pre-miRNA Information
pre-miRNA hsa-mir-6871   
Genomic Coordinates chr20: 41169023 - 41169078
Description Homo sapiens miR-6871 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6871-3p
Sequence 35| CAGCACCCUGUGGCUCCCACAG |56
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN16670239 4 COSMIC
COSN1872096 9 COSMIC
COSM1741616 16 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs545076040 1 dbSNP
rs1273348199 2 dbSNP
rs1202373059 5 dbSNP
rs1340707970 7 dbSNP
rs372994756 8 dbSNP
rs869070782 15 dbSNP
rs931272568 16 dbSNP
rs1333765165 18 dbSNP
Putative Targets

Gene Information
Gene Symbol C8A   
Synonyms -
Description complement C8 alpha chain
Transcript NM_000562   
Expression
Putative miRNA Targets on C8A
3'UTR of C8A
(miRNA target sites are highlighted)
>C8A|NM_000562|3'UTR
   1 GGGCCTCTGGACACAGGCTGGACCAGATGCTGTGGATGTCGACCCCTGCACTGACTATTGGATAAAGACTTCTTTCAACT
  81 AAGAGAAGATGCAAATCAGCACACTTTTTTCTTTGTTCTGCCAGCTTCCAGGCCTAAGACTAGGTTTTGCTGTCTACAGC
 161 CAACTATTCTATTAGTTACAAAACTCAATCATTTTATTCAGCAACTGGATGTTGACTGTTAACTAGAAGCTCTGTCCTAC
 241 TTACAGCACTTTGGATCATCAAAAAAATAAAGTAAAATAGAAAACTGAGAAAACTCAATCCATGACCAGGGAGAACTTAC
 321 AGGATGTTAGAGACAAAACAAGCAGACACCTGAAACAATCAACGCCCAATAAAACAAAGTAGGATGAAAATTCTCTTAGT
 401 TCTTTGATAACAATTTGTTCACTCATAGAAACATTATTAATTGGTAGGGTAAGCAGACACTCTGAAACAATGAGAAAAAT
 481 ACTAAAAATTGACTTGAGTTATTTC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gacaCCCUC---GGUGUCCCACGAc 5'
              |||||   ::||||| ||:| 
Target 5' accaGGGAGAACTTACAGGATGTTa 3'
305 - 329 122.00 -18.70
2
miRNA  3' gacacccUCGGUGUCCCACGAc 5'
                 ||| || || ||:| 
Target 5' tttattcAGCAACTGGATGTTg 3'
193 - 214 111.00 -11.70
3
miRNA  3' gacacCCUCGGUGUCCCACgac 5'
               |||  |||||| ||   
Target 5' cctctGGA--CACAGGCTGgac 3'
4 - 23 93.00 -13.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31502038 2 COSMIC
COSN28510262 11 COSMIC
COSN8862392 11 COSMIC
COSN30448366 21 COSMIC
COSN30540631 22 COSMIC
COSN1106326 38 COSMIC
COSN30483842 39 COSMIC
COSN30455861 45 COSMIC
COSN30133210 46 COSMIC
COSN30535121 46 COSMIC
COSN31502968 46 COSMIC
COSN30192877 50 COSMIC
COSN30182538 52 COSMIC
COSN30478924 54 COSMIC
COSN30473924 65 COSMIC
COSN30145101 81 COSMIC
COSN31511995 144 COSMIC
COSN32057551 295 COSMIC
COSN8475074 396 COSMIC
COSN7224865 409 COSMIC
COSN23571573 455 COSMIC
COSN6039616 455 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1361617561 2 dbSNP
rs1452187095 5 dbSNP
rs755143015 19 dbSNP
rs1376408059 21 dbSNP
rs765277297 22 dbSNP
rs1311498157 28 dbSNP
rs377721032 29 dbSNP
rs1229314963 35 dbSNP
rs758345946 37 dbSNP
rs200534363 39 dbSNP
rs371389558 41 dbSNP
rs778334926 42 dbSNP
rs751923527 43 dbSNP
rs779907800 44 dbSNP
rs373746968 49 dbSNP
rs867560757 50 dbSNP
rs1203702498 51 dbSNP
rs1483169897 53 dbSNP
rs1469437954 55 dbSNP
rs893789993 57 dbSNP
rs1397249664 58 dbSNP
rs1006194626 61 dbSNP
rs1290971609 68 dbSNP
rs1325744144 70 dbSNP
rs1221766302 73 dbSNP
rs1320002182 84 dbSNP
rs180786166 93 dbSNP
rs1020954176 97 dbSNP
rs111368508 99 dbSNP
rs1222711809 100 dbSNP
rs1286889282 105 dbSNP
rs1412102099 108 dbSNP
rs575956172 111 dbSNP
rs14626 112 dbSNP
rs1303096144 122 dbSNP
rs1008993043 133 dbSNP
rs116013219 144 dbSNP
rs1399808014 150 dbSNP
rs1405377205 155 dbSNP
rs1036310111 156 dbSNP
rs1472802156 158 dbSNP
rs1202205519 160 dbSNP
rs1259745129 161 dbSNP
rs1487538672 168 dbSNP
rs1248579403 192 dbSNP
rs1446867297 206 dbSNP
rs867955095 209 dbSNP
rs1316517192 213 dbSNP
rs1266496789 222 dbSNP
