pre-miRNA Information | |
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pre-miRNA | hsa-mir-6737 |
Genomic Coordinates | chr1: 153962351 - 153962420 |
Description | Homo sapiens miR-6737 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | ||||||||||||||||||||||
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Mature miRNA | hsa-miR-6737-5p | |||||||||||||||||||||
Sequence | 6| UUGGGGUGGUCGGCCCUGGAG |26 | |||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||
Experiments | Meta-analysis | |||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | GDE1 | ||||||||||||||||||||
Synonyms | 363E6.2, MIR16 | ||||||||||||||||||||
Description | glycerophosphodiester phosphodiesterase 1 | ||||||||||||||||||||
Transcript | NM_016641 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on GDE1 | |||||||||||||||||||||
3'UTR of GDE1 (miRNA target sites are highlighted) |
>GDE1|NM_016641|3'UTR 1 ACTTTCACGGTGGGACGAAACGGGTTCAGAAACTGCCAGGGGCCTCATACAGGGATATCAAAATACCCTTTGTGCTAGCC 81 CAGGCCCTGGGGAATCAGGTGACTCACACAAATGCAATAGTTGGTCACTGCATTTTTACCTGAACCAAAGCTAAACCCGG 161 TGTTGCCACCATGCACCATGGCATGCCAGAGTTCAACACTGTTGCTCTTGAAAATCTGGGTCTGAAAAAACGCACAAGAG 241 CCCCTGCCCTGCCCTAGCTGAGGCACACAGGGAGACCCAGTGAGGATAAGCACAGATTGAATTGTACAGTTTGCAGATGC 321 AGATGTAAATGCATGGGACATGCATGATAACTCAGAGTTGACATTTTAAAACTTGCCACACTTATTTCAAATATTTGTAC 401 TCAGCTATGTTAACATGTACTGTAGACATCAAACTTGTGGCCATACTAATAAAATTATTAAAAGGAGCACTAAAGGAAAA 481 CTGTGTGCCAAGCATCATATCCTAAGGCATACGGAATTTGGGGAAGCCACCATGCAATCCAGTGAGGCTTCAGTGTACAG 561 CAACCAAAATGGTAGGGAGGTCTTGAAGCCAATGAGGGATTTATAGCATCTTGAATAGAGAGCTGCAAACCACCAGGGGG 641 CAGAGTTGCATTTTTCCAGGCTTTTTAGGAAGCTCTGCAACAGATGTGATCTGATCATAGGCAATTAGAACTGGAAGAAA 721 CTTCCAAAAATATCTAGGTTTGTCCTCATTTTACAAATGAGGAAACTAAACTCTGTGGAAGGGAAGGGGTTGCCTCAAAA 801 GTCACAGCTTAGCTGGGCACAGTGGCTCATGCCGATAATCCCAGCAATTCAGAAAGCTGAGGCAGGAGGATTACTTGAGG 881 CCAGACTGGGCAATATAGCAAGACCCCATCTCTAAAAAATTAGGCATGGTGGTGCATGCCTGTATTCCCAGCTACTCAGG 961 AGGTTGAGGTGGGAGGATCACTTGAGCCCAGAAGTTCAAGGCTGCAATGAGCCATGATTACACCACGGCACTACAACCTT 1041 GGTGGCACAGTGAGAACCTGACTCTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGATAACTAGAACTTCTAGAACATCT 1121 TGTTTACAGTTAGCCAGAAACTATACAAGTGGTTTAACATGCATTATCTTACTCAATCCATACAAAAGTCTTATGGAGGT 1201 GTTAGCACTCTTTCTACTGATGAAGAACTGAGGTACTTCATAAAACCACTTACCCAAGGTGTCTTGAGTCTGGTACAACT 1281 GGCATTCAAATCTAGGTCAGTCTGCCCCCAGAGCCACTACCCTTACCCCTCACTGAATCTGCCTTTATATTGTTGAGCCC 1361 ATGACCCCAAACTGCTCTTTCCAATTTGAACTTCCAGGGATTTTATTGTGAACTTACATAGCAACATTAAAATGAAGTTG 1441 AATTGTTTTTAATGGCAACGCCGTCTGTCTCCTCTAGCTTACCGCTTCTCACCTTTCAACCCCATCTGTGGCCTTTGTCC 1521 AGGCCCACAGCTTAGCCATGGCTTCCCTCCTGCATCCCTGCCGTGGGTTGCTGGCCTCACACTTGCAGCAGCTGGACAGT 1601 GATTTTAGAAGGCCACCAGTCCCCATAGCTATGTGACAATGAGAAGCAAACTTTTTTGTGACAGATTGTATTGGCATAGG 1681 CATGATAGATGGGGATTGGTACGTTTTGAATCAGCATTTGCAAAAAAATTGTCTTGAATTTTAAAATAAACAACAAAGAT 1761 TTGTTCATTGAGTGCAAAAAAAAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HeLa | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in Chi_124A_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + A
... - Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Chi SW; Zang JB; Mele A; Darnell RB - Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
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CLIP-seq Support 1 for dataset Chi_124A_2A8_130_50 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | HeLa / HeLa cell miR-124 + A |
Location of target site | ENST00000353258.3 | 3UTR | UUGAGCCCAUGACCC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 19536157 / Chi_HITSCLIP |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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67 hsa-miR-6737-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT066215 | MARCH9 | membrane associated ring-CH-type finger 9 | ![]() |
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2 | 2 | ||||||
MIRT074413 | TNRC6A | trinucleotide repeat containing 6A | ![]() |
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2 | 2 | ||||||
MIRT125300 | MID1IP1 | MID1 interacting protein 1 | ![]() |
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2 | 2 | ||||||
MIRT153951 | NCOA3 | nuclear receptor coactivator 3 | ![]() |
