pre-miRNA Information
pre-miRNA hsa-mir-6819   
Genomic Coordinates chr22: 36286847 - 36286907
Description Homo sapiens miR-6819 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6819-3p
Sequence 41| AAGCCUCUGUCCCCACCCCAG |61
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1279530967 2 dbSNP
rs967579979 3 dbSNP
rs776891214 4 dbSNP
rs771166635 8 dbSNP
rs747037324 9 dbSNP
rs879248090 11 dbSNP
rs1485325191 12 dbSNP
rs778157316 16 dbSNP
Putative Targets

Gene Information
Gene Symbol PSG4   
Synonyms PSBG-4, PSBG-9, PSG9
Description pregnancy specific beta-1-glycoprotein 4
Transcript NM_002780   
Other Transcripts NM_213633   
Expression
Putative miRNA Targets on PSG4
3'UTR of PSG4
(miRNA target sites are highlighted)
>PSG4|NM_002780|3'UTR
   1 ATTCTACTAGTTCCTCCAATTCCATTTTCTCCCATGGAATCACGAAGAGCAAGACCCACTCTGTTCCAGAAGCCCTATAA
  81 GCTGGAGGTGGACAACTCGATGTAAATTTCATGGGAAAACCCTTGTACCTGACATGTGAGCCACTCAGAACTCACCAAAA
 161 TGTTCGACACCATAACAACAGCTACTCAAACTGTAAACCAGGATAACAAGTTGATGACTTCACACTGTGGACAGTTTTTC
 241 CAAAGATGTCAGAACAAGACTCCCCATCATGATAAGGCTCCCACCCCTCTTAACCGTCCTTGCTCATGCCTGCCTCTTTC
 321 ACTTGGCAGGATAATGCAGTCATTAGAATTTCACATGTAGTAGCTTCTGAGGGTAACAACAGAGTGTCAGATATGTCATC
 401 TCAACCTCAAACTTTTACGTAACATCTCAGGGGAAATGTGGCTCTCTCCATCTTGCATACAGGGCTCCCAATAGAAATGA
 481 ACACAGAGATATTGCCTGTGTGTTTGCAGAGAAGATGGTTTCTATAAAGAGTAGGAAAGCTGAAATTATAGTAGAGTCTC
 561 CTTTAAATGCACATTGTGTGGATGGCTCTCACCATTTCCTAAGAGATACAGTGTAAAACGTGACAGTAATACTGATTCTA
 641 GCAGAATAAAACATGTACCACATTTGCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaccccaccccUGUCUCCGAa 5'
                     ::|||| || 
Target 5' ctgaaattataGTAGAGTCTc 3'
540 - 560 110.00 -5.17
2
miRNA  3' gaccccaccccugucUCCGAa 5'
                         ||||| 
Target 5' ctccccatcatgataAGGCTc 3'
260 - 280 100.00 -7.10
3
miRNA  3' gaccccACCCCUGUCUCCGAa 5'
                ||   |||| |||| 
Target 5' ccatctTGCATACAG-GGCTc 3'
448 - 467 99.00 -8.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN18430107 8 COSMIC
COSN30449686 13 COSMIC
COSN31585380 29 COSMIC
COSN30457346 33 COSMIC
COSN30479354 41 COSMIC
COSN31932903 42 COSMIC
COSN31593646 43 COSMIC
COSN19704524 44 COSMIC
COSN26669004 44 COSMIC
COSN30180495 57 COSMIC
COSN31490230 61 COSMIC
COSN30451579 66 COSMIC
COSN31494277 69 COSMIC
COSN31497647 69 COSMIC
COSN30165553 74 COSMIC
COSN30486182 75 COSMIC
COSN18143936 83 COSMIC
COSN30449246 85 COSMIC
COSN30461462 90 COSMIC
COSN31499308 90 COSMIC
COSN31568367 98 COSMIC
COSN26559355 99 COSMIC
COSN31582716 105 COSMIC
COSN30503925 107 COSMIC
COSN31558481 108 COSMIC
COSN13811577 110 COSMIC
COSN30158957 110 COSMIC
COSN30518691 115 COSMIC
COSN30497698 138 COSMIC
COSN13811576 146 COSMIC
COSN17182082 146 COSMIC
COSN31509437 149 COSMIC
COSN13811573 165 COSMIC
COSN21309132 166 COSMIC