rs1195024189 233 dbSNP
rs1426499953 235 dbSNP
rs543369656 250 dbSNP
rs1283202356 252 dbSNP
rs1176225647 261 dbSNP
rs974062697 261 dbSNP
rs960218455 269 dbSNP
rs1293558099 270 dbSNP
rs34386234 274 dbSNP
rs1385911162 279 dbSNP
rs1429437100 279 dbSNP
rs992348297 281 dbSNP
rs577411675 286 dbSNP
rs1774889 295 dbSNP
rs947763806 296 dbSNP
rs1428408903 297 dbSNP
rs1286543634 299 dbSNP
rs979095776 300 dbSNP
rs868378970 301 dbSNP
rs544182010 321 dbSNP
rs1485593489 323 dbSNP
rs908261332 326 dbSNP
rs564578680 327 dbSNP
rs554602204 335 dbSNP
rs1231674931 337 dbSNP
rs1314420222 342 dbSNP
rs1302595732 348 dbSNP
rs1052344279 350 dbSNP
rs901702325 357 dbSNP
rs776420160 364 dbSNP
rs1050192960 365 dbSNP
rs1235708755 367 dbSNP
rs576559313 372 dbSNP
rs889200665 380 dbSNP
rs574526182 383 dbSNP
rs1016251173 384 dbSNP
rs1300814599 385 dbSNP
rs1467419182 387 dbSNP
rs1350045321 391 dbSNP
rs1169672201 395 dbSNP
rs1448924351 396 dbSNP
rs1388468106 400 dbSNP
rs897820260 403 dbSNP
rs753165852 409 dbSNP
rs994181742 412 dbSNP
rs1490009760 414 dbSNP
rs1035934970 427 dbSNP
rs960542496 429 dbSNP
rs115017133 433 dbSNP
rs991692357 464 dbSNP
rs1268500509 476 dbSNP
rs77503860 477 dbSNP
rs1381536743 481 dbSNP
rs748299276 484 dbSNP
rs770067502 490 dbSNP
rs375632191 492 dbSNP
rs890570399 494 dbSNP
rs1297531396 497 dbSNP
rs1008919417 499 dbSNP
rs1368759738 504 dbSNP
rs1419747361 508 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124A_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + A ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gacacccucggugucCCACGac 5'
                         ||| |  
Target 5' ---------gcuggaGGUUCag 3'
1 - 13
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_124A_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + A
Location of target site ENST00000361249.3 | 3UTR | GCUGGAGGUUCAGAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
88 hsa-miR-6871-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061678 BTG2 BTG anti-proliferation factor 2 2 4
MIRT116181 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT150139 MIDN midnolin 2 2
MIRT197058 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT225108 GOLGA7 golgin A7 2 2
MIRT376288 CALM3 calmodulin 3 2 2
MIRT454810 NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2 2
MIRT464228 VEGFA vascular endothelial growth factor A 2 6
MIRT466961 STAT3 signal transducer and activator of transcription 3 2 2
MIRT468219 SGK1 serum/glucocorticoid regulated kinase 1 2 2
MIRT472460 NASP nuclear autoantigenic sperm protein 2 2
MIRT474203 LEPRE1 prolyl 3-hydroxylase 1 1 1
MIRT475836 HDGF heparin binding growth factor 2 4
MIRT478667 CTC1 CST telomere replication complex component 1 2 14
MIRT478707 CSRNP2 cysteine and serine rich nuclear protein 2 2 2
MIRT478982 COMMD2 COMM domain containing 2 2 2
MIRT479693 CCNT2 cyclin T2 2 6
MIRT488440 ULBP2 UL16 binding protein 2 2 2
MIRT492511 RAET1L retinoic acid early transcript 1L 2 2
MIRT492975 NCS1 neuronal calcium sensor 1 2 2
MIRT494158 COL4A1 collagen type IV alpha 1 chain 2 6
MIRT495934 SLC7A5P2 solute carrier family 7 member 5 pseudogene 2 2 2
MIRT496210 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT496356 PPY pancreatic polypeptide 2 2
MIRT496385 ZC3H6 zinc finger CCCH-type containing 6 2 2
MIRT496463 DCTN5 dynactin subunit 5 2 2
MIRT497642 GLDN gliomedin 2 2
MIRT498496 FRK fyn related Src family tyrosine kinase 2 2
MIRT501928 MCL1 MCL1, BCL2 family apoptosis regulator 2 8
