pre-miRNA Information
pre-miRNA hsa-mir-6751   
Genomic Coordinates chr11: 65129916 - 65129978
Description Homo sapiens miR-6751 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6751-3p
Sequence 43| ACUGAGCCUCUCUCUCUCCAG |63
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM6795708 8 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs749989972 2 dbSNP
rs1266150108 3 dbSNP
rs1488089412 6 dbSNP
rs1259846893 8 dbSNP
rs3802937 10 dbSNP
rs371083440 12 dbSNP
rs1264909843 13 dbSNP
rs751042478 14 dbSNP
rs757551063 19 dbSNP
Putative Targets

Gene Information
Gene Symbol VKORC1   
Synonyms EDTP308, MST134, MST576, VKCFD2, VKOR
Description vitamin K epoxide reductase complex subunit 1
Transcript NM_206824   
Other Transcripts NM_024006   
Expression
Putative miRNA Targets on VKORC1
3'UTR of VKORC1
(miRNA target sites are highlighted)
>VKORC1|NM_206824|3'UTR
   1 TTTCTGCATTGTTTGTATCACCACCTATGCTATCAACGTGAGCCTGATGTGGCTCAGTTTCCGGAAGGTCCAAGAACCCC
  81 AGGGCAAGGCTAAGAGGCACTGAGCCCTCAACCCAAGCCAGGCTGACCTCATCTGCTTTGCTTTGGCATGTGAGCCTTGC
 161 CTAAGGGGGCATATCTGGGTCCCTAGAAGGCCCTAGATGTGGGGCTTCTAGATTACCCCCTCCTCCTGCCATACCCGCAC
 241 ATGACAATGGACCAAATGTGCCACACGCTCGCTCTTTTTTACACCCAGTGCCTCTGACTCTGTCCCCATGGGCTGGTCTC
 321 CAAAGCTCTTTCCATTGCCCAGGGAGGGAAGGTTCTGAGCAATAAAGTTTCTTAGATCAATCAGCCAAGTCTGAAAAAAA
 401 AAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gacCUCUCUCU-CUCCGAGUCa 5'
             |||   || | ||||||| 
Target 5' cgtGAGCCTGATGTGGCTCAGt 3'
37 - 58 150.00 -16.30
2
miRNA  3' gaccucUCUCUCUCCGAGUCa 5'
                ||:|  ||||| || 
Target 5' aaccccAGGGCAAGGCTAAGa 3'
75 - 95 123.00 -10.50
3
miRNA  3' gaccUCUCUCUC-UCCGAGUCa 5'
              ||:|||:| |||:|| | 
Target 5' gcccAGGGAGGGAAGGTTCTGa 3'
337 - 358 121.00 -18.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
887423 58 ClinVar
887422 113 ClinVar
226016 237 ClinVar
318974 248 ClinVar
887421 275 ClinVar
887420 346 ClinVar
318973 348 ClinVar
COSM8956884 9 COSMIC
COSM417034 17 COSMIC
COSM9217108 29 COSMIC
COSM9137890 34 COSMIC
COSM8005108 36 COSMIC
COSM7307346 37 COSMIC
COSM6820005 51 COSMIC
COSM3948495 57 COSMIC
COSM4548780 67 COSMIC
COSM970110 78 COSMIC
COSM8133075 79 COSMIC
COSM9305429 83 COSMIC
COSM7719109 94 COSMIC
COSN31614013 105 COSMIC
COSN31510373 124 COSMIC
COSN31524946 166 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs183024280 1 dbSNP
rs568434676 8 dbSNP
rs1321666296 14 dbSNP
rs781537497 17 dbSNP
rs1396849650 19 dbSNP
rs755295304 24 dbSNP
rs1405753384 34 dbSNP
rs752029430 37 dbSNP
rs372656557 38 dbSNP
rs966141166 41 dbSNP
rs763337263 44 dbSNP
rs1349022789 47 dbSNP
rs867663922 55 dbSNP
rs753446794 62 dbSNP
rs199952041 63 dbSNP
rs760409299 67 dbSNP
rs1477345743 68 dbSNP
rs367785325 70 dbSNP
rs775243992 84 dbSNP
rs1028233658 90 dbSNP
rs1200663194 106 dbSNP
rs767445995 107 dbSNP
rs759428357 111 dbSNP
rs1346449851 114 dbSNP
rs1203390842 117 dbSNP
rs1437837167 118 dbSNP
rs370671043 121 dbSNP
rs191619949 125 dbSNP
rs1322794454 127 dbSNP
rs1283645712 131 dbSNP
rs749165172 132 dbSNP
rs773290721 133 dbSNP
rs1296611440 141 dbSNP
rs1441760582 142 dbSNP
rs769795248 143 dbSNP
rs1331004116 150 dbSNP