COSN30479014 171 COSMIC
COSN30176387 183 COSMIC
COSN31550446 201 COSMIC
COSN30462535 202 COSMIC
COSN31573785 204 COSMIC
COSN28750108 223 COSMIC
COSN31560158 238 COSMIC
COSN13811570 245 COSMIC
COSN31485459 285 COSMIC
COSN20794309 429 COSMIC
COSN26390986 429 COSMIC
COSN15662100 471 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1396935953 4 dbSNP
rs1435943362 5 dbSNP
rs771769400 6 dbSNP
rs577715054 7 dbSNP
rs1463769745 11 dbSNP
rs745387128 12 dbSNP
rs773929489 13 dbSNP
rs770929074 17 dbSNP
rs1388260735 23 dbSNP
rs1334831525 24 dbSNP
rs777667689 25 dbSNP
rs1011152349 26 dbSNP
rs769444492 28 dbSNP
rs747297293 29 dbSNP
rs780240016 31 dbSNP
rs1274862816 35 dbSNP
rs1371072994 36 dbSNP
rs1274603963 37 dbSNP
rs1254179684 41 dbSNP
rs200689727 42 dbSNP
rs375091217 43 dbSNP
rs142156065 44 dbSNP
rs764590142 47 dbSNP
rs1176982684 49 dbSNP
rs1331012122 50 dbSNP
rs933617576 56 dbSNP
rs1376450561 58 dbSNP
rs1313243441 59 dbSNP
rs753810523 62 dbSNP
rs900862095 66 dbSNP
rs1399993388 72 dbSNP
rs1376621808 73 dbSNP
rs200149659 77 dbSNP
rs537610679 81 dbSNP
rs1400790619 83 dbSNP
rs1360031504 87 dbSNP
rs1394680370 88 dbSNP
rs188794397 99 dbSNP
rs939796224 100 dbSNP
rs183902375 101 dbSNP
rs1328160813 103 dbSNP
rs1228029565 105 dbSNP
rs1269430616 111 dbSNP
rs1315825708 112 dbSNP
rs1197062600 113 dbSNP
rs1275292550 114 dbSNP
rs1481824097 120 dbSNP
rs909705946 121 dbSNP
rs148673819 122 dbSNP
rs1265315403 123 dbSNP
rs566496995 125 dbSNP
rs1449279486 128 dbSNP
rs984393695 129 dbSNP
rs1350973895 131 dbSNP
rs1164612017 133 dbSNP
rs546254579 133 dbSNP
rs539587816 134 dbSNP
rs570550793 135 dbSNP
rs1426167047 136 dbSNP
rs1457062363 141 dbSNP
rs1291327824 145 dbSNP
rs1195440421 151 dbSNP
rs1477930565 157 dbSNP
rs191651542 165 dbSNP
rs867176824 166 dbSNP
rs1489136248 168 dbSNP
rs370015002 169 dbSNP
rs531892096 181 dbSNP
rs563058708 182 dbSNP
rs549687402 184 dbSNP
rs529542133 186 dbSNP
rs1259721528 188 dbSNP
rs966820489 191 dbSNP
rs1263815526 198 dbSNP
rs1486886540 199 dbSNP
rs560583568 204 dbSNP
rs1263118452 206 dbSNP
rs1136228 207 dbSNP
rs1276460498 211 dbSNP
rs1388599261 212 dbSNP
rs1422931118 215 dbSNP
rs1162244286 218 dbSNP
rs185984154 227 dbSNP
rs1453862475 229 dbSNP
rs549353981 232 dbSNP
rs564196017 242 dbSNP
rs1804229 245 dbSNP
rs1313308327 259 dbSNP
rs544024762 262 dbSNP
rs998413019 264 dbSNP
rs575362866 265 dbSNP
rs1240993118 267 dbSNP
rs1285348697 270 dbSNP
rs1465876205 270 dbSNP
rs900827901 274 dbSNP
rs1190501168 277 dbSNP
rs1036683821 278 dbSNP
rs1434417903 286 dbSNP
rs1252251727 287 dbSNP
rs1419255691 289 dbSNP
rs1267384627 294 dbSNP
rs8603 295 dbSNP
rs1174179294 296 dbSNP
rs1358437676 296 dbSNP
rs939765110 298 dbSNP
rs888231950 299 dbSNP
rs1048142849 303 dbSNP
rs1374746816 308 dbSNP
rs182782009 310 dbSNP
