pre-miRNA Information
pre-miRNA hsa-mir-6819   
Genomic Coordinates chr22: 36286847 - 36286907
Description Homo sapiens miR-6819 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6819-3p
Sequence 41| AAGCCUCUGUCCCCACCCCAG |61
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1279530967 2 dbSNP
rs967579979 3 dbSNP
rs776891214 4 dbSNP
rs771166635 8 dbSNP
rs747037324 9 dbSNP
rs879248090 11 dbSNP
rs1485325191 12 dbSNP
rs778157316 16 dbSNP
Putative Targets

Gene Information
Gene Symbol SUSD1   
Synonyms -
Description sushi domain containing 1
Transcript NM_022486   
Expression
Putative miRNA Targets on SUSD1
3'UTR of SUSD1
(miRNA target sites are highlighted)
>SUSD1|NM_022486|3'UTR
   1 TGGCAGATGGACACTGAGTGGGGAGGATGCACTGCTGCTGGGCAGGTGTTCTGGCAGCTTCTCAGGTGCCCGCACAGAGG
  81 CTCCGTGTGACTTCCGTCCAGGGAGCATGTGGGCCTGCAACTTTCTCCATTCCCAGCTGGGCCCCATTCCTGGATTTAAG
 161 ATGGTGGCTATCCCTGAGGAGTCACCATAAGGAGAAAACTCAGGAATTCTGAGTCTTCCCTGCTACAGGACCAGTTCTGT
 241 GCAATGAACTTGAGACTCCTGATGTACACTGTGATATTGACCGAAGGCTACATACAGATCTGTGAATCTTGGCTGGGACT
 321 TCCTCTGAGTGATGCCTGAGGGTCAGCTCCTCTAGACATTGACTGCAAGAGAATCTCTGCAACCTCCTATATAAAAGCAT
 401 TTCTGTTAATTCATTCAGAATCCATTCTTTACAATATGCAGTGAGATGGGCTTAAGTTTGGGCTAGAGTTTGACTTTATG
 481 AAGGAGGTCATTGAAAAAGAGAACAGTGACGTAGGCAAATGTTTCAAGCACTTTAGAAACAGTACTTTTCCTATAATTAG
 561 TTGATATACTAATGAGAAAATATACTAGCCTGGCCATGCCAATAAGTTTCCTGCTGTGTCTGTTAGGCAGCATTGCTTTG
 641 ATGCAATTTCTATTGTCCTATATATTCAAAAGTAATGTCTACATTCCAGTAAAAATATCCCGTAATTAAGAAAAAAAAAA
 721 AAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaccCCAC--CCCUGUCUCCGAa 5'
              ||||   | ||||||||| 
Target 5' ctcaGGTGCCCGCACAGAGGCTc 3'
61 - 83 159.00 -18.60
2
miRNA  3' gaccCCACCCCUGUCUCCGAa 5'
              | | ||| :|||| :| 
Target 5' ttaaGTTTGGGCTAGAGTTTg 3'
452 - 472 109.00 -9.40
3
miRNA  3' gaccccacccCUGUCUCCGAa 5'
                    ||::| |||| 
Target 5' ctggatttaaGATGGTGGCTa 3'
150 - 170 103.00 -11.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26997513 21 COSMIC
COSN21667214 25 COSMIC
COSN30124448 46 COSMIC
COSN31573646 61 COSMIC
COSN31500210 63 COSMIC
COSN26635492 69 COSMIC
COSN30469933 94 COSMIC
COSN30502697 102 COSMIC
COSN31545637 103 COSMIC
COSN31539350 113 COSMIC
COSN31581818 118 COSMIC
COSN9275694 131 COSMIC
COSN14850014 141 COSMIC
COSN30141232 144 COSMIC
rs2281789 439 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1431959360 1 dbSNP
rs751506826 4 dbSNP
rs779793096 8 dbSNP
rs758231333 9 dbSNP
rs750172263 11 dbSNP
rs765475640 18 dbSNP
rs373388512 21 dbSNP
rs368926094 23 dbSNP
rs764221933 28 dbSNP
rs760604186 29 dbSNP
rs776077272 37 dbSNP
rs767417499 38 dbSNP
rs772407732 40 dbSNP
rs749508433 42 dbSNP
rs774822672 43 dbSNP
rs200435366 47 dbSNP
rs534529462 52 dbSNP
rs565834339 53 dbSNP
rs1456839558 54 dbSNP
rs1177406000 55 dbSNP
rs1361345406 65 dbSNP
rs1189826412 66 dbSNP
rs1446470050 70 dbSNP
rs368841685 71 dbSNP
rs376440859 72 dbSNP
rs1286119814 78 dbSNP
rs1012084594 81 dbSNP
rs960496726 84 dbSNP
rs150720171 85 dbSNP
rs1280146641 90 dbSNP
rs1310324576 94 dbSNP
rs776833707 95 dbSNP
rs999377652 96 dbSNP
rs549849093 98 dbSNP
rs902548577 100 dbSNP
