pre-miRNA Information
pre-miRNA hsa-mir-3120   
Genomic Coordinates chr1: 172138808 - 172138888
Description Homo sapiens miR-3120 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3120-5p
Sequence 13| CCUGUCUGUGCCUGCUGUACA |33
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 19 1 + 172138838 26449202, 27587585 MiREDiBase
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN26637643 8 COSMIC
COSN31603497 11 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs750386761 8 dbSNP
rs760725207 9 dbSNP
rs766486759 10 dbSNP
rs754055278 12 dbSNP
rs755288536 19 dbSNP
rs754726014 21 dbSNP
Putative Targets

Gene Information
Gene Symbol ENTHD1   
Synonyms CACNA1I, dJ370M22.3
Description ENTH domain containing 1
Transcript NM_152512   
Expression
Putative miRNA Targets on ENTHD1
3'UTR of ENTHD1
(miRNA target sites are highlighted)
>ENTHD1|NM_152512|3'UTR
   1 TCATCACAATATCTATTTTTGATAGAACTCGTGTGGTTCCACTTCCCCAAGACTTACGTTAGCATTGTATAAATTCATAT
  81 TATTATGGCAAAAAAGGGGATGGTTTAATTTTTCCTTGTCAGGTTTATTAGCAAGTATCTTTCAAACTAATACTTTCATT
 161 TGGGTGGTTTATTTTTTAAAAGGGAAAGATGTCACCTTTGATAATTTCAGATTTAGATATTAGTTCATTTGAAACAGAAG
 241 AGAATTTCATTCTTTCATGCTCTGTACCTCAAATGGGTTAAGCATTAGTGAAAATTGTGGTAAGACCTCAAACTGCAAAT
 321 GACTATTCAAGAGCTTTTGGATAAGGAGGCAGGAAGAAGCTCTTTATCTTTCAACTGTATGGAGCTTGTTAACAAGCCTC
 401 TGAGGTGACCTAGGAGGATTGAGTTTGGGGGTATACATTTCACACATTCTTTTGCAAGTTTTAGGTTCTGCAACCAAGGG
 481 CCAGAAATCTTTTCTTTCTTCCAGATGCTAGTGTTAGGAGTTAAATGGAAACAAGAAGGACATGGGGCAAATGTTTTTAC
 561 TGTCAATGTATATTGCAAGGTGAATTCAAATGCATCCTTTTATTCTACTTCAGAAAATAAATTTGATATTTTTCAAAAAA
 641 AAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acAUGUCGUCCGUGUCUGUCc 5'
            || || |||  |||: || 
Target 5' gaTA-AGGAGG--CAGGAAGa 3'
340 - 357 106.00 -11.90
2
miRNA  3' acAUGUCG--UCCGUGUCUGUcc 5'
            |:|| |  |||  |||| |  
Target 5' tcTGCAACCAAGGGCCAGAAAtc 3'
467 - 489 105.00 -8.96
3
miRNA  3' acAUGUCGUCCGUGUCUGUCc 5'
            | || : |  ||||| || 
Target 5' agTTCATTTGAAACAGA-AGa 3'
222 - 241 99.00 -5.44
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31525370 13 COSMIC
COSN26975053 25 COSMIC
COSN20080082 30 COSMIC
COSN29045649 30 COSMIC
COSN30181705 35 COSMIC
COSN20080142 46 COSMIC
COSN30167791 51 COSMIC
COSN26244902 57 COSMIC
COSN30108787 73 COSMIC
COSN30182865 79 COSMIC
COSN30150083 85 COSMIC
COSN30454087 115 COSMIC
COSN30120771 139 COSMIC
COSN31959847 231 COSMIC
COSN30115390 242 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs759134141 3 dbSNP
rs751042972 5 dbSNP
rs375082685 7 dbSNP
rs1214841539 13 dbSNP
rs927884828 17 dbSNP
rs531829824 26 dbSNP
rs768975090 28 dbSNP
rs1227958925 30 dbSNP
rs372057225 31 dbSNP
rs969182999 34 dbSNP
rs775738187 36 dbSNP
rs1450180806 39 dbSNP
rs772294347 41 dbSNP
rs746080228 42 dbSNP
rs1318984588 45 dbSNP
rs1417568577 48 dbSNP
rs34434153 49 dbSNP
rs1362063824 50 dbSNP
rs1328263263 56 dbSNP
rs1225400797 57 dbSNP
rs773509660 58 dbSNP
rs924624631 68 dbSNP
rs1336151655 70 dbSNP
rs1235475220 74 dbSNP
rs1271681240 79 dbSNP
rs1363492361 80 dbSNP
rs956405281 85 dbSNP
rs1436091917 90 dbSNP
rs1031044015 91 dbSNP
rs1444754989 96 dbSNP
rs368264772 96 dbSNP
rs1191893661 99 dbSNP
rs955848444 100 dbSNP
rs552598978 101 dbSNP
rs968830271 108 dbSNP
rs1459550708 113 dbSNP
rs769306841 115 dbSNP
rs1350362974 124 dbSNP
rs1454179280 128 dbSNP
rs1169689250 129 dbSNP
rs527243402 130 dbSNP
rs565138921 133 dbSNP
