pre-miRNA Information
pre-miRNA hsa-mir-2115   
Genomic Coordinates chr3: 48316360 - 48316459
Description Homo sapiens miR-2115 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2115-5p
Sequence 21| AGCUUCCAUGACUCCUGAUGGA |42
Evidence Experimental
Experiments 454
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs372327506 9 dbSNP
rs1259362191 10 dbSNP
rs1215292065 12 dbSNP
rs1197671843 16 dbSNP
rs1468768022 20 dbSNP
rs1273755407 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ENTHD1   
Synonyms CACNA1I, dJ370M22.3
Description ENTH domain containing 1
Transcript NM_152512   
Expression
Putative miRNA Targets on ENTHD1
3'UTR of ENTHD1
(miRNA target sites are highlighted)
>ENTHD1|NM_152512|3'UTR
   1 TCATCACAATATCTATTTTTGATAGAACTCGTGTGGTTCCACTTCCCCAAGACTTACGTTAGCATTGTATAAATTCATAT
  81 TATTATGGCAAAAAAGGGGATGGTTTAATTTTTCCTTGTCAGGTTTATTAGCAAGTATCTTTCAAACTAATACTTTCATT
 161 TGGGTGGTTTATTTTTTAAAAGGGAAAGATGTCACCTTTGATAATTTCAGATTTAGATATTAGTTCATTTGAAACAGAAG
 241 AGAATTTCATTCTTTCATGCTCTGTACCTCAAATGGGTTAAGCATTAGTGAAAATTGTGGTAAGACCTCAAACTGCAAAT
 321 GACTATTCAAGAGCTTTTGGATAAGGAGGCAGGAAGAAGCTCTTTATCTTTCAACTGTATGGAGCTTGTTAACAAGCCTC
 401 TGAGGTGACCTAGGAGGATTGAGTTTGGGGGTATACATTTCACACATTCTTTTGCAAGTTTTAGGTTCTGCAACCAAGGG
 481 CCAGAAATCTTTTCTTTCTTCCAGATGCTAGTGTTAGGAGTTAAATGGAAACAAGAAGGACATGGGGCAAATGTTTTTAC
 561 TGTCAATGTATATTGCAAGGTGAATTCAAATGCATCCTTTTATTCTACTTCAGAAAATAAATTTGATATTTTTCAAAAAA
 641 AAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agGUAGUCCUCAG--UACCUUCGa 5'
            ::|:||||||:  |||||| | 
Target 5' agTGTTAGGAGTTAAATGGAAACa 3'
510 - 533 142.00 -16.00
2
miRNA  3' aggUAGUCCUCAGUACCUUCga 5'
             || ||||| |  |||||  
Target 5' tggATAAGGAGGC-AGGAAGaa 3'
338 - 358 114.00 -15.40
3
miRNA  3' agGUAGUC-C--UCAGUACC-UUCga 5'
            |||:|| |  | |::||| |||  
Target 5' agCATTAGTGAAAATTGTGGTAAGac 3'
281 - 306 110.00 -10.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31525370 13 COSMIC
COSN26975053 25 COSMIC
COSN20080082 30 COSMIC
COSN29045649 30 COSMIC
COSN30181705 35 COSMIC
COSN20080142 46 COSMIC
COSN30167791 51 COSMIC
COSN26244902 57 COSMIC
COSN30108787 73 COSMIC
COSN30182865 79 COSMIC
COSN30150083 85 COSMIC
COSN30454087 115 COSMIC
COSN30120771 139 COSMIC
COSN31959847 231 COSMIC
COSN30115390 242 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs759134141 3 dbSNP
rs751042972 5 dbSNP
rs375082685 7 dbSNP
rs1214841539 13 dbSNP
rs927884828 17 dbSNP
rs531829824 26 dbSNP
rs768975090 28 dbSNP
rs1227958925 30 dbSNP
rs372057225 31 dbSNP
rs969182999 34 dbSNP
rs775738187 36 dbSNP
rs1450180806 39 dbSNP
rs772294347 41 dbSNP
rs746080228 42 dbSNP
rs1318984588 45 dbSNP
rs1417568577 48 dbSNP
rs34434153 49 dbSNP
rs1362063824 50 dbSNP
rs1328263263 56 dbSNP
rs1225400797 57 dbSNP
rs773509660 58 dbSNP
rs924624631 68 dbSNP
rs1336151655 70 dbSNP
rs1235475220 74 dbSNP
rs1271681240 79 dbSNP
rs1363492361 80 dbSNP
rs956405281 85 dbSNP
rs1436091917 90 dbSNP
rs1031044015 91 dbSNP
rs1444754989 96 dbSNP
rs368264772 96 dbSNP
rs1191893661 99 dbSNP
rs955848444 100 dbSNP
rs552598978 101 dbSNP
rs968830271 108 dbSNP
rs1459550708 113 dbSNP
rs769306841 115 dbSNP
rs1350362974 124 dbSNP
rs1454179280 128 dbSNP
rs1169689250 129 dbSNP
rs527243402 130 dbSNP
rs565138921 133 dbSNP
rs1391802092 152 dbSNP
rs1417169175 165 dbSNP
rs188710377 167 dbSNP
rs1029906241 178 dbSNP
rs1007654614 188 dbSNP
rs1321478436 195 dbSNP
rs541874412 210 dbSNP
rs1240267677 224 dbSNP
rs1262087595 228 dbSNP
rs761269796 229 dbSNP
rs1348133407 239 dbSNP
rs202135360 240 dbSNP
rs737793 245 dbSNP
rs899977712 252 dbSNP
rs1038477508 260 dbSNP