rs1468679206 152 dbSNP
rs748397246 154 dbSNP
rs545947564 155 dbSNP
rs1003983905 158 dbSNP
rs886825177 166 dbSNP
rs952105156 172 dbSNP
rs1167404741 190 dbSNP
rs1027575163 193 dbSNP
rs1411875495 199 dbSNP
rs1332601665 201 dbSNP
rs1345231202 204 dbSNP
rs1045843 208 dbSNP
rs1385618444 211 dbSNP
rs1303595586 213 dbSNP
rs941300305 215 dbSNP
rs993797148 220 dbSNP
rs1363677114 222 dbSNP
rs80172895 224 dbSNP
rs1048544787 231 dbSNP
rs11540137 234 dbSNP
rs139827974 236 dbSNP
rs7294 237 dbSNP
rs1490108322 241 dbSNP
rs1189402957 243 dbSNP
rs1431646806 245 dbSNP
rs886051933 248 dbSNP
rs527913468 252 dbSNP
rs1420328896 259 dbSNP
rs1034842844 264 dbSNP
rs1003310348 266 dbSNP
rs186322246 267 dbSNP
rs150560447 270 dbSNP
rs1010575442 271 dbSNP
rs1169414435 276 dbSNP
rs928818958 277 dbSNP
rs1456654211 281 dbSNP
rs1200655854 282 dbSNP
rs1295652099 284 dbSNP
rs1490298098 285 dbSNP
rs556631171 287 dbSNP
rs893439717 292 dbSNP
rs1207938400 296 dbSNP
rs1230175715 304 dbSNP
rs767194687 310 dbSNP
rs777842389 312 dbSNP
rs967867586 321 dbSNP
rs914627310 339 dbSNP
rs1219179297 341 dbSNP
rs141753512 346 dbSNP
rs886051932 348 dbSNP
rs1046030 355 dbSNP
rs1207991015 357 dbSNP
rs1028687422 373 dbSNP
rs924839688 378 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124A_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + A ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaccucucuCU-CUCCGAGUCa 5'
                   || | ||||||| 
Target 5' --------uGAUGUGGCUCAGu 3'
1 - 14
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_124A_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + A
Location of target site ENST00000300851.6 | 3UTR | ugauguggcucaguu
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
77 hsa-miR-6751-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT130738 GATAD2B GATA zinc finger domain containing 2B 2 4
MIRT134924 CCND2 cyclin D2 2 2
MIRT273034 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT276645 KPNA3 karyopherin subunit alpha 3 2 6
MIRT446531 OAS2 2'-5'-oligoadenylate synthetase 2 2 2
MIRT456268 TDRKH tudor and KH domain containing 2 12
MIRT494454 BTG2 BTG anti-proliferation factor 2 2 2
MIRT494965 USP46 ubiquitin specific peptidase 46 2 2
MIRT496689 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT496697 RGS11 regulator of G protein signaling 11 2 2
MIRT504376 IRF4 interferon regulatory factor 4 2 6
MIRT510980 PFN2 profilin 2 2 6
MIRT512548 MFN2 mitofusin 2 2 6
MIRT513639 TP53INP2 tumor protein p53 inducible nuclear protein 2 2 2
MIRT514016 CAMSAP1 calmodulin regulated spectrin associated protein 1 2 4
MIRT514074 MTRNR2L6 MT-RNR2-like 6 2 2
MIRT515300 C15orf38-AP3S2 C15orf38-AP3S2 readthrough 2 4
MIRT517285 AP3S2 adaptor related protein complex 3 sigma 2 subunit 2 4
MIRT519075 KCNK6 potassium two pore domain channel subfamily K member 6 2 2
MIRT520779 TCF23 transcription factor 23 2 2
MIRT522485 MFSD9 major facilitator superfamily domain containing 9 2 2
MIRT528856 PKP1 plakophilin 1 2 2
MIRT529081 PATE2 prostate and testis expressed 2 2 2
MIRT531209 PLA2G4D phospholipase A2 group IVD 2 2
MIRT533988 TAB3 TGF-beta activated kinase 1 and MAP3K7 binding protein 3 2 2
