miRTarBase - #MIRT723499


—
pre-miRNA Information
pre-miRNA hsa-mir-378f   
Genomic Coordinates chr1: 23929070 - 23929147
Description Homo sapiens miR-378f stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-378f
Sequence 52| ACUGGACUUGGAGCCAGAAG |71
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 18 1 + 23929138 29233923 MiREDiBase
A-to-I 19 1 + 23929139 29233923 MiREDiBase
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol WDR33   
Synonyms NET14, WDC146
Description WD repeat domain 33
Transcript NM_001006623   
Other Transcripts NM_001006622 , NM_018383   
Expression
Putative miRNA Targets on WDR33
3'UTR of WDR33
(miRNA target sites are highlighted)		 
>WDR33|NM_001006623|3'UTR
   1 ATAACAGTAGGTGGACAAAGTTTAGGGAGCCACATTTACCAACTTCTGTGAATATACCCAAGAAGATTCTGGCAAAACAT
  81 AGATTCAAATTACAGTTGATGCTGTGGATGGCTATGGGTTAACTACTCTTCTACTTTGACACGGATTATTTGTTGCTTTT
 161 ATGTTTCTAAATTCTCAATTAAAAAGAAGTGTATCCTTAATCTGGCCAACTGAAAGTGAACTTGTTCATTCACCTCTACC
 241 TTGCTTTCAAAAGGACTGCTTACCATGGAAGTGCTCCAGAAGAATCATTTGAAACATCTTTTGTTTTCCTTCTTGGTTCT
 321 GCGTTTTCTTCCTTACCAGGGGCTTCAGTCATGGCTTCTCTTTATTCTTGGCCTGGGTTGTCTGCTGGCACTAATACATC
 401 TATTATTAACGTAGTGTAGGTACTGGCCTTTCTAATAGTCTTGGTATTTAGTGCCAGACTCCCATCAATCTTTTGAATGT
 481 CTTTTCTTTTTCTTTTTGCACTTTTCTAGCTTTTCAAGTGATGACTATATACTGCTTTTCTTGACTGTATATATTGTTAC
 561 TGAATTGTGAATATCTGCAGAAATGTTTACTAGAGAACCTGTGACTGTTGAATAACATGTGCCCGAACATACACACACAC
 641 ATATGTACACACACACCTCAGAGTACTCTTTCTTACAGCGGACTTTGCTGCTGCTTTCTGCATGTGTGGGACACTGGTAT
 721 CTCCCGTCTCAGACAAATGGCTGATGTTCTCTATGATATTGGTGTTAATATCAAAGAATTGAATGAATACAACAGAATTG
 801 AGGTTGAAAAATATTTGATTGCCACATTCCTTTAAGCATCTTTGATGAATACTCTGCAAAGTAGCCTTTAAAAAAATGTA
 881 AATTTTTTAAAAAGTCCACAGAGGAGAATTTGCTGGTTAGCACAAAACATACTGCAAAATTGCTTCTTTCTGGTTATTAT
 961 AACTGAAGAATATAGAAGATTGACACACATTTTATACACCCTCAGGCAGTGTTTTGGAATAATATTGTACCTTTTCAAAT
1041 TGTTATCAATTAACTGTTTTTCTCCATTTCATAATTCTCAAGATTTTTCTAAATACAGCCTTTAAATTTGACTCAAATGG
1121 AAATTGTGCACTTTCCTGTTTATACCCTTCCCCACGTTATTGTAAAAGAGTTTAACAGCAGCCTGATATGTAAGTTTCAG
1201 CAAAACTTATACCTGTATATGTTTTTATTTGACTCAAAAATTAGATATTTTACCATATAGTCATAAGAATTTGCTCACTT
1281 TGATGCCAGAAGTACTTAAGAAGTTACACGGCACTAATTTTATGAGTTGTATGCCTAATTTCAATTTCTAACCTATTTGA
1361 CAGTTTCTTTTAGGTCAGCCTTTGTTGGTCTTCCATGTAAATACAAGTTGGTACAAATCAATAGAAACCATTTTACCTAC
1441 ATAGGCAAAGTAAATGTGTGACTTAGAGACTGCCAGATTTATGGTGCATCTACCTTTTTATCCATTTGAGCTTGCTTTTT
1521 TATGTTTGTGTATTGGTTGCTCCTGACACTATACATTTCAAAATTTTTTATAACTTGAAAAACACTTCTGTGCTACCACT
1601 CAGTTCTGATCAAATCCTTACATTTTGCAACACTCATTTCTGAATTTTCAGTAAAGAAATACACATTACAAATTAAAGGT
1681 TAAAGGCCCCTTTACATGCCCTTCCCCAGTCTCCTCTTCCTCCCCCGGAAGTGTCCATTCTGCTGAATTCAGGTTCATCA
1761 TTGCCAGACAAATGTAGTAAGCTAGTGTTTCACATTTCCAAAATCAGCCTTCTGGCAGACTTGGAAGTACTCTTGAGAAA
1841 AGAAGACTCGTGACCAAATTCTCCCACAGATTTGTAATAATGTACATATTGAAAGGACTGAAGGCTCTCAGACTGGGAAA
