pre-miRNA Information
pre-miRNA hsa-mir-216a   
Genomic Coordinates chr2: 55988950 - 55989059
Description Homo sapiens miR-216a stem-loop
Comment This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-216a-5p
Sequence 19| UAAUCUCAGCUGGCAACUGUGA |40
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 15 2 - 55989027 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757094946 2 dbSNP
rs746980700 8 dbSNP
rs1249388997 12 dbSNP
rs1188616124 15 dbSNP
rs1490501989 19 dbSNP
rs1465789697 20 dbSNP
rs370221981 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Tissue .
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma MiRNA qPCR analyses
Gene Information
Gene Symbol MCM8   
Synonyms C20orf154, POF10, dJ967N21.5
Description minichromosome maintenance 8 homologous recombination repair factor
Transcript NM_032485   
Other Transcripts NM_182802   
Expression
Putative miRNA Targets on MCM8
3'UTR of MCM8
(miRNA target sites are highlighted)
>MCM8|NM_032485|3'UTR
   1 AAGGACTTCACCAAGTTAGGGCCTCCTGGGTTTATTGCAGATTAAAGCCATCTCAGTGAAGATATGCGTGCACGCACAGA
  81 CAGACAGACACACACACACACACACACACACACACACACACACACACACACAGTCAAATACTGTTCTCTGAAAAATGATG
 161 TCCCAAAAGTATTATAATAGGAAAAAAGCATTAAATATAATAAACTAATTTAAGAAGTGATAAAGTCTCCAGATGCAGTA
 241 GCTCACACTGTAATCACAGTGACTCAGGAGGCTGAGGTGAGAGGATTCCTTGAGGCCAGGGTTCGAGACCAACCTTGGGC
 321 AACATAGCAAGACCCCATTTCTTAAAAAAAAAAAAAAAAAATTTAAACTTAGCTGGGTATGGTGGCACATGCCTATAGTC
 401 TCAGCTACTTGTGAGGCTGAGGCAGGAGGATTCTTTGAGCCCAGGAGTTTGAGGTTACAGTGAGCCACAATCACACCAAT
 481 CACTGCACTCCAGCCTGGGCAATAAAGTAACTCTTGACTCAAAAAAATAAAAAAAATTGTAGTGGTAGCCATGTGTTAAT
 561 TGTTAAATAAATTCTCCAAAGGGCTAAAAGTAAATTACTTATAAATTTTTTATAGTTGTATTTTTGACCTGCCTTTTATA
 641 TGTATGAATATTTCATAGTTTTGCATATCAGATGTAGGCATACAGACAAATACATAAACCAATGAATATATTACATATTC
 721 TGTGTTCCAATAAAACTTTATTTATGGACACTAAAATTTGAATTTCATAAAATTTTCCCATGTCAAGAATACAAAATACT
 801 TGAGTTTTGTTTTTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agugucAAC---GGUC----GACUCUAAu 5'
                |||   ||||    :||||:|| 
Target 5' gattctTTGAGCCCAGGAGTTTGAGGTTa 3'
429 - 457 134.00 -12.80
2
miRNA  3' agUGUCAACG-GU----CGACUCUAau 5'
            |||||  | ||    ||||||:|  
Target 5' tcACAGTGACTCAGGAGGCTGAGGTga 3'
254 - 280 126.00 -19.00
3
miRNA  3' agugUCAA---CGGUCGACUCUAAu 5'
              ||||   |||  |||:| || 
Target 5' accaAGTTAGGGCCTCCTGGGTTTa 3'
10 - 34 114.00 -12.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30447288 4 COSMIC
COSN30491765 13 COSMIC
COSN30450035 20 COSMIC
COSN30483098 27 COSMIC
COSN30132242 69 COSMIC
COSN30599116 88 COSMIC
COSN28201539 92 COSMIC
COSN32065401 132 COSMIC
COSN16448737 159 COSMIC
COSN1879209 215 COSMIC
COSN7101114 465 COSMIC
COSN10019531 473 COSMIC
COSN5447275 1806 COSMIC
COSN8563878 2094 COSMIC
COSN27958349 2105 COSMIC
COSN15409631 2121 COSMIC
COSN10019535 2603 COSMIC
COSN14936742 2762 COSMIC
COSN17987486 2788 COSMIC
COSN23723041 3033 COSMIC
COSN22282343 3545 COSMIC
COSN16265555 3655 COSMIC
COSN20203587 3734 COSMIC
COSN32014753 3775 COSMIC
COSN22631436 3838 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1419460198 6 dbSNP
rs764835365 8 dbSNP
rs1381504193 10 dbSNP
rs752371390 13 dbSNP
rs762710702 16 dbSNP
rs1282349069 22 dbSNP
rs977049067 25 dbSNP
rs376518845 34 dbSNP
rs1442864546 38 dbSNP
rs751285294 44 dbSNP
rs1279472390 50 dbSNP
rs1255491783 51 dbSNP
rs746438411 55 dbSNP
rs1484381755 60 dbSNP
rs930153918 61 dbSNP
rs1172149495 62 dbSNP
rs1055942136 64 dbSNP
rs1354098823 66 dbSNP
rs892892367 68 dbSNP
rs567007907 69 dbSNP
rs1047254799 74 dbSNP
rs1359493356 76 dbSNP
rs1393448199 76 dbSNP
rs1296466288 80 dbSNP
rs1011450375 84 dbSNP
rs1165632098 84 dbSNP
rs1193133416 84 dbSNP
rs1361501135 84 dbSNP
rs1368365393 84 dbSNP
rs1417670127 84 dbSNP
rs1425578039 84 dbSNP
rs888528120 84 dbSNP
rs1488502253 86 dbSNP
rs11472210 88 dbSNP
rs1198726769 88 dbSNP
rs1211498960 88 dbSNP
rs1231563668 88 dbSNP
rs1256934981 88 dbSNP
rs1268009421 88 dbSNP
rs1280916130 88 dbSNP
rs1319614245 88 dbSNP
rs1426014905 88 dbSNP
rs1432335560 88 dbSNP
rs1457025318 88 dbSNP
rs1479382214 88 dbSNP
rs201714626 88 dbSNP
rs33960795 88 dbSNP
rs57347411 88 dbSNP
rs879023467 88 dbSNP
rs879141925 88 dbSNP
rs879200007 88 dbSNP
rs1339730044 90 dbSNP
rs1387238895 91 dbSNP
rs11546315 92 dbSNP
rs1303324621 93 dbSNP
rs1045462382 94 dbSNP
rs1232337515 95 dbSNP
rs1286284340 96 dbSNP
rs1466188630 98 dbSNP
rs1402759443 99 dbSNP
rs905207625 102 dbSNP
rs1001836128 104 dbSNP
rs902744368 106 dbSNP
rs1213803140 107 dbSNP
rs386393202 108 dbSNP
rs999718127 113 dbSNP
rs1284630114 123 dbSNP
rs1178734649 127 dbSNP
rs1035617044 128 dbSNP
rs1458683708 129 dbSNP
rs1260868201 131 dbSNP
rs1199468184 132 dbSNP
rs181475758 132 dbSNP
rs10645380 133 dbSNP
rs1192210021 133 dbSNP
rs1010069611 134 dbSNP
rs1020151408 135 dbSNP
rs1431786380 137 dbSNP
rs1193473406 138 dbSNP
rs147617435 153 dbSNP
rs1018741320 159 dbSNP
rs1157104563 163 dbSNP
rs962830197 165 dbSNP
rs531373019 166 dbSNP
rs1379642909 167 dbSNP
rs1359907884 174 dbSNP
rs548375669 182 dbSNP
rs974292659 190 dbSNP
rs1295207954 196 dbSNP
rs561584463 199 dbSNP