rs1217486634 101 dbSNP
rs1184608672 104 dbSNP
rs532932132 110 dbSNP
rs1046334832 112 dbSNP
rs540282935 114 dbSNP
rs1427394447 120 dbSNP
rs1413216037 129 dbSNP
rs2281790 141 dbSNP
rs142040646 142 dbSNP
rs984329690 144 dbSNP
rs1305785918 149 dbSNP
rs889873367 163 dbSNP
rs1405211289 164 dbSNP
rs1345480494 165 dbSNP
rs528698359 166 dbSNP
rs918644301 172 dbSNP
rs1412203883 174 dbSNP
rs1428026278 187 dbSNP
rs934182547 188 dbSNP
rs972797581 190 dbSNP
rs965393357 194 dbSNP
rs1200724785 199 dbSNP
rs1020029557 204 dbSNP
rs922735718 220 dbSNP
rs183598613 231 dbSNP
rs1222618686 239 dbSNP
rs1186372207 244 dbSNP
rs1248506094 263 dbSNP
rs1486403835 264 dbSNP
rs745878113 266 dbSNP
rs1391391346 268 dbSNP
rs1037305379 273 dbSNP
rs1167033349 275 dbSNP
rs559483954 282 dbSNP
rs1405567671 283 dbSNP
rs1021798004 292 dbSNP
rs1325157970 293 dbSNP
rs907574482 304 dbSNP
rs757719231 314 dbSNP
rs546442131 316 dbSNP
rs984471424 323 dbSNP
rs1347602316 332 dbSNP
rs1435201537 333 dbSNP
rs1320655235 335 dbSNP
rs542795019 336 dbSNP
rs1367187526 342 dbSNP
rs1226133430 343 dbSNP
rs1296538842 346 dbSNP
rs1322847661 351 dbSNP
rs951763606 359 dbSNP
rs73530687 360 dbSNP
rs990948936 361 dbSNP
rs999214100 366 dbSNP
rs960548557 371 dbSNP
rs1248732662 372 dbSNP
rs1466598495 373 dbSNP
rs1389903354 377 dbSNP
rs1034800335 382 dbSNP
rs1046480894 393 dbSNP
rs1381386685 395 dbSNP
rs948007915 397 dbSNP
rs1159206106 398 dbSNP
rs1390235011 399 dbSNP
rs1432783194 400 dbSNP
rs148609544 406 dbSNP
rs1048235452 409 dbSNP
rs966589390 410 dbSNP
rs1282230130 419 dbSNP
rs1022755992 421 dbSNP
rs764431344 424 dbSNP
rs1404699160 431 dbSNP
rs1268826097 436 dbSNP
rs368276605 437 dbSNP
rs931160301 438 dbSNP
rs2281789 439 dbSNP
rs1248009371 449 dbSNP
rs753534314 473 dbSNP
rs2281788 486 dbSNP
rs912570838 487 dbSNP
rs985826044 499 dbSNP
rs998653358 504 dbSNP
rs901364644 510 dbSNP
rs557974238 511 dbSNP
rs569974052 517 dbSNP
rs956231977 519 dbSNP
rs11284956 535 dbSNP
rs1416109569 535 dbSNP
rs769538300 535 dbSNP
rs940295355 538 dbSNP
rs910139825 545 dbSNP
rs1049088753 567 dbSNP
rs183865858 568 dbSNP
rs78229426 571 dbSNP
rs75946912 573 dbSNP
rs1339704311 587 dbSNP
rs555636641 590 dbSNP
rs1414364236 594 dbSNP
rs1289288864 611 dbSNP
rs757734614 632 dbSNP
rs1226588657 636 dbSNP
rs1260223053 637 dbSNP
rs1202728005 638 dbSNP
rs1276920107 639 dbSNP
rs1442249127 640 dbSNP
rs535641733 659 dbSNP
rs1182446990 662 dbSNP
rs1253602201 665 dbSNP
rs1461070142 669 dbSNP
rs930341129 682 dbSNP
rs1243817112 688 dbSNP
rs916210788 690 dbSNP
rs1180750100 697 dbSNP
rs1205712774 699 dbSNP
rs1316161277 701 dbSNP
rs550117565 702 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124A_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + A ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaccccacccCUGUCUCCGAa 5'
                    |||||||||| 
Target 5' --gaaggaaaGACAGAGGCUu 3'
1 - 19
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_124A_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + A