rs1199036126 313 dbSNP
rs1317004142 314 dbSNP
rs1208498981 319 dbSNP
rs915757630 320 dbSNP
rs993128948 323 dbSNP
rs938611164 329 dbSNP
rs1455193781 331 dbSNP
rs190186813 335 dbSNP
rs978128523 349 dbSNP
rs553044366 354 dbSNP
rs1431329389 364 dbSNP
rs1172320160 367 dbSNP
rs1300641574 372 dbSNP
rs1385650004 373 dbSNP
rs539397261 374 dbSNP
rs369238307 377 dbSNP
rs570563276 379 dbSNP
rs1022767656 390 dbSNP
rs557062952 397 dbSNP
rs1332550826 398 dbSNP
rs1217950516 401 dbSNP
rs1298258304 402 dbSNP
rs989593514 403 dbSNP
rs1255771542 409 dbSNP
rs1398492328 411 dbSNP
rs1221699275 413 dbSNP
rs751803861 418 dbSNP
rs537130380 419 dbSNP
rs1420050333 422 dbSNP
rs1377743688 423 dbSNP
rs1174734628 424 dbSNP
rs144106909 426 dbSNP
rs1324333576 427 dbSNP
rs1452580149 428 dbSNP
rs201480136 429 dbSNP
rs1349354393 430 dbSNP
rs1382104046 432 dbSNP
rs1179115860 434 dbSNP
rs1291144662 437 dbSNP
rs1341613650 438 dbSNP
rs879545129 442 dbSNP
rs1457173185 449 dbSNP
rs1248102762 450 dbSNP
rs185468639 451 dbSNP
rs1483693248 456 dbSNP
rs180863535 457 dbSNP
rs1217228916 458 dbSNP
rs189269017 460 dbSNP
rs1355871094 463 dbSNP
rs1191280183 467 dbSNP
rs200538538 471 dbSNP
rs1473928462 477 dbSNP
rs901465692 478 dbSNP
rs1413256716 481 dbSNP
rs187213116 482 dbSNP
rs1003793143 486 dbSNP
rs1336528952 497 dbSNP
rs888125836 499 dbSNP
rs867399992 506 dbSNP
rs1048588609 517 dbSNP
rs1012684632 518 dbSNP
rs1283241345 523 dbSNP
rs1162918608 524 dbSNP
rs1376448603 525 dbSNP
rs1286063926 535 dbSNP
rs1352951882 536 dbSNP
rs894288320 539 dbSNP
rs1301833487 542 dbSNP
rs12426 549 dbSNP
rs1057024323 550 dbSNP
rs1186502917 551 dbSNP
rs1159213563 552 dbSNP
rs938580117 554 dbSNP
rs924486699 556 dbSNP
rs1438975030 557 dbSNP
rs1041664960 558 dbSNP
rs1189355474 559 dbSNP
rs1424108457 566 dbSNP
rs945331450 569 dbSNP
rs1208938331 574 dbSNP
rs915265071 576 dbSNP
rs1286782710 578 dbSNP
rs989954561 580 dbSNP
rs1338371583 585 dbSNP
rs1443889840 588 dbSNP
rs1349140958 591 dbSNP
rs954182743 593 dbSNP
rs1376074958 594 dbSNP
rs1237957564 597 dbSNP
rs1286397631 598 dbSNP
rs1345174794 602 dbSNP
rs533127987 609 dbSNP
rs182239191 611 dbSNP
rs1441002182 618 dbSNP
rs965519941 619 dbSNP
rs190069950 620 dbSNP
rs184253521 623 dbSNP
rs561963177 624 dbSNP
rs541649161 630 dbSNP
rs1478418787 635 dbSNP
rs952456537 639 dbSNP
rs1026674223 640 dbSNP
rs1013074096 642 dbSNP
rs894266566 646 dbSNP
rs1056906448 650 dbSNP
rs1331143771 652 dbSNP
rs573099796 653 dbSNP
rs553255189 667 dbSNP
rs1458240326 669 dbSNP
rs1341043152 671 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124A_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + A ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaccccaccccUGUCUCCgaa 5'
                     | |||||   
Target 5' --------uucAGAGAGGgac 3'