rs951224351 229 dbSNP
rs527379236 230 dbSNP
rs1018333384 237 dbSNP
rs577864424 238 dbSNP
rs977375770 239 dbSNP
rs1285937410 240 dbSNP
rs1051583 241 dbSNP
rs1241439355 245 dbSNP
rs928568452 256 dbSNP
rs1308077917 263 dbSNP
rs186725332 268 dbSNP
rs922850271 272 dbSNP
rs1055465010 289 dbSNP
rs1315566186 291 dbSNP
rs757195870 292 dbSNP
rs1397916909 299 dbSNP
rs767396583 305 dbSNP
rs982896094 306 dbSNP
rs1212765482 313 dbSNP
rs910083321 314 dbSNP
rs1411493597 315 dbSNP
rs947169632 317 dbSNP
rs1475128661 323 dbSNP
rs1369869819 328 dbSNP
rs1195072951 330 dbSNP
rs1425804597 333 dbSNP
rs1190972457 336 dbSNP
rs1476909373 337 dbSNP
rs1487521103 340 dbSNP
rs1041886958 341 dbSNP
rs745355197 341 dbSNP
rs941415023 342 dbSNP
rs1415944983 343 dbSNP
rs1045176455 344 dbSNP
rs11422423 344 dbSNP
rs1278650030 344 dbSNP
rs1373095666 344 dbSNP
rs397715439 344 dbSNP
rs755696022 344 dbSNP
rs768449987 344 dbSNP
rs77873783 344 dbSNP
rs1331882666 345 dbSNP
rs1374636415 354 dbSNP
rs902670642 357 dbSNP
rs1185512101 360 dbSNP
rs1491476750 361 dbSNP
rs905154775 363 dbSNP
rs935539778 369 dbSNP
rs1477330801 378 dbSNP
rs1337746943 382 dbSNP
rs888233672 384 dbSNP
rs1226113118 386 dbSNP
rs1194911919 391 dbSNP
rs939357349 394 dbSNP
rs1131807 396 dbSNP
rs1131808 398 dbSNP
rs553701908 399 dbSNP
rs748529134 400 dbSNP
rs1485561510 402 dbSNP
rs891386689 406 dbSNP
rs1173157547 416 dbSNP
rs1167057294 427 dbSNP
rs1007263235 435 dbSNP
rs1131810 439 dbSNP
rs1196790760 443 dbSNP
rs1366627113 453 dbSNP
rs1131812 460 dbSNP
rs1018296395 475 dbSNP
rs1460816198 478 dbSNP
rs1056905396 489 dbSNP
rs895716474 492 dbSNP
rs1010184295 500 dbSNP
rs1444319986 501 dbSNP
rs995592421 508 dbSNP
rs1330248999 513 dbSNP
rs1365141466 514 dbSNP
rs1274199126 521 dbSNP
rs1379524933 523 dbSNP
rs1025759407 529 dbSNP
rs1332759157 529 dbSNP
rs1310015873 537 dbSNP
rs192085182 540 dbSNP
rs948260816 542 dbSNP
rs1035564438 552 dbSNP
rs1020099378 555 dbSNP
rs542825164 562 dbSNP
rs991532718 571 dbSNP
rs904374578 579 dbSNP
rs1190971801 586 dbSNP
rs1309496183 590 dbSNP
rs1000313831 593 dbSNP
rs1018030903 603 dbSNP
rs1457341211 604 dbSNP
rs1459359887 609 dbSNP
rs547217434 639 dbSNP
rs976441923 641 dbSNP
rs1206820546 649 dbSNP
rs1310653933 655 dbSNP
rs1277741507 657 dbSNP
rs1219559050 658 dbSNP
rs1232490124 664 dbSNP
rs1029309716 666 dbSNP
rs951619203 672 dbSNP
rs983010575 679 dbSNP
rs1483730938 682 dbSNP
rs977138113 689 dbSNP
rs1376916025 694 dbSNP
rs1332774458 695 dbSNP
rs149073298 698 dbSNP
rs1358183731 700 dbSNP
rs763408564 703 dbSNP
rs1415351857 710 dbSNP
rs1474926213 715 dbSNP
rs935469266 716 dbSNP
rs376226983 718 dbSNP
rs754720697 719 dbSNP
rs981232059 721 dbSNP
rs891355449 722 dbSNP
rs1425757506 728 dbSNP
rs942980409 734 dbSNP
rs926723302 735 dbSNP
rs1169531636 753 dbSNP
rs1237100764 759 dbSNP
rs746678088 768 dbSNP
rs1210590224 772 dbSNP
rs1040391005 773 dbSNP
rs1283809314 781 dbSNP
rs1239405097 785 dbSNP
rs1354317683 789 dbSNP
rs544281487 795 dbSNP
rs1308563294 796 dbSNP
rs898479316 800 dbSNP
rs1378017387 815 dbSNP
rs768855655 820 dbSNP
rs774645792 834 dbSNP
rs562858967 836 dbSNP
rs114567058 844 dbSNP
rs1449219266 847 dbSNP
rs1377593604 853 dbSNP
rs1296724926 878 dbSNP
rs1300749402 879 dbSNP
rs1419694470 879 dbSNP
rs913915827 881 dbSNP
rs945921871 882 dbSNP
rs1161441623 892 dbSNP
rs760628000 897 dbSNP
rs1422085536 901 dbSNP
rs1377738742 903 dbSNP
rs1025698738 906 dbSNP
rs1400142752 916 dbSNP
rs570446641 934 dbSNP
rs904322711 935 dbSNP
rs1262367846 937 dbSNP
rs236124 943 dbSNP
rs566801387 948 dbSNP
rs1232830112 963 dbSNP
rs1039982879 965 dbSNP
rs958815701 967 dbSNP
rs1272685632 979 dbSNP
rs1337958501 983 dbSNP
rs1276746097 992 dbSNP
rs1313189534 992 dbSNP
rs899563755 993 dbSNP
rs1212432073 995 dbSNP
rs1235955153 997 dbSNP
rs998373387 1002 dbSNP
rs182009921 1005 dbSNP
rs6107733 1023 dbSNP
rs1165562582 1031 dbSNP
rs951071119 1033 dbSNP
rs1004384366 1034 dbSNP
rs1265204816 1041 dbSNP
rs968404727 1042 dbSNP
rs1478001856 1044 dbSNP
rs1263767303 1047 dbSNP
rs1189339944 1051 dbSNP
rs1017151090 1067 dbSNP
rs1265587415 1070 dbSNP
rs1214983969 1073 dbSNP
rs73070617 1074 dbSNP
rs1256979166 1075 dbSNP
rs1425557154 1076 dbSNP
rs1415965807 1079 dbSNP
rs980942467 1082 dbSNP
rs933090080 1083 dbSNP
rs986902208 1084 dbSNP
rs926811927 1085 dbSNP
rs11616 1105 dbSNP
rs960792190 1107 dbSNP
rs992261800 1111 dbSNP
rs1367476168 1121 dbSNP
rs187614563 1128 dbSNP
rs942887829 1130 dbSNP
rs189585261 1131 dbSNP
rs1398412639 1133 dbSNP
rs374430931 1134 dbSNP
rs1170155413 1135 dbSNP
rs182275998 1136 dbSNP
rs1337808184 1141 dbSNP
rs758231752 1143 dbSNP
rs1429193692 1146 dbSNP
rs1432563775 1159 dbSNP
rs1270136879 1160 dbSNP
rs925890601 1163 dbSNP
rs935940812 1164 dbSNP
rs1039527524 1170 dbSNP
rs899678812 1176 dbSNP
rs1456041243 1178 dbSNP
rs1221347487 1179 dbSNP
rs1237193808 1180 dbSNP
rs997869277 1202 dbSNP
rs1276761589 1206 dbSNP
rs1253486495 1213 dbSNP
rs140486177 1215 dbSNP
rs1002944550 1222 dbSNP
rs555898258 1226 dbSNP
rs1050805766 1227 dbSNP
rs1443201381 1228 dbSNP
rs1347477171 1238 dbSNP