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2 | 2 | ||||||
MIRT452776 | FAM136A | family with sequence similarity 136 member A | ![]() |
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2 | 2 | ||||||
MIRT452977 | CABP4 | calcium binding protein 4 | ![]() |
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2 | 2 | ||||||
MIRT454128 | FOXRED2 | FAD dependent oxidoreductase domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT455242 | DDX39B | DExD-box helicase 39B | ![]() |
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2 | 10 | ||||||
MIRT459007 | UQCRH | ubiquinol-cytochrome c reductase hinge protein | ![]() |
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2 | 2 | ||||||
MIRT459463 | MUC17 | mucin 17, cell surface associated | ![]() |
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2 | 4 | ||||||
MIRT460871 | UBE2S | ubiquitin conjugating enzyme E2 S | ![]() |
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2 | 2 | ||||||
MIRT461264 | COX10 | COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor | ![]() |
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2 | 2 | ||||||
MIRT464540 | UBTF | upstream binding transcription factor, RNA polymerase I | ![]() |
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2 | 2 | ||||||
MIRT465268 | TRIM28 | tripartite motif containing 28 | ![]() |
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2 | 2 | ||||||
MIRT465871 | TMEM43 | transmembrane protein 43 | ![]() |
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2 | 4 | ||||||
MIRT466228 | TMED10 | transmembrane p24 trafficking protein 10 | ![]() |
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2 | 2 | ||||||
MIRT468417 | SETD1B | SET domain containing 1B | ![]() |
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2 | 2 | ||||||
MIRT468684 | SEC22C | SEC22 homolog C, vesicle trafficking protein | ![]() |
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2 | 4 | ||||||
MIRT473399 | MDM4 | MDM4, p53 regulator | ![]() |
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2 | 2 | ||||||
MIRT473517 | MAX | MYC associated factor X | ![]() |
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2 | 2 | ||||||
MIRT474511 | KLHDC8A | kelch domain containing 8A | ![]() |
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2 | 2 | ||||||
MIRT475801 | HDGF | heparin binding growth factor | ![]() |
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2 | 2 | ||||||
MIRT479493 | CDH6 | cadherin 6 | ![]() |
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2 | 2 | ||||||
MIRT480770 | BMP2 | bone morphogenetic protein 2 | ![]() |
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2 | 2 | ||||||
MIRT481418 | ASB6 | ankyrin repeat and SOCS box containing 6 | ![]() |
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2 | 2 | ||||||
MIRT482966 | CSTF2 | cleavage stimulation factor subunit 2 | ![]() |
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2 | 2 | ||||||
MIRT483380 | SPATA6 | spermatogenesis associated 6 | ![]() |
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2 | 4 | ||||||
MIRT483677 | CYP11A1 | cytochrome P450 family 11 subfamily A member 1 | ![]() |
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2 | 2 | ||||||
MIRT484328 | EPN1 | epsin 1 | ![]() |
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2 | 4 | ||||||
MIRT484963 | UCK1 | uridine-cytidine kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT485908 | PGPEP1 | pyroglutamyl-peptidase I | ![]() |
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2 | 4 | ||||||
MIRT488149 | PRRC2B | proline rich coiled-coil 2B | ![]() |
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2 | 4 | ||||||
MIRT488943 | CYP2W1 | cytochrome P450 family 2 subfamily W member 1 | ![]() |
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2 | 6 | ||||||
MIRT491835 | ZBTB7A | zinc finger and BTB domain containing 7A | ![]() |
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2 | 4 | ||||||
MIRT493026 | NAA50 | N(alpha)-acetyltransferase 50, NatE catalytic subunit | ![]() |
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2 | 2 | ||||||
MIRT499374 | PLCG2 | phospholipase C gamma 2 | ![]() |