1921 GAAACTTACCCATTTTAAAATTCAGCATTGCTCAACTTACCTGACTGCCGGACCCCTTCACCCATGATTCTATGCACTGT
2001 ATTGTTGGAACATACATTGTGAAAACACTGCCCTGCCTAGGCATACCCCCTTTCCAGAATTAACTTTCCATTTAATTCTA
2081 TAGTTTTTCACTGATGTAACTTTCTAGACTGGACAACAAAGATGACTAATAGTAATCACTCCAAGTTGATGTTGACTGTT
2161 GGGTTGTGGTGAAATCATTTTGCATTAAAGGAAGGTAAAATACTAATAAATTGCATATTCCTTGACCAGAGCACAGATTA
2241 CTTATGCTTCTTAATTTTTTAAAATCTTAAATCCTCTGTCCAACTGGAGTATCTGGCTATGGGCCATGGGTACTCATATA
2321 CCCTTTGTCTTAAACTGATCTGTTACATTTTATGTTCTTGTGGCTAGAAGTAGCCTGAGTTTGCTGTTAATGTTTAACAC
2401 ATTTTCTTGAGTAACAGTTCTGTTAATATTGTACAAGATGGTACTTGAATTCTTTGTTTGCCTTTTTTCTTCCTGTATTA
2481 GAAAATCTTGGTGCTTTTTATAAGTTTTGTATAAAAGAATTTTTTTTAAGATTTGTTCATAAAATGGTCTGATCCAGGAA
2561 AAATAAAATGGGAACATGGACACCATTTCTGACCTTCAAATAAAACTTATTATGTATTGGTTTTC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaagaccgaggUUCAGGUca 5'
                     |||||||  
Target 5' aattttttaaaAAGTCCAca 3'
 881 - 900 125.00 -7.00
2 
miRNA  3' gaAG-ACCGAGGUUCA-GGUCa 5'
            || |||: :: ||| |||| 
Target 5' agTCTTGGTATTTAGTGCCAGa 3'
 437 - 458 122.00 -11.20
3 
miRNA  3' gaagACCGAGGUUCAGGUCa 5'
              |||  | ||||::|| 
Target 5' taggTGG-ACAAAGTTTAGg 3'
 8 - 26 119.00 -10.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN15668631 4 COSMIC
COSN30477499 40 COSMIC
COSN20054747 46 COSMIC
COSN28184499 95 COSMIC
COSN30447418 102 COSMIC
COSN30143175 113 COSMIC
COSN30154060 123 COSMIC
COSN28186325 126 COSMIC
COSN30184002 133 COSMIC
COSN30143665 136 COSMIC
COSN30121547 186 COSMIC
COSN31570549 206 COSMIC
COSN19049523 551 COSMIC
COSN9858418 661 COSMIC
COSN32056300 979 COSMIC
COSN31959789 1028 COSMIC
COSN20097137 1040 COSMIC
COSN27976321 1096 COSMIC
COSN14509460 1204 COSMIC
COSN9858417 1616 COSMIC
COSN24587036 1665 COSMIC
COSN16037995 1832 COSMIC
COSN23850146 1921 COSMIC
COSN6207968 2094 COSMIC
COSN27656216 2142 COSMIC
COSN23550407 2397 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs372652956 5 dbSNP
rs1174742057 8 dbSNP
rs1262330442 10 dbSNP
rs865977763 11 dbSNP
rs758185617 15 dbSNP
rs761799424 16 dbSNP
rs776835359 19 dbSNP
rs1405947433 24 dbSNP
rs768847878 28 dbSNP
rs747288405 33 dbSNP
rs775826720 34 dbSNP
rs745667965 38 dbSNP
rs772027031 39 dbSNP
rs749788800 42 dbSNP
rs776103990 44 dbSNP
rs769739610 45 dbSNP
rs777313154 46 dbSNP
rs1318384483 53 dbSNP
rs550563305 55 dbSNP
rs1256142891 56 dbSNP
rs993556013 62 dbSNP
rs1191268952 67 dbSNP
rs79249066 72 dbSNP
rs565276433 79 dbSNP
rs1431115353 80 dbSNP
rs1198292118 82 dbSNP
rs1429004683 93 dbSNP
rs1221061471 104 dbSNP
rs1466525898 109 dbSNP
rs1368876349 114 dbSNP
rs187773811 115 dbSNP
rs948866557 141 dbSNP
rs894612498 142 dbSNP
rs528709893 143 dbSNP
rs1015979535 144 dbSNP
rs1057321358 147 dbSNP
rs891197999 152 dbSNP
rs182829527 157 dbSNP