rs1217400316 1243 dbSNP
rs567314953 1244 dbSNP
rs886743317 1249 dbSNP
rs777367199 1256 dbSNP
rs1398870788 1258 dbSNP
rs142228967 1265 dbSNP
rs1247278399 1269 dbSNP
rs1021509691 1274 dbSNP
rs1395615333 1276 dbSNP
rs1016577185 1289 dbSNP
rs751294407 1302 dbSNP
rs1437298341 1313 dbSNP
rs1379203307 1319 dbSNP
rs1178714548 1323 dbSNP
rs1439255897 1327 dbSNP
rs1253575509 1329 dbSNP
rs1199101074 1336 dbSNP
rs151218038 1353 dbSNP
rs1237209217 1359 dbSNP
rs780902432 1359 dbSNP
rs745340246 1362 dbSNP
rs1308703604 1363 dbSNP
rs1033827618 1366 dbSNP
rs1239841842 1368 dbSNP
rs538580732 1370 dbSNP
rs998454067 1373 dbSNP
rs140952731 1375 dbSNP
rs1395269127 1379 dbSNP
rs1375778334 1382 dbSNP
rs954408899 1387 dbSNP
rs987166091 1392 dbSNP
rs55961635 1405 dbSNP
rs1021041301 1410 dbSNP
rs975987724 1415 dbSNP
rs920165365 1416 dbSNP
rs1186341678 1422 dbSNP
rs1358001740 1424 dbSNP
rs1424008563 1428 dbSNP
rs111979716 1437 dbSNP
rs554755954 1439 dbSNP
rs138907854 1448 dbSNP
rs925305452 1449 dbSNP
rs1352876924 1453 dbSNP
rs1439010513 1453 dbSNP
rs1057208940 1456 dbSNP
rs769067868 1462 dbSNP
rs975755593 1463 dbSNP
rs1012713891 1474 dbSNP
rs1359831405 1475 dbSNP
rs1043301341 1480 dbSNP
rs1241093987 1483 dbSNP
rs138771663 1485 dbSNP
rs921068426 1490 dbSNP
rs140616672 1502 dbSNP
rs1162095054 1504 dbSNP
rs562761761 1506 dbSNP
rs1050921781 1507 dbSNP
rs1419553385 1525 dbSNP
rs1351526630 1530 dbSNP
rs904411161 1536 dbSNP
rs1204697829 1538 dbSNP
rs1290468173 1540 dbSNP
rs1449209774 1541 dbSNP
rs1287859540 1543 dbSNP
rs998716055 1552 dbSNP
rs1335749136 1555 dbSNP
rs1453307237 1564 dbSNP
rs1275213000 1572 dbSNP
rs1216608700 1588 dbSNP
rs533390999 1597 dbSNP
rs1270530631 1599 dbSNP
rs79177862 1600 dbSNP
rs1329270531 1604 dbSNP
rs1322370776 1608 dbSNP
rs748460285 1611 dbSNP
rs1017312888 1613 dbSNP
rs145668045 1615 dbSNP
rs964834654 1619 dbSNP
rs772258677 1625 dbSNP
rs898171556 1631 dbSNP
rs527976903 1644 dbSNP
rs1378157252 1645 dbSNP
rs975576250 1650 dbSNP
rs1002419423 1656 dbSNP
rs773317584 1657 dbSNP
rs1468938058 1673 dbSNP
rs896774702 1686 dbSNP
rs549170916 1695 dbSNP
rs1197039957 1697 dbSNP
rs1307106437 1708 dbSNP
rs1273531409 1714 dbSNP
rs908828190 1717 dbSNP
rs372418390 1718 dbSNP
rs1274105361 1721 dbSNP
rs1130013 1724 dbSNP
rs1130014 1726 dbSNP
rs1130015 1728 dbSNP
rs1394121325 1732 dbSNP
rs1013758798 1736 dbSNP
rs993240277 1747 dbSNP
rs1334243675 1748 dbSNP
rs1021157491 1757 dbSNP
rs1354744092 1758 dbSNP
rs915974994 1762 dbSNP
rs557857408 1767 dbSNP
rs979526168 1768 dbSNP
rs1173511597 1781 dbSNP
rs1231305445 1782 dbSNP
rs1455068830 1783 dbSNP
rs1272483162 1792 dbSNP
rs1176853192 1806 dbSNP
rs531324148 1808 dbSNP
rs1200382463 1809 dbSNP
rs1440439378 1811 dbSNP
rs1235948096 1813 dbSNP
rs1279547825 1815 dbSNP
rs1436916814 1822 dbSNP
rs1234987919 1833 dbSNP
rs34366842 1838 dbSNP
rs1052960486 1844 dbSNP
rs1306533696 1844 dbSNP
rs571235331 1852 dbSNP
rs1373618679 1864 dbSNP
rs1471527165 1865 dbSNP
rs1280890863 1870 dbSNP
rs879266495 1870 dbSNP
rs1417847369 1871 dbSNP
rs1354450029 1875 dbSNP
rs538666032 1877 dbSNP
rs1173335844 1878 dbSNP
rs1394809071 1883 dbSNP
rs1390998250 1884 dbSNP
rs1312623233 1885 dbSNP
rs1435960894 1885 dbSNP
rs1335105704 1888 dbSNP
rs1211323168 1889 dbSNP
rs1486643161 1889 dbSNP
rs200830996 1889 dbSNP
rs35939975 1889 dbSNP
rs398061286 1889 dbSNP
rs71334370 1889 dbSNP
rs748892874 1889 dbSNP
rs796233264 1889 dbSNP
rs1342279566 1890 dbSNP
rs397865902 1903 dbSNP
rs79961663 1904 dbSNP
rs975324624 1905 dbSNP
rs1226298378 1912 dbSNP
rs1354426220 1915 dbSNP
rs1293122744 1916 dbSNP
rs900192476 1918 dbSNP
rs1357920907 1928 dbSNP
rs994975657 1931 dbSNP
rs547410812 1934 dbSNP
rs236125 1938 dbSNP
rs1220218899 1950 dbSNP
rs933951439 1959 dbSNP
rs1249356562 1964 dbSNP
rs986581560 1972 dbSNP
rs952848146 1975 dbSNP
rs1417394346 1976 dbSNP
rs982955976 1977 dbSNP
rs1476044054 1983 dbSNP
rs1260970779 1991 dbSNP
rs1491118577 1992 dbSNP
rs1491537646 1993 dbSNP
rs1262046936 2003 dbSNP
rs1200612789 2007 dbSNP
rs113799759 2014 dbSNP
rs1333722239 2026 dbSNP
rs960297577 2032 dbSNP
rs992814479 2033 dbSNP
rs939748615 2043 dbSNP
rs1293853224 2048 dbSNP
rs1363261281 2050 dbSNP
rs1290764704 2058 dbSNP
rs1186653594 2065 dbSNP
rs144407709 2074 dbSNP
rs1478406219 2078 dbSNP
rs898125943 2079 dbSNP
rs1421265829 2080 dbSNP
rs576157515 2081 dbSNP
rs948773348 2091 dbSNP
rs979254690 2100 dbSNP
rs566302516 2101 dbSNP
rs1054838130 2104 dbSNP
rs1188958153 2105 dbSNP
rs536822496 2107 dbSNP
rs1404698313 2115 dbSNP
rs1052899582 2117 dbSNP
rs377123209 2117 dbSNP
rs764012323 2118 dbSNP
rs1233948328 2119 dbSNP
rs1250042642 2121 dbSNP
rs578026936 2129 dbSNP
rs201670403 2130 dbSNP
rs1298282754 2131 dbSNP
rs1401726067 2135 dbSNP
rs1305694659 2142 dbSNP
rs760770667 2144 dbSNP
rs1021106467 2145 dbSNP
rs1038973144 2153 dbSNP
rs140181005 2153 dbSNP
rs74799502 2153 dbSNP
rs545431898 2160 dbSNP
rs902702774 2161 dbSNP
rs1394590565 2162 dbSNP
rs1000919319 2165 dbSNP
rs1032850864 2170 dbSNP
rs964860727 2178 dbSNP
rs996580814 2185 dbSNP
rs1030358307 2189 dbSNP