rs993731870 262 dbSNP
rs898099594 265 dbSNP
rs1365707249 268 dbSNP
rs1266508157 278 dbSNP
rs1451917316 278 dbSNP
rs183316478 285 dbSNP
rs762550950 306 dbSNP
rs747520238 310 dbSNP
rs1005668785 317 dbSNP
rs888129046 323 dbSNP
rs1376143204 324 dbSNP
rs1340394722 328 dbSNP
rs1044096266 345 dbSNP
rs1436729683 347 dbSNP
rs1300261305 350 dbSNP
rs948492185 357 dbSNP
rs1311566689 359 dbSNP
rs576967520 364 dbSNP
rs1056925252 367 dbSNP
rs1309628066 372 dbSNP
rs934589957 374 dbSNP
rs1333565473 377 dbSNP
rs924564545 384 dbSNP
rs796949393 397 dbSNP
rs978705557 402 dbSNP
rs1280680015 405 dbSNP
rs1044945928 416 dbSNP
rs1330716981 417 dbSNP
rs191145452 428 dbSNP
rs1279474658 429 dbSNP
rs1480931939 432 dbSNP
rs111998827 436 dbSNP
rs986188951 449 dbSNP
rs28637921 464 dbSNP
rs1368420085 465 dbSNP
rs772450016 471 dbSNP
rs956698584 475 dbSNP
rs747765160 489 dbSNP
rs1395968201 492 dbSNP
rs1455618046 495 dbSNP
rs987570956 513 dbSNP
rs572850656 523 dbSNP
rs1462955790 527 dbSNP
rs553728921 534 dbSNP
rs1030491487 550 dbSNP
rs1394775012 570 dbSNP
rs1433923429 571 dbSNP
rs954342878 573 dbSNP
rs1303652585 589 dbSNP
rs186383857 592 dbSNP
rs1231376399 594 dbSNP
rs181016845 599 dbSNP
rs1016887808 605 dbSNP
rs1433203317 609 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124A_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + A ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agguaguccucaguaCCUUCGa 5'
                         |||||| 
Target 5' ------------gagGGAAGCa 3'
1 - 10
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_124A_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + A
Location of target site ENST00000402142.3 | 3UTR | GAGGGAAGCAGACAGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC -0.879 0.01 -0.771 0.04 6 Click to see details
LUSC -0.502 0.1 -0.310 0.23 8 Click to see details
BLCA -0.915 0.13 -0.500 0.33 3 Click to see details
BRCA -0.258 0.21 -0.308 0.17 12 Click to see details
BRCA -0.258 0.21 -0.308 0.17 12 Click to see details
BRCA -0.258 0.21 -0.308 0.17 12 Click to see details
BRCA -0.258 0.21 -0.308 0.17 12 Click to see details
84 hsa-miR-2115-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT155281 IFNAR2 interferon alpha and beta receptor subunit 2 2 6
MIRT257301 MYLIP myosin regulatory light chain interacting protein 2 8
MIRT441907 SEPN1 selenoprotein N 2 2
MIRT442300 ZNF496 zinc finger protein 496 2 2
MIRT468235 SGK1 serum/glucocorticoid regulated kinase 1 2 2
MIRT469331 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT470203 PSAT1 phosphoserine aminotransferase 1 2 6
MIRT475945 GXYLT1 glucoside xylosyltransferase 1 2 4
MIRT481449 ARRB2 arrestin beta 2 2 2
MIRT497440 SLC16A10 solute carrier family 16 member 10 2 2
MIRT498270 KIAA1644 KIAA1644 2 2
MIRT499225 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT501742 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT501762 NRF1 nuclear respiratory factor 1 2 6
MIRT527902 B3GALT5 beta-1,3-galactosyltransferase 5 2 4
MIRT528559 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT531252 PDF peptide deformylase, mitochondrial 2 2
MIRT539490 ACTN4 actinin alpha 4 2 2
MIRT550683 YARS tyrosyl-tRNA synthetase 2 2
MIRT573441 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT616740 DCTN5 dynactin subunit 5 2 2
MIRT617626 RAB3IP RAB3A interacting protein 2 2
MIRT620780 MT1A metallothionein 1A 2 2
MIRT623174 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT624880 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT625799 MDC1 mediator of DNA damage checkpoint 1 2 2