rs924846063 178 dbSNP
rs1306857458 183 dbSNP
rs868132811 183 dbSNP
rs755906926 186 dbSNP
rs760757039 188 dbSNP
rs899962908 190 dbSNP
rs1054650133 193 dbSNP
rs936221906 199 dbSNP
rs1434441975 201 dbSNP
rs368766023 221 dbSNP
rs1263542968 231 dbSNP
rs781324815 233 dbSNP
rs1478317729 244 dbSNP
rs914664938 249 dbSNP
rs1196320217 268 dbSNP
rs1417935836 274 dbSNP
rs574604308 279 dbSNP
rs190196778 289 dbSNP
rs142655470 290 dbSNP
rs964088828 296 dbSNP
rs1351663737 298 dbSNP
rs1017430479 301 dbSNP
rs1302771497 308 dbSNP
rs534942909 313 dbSNP
rs11686607 314 dbSNP
rs1268220627 316 dbSNP
rs954677730 322 dbSNP
rs917659545 323 dbSNP
rs762092266 339 dbSNP
rs777464358 342 dbSNP
rs1026619265 348 dbSNP
rs1314838851 351 dbSNP
rs1356639375 354 dbSNP
rs1452622930 358 dbSNP
rs1259222331 374 dbSNP
rs1244610051 384 dbSNP
rs991838522 397 dbSNP
rs558861566 408 dbSNP
rs993194866 410 dbSNP
rs1348716095 411 dbSNP
rs530094105 413 dbSNP
rs1303241083 414 dbSNP
rs1485772738 415 dbSNP
rs1182933264 416 dbSNP
rs1232747451 418 dbSNP
rs1387703139 418 dbSNP
rs898785930 419 dbSNP
rs973944014 420 dbSNP
rs573028428 423 dbSNP
rs962932073 426 dbSNP
rs1016026909 428 dbSNP
rs186141276 434 dbSNP
rs1298781204 435 dbSNP
rs1316564810 437 dbSNP
rs1004212969 449 dbSNP
rs752559030 450 dbSNP
rs536011016 455 dbSNP
rs1309397640 458 dbSNP
rs1057351996 466 dbSNP
rs571370112 468 dbSNP
rs1467090083 470 dbSNP
rs1316690126 471 dbSNP
rs1211265887 473 dbSNP
rs1245448630 475 dbSNP
rs551504879 479 dbSNP
rs567429400 484 dbSNP
rs1172544141 490 dbSNP
rs1238832226 491 dbSNP
rs1432766263 491 dbSNP
rs754528634 496 dbSNP
rs947417616 500 dbSNP
rs753399817 501 dbSNP
rs914591488 504 dbSNP
rs1039676309 505 dbSNP
rs942810687 506 dbSNP
rs1055019932 507 dbSNP
rs912633237 508 dbSNP
rs987277733 513 dbSNP
rs766069281 522 dbSNP
rs1278518264 525 dbSNP
rs1000395157 528 dbSNP
rs1220128778 531 dbSNP
rs1265422120 534 dbSNP
rs919182426 544 dbSNP
rs1427734386 547 dbSNP
rs1003176912 555 dbSNP
rs972354762 555 dbSNP
rs1183829597 557 dbSNP
rs950312090 560 dbSNP
rs1179765744 561 dbSNP
rs1232471619 562 dbSNP
rs963314549 563 dbSNP
rs1279699128 576 dbSNP
rs1475053991 578 dbSNP
rs1015962696 592 dbSNP
rs1344909815 594 dbSNP
rs1469151744 605 dbSNP
rs760594061 612 dbSNP
rs550651044 617 dbSNP
rs1012577044 618 dbSNP
rs1407651928 620 dbSNP
rs181454210 624 dbSNP
rs1292930948 625 dbSNP
rs1035416720 630 dbSNP
rs1003047298 632 dbSNP
rs941243427 633 dbSNP
rs1223287904 635 dbSNP
rs571284319 638 dbSNP
rs908445907 642 dbSNP
rs1194115064 644 dbSNP
rs529597730 657 dbSNP
rs982661695 657 dbSNP
rs1452309250 658 dbSNP
rs1224993280 661 dbSNP
rs1267116990 663 dbSNP
rs1479948246 666 dbSNP
rs955293367 667 dbSNP
rs1374671873 668 dbSNP
rs903316796 669 dbSNP
rs552084264 671 dbSNP
rs1041882584 679 dbSNP
rs528796418 680 dbSNP