rs1395199719 2201 dbSNP
rs1453700352 2201 dbSNP
rs1004361599 2212 dbSNP
rs1456212312 2213 dbSNP
rs1249306113 2218 dbSNP
rs1015784186 2220 dbSNP
rs1481138449 2222 dbSNP
rs564608074 2225 dbSNP
rs370061064 2230 dbSNP
rs1347789365 2236 dbSNP
rs560070577 2239 dbSNP
rs1236515795 2247 dbSNP
rs1334207895 2248 dbSNP
rs1488986265 2250 dbSNP
rs186835350 2251 dbSNP
rs1260330103 2252 dbSNP
rs542880794 2257 dbSNP
rs561170034 2259 dbSNP
rs1310814663 2280 dbSNP
rs148370672 2282 dbSNP
rs1200068289 2292 dbSNP
rs550069117 2293 dbSNP
rs76712193 2297 dbSNP
rs1452762111 2302 dbSNP
rs1173285177 2315 dbSNP
rs978795637 2316 dbSNP
rs973966783 2320 dbSNP
rs1421607474 2323 dbSNP
rs1420472882 2324 dbSNP
rs1253195645 2325 dbSNP
rs1287035876 2336 dbSNP
rs1384249117 2338 dbSNP
rs1485639095 2340 dbSNP
rs6117029 2347 dbSNP
rs1213153634 2349 dbSNP
rs1303073613 2361 dbSNP
rs1348567620 2369 dbSNP
rs937799087 2370 dbSNP
rs1055186829 2384 dbSNP
rs1240079364 2389 dbSNP
rs1368552507 2394 dbSNP
rs1337749359 2395 dbSNP
rs917603057 2408 dbSNP
rs1291267526 2409 dbSNP
rs949593060 2417 dbSNP
rs1233022493 2418 dbSNP
rs865911904 2420 dbSNP
rs1314599965 2427 dbSNP
rs1042666206 2428 dbSNP
rs1383671784 2430 dbSNP
rs944593022 2433 dbSNP
rs1455079525 2445 dbSNP
rs1415137331 2455 dbSNP
rs761975447 2466 dbSNP
rs1475063722 2467 dbSNP
rs902650837 2470 dbSNP
rs767309181 2472 dbSNP
rs750049763 2485 dbSNP
rs930265640 2489 dbSNP
rs1485857726 2492 dbSNP
rs1048777366 2498 dbSNP
rs1205776350 2499 dbSNP
rs1001435244 2500 dbSNP
rs547459560 2508 dbSNP
rs886161562 2509 dbSNP
rs1255244910 2515 dbSNP
rs1271428140 2519 dbSNP
rs755700922 2532 dbSNP
rs779638325 2535 dbSNP
rs565665299 2536 dbSNP
rs996285771 2538 dbSNP
rs1193181022 2545 dbSNP
rs2174225 2547 dbSNP
rs1030263680 2557 dbSNP
rs1325777854 2562 dbSNP
rs954710430 2564 dbSNP
rs35744569 2569 dbSNP
rs1420954027 2578 dbSNP
rs1157063180 2584 dbSNP
rs1008063931 2587 dbSNP
rs1163699950 2589 dbSNP
rs1015455984 2591 dbSNP
rs749870773 2606 dbSNP
rs974294541 2611 dbSNP
rs148602368 2612 dbSNP
rs919800004 2612 dbSNP
rs547495877 2621 dbSNP
rs1466275833 2625 dbSNP
rs1259141219 2626 dbSNP
rs1023606624 2629 dbSNP
rs1469073858 2630 dbSNP
rs959354136 2640 dbSNP
rs61058279 2643 dbSNP
rs917550349 2644 dbSNP
rs956062166 2647 dbSNP
rs537971836 2648 dbSNP
rs1378703096 2649 dbSNP
rs1389148618 2653 dbSNP
rs1324598692 2656 dbSNP
rs912010398 2658 dbSNP
rs1396205891 2659 dbSNP
rs966236253 2671 dbSNP
rs1419457389 2675 dbSNP
rs1168944957 2677 dbSNP
rs1451852980 2678 dbSNP
rs1393422566 2680 dbSNP
rs1193074612 2689 dbSNP
rs1454884264 2694 dbSNP
rs556381509 2701 dbSNP
rs1248609117 2705 dbSNP
rs1202223121 2711 dbSNP
rs1305616951 2715 dbSNP
rs190138439 2719 dbSNP
rs1042112312 2721 dbSNP
rs924189467 2722 dbSNP
rs569817359 2723 dbSNP
rs1321832739 2724 dbSNP
rs1246085607 2728 dbSNP
rs1234307117 2729 dbSNP
rs1054331842 2731 dbSNP
rs930591446 2734 dbSNP
rs1333134957 2736 dbSNP
rs779382468 2736 dbSNP
rs1049036133 2744 dbSNP
rs996623154 2760 dbSNP
rs1354365761 2764 dbSNP
rs113502514 2768 dbSNP
rs1432236102 2769 dbSNP
rs1374119713 2772 dbSNP
rs1427554947 2778 dbSNP
rs1435376089 2778 dbSNP
rs907521363 2778 dbSNP
rs532914426 2779 dbSNP
rs1469792103 2780 dbSNP
rs1481770469 2781 dbSNP
rs1056220336 2782 dbSNP
rs1175732435 2783 dbSNP
rs141174250 2784 dbSNP
rs1279437354 2785 dbSNP
rs1313386189 2786 dbSNP
rs28752046 2787 dbSNP
rs1014801052 2788 dbSNP
rs1222888290 2788 dbSNP
rs1373593305 2788 dbSNP
rs1411996615 2788 dbSNP
rs28444721 2788 dbSNP
rs1004836224 2791 dbSNP
rs28539342 2794 dbSNP
rs369565402 2794 dbSNP
rs1044590015 2795 dbSNP
rs112352741 2795 dbSNP
rs1161108802 2795 dbSNP
rs1188631326 2795 dbSNP
rs1256741958 2795 dbSNP
rs1491061290 2795 dbSNP
rs367752719 2795 dbSNP
rs397708380 2795 dbSNP
rs560494970 2795 dbSNP
rs71334371 2795 dbSNP
rs1484175390 2797 dbSNP
rs1166988600 2798 dbSNP
rs1415669100 2799 dbSNP
rs1317150849 2800 dbSNP
rs578082806 2800 dbSNP
rs796154245 2801 dbSNP
rs1269590026 2802 dbSNP
rs1230647998 2811 dbSNP
rs1185505088 2812 dbSNP
rs1356088541 2813 dbSNP
rs1439525002 2814 dbSNP
rs1397192857 2816 dbSNP
rs183428465 2820 dbSNP
rs1379193542 2822 dbSNP
rs1397329983 2824 dbSNP
rs1295654452 2825 dbSNP
rs1354158576 2826 dbSNP
rs956328369 2828 dbSNP
rs1287203769 2829 dbSNP
rs1259063698 2833 dbSNP
rs1309637175 2834 dbSNP
rs1202623298 2835 dbSNP
rs1346044363 2842 dbSNP
rs1322746742 2849 dbSNP
rs1000383074 2850 dbSNP
rs112525182 2855 dbSNP
rs541713594 2856 dbSNP
rs995449951 2857 dbSNP
rs1417224090 2858 dbSNP
rs1027211546 2863 dbSNP
rs959239824 2865 dbSNP
rs553782049 2871 dbSNP
rs772381905 2872 dbSNP
rs1194346426 2873 dbSNP
rs1019406383 2877 dbSNP
rs1421308275 2880 dbSNP
rs1408016944 2881 dbSNP
rs1294010673 2882 dbSNP
rs1214080560 2897 dbSNP
rs966172792 2898 dbSNP
rs970506943 2904 dbSNP
rs1359452018 2919 dbSNP
rs1028813156 2921 dbSNP
rs1393950139 2930 dbSNP
rs780798636 2933 dbSNP
rs1326342672 2937 dbSNP
rs147349727 2941 dbSNP
rs1352713514 2946 dbSNP
rs1374345975 2948 dbSNP
rs1429018830 2950 dbSNP
rs1391555190 2960 dbSNP
rs1414633198 2971 dbSNP