MIRT513286 PDPK1 3-phosphoinositide dependent protein kinase 1 2 2
MIRT514767 RBM4B RNA binding motif protein 4B 2 2
MIRT514916 MDM2 MDM2 proto-oncogene 2 6
MIRT515669 LRRC27 leucine rich repeat containing 27 2 2
MIRT520367 UBE2G2 ubiquitin conjugating enzyme E2 G2 2 2
MIRT523960 DYNLT1 dynein light chain Tctex-type 1 2 4
MIRT526859 KIFC1 kinesin family member C1 2 2
MIRT527673 CASP8 caspase 8 2 2
MIRT527828 TMEM74B transmembrane protein 74B 2 2
MIRT529553 EI24 EI24, autophagy associated transmembrane protein 2 2
MIRT530547 SYNPO synaptopodin 2 2
MIRT531725 TARS threonyl-tRNA synthetase 2 2
MIRT533340 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT533620 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT537226 GAN gigaxonin 2 2
MIRT544430 ZNF460 zinc finger protein 460 2 4
MIRT546905 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT547102 PLAG1 PLAG1 zinc finger 2 2
MIRT547820 ISG20L2 interferon stimulated exonuclease gene 20 like 2 2 2
MIRT548236 FEM1B fem-1 homolog B 2 2
MIRT550034 WWTR1 WW domain containing transcription regulator 1 2 2
MIRT554337 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 4
MIRT565483 SPRTN SprT-like N-terminal domain 2 2
MIRT568200 CBX6 chromobox 6 2 2
MIRT569754 C2orf71 chromosome 2 open reading frame 71 2 2
MIRT571369 ZNF45 zinc finger protein 45 2 2
MIRT609886 CLASP1 cytoplasmic linker associated protein 1 2 4
MIRT640543 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT640885 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT643494 LRCH3 leucine rich repeats and calponin homology domain containing 3 2 2
MIRT643627 YY2 YY2 transcription factor 2 2
MIRT644384 ZNF286A zinc finger protein 286A 2 2
MIRT646126 SLC26A9 solute carrier family 26 member 9 2 2
MIRT655939 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT656057 MYLK4 myosin light chain kinase family member 4 2 2
MIRT658767 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT661583 EPHX2 epoxide hydrolase 2 2 2
MIRT664285 RNMTL1 mitochondrial rRNA methyltransferase 3 2 2
MIRT689391 ZNF850 zinc finger protein 850 2 2
MIRT694530 TRIM72 tripartite motif containing 72 2 2
MIRT694626 ZFPM1 zinc finger protein, FOG family member 1 2 2
MIRT695133 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695150 PRY PTPN13-like, Y-linked 2 2
MIRT697468 ZC3H4 zinc finger CCCH-type containing 4 2 2
MIRT701919 MLXIP MLX interacting protein 2 2
MIRT704548 CNBP CCHC-type zinc finger nucleic acid binding protein 2 2
MIRT704791 CDK6 cyclin dependent kinase 6 2 2
MIRT705696 ANKRD13A ankyrin repeat domain 13A 2 2
MIRT707992 OTUD4 OTU deubiquitinase 4 2 2
MIRT708739 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT713401 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT713846 FAM3D family with sequence similarity 3 member D 2 2
MIRT716998 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT718511 DIRAS1 DIRAS family GTPase 1 2 2
MIRT718698 BTBD9 BTB domain containing 9 2 2
MIRT719578 TYRO3 TYRO3 protein tyrosine kinase 2 2
MIRT720892 CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2 2
MIRT722633 C8A complement C8 alpha chain 2 2
MIRT723333 DGAT1 diacylglycerol O-acyltransferase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6871-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6871-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6871-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6871-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)

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