Location of target site ENST00000374263.3 | 3UTR | GAAGGAAAGACAGAGGCUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-6819-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT358318 PANK3 pantothenate kinase 3 2 2
MIRT454719 UBQLNL ubiquilin like 2 2
MIRT471362 PEG10 paternally expressed 10 2 2
MIRT478101 DLG5 discs large MAGUK scaffold protein 5 2 4
MIRT495554 GOLGA6L4 golgin A6 family-like 4 2 2
MIRT495587 GOLGA6L10 golgin A6 family-like 10 2 2
MIRT508315 RPL18 ribosomal protein L18 2 4
MIRT529183 ADAM33 ADAM metallopeptidase domain 33 2 2
MIRT532035 FHDC1 FH2 domain containing 1 2 2
MIRT545131 ANXA5 annexin A5 2 2
MIRT567288 HNRNPL heterogeneous nuclear ribonucleoprotein L 2 2
MIRT568094 CEBPG CCAAT/enhancer binding protein gamma 2 2
MIRT573291 DLX4 distal-less homeobox 4 2 2
MIRT575169 Fam120c family with sequence similarity 120, member C 2 2
MIRT609495 DNASE1L3 deoxyribonuclease 1 like 3 2 2
MIRT611264 EHD3 EH domain containing 3 2 2
MIRT613580 POC5 POC5 centriolar protein 2 2
MIRT616520 C9orf170 chromosome 9 open reading frame 170 2 2
MIRT617098 ZNF667 zinc finger protein 667 2 2
MIRT618268 DDX51 DEAD-box helicase 51 2 2
MIRT618294 ZNF682 zinc finger protein 682 2 2
MIRT618617 SHOX short stature homeobox 2 2
MIRT619741 SRFBP1 serum response factor binding protein 1 2 2
MIRT619784 NRIP2 nuclear receptor interacting protein 2 2 2
MIRT621119 SP110 SP110 nuclear body protein 2 2
MIRT622530 RAD51 RAD51 recombinase 2 2
MIRT623088 NME6 NME/NM23 nucleoside diphosphate kinase 6 2 2
MIRT623938 FKBP14 FK506 binding protein 14 2 2
MIRT624389 CD84 CD84 molecule 2 2
MIRT624860 ABI2 abl interactor 2 2 2
MIRT628752 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT632243 VTA1 vesicle trafficking 1 2 2
MIRT632987 E2F2 E2F transcription factor 2 2 2
MIRT633695 RBM43 RNA binding motif protein 43 2 2
MIRT633766 CENPBD1 CENPB DNA-binding domain containing 1 2 2
MIRT633808 ZNF91 zinc finger protein 91 2 2
MIRT638914 CBLN2 cerebellin 2 precursor 2 2
MIRT641298 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT642123 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT642179 HEBP2 heme binding protein 2 2 2
MIRT642617 CDKN3 cyclin dependent kinase inhibitor 3 2 2
MIRT643325 TMEM151B transmembrane protein 151B 2 2
MIRT644534 TMEM134 transmembrane protein 134 2 2
MIRT645820 OMA1 OMA1 zinc metallopeptidase 2 2
MIRT646093 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646861 SLC35E4 solute carrier family 35 member E4 2 2
MIRT647466 DZIP1L DAZ interacting zinc finger protein 1 like 2 2
MIRT647702 NADSYN1 NAD synthetase 1 2 2
MIRT648082 ZMIZ2 zinc finger MIZ-type containing 2 2 2
MIRT648547 TMEM169 transmembrane protein 169 2 2
MIRT648690 AP1M1 adaptor related protein complex 1 mu 1 subunit 2 2
MIRT649747 GNB5 G protein subunit beta 5 2 2
MIRT650154 ZNF426 zinc finger protein 426 2 2
MIRT650450 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT650943 CTNS cystinosin, lysosomal cystine transporter 2 2
MIRT651544 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT652304 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT652890 SYVN1 synoviolin 1 2 2
MIRT654222 RNF19B ring finger protein 19B 2 2
MIRT654676 PSMB5 proteasome subunit beta 5 2 2