rs1453434182 2975 dbSNP
rs923633232 2978 dbSNP
rs542581032 2979 dbSNP
rs1489643348 2986 dbSNP
rs936893768 2991 dbSNP
rs989748928 2992 dbSNP
rs7271801 2993 dbSNP
rs1343491059 3001 dbSNP
rs932160536 3003 dbSNP
rs78683040 3017 dbSNP
rs367806040 3018 dbSNP
rs1313044633 3025 dbSNP
rs1370574478 3026 dbSNP
rs755760019 3037 dbSNP
rs747172705 3040 dbSNP
rs1045237995 3041 dbSNP
rs1370960897 3044 dbSNP
rs544043733 3053 dbSNP
rs565330831 3057 dbSNP
rs117296352 3058 dbSNP
rs995791895 3059 dbSNP
rs1026912117 3060 dbSNP
rs188364706 3070 dbSNP
rs1395330145 3071 dbSNP
rs1474302216 3075 dbSNP
rs1416902385 3078 dbSNP
rs1010168787 3079 dbSNP
rs1018959573 3088 dbSNP
rs145134040 3092 dbSNP
rs200190039 3095 dbSNP
rs1374263402 3098 dbSNP
rs1347313532 3100 dbSNP
rs236126 3105 dbSNP
rs970454805 3107 dbSNP
rs1235791614 3126 dbSNP
rs566239398 3130 dbSNP
rs193179810 3134 dbSNP
rs1031042609 3135 dbSNP
rs984632207 3137 dbSNP
rs147158901 3140 dbSNP
rs1310939337 3143 dbSNP
rs1347502027 3150 dbSNP
rs957733344 3154 dbSNP
rs989584109 3162 dbSNP
rs530710875 3167 dbSNP
rs1173815960 3188 dbSNP
rs1451248983 3195 dbSNP
rs1362798804 3197 dbSNP
rs922205291 3203 dbSNP
rs932258743 3205 dbSNP
rs1158936356 3206 dbSNP
rs1473095862 3208 dbSNP
rs1288601771 3209 dbSNP
rs1186474184 3210 dbSNP
rs1372217747 3211 dbSNP
rs1236693933 3213 dbSNP
rs1257024723 3217 dbSNP
rs961975537 3226 dbSNP
rs987586111 3227 dbSNP
rs912074908 3246 dbSNP
rs1331004679 3257 dbSNP
rs1291176962 3259 dbSNP
rs1241050727 3263 dbSNP
rs940756301 3264 dbSNP
rs1379989479 3275 dbSNP
rs1036407856 3276 dbSNP
rs1320870891 3286 dbSNP
rs980536803 3286 dbSNP
rs1458460433 3289 dbSNP
rs899127829 3296 dbSNP
rs1215010907 3297 dbSNP
rs1247027555 3298 dbSNP
rs930653936 3302 dbSNP
rs936130432 3309 dbSNP
rs1056239413 3312 dbSNP
rs1261097097 3318 dbSNP
rs1445302037 3318 dbSNP
rs892018681 3321 dbSNP
rs748853306 3323 dbSNP
rs1212775762 3326 dbSNP
rs1356967387 3334 dbSNP
rs1439738792 3337 dbSNP
rs1159842583 3349 dbSNP
rs1285833067 3350 dbSNP
rs1405187993 3357 dbSNP
rs1399418382 3359 dbSNP
rs1159028115 3364 dbSNP
rs1395603973 3366 dbSNP
rs1443646537 3370 dbSNP
rs1012202519 3376 dbSNP
rs1046237558 3378 dbSNP
rs906364534 3379 dbSNP
rs901840970 3380 dbSNP
rs1324311015 3386 dbSNP
rs1405098923 3387 dbSNP
rs1415550004 3396 dbSNP
rs1910492 3402 dbSNP
rs1370584263 3414 dbSNP
rs1474693202 3423 dbSNP
rs1030741017 3427 dbSNP
rs185485807 3429 dbSNP
rs1442994735 3437 dbSNP
rs958052300 3438 dbSNP
rs763911164 3451 dbSNP
rs1010570301 3457 dbSNP
rs139588255 3459 dbSNP
rs761722443 3461 dbSNP
rs1291723544 3464 dbSNP
rs1014780726 3465 dbSNP
rs1194072595 3466 dbSNP
rs961903740 3467 dbSNP
rs767364396 3473 dbSNP
rs1274755380 3480 dbSNP
rs553867931 3483 dbSNP
rs565799148 3488 dbSNP
rs1302173414 3489 dbSNP
rs1436719454 3493 dbSNP
rs969045948 3500 dbSNP
rs536252740 3504 dbSNP
rs1325932520 3505 dbSNP
rs980847778 3506 dbSNP
rs367855838 3514 dbSNP
rs75616125 3515 dbSNP
rs962197902 3523 dbSNP
rs1336667258 3533 dbSNP
rs1211629848 3534 dbSNP
rs1370422869 3537 dbSNP
rs1169306592 3556 dbSNP
rs1359889461 3559 dbSNP
rs972669572 3566 dbSNP
rs750106916 3568 dbSNP
rs755823520 3569 dbSNP
rs930759863 3572 dbSNP
rs987879118 3576 dbSNP
rs913384176 3582 dbSNP
rs1055789594 3587 dbSNP
rs915920187 3591 dbSNP
rs1183572831 3592 dbSNP
rs947931397 3609 dbSNP
rs73896706 3610 dbSNP
rs1469196609 3613 dbSNP
rs1345176857 3615 dbSNP
rs906479219 3621 dbSNP
rs1219511352 3622 dbSNP
rs999342926 3633 dbSNP
rs1052739711 3637 dbSNP
rs753266024 3651 dbSNP
rs1350444192 3660 dbSNP
rs931963523 3662 dbSNP
rs1163288217 3663 dbSNP
rs189108517 3664 dbSNP
rs1028618358 3665 dbSNP
rs887835539 3666 dbSNP
rs1427453896 3683 dbSNP
rs1156629293 3691 dbSNP
rs953067710 3692 dbSNP
rs191308444 3694 dbSNP
rs543552609 3700 dbSNP
rs1252241084 3701 dbSNP
rs149713580 3702 dbSNP
rs183835035 3712 dbSNP
rs1036486041 3713 dbSNP
rs1236442500 3716 dbSNP
rs1210137907 3717 dbSNP
rs1443791882 3718 dbSNP
rs1357338532 3719 dbSNP
rs1231398486 3720 dbSNP
rs1281647119 3720 dbSNP
rs866808817 3722 dbSNP
rs1019141358 3724 dbSNP
rs962292602 3741 dbSNP
rs1328956107 3752 dbSNP
rs897652686 3756 dbSNP
rs1013843498 3761 dbSNP
rs1354049939 3763 dbSNP
rs755549151 3764 dbSNP
rs1272267021 3767 dbSNP
rs1302344216 3779 dbSNP
rs1339833254 3790 dbSNP
rs1197125933 3791 dbSNP
rs541604389 3795 dbSNP
rs1456881262 3797 dbSNP
rs145674608 3798 dbSNP
rs753195173 3799 dbSNP
rs758773294 3800 dbSNP
rs1258803662 3802 dbSNP
rs1412894754 3803 dbSNP
rs1476445499 3805 dbSNP
rs1239831111 3812 dbSNP
rs1186466596 3813 dbSNP
rs1465058388 3814 dbSNP
rs1031954816 3821 dbSNP
rs952127172 3822 dbSNP
rs991983604 3823 dbSNP
rs1417509200 3833 dbSNP
rs1475978226 3838 dbSNP
rs1210904510 3839 dbSNP
rs529768386 3843 dbSNP
rs915887698 3846 dbSNP
rs1320478784 3848 dbSNP
rs188451321 3849 dbSNP
rs1312575813 3861 dbSNP
rs1229374086 3865 dbSNP
rs1381479454 3873 dbSNP
rs778043295 3881 dbSNP
rs1295488163 3883 dbSNP
rs557794101 3886 dbSNP
rs779407189 3893 dbSNP
rs200320058 3895 dbSNP
rs957723882 3895 dbSNP
rs950020098 3897 dbSNP
rs148479623 3907 dbSNP
rs1349246165 3908 dbSNP