MIRT537024 GRIN2B glutamate ionotropic receptor NMDA type subunit 2B 2 2
MIRT537498 FAM168B family with sequence similarity 168 member B 2 2
MIRT553125 UBE2Z ubiquitin conjugating enzyme E2 Z 2 2
MIRT555591 PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma 2 2
MIRT556370 LUZP1 leucine zipper protein 1 2 2
MIRT569745 C2orf71 chromosome 2 open reading frame 71 2 2
MIRT570149 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT571243 FADS6 fatty acid desaturase 6 2 2
MIRT573065 TRIB1 tribbles pseudokinase 1 2 2
MIRT575533 Map4 microtubule-associated protein 4 2 2
MIRT575777 Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b 2 2
MIRT616558 ZNF512B zinc finger protein 512B 2 2
MIRT624851 ABI2 abl interactor 2 2 2
MIRT630078 GRWD1 glutamate rich WD repeat containing 1 2 2
MIRT631479 KLHL21 kelch like family member 21 2 2
MIRT632173 CCL22 C-C motif chemokine ligand 22 2 2
MIRT638397 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT641192 ISG20L2 interferon stimulated exonuclease gene 20 like 2 2 2
MIRT642562 TEX9 testis expressed 9 2 2
MIRT642935 KRTAP5-9 keratin associated protein 5-9 2 2
MIRT649703 ZNF175 zinc finger protein 175 2 2
MIRT650437 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT652113 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT652273 TOMM20 translocase of outer mitochondrial membrane 20 2 2
MIRT655215 PFKM phosphofructokinase, muscle 2 2
MIRT682778 ZNF852 zinc finger protein 852 2 2
MIRT683001 MUC20 mucin 20, cell surface associated 2 2
MIRT684320 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT689435 CYB561 cytochrome b561 2 2
MIRT693847 ZNF107 zinc finger protein 107 2 2
MIRT696715 TAX1BP3 Tax1 binding protein 3 2 2
MIRT698597 TEX261 testis expressed 261 2 2
MIRT699973 RREB1 ras responsive element binding protein 1 2 2
MIRT703310 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT706796 RAI1 retinoic acid induced 1 2 2
MIRT709004 CD109 CD109 molecule 2 2
MIRT709181 TBC1D10B TBC1 domain family member 10B 2 2
MIRT709835 PAQR7 progestin and adipoQ receptor family member 7 2 2
MIRT711627 CORO1C coronin 1C 2 2
MIRT712634 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 2
MIRT713694 CYB5R4 cytochrome b5 reductase 4 2 2
MIRT713752 SLC9A8 solute carrier family 9 member A8 2 2
MIRT714908 CHMP3 charged multivesicular body protein 3 2 2
MIRT716371 CBLL1 Cbl proto-oncogene like 1 2 2
MIRT718303 XPOT exportin for tRNA 2 2
MIRT718713 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT718740 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT719441 NPTX2 neuronal pentraxin 2 2 2
MIRT720896 OTUD4 OTU deubiquitinase 4 2 2
MIRT722448 RXFP4 relaxin/insulin like family peptide receptor 4 2 2
MIRT723882 VKORC1 vitamin K epoxide reductase complex subunit 1 2 2
MIRT724586 SYNJ2BP synaptojanin 2 binding protein 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6751 Cisplatin 5460033 NSC119875 approved sensitive Low Ovarian Cancer cell line (A2780)
hsa-mir-6751 Triptolide 107985 NSC163062 sensitive Low Ovarian Cancer cell line (A2780)

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