MIRT629790 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT630535 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT630762 ZNF445 zinc finger protein 445 2 2
MIRT630921 UNC93A unc-93 homolog A 2 2
MIRT630949 PANK1 pantothenate kinase 1 2 2
MIRT631688 NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 2 2
MIRT633898 FGF10 fibroblast growth factor 10 2 2
MIRT635935 PLA2G12A phospholipase A2 group XIIA 2 2
MIRT636177 THBD thrombomodulin 2 2
MIRT636730 AFAP1 actin filament associated protein 1 2 2
MIRT638038 SHPK sedoheptulokinase 2 2
MIRT639164 LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 2 2
MIRT639260 MANEAL mannosidase endo-alpha like 2 2
MIRT639327 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT639849 YY1 YY1 transcription factor 2 2
MIRT641474 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
MIRT642783 CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2 2
MIRT643653 MYOCD myocardin 2 2
MIRT645717 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT648018 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT648236 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT648563 MEMO1 mediator of cell motility 1 2 2
MIRT648731 HIST1H2BD histone cluster 1 H2B family member d 2 2
MIRT650179 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT650721 TNFSF8 TNF superfamily member 8 2 2
MIRT652179 TRIM44 tripartite motif containing 44 2 2
MIRT654272 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT654493 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT654861 PPM1F protein phosphatase, Mg2+/Mn2+ dependent 1F 2 2
MIRT656392 MCU mitochondrial calcium uniporter 2 2
MIRT656623 LRRC15 leucine rich repeat containing 15 2 2
MIRT657085 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT659793 CBLB Cbl proto-oncogene B 2 2
MIRT660155 BRCC3 BRCA1/BRCA2-containing complex subunit 3 2 2
MIRT662444 SERPINB5 serpin family B member 5 2 2
MIRT663116 SPTA1 spectrin alpha, erythrocytic 1 2 2
MIRT665759 TMEM43 transmembrane protein 43 2 2
MIRT666357 SIKE1 suppressor of IKBKE 1 2 2
MIRT668521 ESRRG estrogen related receptor gamma 2 2
MIRT677776 FKTN fukutin 2 2
MIRT678900 TTLL12 tubulin tyrosine ligase like 12 2 2
MIRT702825 HOOK3 hook microtubule tethering protein 3 2 2
MIRT704424 CTNNBIP1 catenin beta interacting protein 1 2 2
MIRT709470 KRTAP19-1 keratin associated protein 19-1 2 2
MIRT710939 MRPL45 mitochondrial ribosomal protein L45 2 2
MIRT713306 TYRP1 tyrosinase related protein 1 2 2
MIRT716932 FAM13A family with sequence similarity 13 member A 2 2
MIRT717539 PYGO2 pygopus family PHD finger 2 2 2
MIRT718060 CYP3A5 cytochrome P450 family 3 subfamily A member 5 2 2
MIRT718934 TRIM66 tripartite motif containing 66 2 2
MIRT719770 ZNF236 zinc finger protein 236 2 2
MIRT720164 PNPO pyridoxamine 5'-phosphate oxidase 2 2
MIRT721280 RAD54L2 RAD54 like 2 2 2
MIRT721359 ENTHD1 ENTH domain containing 1 2 2
MIRT721506 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT721920 LINGO2 leucine rich repeat and Ig domain containing 2 2 2
MIRT722791 FUT4 fucosyltransferase 4 2 2
MIRT723933 SVOP SV2 related protein 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2115 Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-mir-2115 Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-2115-5p Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-2115-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-2115-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2115-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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