rs1391802092 152 dbSNP
rs1417169175 165 dbSNP
rs188710377 167 dbSNP
rs1029906241 178 dbSNP
rs1007654614 188 dbSNP
rs1321478436 195 dbSNP
rs541874412 210 dbSNP
rs1240267677 224 dbSNP
rs1262087595 228 dbSNP
rs761269796 229 dbSNP
rs1348133407 239 dbSNP
rs202135360 240 dbSNP
rs737793 245 dbSNP
rs899977712 252 dbSNP
rs1038477508 260 dbSNP
rs993731870 262 dbSNP
rs898099594 265 dbSNP
rs1365707249 268 dbSNP
rs1266508157 278 dbSNP
rs1451917316 278 dbSNP
rs183316478 285 dbSNP
rs762550950 306 dbSNP
rs747520238 310 dbSNP
rs1005668785 317 dbSNP
rs888129046 323 dbSNP
rs1376143204 324 dbSNP
rs1340394722 328 dbSNP
rs1044096266 345 dbSNP
rs1436729683 347 dbSNP
rs1300261305 350 dbSNP
rs948492185 357 dbSNP
rs1311566689 359 dbSNP
rs576967520 364 dbSNP
rs1056925252 367 dbSNP
rs1309628066 372 dbSNP
rs934589957 374 dbSNP
rs1333565473 377 dbSNP
rs924564545 384 dbSNP
rs796949393 397 dbSNP
rs978705557 402 dbSNP
rs1280680015 405 dbSNP
rs1044945928 416 dbSNP
rs1330716981 417 dbSNP
rs191145452 428 dbSNP
rs1279474658 429 dbSNP
rs1480931939 432 dbSNP
rs111998827 436 dbSNP
rs986188951 449 dbSNP
rs28637921 464 dbSNP
rs1368420085 465 dbSNP
rs772450016 471 dbSNP
rs956698584 475 dbSNP
rs747765160 489 dbSNP
rs1395968201 492 dbSNP
rs1455618046 495 dbSNP
rs987570956 513 dbSNP
rs572850656 523 dbSNP
rs1462955790 527 dbSNP
rs553728921 534 dbSNP
rs1030491487 550 dbSNP
rs1394775012 570 dbSNP
rs1433923429 571 dbSNP
rs954342878 573 dbSNP
rs1303652585 589 dbSNP
rs186383857 592 dbSNP
rs1231376399 594 dbSNP
rs181016845 599 dbSNP
rs1016887808 605 dbSNP
rs1433203317 609 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124A_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + A ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acauguCGUCCGU-GUCUGUCc 5'
                | :|| | ||||||| 
Target 5' ------GAGGGAAGCAGACAGa 3'
1 - 16
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_124A_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + A
Location of target site ENST00000402142.3 | 3UTR | GAGGGAAGCAGACAGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
134 hsa-miR-3120-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT096972 BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 2 2
MIRT442624 LOX lysyl oxidase 2 2
MIRT473438 MDM4 MDM4, p53 regulator 2 2
MIRT490011 KIFC2 kinesin family member C2 2 2
MIRT496449 N6AMT1 N-6 adenine-specific DNA methyltransferase 1 2 2
MIRT496752 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT497721 CYP1A1 cytochrome P450 family 1 subfamily A member 1 2 2
MIRT498287 PADI3 peptidyl arginine deiminase 3 2 2
MIRT503195 ACVR1B activin A receptor type 1B 2 4
MIRT504760 TEP1 telomerase associated protein 1 2 4
MIRT517810 UGDH UDP-glucose 6-dehydrogenase 2 6
MIRT519686 ZNF622 zinc finger protein 622 2 4
MIRT520263 URGCP upregulator of cell proliferation 2 2
MIRT523051 ICMT isoprenylcysteine carboxyl methyltransferase 2 2
MIRT525601 OLR1 oxidized low density lipoprotein receptor 1 2 4
MIRT526995 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT528699 TRAF3IP2 TRAF3 interacting protein 2 2 4
MIRT533142 WNT10A Wnt family member 10A 2 2
MIRT537618 ERI1 exoribonuclease 1 2 2
MIRT539707 EIF3H eukaryotic translation initiation factor 3 subunit H 2 2
MIRT539752 CNBP CCHC-type zinc finger nucleic acid binding protein 2 2