rs1426067602 682 dbSNP
rs964458034 683 dbSNP
rs771811183 698 dbSNP
rs1461244649 716 dbSNP
rs1033138747 723 dbSNP
rs751910170 725 dbSNP
rs1166740142 726 dbSNP
rs1410500047 728 dbSNP
rs559965513 732 dbSNP
rs1270190344 733 dbSNP
rs1357133924 737 dbSNP
rs1039708227 739 dbSNP
rs942674382 741 dbSNP
rs903317985 752 dbSNP
rs1490253205 757 dbSNP
rs1217017453 758 dbSNP
rs912664146 762 dbSNP
rs1263548099 774 dbSNP
rs1445114504 781 dbSNP
rs192397121 789 dbSNP
rs529471951 792 dbSNP
rs933174764 795 dbSNP
rs764332854 803 dbSNP
rs1445861488 814 dbSNP
rs561007959 818 dbSNP
rs919116086 824 dbSNP
rs1384179330 828 dbSNP
rs1419900029 830 dbSNP
rs1290319936 836 dbSNP
rs1020414248 837 dbSNP
rs971917513 838 dbSNP
rs544323320 840 dbSNP
rs1014434465 843 dbSNP
rs896084144 850 dbSNP
rs1384197771 856 dbSNP
rs763424650 857 dbSNP
rs1313045546 865 dbSNP
rs1251815060 869 dbSNP
rs963656181 870 dbSNP
rs1262773522 877 dbSNP
rs6737236 877 dbSNP
rs904938565 888 dbSNP
rs1256712948 895 dbSNP
rs1462622839 897 dbSNP
rs991172885 906 dbSNP
rs958321780 921 dbSNP
rs1181725579 944 dbSNP
rs1038156354 958 dbSNP
rs1439837727 969 dbSNP
rs941114105 974 dbSNP
rs564712228 978 dbSNP
rs1361708498 990 dbSNP
rs1452002929 990 dbSNP
rs908348280 994 dbSNP
rs775846835 1003 dbSNP
rs1035447725 1006 dbSNP
rs1003071131 1007 dbSNP
rs1335376774 1009 dbSNP
rs982626001 1014 dbSNP
rs1392101518 1015 dbSNP
rs1309351358 1025 dbSNP
rs933883549 1027 dbSNP
rs967151657 1031 dbSNP
rs922537797 1037 dbSNP
rs544954972 1042 dbSNP
rs141777908 1045 dbSNP
rs771970109 1045 dbSNP
rs1020895807 1046 dbSNP
rs774092164 1046 dbSNP
rs187057240 1047 dbSNP
rs1267587147 1058 dbSNP
rs1457771793 1060 dbSNP
rs893401752 1083 dbSNP
rs1247918056 1099 dbSNP
rs550346742 1105 dbSNP
rs1199174559 1128 dbSNP
rs759554271 1129 dbSNP
rs1481656916 1134 dbSNP
rs1033437220 1135 dbSNP
rs1006846898 1138 dbSNP
rs1230871485 1141 dbSNP
rs1337031323 1146 dbSNP
rs1462519448 1152 dbSNP
rs891090478 1155 dbSNP
rs1051092298 1156 dbSNP
rs1391021618 1161 dbSNP
rs1284238877 1168 dbSNP
rs1347158834 1168 dbSNP
rs1221471482 1180 dbSNP
rs967883675 1181 dbSNP
rs776716085 1184 dbSNP
rs897227182 1187 dbSNP
rs771105506 1188 dbSNP
rs1308025541 1189 dbSNP
rs182326551 1193 dbSNP
rs573496253 1194 dbSNP
rs909134064 1206 dbSNP
rs991370836 1209 dbSNP
rs1270679343 1210 dbSNP
rs189288276 1210 dbSNP
rs1417372143 1217 dbSNP
rs1034602127 1242 dbSNP
rs778110000 1253 dbSNP
rs1429154048 1256 dbSNP
rs1429596991 1258 dbSNP
rs771754166 1263 dbSNP
rs1173225413 1269 dbSNP
rs1002268111 1279 dbSNP
rs1473582751 1283 dbSNP
rs967561433 1288 dbSNP
rs1461607150 1294 dbSNP
rs530831304 1300 dbSNP
rs1241966859 1304 dbSNP
rs990741207 1309 dbSNP
rs748038986 1311 dbSNP
rs1302340183 1317 dbSNP
rs1436552554 1321 dbSNP
rs957495427 1325 dbSNP
rs1018487035 1326 dbSNP