MIRT658249 FAXC failed axon connections homolog 2 2
MIRT658363 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT659622 CELF1 CUGBP Elav-like family member 1 2 2
MIRT660171 BNIP3L BCL2 interacting protein 3 like 2 2
MIRT660634 ANKRD52 ankyrin repeat domain 52 2 2
MIRT662428 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT662984 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT663939 ZNF554 zinc finger protein 554 2 2
MIRT666960 PKHD1 PKHD1, fibrocystin/polyductin 2 2
MIRT667945 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT668847 CYCS cytochrome c, somatic 2 2
MIRT671792 RGS17 regulator of G protein signaling 17 2 2
MIRT672382 RPL37 ribosomal protein L37 2 2
MIRT673516 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 4
MIRT674716 FAM73A mitoguardin 1 2 2
MIRT676352 KLF8 Kruppel like factor 8 2 2
MIRT677820 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT678440 PDE4C phosphodiesterase 4C 2 2
MIRT678499 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT679243 LRP10 LDL receptor related protein 10 2 2
MIRT693607 SLC39A1 solute carrier family 39 member 1 2 2
MIRT695927 ZNF174 zinc finger protein 174 2 2
MIRT697987 TSPAN6 tetraspanin 6 2 2
MIRT700821 PHLDA2 pleckstrin homology like domain family A member 2 2 2
MIRT701350 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT702348 KLHL7 kelch like family member 7 2 2
MIRT703387 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT703883 ERBB2IP erbb2 interacting protein 2 2
MIRT708237 PPP1R26 protein phosphatase 1 regulatory subunit 26 2 2
MIRT708629 NUDT18 nudix hydrolase 18 2 2
MIRT708990 CABP4 calcium binding protein 4 2 2
MIRT709804 FOXE1 forkhead box E1 2 2
MIRT710203 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT710248 VAMP1 vesicle associated membrane protein 1 2 2
MIRT710281 FGF1 fibroblast growth factor 1 2 2
MIRT712992 IRGQ immunity related GTPase Q 2 2
MIRT713887 MOB3A MOB kinase activator 3A 2 2
MIRT715600 ADAM17 ADAM metallopeptidase domain 17 2 2
MIRT715639 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715686 FRK fyn related Src family tyrosine kinase 2 2
MIRT717053 WIZ widely interspaced zinc finger motifs 2 2
MIRT717611 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT721539 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT722096 SUSD1 sushi domain containing 1 2 2
MIRT722435 HRNR hornerin 2 2
MIRT722855 NEGR1 neuronal growth regulator 1 2 2
MIRT724621 SNAP25 synaptosome associated protein 25 2 2
MIRT724777 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6819 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6819-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6819-3p Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-6819-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-6819-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-6819-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6819-3p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-6819-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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