MIRT539808 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT539941 IFNAR2 interferon alpha and beta receptor subunit 2 2 2
MIRT540424 FAM83F family with sequence similarity 83 member F 2 2
MIRT540509 CXCL10 C-X-C motif chemokine ligand 10 2 2
MIRT540720 GUF1 GUF1 homolog, GTPase 2 2
MIRT541630 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT542286 POLR3K RNA polymerase III subunit K 2 2
MIRT542456 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT542550 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542771 PPAP2B phospholipid phosphatase 3 2 2
MIRT550085 TRAPPC2 trafficking protein particle complex 2 2 2
MIRT551458 CARKD NAD(P)HX dehydratase 2 2
MIRT555622 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 2
MIRT569136 KATNAL1 katanin catalytic subunit A1 like 1 2 2
MIRT572328 HSPB6 heat shock protein family B (small) member 6 2 2
MIRT574607 LZIC leucine zipper and CTNNBIP1 domain containing 2 2
MIRT575583 Mcm8 minichromosome maintenance 8 homologous recombination repair factor 2 4
MIRT576125 Hrk harakiri, BCL2 interacting protein (contains only BH3 domain) 2 5
MIRT576657 Fam216a family with sequence similarity 216, member A 2 2
MIRT607222 ACSM2A acyl-CoA synthetase medium chain family member 2A 2 4
MIRT607292 CD300E CD300e molecule 2 6
MIRT607746 ANGPT4 angiopoietin 4 2 2
MIRT607905 SPRYD4 SPRY domain containing 4 2 2
MIRT608159 HRK harakiri, BCL2 interacting protein 2 7
MIRT608657 ABCF3 ATP binding cassette subfamily F member 3 2 4
MIRT609115 ZNF703 zinc finger protein 703 2 6
MIRT610231 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT610870 NUDCD3 NudC domain containing 3 2 2
MIRT611217 MC2R melanocortin 2 receptor 2 2
MIRT614858 PLEKHA6 pleckstrin homology domain containing A6 2 2
MIRT616966 LMX1A LIM homeobox transcription factor 1 alpha 2 2
MIRT617258 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT618009 SLC9A3R2 SLC9A3 regulator 2 2 2
MIRT619067 BSND barttin CLCNK type accessory beta subunit 2 4
MIRT619295 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT619348 GINM1 glycoprotein integral membrane 1 2 2
MIRT619362 CFHR5 complement factor H related 5 2 2
MIRT619541 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT619782 NRIP2 nuclear receptor interacting protein 2 2 2
MIRT619994 NPAP1 nuclear pore associated protein 1 2 2
MIRT621030 CDC14B cell division cycle 14B 2 2
MIRT622033 STAT5A signal transducer and activator of transcription 5A 2 2
MIRT622728 PITPNM3 PITPNM family member 3 2 2
MIRT623144 NAV2 neuron navigator 2 2 2
MIRT623600 IPO9 importin 9 2 2
MIRT624608 B3GALT5 beta-1,3-galactosyltransferase 5 2 2
MIRT624905 CTCFL CCCTC-binding factor like 2 2
MIRT625030 SPC24 SPC24, NDC80 kinetochore complex component 2 2
MIRT625688 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 5
MIRT626531 EMCN endomucin 2 2
MIRT627204 ZDHHC20 zinc finger DHHC-type containing 20 2 2
MIRT628033 LSAMP limbic system-associated membrane protein 2 2
MIRT628203 FREM2 FRAS1 related extracellular matrix protein 2 2 2
MIRT631012 LINS lines homolog 1 2 2
MIRT633195 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 2
MIRT633890 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT634023 MOB4 MOB family member 4, phocein 2 2
MIRT634416 PLCXD3 phosphatidylinositol specific phospholipase C X domain containing 3 2 2
MIRT636866 ARSE arylsulfatase E (chondrodysplasia punctata 1) 2 2