rs1165456269 3915 dbSNP
rs1425482773 3916 dbSNP
rs1045787043 3917 dbSNP
rs747292954 3925 dbSNP
rs1187323290 3930 dbSNP
rs927864502 3953 dbSNP
rs530868415 3955 dbSNP
rs571418731 3966 dbSNP
rs1190940677 3972 dbSNP
rs552164905 3974 dbSNP
rs923525099 3981 dbSNP
rs1223027897 4005 dbSNP
rs1412782942 4006 dbSNP
rs932240074 4008 dbSNP
rs1272584638 4011 dbSNP
rs1292608846 4012 dbSNP
rs1366237945 4015 dbSNP
rs1052241449 4016 dbSNP
rs1229425255 4020 dbSNP
rs144129633 4021 dbSNP
rs561897750 4025 dbSNP
rs73600757 4047 dbSNP
rs888893960 4050 dbSNP
rs1281794892 4056 dbSNP
rs1008498956 4070 dbSNP
rs1036412060 4073 dbSNP
rs1352624259 4074 dbSNP
rs546345402 4080 dbSNP
rs1429778211 4089 dbSNP
rs1209286897 4092 dbSNP
rs1391460887 4094 dbSNP
rs3747916 4097 dbSNP
rs3747917 4098 dbSNP
rs1195843030 4101 dbSNP
rs1046671958 4103 dbSNP
rs140484056 4108 dbSNP
rs556935870 4113 dbSNP
rs1032260375 4117 dbSNP
rs376284100 4134 dbSNP
rs932486073 4136 dbSNP
rs569930981 4150 dbSNP
rs145705297 4151 dbSNP
rs1276825327 4152 dbSNP
rs1231414190 4163 dbSNP
rs1311769078 4166 dbSNP
rs1023038806 4184 dbSNP
rs1301725104 4187 dbSNP
rs1388255651 4187 dbSNP
rs1312198539 4192 dbSNP
rs1020623428 4194 dbSNP
rs1385636908 4199 dbSNP
rs1383686559 4206 dbSNP
rs971512484 4210 dbSNP
rs559003798 4211 dbSNP
rs981433720 4213 dbSNP
rs146571450 4215 dbSNP
rs1465244903 4219 dbSNP
rs1177282310 4221 dbSNP
rs935224222 4228 dbSNP
rs1410185285 4230 dbSNP
rs988481671 4251 dbSNP
rs1030905736 4268 dbSNP
rs1254087566 4269 dbSNP
rs1483066491 4273 dbSNP
rs6117030 4274 dbSNP
rs541646925 4287 dbSNP
rs1325671588 4295 dbSNP
rs946528656 4299 dbSNP
rs1234483065 4303 dbSNP
rs953598116 4304 dbSNP
rs553601843 4315 dbSNP
rs1326869430 4316 dbSNP
rs1050244824 4330 dbSNP
rs1287489988 4332 dbSNP
rs888861395 4334 dbSNP
rs1228988038 4347 dbSNP
rs1352190762 4348 dbSNP
rs1345112561 4350 dbSNP
rs1394902542 4351 dbSNP
rs944492256 4355 dbSNP
rs986371654 4361 dbSNP
rs1232977120 4364 dbSNP
rs1039980472 4372 dbSNP
rs372853100 4377 dbSNP
rs1386992439 4386 dbSNP
rs1455289176 4386 dbSNP
rs909469695 4400 dbSNP
rs1473207682 4411 dbSNP
rs1486451276 4412 dbSNP
rs1185540964 4417 dbSNP
rs1423374488 4418 dbSNP
rs897485341 4419 dbSNP
rs1202470587 4420 dbSNP
rs1207439426 4423 dbSNP
rs1267269421 4427 dbSNP
rs1209043647 4435 dbSNP
rs993738133 4442 dbSNP
rs1331177927 4443 dbSNP
rs1282305117 4450 dbSNP
rs1243946590 4453 dbSNP
rs573994272 4461 dbSNP
rs972076690 4464 dbSNP
rs1376897026 4470 dbSNP
rs574625874 4471 dbSNP
rs774171083 4474 dbSNP
rs1162022036 4476 dbSNP
rs541544332 4478 dbSNP
rs1369190064 4481 dbSNP
rs542092694 4482 dbSNP
rs905022203 4496 dbSNP
rs1173151783 4499 dbSNP
rs4393813 4500 dbSNP
rs1466125684 4501 dbSNP
rs773125725 4505 dbSNP
rs981528276 4512 dbSNP
rs1156749227 4514 dbSNP
rs1383899751 4520 dbSNP
rs144566906 4521 dbSNP
rs1441443519 4525 dbSNP
rs1225494049 4526 dbSNP
rs1364039107 4529 dbSNP
rs1297945412 4530 dbSNP
rs1031654641 4532 dbSNP
rs1368392181 4548 dbSNP
rs1439736609 4553 dbSNP
rs760452370 4555 dbSNP
rs956248492 4557 dbSNP
rs1386724828 4559 dbSNP
rs893727379 4562 dbSNP
rs990195595 4565 dbSNP
rs765916087 4569 dbSNP
rs1239882098 4575 dbSNP
rs1307036514 4575 dbSNP
rs191780342 4578 dbSNP
rs236127 4579 dbSNP
rs1476509830 4580 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124A_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + A ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_124A_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + A
Location of target site ENST00000378896.3 | 3UTR | UUUGGAAUGCAGAACU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE42095 Differentiated embryonic stem cells 0.433 2.0e-2 0.538 4.0e-3 23 Click to see details
GSE28260 Renal cortex and medulla 0.567 2.2e-2 0.493 4.3e-2 13 Click to see details
GSE17306 Multiple myeloma 0.262 3.4e-2 0.458 4.7e-4 49 Click to see details
GSE21849 B cell lymphoma 0.324 4.3e-2 0.527 1.7e-3 29 Click to see details
GSE28544 Breast cancer -0.35 4.7e-2 -0.334 5.5e-2 24 Click to see details
GSE21687 Ependynoma primary tumors -0.146 1.2e-1 -0.225 3.7e-2 64 Click to see details
GSE27834 Pluripotent stem cells 0.277 1.5e-1 0.162 2.7e-1 16 Click to see details
GSE26953 Aortic valvular endothelial cells -0.141 2.6e-1 -0.078 3.6e-1 24 Click to see details
GSE38226 Liver fibrosis 0.109 3.2e-1 0.069 3.8e-1 21 Click to see details
GSE14794 Lymphoblastoid cells -0.045 3.4e-1 -0.080 2.3e-1 90 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.073 3.6e-1 0.072 3.7e-1 25 Click to see details
GSE32688 Pancreatic cancer -0.044 4.1e-1 -0.136 2.3e-1 32 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.047 4.1e-1 0.485 7.0e-3 25 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.038 4.4e-1 -0.072 3.8e-1 20 Click to see details
GSE19350 CNS germ cell tumors -0.001 5.0e-1 0.240 2.3e-1 12 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KIRP -0.531 0.01 -0.536 0.01 18 Click to see details
UCEC -0.623 0.03 -0.564 0.04 10 Click to see details
PAAD -0.816 0.09 -0.400 0.3 4 Click to see details