1 - 13
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_124A_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + A
Location of target site ENST00000244293.7 | 3UTR | UUCAGAGAGGGACAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-6819-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT358318 PANK3 pantothenate kinase 3 2 2
MIRT454719 UBQLNL ubiquilin like 2 2
MIRT471362 PEG10 paternally expressed 10 2 2
MIRT478101 DLG5 discs large MAGUK scaffold protein 5 2 4
MIRT495554 GOLGA6L4 golgin A6 family-like 4 2 2
MIRT495587 GOLGA6L10 golgin A6 family-like 10 2 2
MIRT508315 RPL18 ribosomal protein L18 2 4
MIRT529183 ADAM33 ADAM metallopeptidase domain 33 2 2
MIRT532035 FHDC1 FH2 domain containing 1 2 2
MIRT545131 ANXA5 annexin A5 2 2
MIRT567288 HNRNPL heterogeneous nuclear ribonucleoprotein L 2 2
MIRT568094 CEBPG CCAAT/enhancer binding protein gamma 2 2
MIRT573291 DLX4 distal-less homeobox 4 2 2
MIRT575169 Fam120c family with sequence similarity 120, member C 2 2
MIRT609495 DNASE1L3 deoxyribonuclease 1 like 3 2 2
MIRT611264 EHD3 EH domain containing 3 2 2
MIRT613580 POC5 POC5 centriolar protein 2 2
MIRT616520 C9orf170 chromosome 9 open reading frame 170 2 2
MIRT617098 ZNF667 zinc finger protein 667 2 2
MIRT618268 DDX51 DEAD-box helicase 51 2 2
MIRT618294 ZNF682 zinc finger protein 682 2 2
MIRT618617 SHOX short stature homeobox 2 2
MIRT619741 SRFBP1 serum response factor binding protein 1 2 2
MIRT619784 NRIP2 nuclear receptor interacting protein 2 2 2
MIRT621119 SP110 SP110 nuclear body protein 2 2
MIRT622530 RAD51 RAD51 recombinase 2 2
MIRT623088 NME6 NME/NM23 nucleoside diphosphate kinase 6 2 2
MIRT623938 FKBP14 FK506 binding protein 14 2 2
MIRT624389 CD84 CD84 molecule 2 2
MIRT624860 ABI2 abl interactor 2 2 2
MIRT628752 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT632243 VTA1 vesicle trafficking 1 2 2
MIRT632987 E2F2 E2F transcription factor 2 2 2
MIRT633695 RBM43 RNA binding motif protein 43 2 2
MIRT633766 CENPBD1 CENPB DNA-binding domain containing 1 2 2
MIRT633808 ZNF91 zinc finger protein 91 2 2
MIRT638914 CBLN2 cerebellin 2 precursor 2 2
MIRT641298 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT642123 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT642179 HEBP2 heme binding protein 2 2 2
MIRT642617 CDKN3 cyclin dependent kinase inhibitor 3 2 2
MIRT643325 TMEM151B transmembrane protein 151B 2 2
MIRT644534 TMEM134 transmembrane protein 134 2 2
MIRT645820 OMA1 OMA1 zinc metallopeptidase 2 2
MIRT646093 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646861 SLC35E4 solute carrier family 35 member E4 2 2
MIRT647466 DZIP1L DAZ interacting zinc finger protein 1 like 2 2
MIRT647702 NADSYN1 NAD synthetase 1 2 2
MIRT648082 ZMIZ2 zinc finger MIZ-type containing 2 2 2