rs1007129673 1337 dbSNP
rs1216230644 1342 dbSNP
rs1293419679 1344 dbSNP
rs1306410270 1351 dbSNP
rs13408078 1356 dbSNP
rs1293420928 1357 dbSNP
rs1214659697 1362 dbSNP
rs571678988 1372 dbSNP
rs1221333712 1373 dbSNP
rs369470774 1380 dbSNP
rs933852510 1383 dbSNP
rs557885403 1387 dbSNP
rs1188799419 1393 dbSNP
rs1203952695 1401 dbSNP
rs1325197319 1404 dbSNP
rs1427939859 1406 dbSNP
rs1164316891 1408 dbSNP
rs1387266203 1411 dbSNP
rs1422940214 1412 dbSNP
rs994154868 1413 dbSNP
rs754977303 1419 dbSNP
rs753346851 1421 dbSNP
rs1237752893 1436 dbSNP
rs897252080 1438 dbSNP
rs748883620 1442 dbSNP
rs1256584495 1443 dbSNP
rs942617788 1445 dbSNP
rs1305562455 1449 dbSNP
rs1452679881 1456 dbSNP
rs1038418646 1461 dbSNP
rs1441308896 1463 dbSNP
rs1356708161 1470 dbSNP
rs1244773759 1486 dbSNP
rs1393460267 1487 dbSNP
rs941851972 1493 dbSNP
rs534968343 1509 dbSNP
rs1317831710 1521 dbSNP
rs1218404398 1522 dbSNP
rs1240818064 1524 dbSNP
rs1055633807 1528 dbSNP
rs1464862373 1534 dbSNP
rs1184788706 1535 dbSNP
rs1245018907 1541 dbSNP
rs565067716 1551 dbSNP
rs928556094 1553 dbSNP
rs566255007 1554 dbSNP
rs1408987762 1558 dbSNP
rs1386004029 1563 dbSNP
rs1402170642 1566 dbSNP
rs967472807 1568 dbSNP
rs1344431114 1575 dbSNP
rs549692674 1579 dbSNP
rs1470234793 1589 dbSNP
rs72968953 1594 dbSNP
rs570243293 1595 dbSNP
rs1468689608 1599 dbSNP
rs1379938907 1603 dbSNP
rs1379840719 1606 dbSNP
rs1375109278 1608 dbSNP
rs550731501 1611 dbSNP
rs767256549 1621 dbSNP
rs150345055 1630 dbSNP
rs957109746 1635 dbSNP
rs1211044925 1640 dbSNP
rs1459983571 1654 dbSNP
rs141280487 1660 dbSNP
rs148251318 1662 dbSNP
rs1471263391 1668 dbSNP
rs960230207 1672 dbSNP
rs1034486389 1676 dbSNP
rs146495595 1686 dbSNP
rs866332608 1687 dbSNP
rs1178422185 1688 dbSNP
rs1347959446 1695 dbSNP
rs566154114 1696 dbSNP
rs963984353 1699 dbSNP
rs542490033 1705 dbSNP
rs1355811475 1707 dbSNP
rs1439538036 1709 dbSNP
rs1278647949 1719 dbSNP
rs1016587787 1726 dbSNP
rs1224513234 1732 dbSNP
rs573533255 1750 dbSNP
rs1322060529 1759 dbSNP
rs1199902682 1766 dbSNP
rs1300949801 1768 dbSNP
rs1432699445 1769 dbSNP
rs1327199074 1773 dbSNP
rs1439691848 1776 dbSNP
rs1202691406 1777 dbSNP
rs1251367998 1778 dbSNP
rs556751738 1786 dbSNP
rs1490436784 1788 dbSNP
rs1201350560 1792 dbSNP
rs886856271 1799 dbSNP
rs1477636952 1803 dbSNP
rs529202766 1805 dbSNP
rs1046882347 1816 dbSNP
rs1398958251 1830 dbSNP
rs578034039 1832 dbSNP
rs997945134 1847 dbSNP
rs961370340 1848 dbSNP
rs1174404974 1849 dbSNP
rs1434639443 1850 dbSNP
rs1405880288 1854 dbSNP
rs1272496913 1861 dbSNP
rs1393848081 1868 dbSNP
rs753119474 1869 dbSNP
rs183613396 1876 dbSNP
rs900970541 1886 dbSNP
rs534752259 1889 dbSNP
rs765686006 1895 dbSNP
rs895214287 1902 dbSNP
rs942602509 1903 dbSNP
rs760068975 1906 dbSNP
rs547519421 1907 dbSNP
rs1274132597 1929 dbSNP