BRCA -0.241 0.12 -0.082 0.35 25 Click to see details
LIHC 0.172 0.13 0.125 0.21 45 Click to see details
ESCA -0.721 0.14 -0.400 0.3 4 Click to see details
PRAD 0.175 0.17 0.093 0.31 31 Click to see details
LUAD 0.308 0.21 0.250 0.26 9 Click to see details
LUSC -0.19 0.21 -0.180 0.22 20 Click to see details
CHOL -0.33 0.21 -0.119 0.39 8 Click to see details
KICH -0.099 0.39 -0.236 0.24 11 Click to see details
THCA -0.031 0.42 -0.031 0.42 47 Click to see details
KIRC -0.02 0.46 0.036 0.43 29 Click to see details
STAD -0.012 0.48 0.063 0.4 20 Click to see details
BLCA -0.007 0.49 -0.224 0.27 10 Click to see details
HNSC 0.002 0.5 0.105 0.32 23 Click to see details
HNSC 0.002 0.5 0.105 0.32 23 Click to see details
HNSC 0.002 0.5 0.105 0.32 23 Click to see details
148 hsa-miR-216a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000534 PTEN phosphatase and tensin homolog 4 3
MIRT005018 SIRT1 sirtuin 1 3 1
MIRT005964 CDC42 cell division cycle 42 2 1
MIRT005969 CD44 CD44 molecule (Indian blood group) 2 1
MIRT007154 SMAD7 SMAD family member 7 1 1
MIRT054887 BECN1 beclin 1 5 3
MIRT067588 METAP2 methionyl aminopeptidase 2 2 6
MIRT099144 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT162313 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT230668 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT256274 PHAX phosphorylated adaptor for RNA export 2 2
MIRT386817 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT386825 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT438816 HNF4A hepatocyte nuclear factor 4 alpha 1 1
MIRT464699 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465962 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466046 TMEM189 transmembrane protein 189 2 2
MIRT466482 TECPR2 tectonin beta-propeller repeat containing 2 2 7
MIRT472209 NGFRAP1 brain expressed X-linked 3 2 4
MIRT472562 NACC1 nucleus accumbens associated 1 2 4
MIRT478921 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT480121 CALR calreticulin 2 2
MIRT497754 OXGR1 oxoglutarate receptor 1 2 2
MIRT497967 TWISTNB TWIST neighbor 2 2
MIRT502882 CDK4 cyclin dependent kinase 4 2 8
MIRT510191 MON1B MON1 homolog B, secretory trafficking associated 2 4
MIRT512407 CD84 CD84 molecule 2 2
MIRT513739 PSD3 pleckstrin and Sec7 domain containing 3 2 4
MIRT526257 DROSHA drosha ribonuclease III 2 2
MIRT528968 FAM19A3 family with sequence similarity 19 member A3, C-C motif chemokine like 2 2
MIRT529599 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT529776 ZNF486 zinc finger protein 486 2 2
MIRT530110 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530504 FADS6 fatty acid desaturase 6 2 2
MIRT531437 PAK1 p21 (RAC1) activated kinase 1 2 2
MIRT534445 SDR16C5 short chain dehydrogenase/reductase family 16C member 5 2 2
MIRT537286 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT538451 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT543085 ACTB actin beta 2 2
MIRT550982 ZNF254 zinc finger protein 254 2 2
MIRT556259 MAPRE2 microtubule associated protein RP/EB family member 2 2 2
MIRT556639 LAMC1 laminin subunit gamma 1 2 2
MIRT559127 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT561405 TUBB2A tubulin beta 2A class IIa 2 2
MIRT569677 SEC23B Sec23 homolog B, coat complex II component 2 4
MIRT574660 KLHL15 kelch like family member 15 2 2
MIRT575030 Tecpr2 tectonin beta-propeller repeat containing 2 2 5
MIRT617683 JRKL JRK like 2 2
MIRT618540 SEMA5A semaphorin 5A 2 2
MIRT620805 C1orf27 chromosome 1 open reading frame 27 2 2
MIRT621569 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT622133 SP4 Sp4 transcription factor 2 2
MIRT624913 CTCFL CCCTC-binding factor like 2 2
MIRT625010 PAK4 p21 (RAC1) activated kinase 4 2 2
MIRT626644 ZNF551 zinc finger protein 551 2 2
MIRT626646 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 2 2
MIRT626672 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT627945 NNT nicotinamide nucleotide transhydrogenase 2 2
MIRT627963 NLK nemo like kinase 2 2
MIRT628767 SRSF7 serine and arginine rich splicing factor 7 2 2
MIRT629261 KDM2B lysine demethylase 2B 2 2
MIRT629422 ADM2 adrenomedullin 2 2 2
MIRT630238 SORD sorbitol dehydrogenase 2 2
MIRT631272 CENPM centromere protein M 2 4
MIRT631793 CLK4 CDC like kinase 4 2 2
MIRT632058 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT632485 RPS15A ribosomal protein S15a 2 2
MIRT632611 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632708 MTA3 metastasis associated 1 family member 3 2 2
MIRT632815 INO80 INO80 complex subunit 2 2
MIRT635956 PLA2G12A phospholipase A2 group XIIA 2 2
MIRT636152 UBXN2A UBX domain protein 2A 2 2
MIRT636899 C5orf45 MRN complex interacting protein 2 4
MIRT636930 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT637457 ZNF324B zinc finger protein 324B 2 2
MIRT637900 SLC19A3 solute carrier family 19 member 3 2 2
MIRT639826 ZNF638 zinc finger protein 638 2 2
MIRT640445 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT640681 ARSK arylsulfatase family member K 2 2
MIRT641611 CAPN7 calpain 7 2 2
