger protein 641 2 2
MIRT460608 FEM1A fem-1 homolog A 2 2
MIRT462251 LAMA4 laminin subunit alpha 4 2 2
MIRT462469 FIZ1 FLT3 interacting zinc finger 1 2 2
MIRT466656 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 6
MIRT466841 STX6 syntaxin 6 2 2
MIRT471403 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT471517 PCGF3 polycomb group ring finger 3 2 2
MIRT471681 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT472858 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT474813 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 2 2
MIRT474931 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT475814 HDGF heparin binding growth factor 2 2
MIRT480434 C17orf49 chromosome 17 open reading frame 49 2 2
MIRT480903 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT481478 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT484982 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 8
MIRT485019 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 8
MIRT485036 TMEM189 transmembrane protein 189 2 8
MIRT495074 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT496004 CD180 CD180 molecule 2 2
MIRT500675 TRIM37 tripartite motif containing 37 2 2
MIRT504544 ZNF417 zinc finger protein 417 2 6
MIRT506782 KLHL15 kelch like family member 15 2 6
MIRT507256 FGF2 fibroblast growth factor 2 2 6
MIRT507386 EN2 engrailed homeobox 2 2 2
MIRT512505 BTBD19 BTB domain containing 19 2 2
MIRT516903 CTSB cathepsin B 2 2
MIRT528124 PPP1R10 protein phosphatase 1 regulatory subunit 10 2 2
MIRT528874 ATF3 activating transcription factor 3 2 2
MIRT536091 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT541079 RLIM ring finger protein, LIM domain interacting 2 2
MIRT541099 RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2 2
MIRT545360 LIN7C lin-7 homolog C, crumbs cell polarity complex component 2 2
MIRT545831 ZNF367 zinc finger protein 367 2 4
MIRT547115 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 2
MIRT547312 NPTN neuroplastin 2 2
MIRT547959 HIGD1A HIG1 hypoxia inducible domain family member 1A 2 4
MIRT549943 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT550749 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT565145 TUBB2A tubulin beta 2A class IIa 2 2
MIRT571050 POLQ DNA polymerase theta 2 2
MIRT571361 ZNF45 zinc finger protein 45 2 2
MIRT610133 FOXI2 forkhead box I2 2 2
MIRT613145 DSE dermatan sulfate epimerase 2 2
MIRT613379 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT615752 C6 complement C6 2 2
MIRT616460 ADRA2B adrenoceptor alpha 2B 2 2
MIRT616719 FEM1B fem-1 homolog B 2 2
MIRT618312 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT631491 RASSF4 Ras association domain family member 4 2 2
MIRT643134 PLCXD2 phosphatidylinositol specific phospholipase C X domain containing 2 2 2
MIRT643482 DISC1 disrupted in schizophrenia 1 2 2
MIRT649715 TWSG1 twisted gastrulation BMP signaling modulator 1 2 2
MIRT653542 SLC38A7 solute carrier family 38 member 7 2 2
MIRT666307 SLC22A3 solute carrier family 22 member 3 2 2
MIRT692005 NAP1L4 nucleosome assembly protein 1 like 4 2 2
MIRT696838 ARL2BP ADP ribosylation factor like GTPase 2 binding protein 2 2
MIRT698204 TMEM248 transmembrane protein 248 2 2
MIRT703316 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2 2
MIRT709376 FAM13A family with sequence similarity 13 member A 2 2
MIRT710112 MED23 mediator complex subunit 23 2 2
MIRT711975 HOMER2 homer scaffolding protein 2 2 2
MIRT712275 PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2 2
MIRT714108 TMED9 transmembrane p24 trafficking protein 9 2 2
MIRT719113 MAML1 mastermind like transcriptional coactivator 1 2 2
MIRT719727 SLC39A11 solute carrier family 39 member 11 2 2
MIRT720018 TFAP2C transcription factor AP-2 gamma 2 2
MIRT720358 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT720372 NUDT3 nudix hydrolase 3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4291 Platinum-based doublet chemotherapy resistant High Lung Adenocarcinoma tissue
hsa-miR-4291 Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-4291 Paclitaxel 36314 NSC125973 approved resistant High Prostate Cancer cell line (DU-145, PC-3)
hsa-miR-4291 Doxorubicin 31703 NSC123127 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-4291 Radioactivity Iodine resistant High Papillary Thyroid Cancer tissue
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-4291 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4291 Platinum-based doublet chemotherapy resistant tissue (lung adenocarcinoma)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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