rs1446442702 1929 dbSNP
rs1242297043 1943 dbSNP
rs181325543 1945 dbSNP
rs1225059682 1949 dbSNP
rs748647245 1953 dbSNP
rs1043042076 1959 dbSNP
rs1444717526 1960 dbSNP
rs946076457 1961 dbSNP
rs1193801963 1962 dbSNP
rs1243777509 1963 dbSNP
rs777166082 1965 dbSNP
rs1474106957 1967 dbSNP
rs1347035975 1970 dbSNP
rs1382188616 1972 dbSNP
rs1426130654 1976 dbSNP
rs913310480 1977 dbSNP
rs1389022304 1983 dbSNP
rs1386570285 1984 dbSNP
rs1319493922 1985 dbSNP
rs770978897 1986 dbSNP
rs1428679353 1996 dbSNP
rs1296933021 1998 dbSNP
rs556126649 2001 dbSNP
rs1248425744 2009 dbSNP
rs1054046029 2010 dbSNP
rs960116901 2015 dbSNP
rs935773668 2018 dbSNP
rs1428876072 2025 dbSNP
rs1445242183 2048 dbSNP
rs910955937 2049 dbSNP
rs1446003025 2069 dbSNP
rs1313526317 2078 dbSNP
rs867012977 2080 dbSNP
rs760871676 2082 dbSNP
rs536141521 2084 dbSNP
rs980707166 2090 dbSNP
rs963644825 2093 dbSNP
rs1456095586 2095 dbSNP
rs1410814408 2119 dbSNP
rs955530817 2122 dbSNP
rs1320535895 2128 dbSNP
rs1383607142 2141 dbSNP
rs1454650515 2149 dbSNP
rs1419264615 2153 dbSNP
rs1310771803 2156 dbSNP
rs1166572550 2158 dbSNP
rs76755476 2161 dbSNP
rs773306540 2169 dbSNP
rs559837661 2176 dbSNP
rs961927993 2184 dbSNP
rs1348336270 2187 dbSNP
rs1208025584 2192 dbSNP
rs772339193 2197 dbSNP
rs1025318886 2203 dbSNP
rs1005543611 2205 dbSNP
rs1255002457 2207 dbSNP
rs1419274481 2210 dbSNP
rs1183602269 2215 dbSNP
rs1471851527 2221 dbSNP
rs959457004 2227 dbSNP
rs188360575 2228 dbSNP
rs1018091537 2237 dbSNP
rs1301199641 2239 dbSNP
rs1485078423 2245 dbSNP
rs1255237241 2246 dbSNP
rs1331206695 2260 dbSNP
rs533521966 2268 dbSNP
rs1348322955 2272 dbSNP
rs747835489 2280 dbSNP
rs184410432 2283 dbSNP
rs1438384189 2289 dbSNP
rs781177817 2291 dbSNP
rs904435635 2299 dbSNP
rs1043398750 2303 dbSNP
rs551452439 2306 dbSNP
rs1010191388 2313 dbSNP
rs781711795 2315 dbSNP
rs1054075835 2321 dbSNP
rs1197174350 2346 dbSNP
rs1247980440 2347 dbSNP
rs935647610 2351 dbSNP
rs891757774 2352 dbSNP
rs910975685 2354 dbSNP
rs1181931835 2368 dbSNP
rs1430558727 2383 dbSNP
rs1481687114 2398 dbSNP
rs1049436052 2401 dbSNP
rs1294158251 2413 dbSNP
rs1174634351 2428 dbSNP
rs933728808 2431 dbSNP
rs1232707062 2438 dbSNP
rs1462566450 2440 dbSNP
rs533075368 2443 dbSNP
rs373478534 2452 dbSNP
rs1300354904 2461 dbSNP
rs1057078520 2463 dbSNP
rs1303503914 2467 dbSNP
rs1354534720 2468 dbSNP
rs1347224381 2477 dbSNP
rs938738602 2482 dbSNP
rs973294783 2494 dbSNP
rs543151611 2500 dbSNP
rs1228988360 2511 dbSNP
rs1044657844 2515 dbSNP
rs749204383 2517 dbSNP
rs927406016 2517 dbSNP
rs574223974 2528 dbSNP
rs1270020601 2531 dbSNP
rs1490959498 2539 dbSNP
rs909392262 2544 dbSNP
rs984140168 2547 dbSNP
rs1165205027 2550 dbSNP
rs959320635 2553 dbSNP
rs1172665412 2559 dbSNP
rs1474562988 2568 dbSNP
rs1388446344 2569 dbSNP