MIRT641676 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT646786 IL23R interleukin 23 receptor 2 2
MIRT648352 A2ML1 alpha-2-macroglobulin like 1 2 2
MIRT649144 SPATA5 spermatogenesis associated 5 2 2
MIRT649254 TRIM65 tripartite motif containing 65 2 2
MIRT652491 TMEM178B transmembrane protein 178B 2 2
MIRT653308 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT653945 SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 2 2
MIRT654212 RNF19B ring finger protein 19B 2 2
MIRT654839 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT655159 PHF21A PHD finger protein 21A 2 2
MIRT655316 PDCD11 programmed cell death 11 2 2
MIRT655375 PAX3 paired box 3 2 2
MIRT657301 HOXB5 homeobox B5 2 2
MIRT657593 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT658460 FAM117B family with sequence similarity 117 member B 2 2
MIRT658716 ELOVL4 ELOVL fatty acid elongase 4 2 2
MIRT661640 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT661712 MTO1 mitochondrial tRNA translation optimization 1 2 4
MIRT661833 ZNF793 zinc finger protein 793 2 2
MIRT663805 BET1L Bet1 golgi vesicular membrane trafficking protein like 2 2
MIRT663884 CXorf56 chromosome X open reading frame 56 2 2
MIRT664672 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 2
MIRT665814 TMEM168 transmembrane protein 168 2 2
MIRT668159 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT668430 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT672306 GP2 glycoprotein 2 2 2
MIRT673101 SYNPO2L synaptopodin 2 like 2 2
MIRT673437 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT673584 KDELC2 KDEL motif containing 2 2 2
MIRT673718 SLU7 SLU7 homolog, splicing factor 2 2
MIRT673777 MRPL17 mitochondrial ribosomal protein L17 2 2
MIRT674316 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT674820 FAM229B family with sequence similarity 229 member B 2 2
MIRT675179 BPTF bromodomain PHD finger transcription factor 2 2
MIRT675586 WWC1 WW and C2 domain containing 1 2 2
MIRT675812 MED28 mediator complex subunit 28 2 2
MIRT677632 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT683914 PSMB9 proteasome subunit beta 9 2 2
MIRT687135 QPCTL glutaminyl-peptide cyclotransferase like 2 2
MIRT691973 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT693078 AS3MT arsenite methyltransferase 2 2
MIRT694084 RNASEH2B ribonuclease H2 subunit B 2 2
MIRT696292 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT696541 C3 complement C3 2 2
MIRT701955 MITF melanogenesis associated transcription factor 2 2
MIRT703276 GNG12 G protein subunit gamma 12 2 2
MIRT706852 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 2 2
MIRT706993 XPO5 exportin 5 2 2
MIRT710716 KRTAP6-1 keratin associated protein 6-1 2 2
MIRT711305 ACOX1 acyl-CoA oxidase 1 2 2
MIRT711514 ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 2 2
MIRT711648 LIPG lipase G, endothelial type 2 2
MIRT711772 CCDC59 coiled-coil domain containing 59 2 2
MIRT714280 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT715048 PRPF38A pre-mRNA processing factor 38A 2 2
MIRT716934 INCENP inner centromere protein 2 2
MIRT717220 OTUD3 OTU deubiquitinase 3 2 2
MIRT717865 BICD2 BICD cargo adaptor 2 2 2
MIRT718836 SNX20 sorting nexin 20 2 2
MIRT720243 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT721969 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 2
MIRT724000 LMTK2 lemur tyrosine kinase 2 2 2
MIRT725193 SDAD1 SDA1 domain containing 1 2 2
MIRT731669 CBL Cbl proto-oncogene 3 1
MIRT732776 AQP4 aquaporin 4 3 0
MIRT733158 ITGA5 integrin subunit alpha 5 1 0
MIRT735623 TLR4 toll like receptor 4 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-216a Curcumin NULL 969516 Quantitative real-time PCR Y79 RB cells. 22510010 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-216a Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3, 2008, OVCAR10, OVCAR3, HeLa, MCF7, MDA-MB-468)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved sensitive High Small Cell Lung Cancer cell line (NCI-H69)
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant Low Hepatocellular Carcinoma tissue and cell line (HepG2, Hep3B, Huh-7, PLC/PRF/5, HCCLM3, Bel-7404, HLE, SK-HEP-1, SNU-449)
hsa-miR-216a-5p Fluorouracil 3385 NSC19893 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (Huh-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant Low Small Cell Lung Cancer cell line (H69, H446)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant Low Ovarian Cancer cell line (SKOV3, OVCA433)
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant Low Gastric Cancer cell line (MGC, SGC)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM11)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-216a-5p Exemestane 60198 NSC713563 approved sensitive cell line (MCF-7)
hsa-miR-216a-5p Testosterone+Tamoxifen sensitive cell line (MCF-7)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-216a-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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