MIRT642527 ANKRD9 ankyrin repeat domain 9 2 2
MIRT645408 FAM110A family with sequence similarity 110 member A 2 2
MIRT645635 SYTL4 synaptotagmin like 4 2 2
MIRT646013 TNFAIP8L2 TNF alpha induced protein 8 like 2 2 2
MIRT646686 ASGR2 asialoglycoprotein receptor 2 2 2
MIRT652838 TACO1 translational activator of cytochrome c oxidase I 2 2
MIRT655156 PHF21B PHD finger protein 21B 2 2
MIRT658491 EXOC7 exocyst complex component 7 2 2
MIRT659398 CORO2A coronin 2A 2 2
MIRT666825 PRCP prolylcarboxypeptidase 2 2
MIRT666866 POU2F2 POU class 2 homeobox 2 2 2
MIRT668224 GABRA1 gamma-aminobutyric acid type A receptor alpha1 subunit 2 2
MIRT673288 PDE3A phosphodiesterase 3A 2 2
MIRT673878 KLF2 Kruppel like factor 2 2 2
MIRT681721 KCNE4 potassium voltage-gated channel subfamily E regulatory subunit 4 2 2
MIRT682406 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT684109 MCM10 minichromosome maintenance 10 replication initiation factor 2 2
MIRT684423 TUFT1 tuftelin 1 2 2
MIRT684684 OR7D2 olfactory receptor family 7 subfamily D member 2 2 2
MIRT686638 TMEM184C transmembrane protein 184C 2 2
MIRT689457 NXN nucleoredoxin 2 2
MIRT689627 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT690773 PLA2G2C phospholipase A2 group IIC 2 2
MIRT690822 SGSM2 small G protein signaling modulator 2 2 2
MIRT693669 MXRA7 matrix remodeling associated 7 2 2
MIRT695553 CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2 2
MIRT695872 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT698160 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT699933 RUFY2 RUN and FYVE domain containing 2 2 2
MIRT708639 UBE2W ubiquitin conjugating enzyme E2 W 2 2
MIRT710816 RAB11FIP4 RAB11 family interacting protein 4 2 2
MIRT711242 TRAT1 T-cell receptor associated transmembrane adaptor 1 2 2
MIRT711542 MSH3 mutS homolog 3 2 2
MIRT711749 DTX1 deltex E3 ubiquitin ligase 1 2 2
MIRT712303 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT712922 RPF2 ribosome production factor 2 homolog 2 2
MIRT714027 SYDE2 synapse defective Rho GTPase homolog 2 2 2
MIRT714768 TERF1 telomeric repeat binding factor 1 2 2
MIRT714844 ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif 17 2 2
MIRT715223 NPVF neuropeptide VF precursor 2 2
MIRT716110 GMPS guanine monophosphate synthase 2 2
MIRT716174 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT716383 C6orf223 chromosome 6 open reading frame 223 2 2
MIRT716527 KSR2 kinase suppressor of ras 2 2 2
MIRT716962 P2RY6 pyrimidinergic receptor P2Y6 2 2
MIRT717605 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT717696 PTGS1 prostaglandin-endoperoxide synthase 1 2 2
MIRT721360 ENTHD1 ENTH domain containing 1 2 2
MIRT721381 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT721935 RASSF2 Ras association domain family member 2 2 2
MIRT722094 SUSD1 sushi domain containing 1 2 2
MIRT722837 C17orf102 chromosome 17 open reading frame 102 2 2
MIRT722990 TOR1A torsin family 1 member A 2 2
MIRT724174 ABCF2 ATP binding cassette subfamily F member 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3120-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-3120-5p Prednisone/Azathioprine/Methotrexate/Cyclophosphamide/Mycophenolate mofetil sensitive tissue (myasthenia gravis)
hsa-miR-3120-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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