rs34188987 2573 dbSNP
rs1429328161 2585 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124A_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + A ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaagaccgagguuCA-GGUca 5'
                       || |||  
Target 5' -----cagagcguGUGCCAa- 3'
 		1 - 15
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_124A_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + A
Location of target site ENST00000322313.4 | 3UTR | CAGAGCGUGUGCCAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
27 hsa-miR-378f Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT463100 ZNF609 zinc finger protein 609 2 2
MIRT469371 REST RE1 silencing transcription factor 2 6
MIRT495441 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 2
MIRT513606 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT520414 TXNL1 thioredoxin like 1 2 4
MIRT525111 PRKD2 protein kinase D2 2 2
MIRT525979 SPA17 sperm autoantigenic protein 17 2 2
MIRT527002 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT529215 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT529835 ARGFX arginine-fifty homeobox 2 2
MIRT532300 HAUS3 HAUS augmin like complex subunit 3 2 2
MIRT537577 ESYT2 extended synaptotagmin 2 2 2
MIRT543140 AKT1 AKT serine/threonine kinase 1 2 2
MIRT554924 RAP1B RAP1B, member of RAS oncogene family 2 2
MIRT564970 WTAP WT1 associated protein 2 2
MIRT570115 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT652734 TGFB2 transforming growth factor beta 2 2 2
MIRT655948 NDST1 N-deacetylase and N-sulfotransferase 1 2 2
MIRT655997 MYRF myelin regulatory factor 2 2
MIRT684875 P4HB prolyl 4-hydroxylase subunit beta 2 2
MIRT692969 LGSN lengsin, lens protein with glutamine synthetase domain 2 2
MIRT693737 ACACA acetyl-CoA carboxylase alpha 2 2
MIRT710991 PPARGC1B PPARG coactivator 1 beta 2 2
MIRT712247 RCC2 regulator of chromosome condensation 2 2 2
MIRT718602 DCTPP1 dCTP pyrophosphatase 1 2 2
MIRT723499 WDR33 WD repeat domain 33 2 2
MIRT725448 HIPK3 homeodomain interacting protein kinase 3 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378f Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378f Doxorubicin 31703 NSC123127 approved sensitive High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-miR-378f Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (SW480, HCT-116)
hsa-miR-378f Erlotinib 176870 NSC718781 approved resistant High Head And Neck Squamous Cell Carcinoma cell line (HN6)
hsa-mir-378f Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-miR-378f Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-378f Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-378f Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)

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