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2 | 11 | ||||||
MIRT499723 | USH1G | USH1 protein network component sans | ![]() |
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2 | 4 | ||||||
MIRT500349 | ZNF385A | zinc finger protein 385A | ![]() |
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2 | 2 | ||||||
MIRT509574 | HIST2H2AB | histone cluster 2 H2A family member b | ![]() |
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2 | 4 | ||||||
MIRT512794 | GLRX | glutaredoxin | ![]() |
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2 | 2 | ||||||
MIRT513291 | SETBP1 | SET binding protein 1 | ![]() |
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2 | 2 | ||||||
MIRT515697 | ZNF321P | zinc finger protein 321, pseudogene | ![]() |
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2 | 2 | ||||||
MIRT518255 | LEAP2 | liver enriched antimicrobial peptide 2 | ![]() |
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2 | 2 | ||||||
MIRT522026 | PAQR3 | progestin and adipoQ receptor family member 3 | ![]() |
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2 | 4 | ||||||
MIRT523169 | HIST3H3 | histone cluster 3 H3 | ![]() |
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2 | 2 | ||||||
MIRT524036 | DNAJC8 | DnaJ heat shock protein family (Hsp40) member C8 | ![]() |
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2 | 2 | ||||||
MIRT533476 | TRIM71 | tripartite motif containing 71 | ![]() |
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2 | 2 | ||||||
MIRT541488 | ADM | adrenomedullin | ![]() |
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2 | 2 | ||||||
MIRT553987 | SRPR | SRP receptor alpha subunit | ![]() |
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2 | 2 | ||||||
MIRT571445 | YKT6 | YKT6 v-SNARE homolog | ![]() |
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2 | 2 | ||||||
MIRT574889 | Plcg2 | phospholipase C, gamma 2 | ![]() |
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2 | 7 | ||||||
MIRT607544 | GLI2 | GLI family zinc finger 2 | ![]() |
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2 | 2 | ||||||
MIRT607688 | MAPK10 | mitogen-activated protein kinase 10 | ![]() |
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2 | 2 | ||||||
MIRT610072 | CRLF1 | cytokine receptor like factor 1 | ![]() |
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2 | 2 | ||||||
MIRT610573 | CACUL1 | CDK2 associated cullin domain 1 | ![]() |
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2 | 2 | ||||||
MIRT614041 | THBS2 | thrombospondin 2 | ![]() |
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2 | 2 | ||||||
MIRT626318 | LRTOMT | leucine rich transmembrane and O-methyltransferase domain containing | ![]() |
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2 | 2 | ||||||
MIRT634005 | RIF1 | replication timing regulatory factor 1 | ![]() |
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2 | 2 | ||||||
MIRT639619 | FGF19 | fibroblast growth factor 19 | ![]() |
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2 | 2 | ||||||
MIRT647343 | RPH3AL | rabphilin 3A like (without C2 domains) | ![]() |
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2 | 2 | ||||||
MIRT689704 | ATXN2 | ataxin 2 | ![]() |
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2 | 2 | ||||||
MIRT691170 | APOL6 | apolipoprotein L6 | ![]() |
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2 | 2 | ||||||
MIRT693165 | NPR1 | natriuretic peptide receptor 1 | ![]() |
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2 | 2 | ||||||
MIRT711727 | NUPL2 | nucleoporin like 2 | ![]() |
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2 | 2 | ||||||
MIRT711806 | ELN | elastin | ![]() |
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2 | 2 | ||||||
MIRT721546 | FXN | frataxin | ![]() |
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2 | 2 | ||||||
MIRT722979 | GDE1 | glycerophosphodiester phosphodiesterase 1 | ![]() |
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2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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