MIRT648547 TMEM169 transmembrane protein 169 2 2
MIRT648690 AP1M1 adaptor related protein complex 1 mu 1 subunit 2 2
MIRT649747 GNB5 G protein subunit beta 5 2 2
MIRT650154 ZNF426 zinc finger protein 426 2 2
MIRT650450 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT650943 CTNS cystinosin, lysosomal cystine transporter 2 2
MIRT651544 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT652304 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT652890 SYVN1 synoviolin 1 2 2
MIRT654222 RNF19B ring finger protein 19B 2 2
MIRT654676 PSMB5 proteasome subunit beta 5 2 2
MIRT658249 FAXC failed axon connections homolog 2 2
MIRT658363 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT659622 CELF1 CUGBP Elav-like family member 1 2 2
MIRT660171 BNIP3L BCL2 interacting protein 3 like 2 2
MIRT660634 ANKRD52 ankyrin repeat domain 52 2 2
MIRT662428 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT662984 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT663939 ZNF554 zinc finger protein 554 2 2
MIRT666960 PKHD1 PKHD1, fibrocystin/polyductin 2 2
MIRT667945 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT668847 CYCS cytochrome c, somatic 2 2
MIRT671792 RGS17 regulator of G protein signaling 17 2 2
MIRT672382 RPL37 ribosomal protein L37 2 2
MIRT673516 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 4
MIRT674716 FAM73A mitoguardin 1 2 2
MIRT676352 KLF8 Kruppel like factor 8 2 2
MIRT677820 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT678440 PDE4C phosphodiesterase 4C 2 2
MIRT678499 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT679243 LRP10 LDL receptor related protein 10 2 2
MIRT693607 SLC39A1 solute carrier family 39 member 1 2 2
MIRT695927 ZNF174 zinc finger protein 174 2 2
MIRT697987 TSPAN6 tetraspanin 6 2 2
MIRT700821 PHLDA2 pleckstrin homology like domain family A member 2 2 2
MIRT701350 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT702348 KLHL7 kelch like family member 7 2 2
MIRT703387 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT703883 ERBB2IP erbb2 interacting protein 2 2
MIRT708237 PPP1R26 protein phosphatase 1 regulatory subunit 26 2 2
MIRT708629 NUDT18 nudix hydrolase 18 2 2
MIRT708990 CABP4 calcium binding protein 4 2 2
MIRT709804 FOXE1 forkhead box E1 2 2
MIRT710203 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT710248 VAMP1 vesicle associated membrane protein 1 2 2
MIRT710281 FGF1 fibroblast growth factor 1 2 2
MIRT712992 IRGQ immunity related GTPase Q 2 2
MIRT713887 MOB3A MOB kinase activator 3A 2 2
MIRT715600 ADAM17 ADAM metallopeptidase domain 17 2 2
MIRT715639 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715686 FRK fyn related Src family tyrosine kinase 2 2
MIRT717053 WIZ widely interspaced zinc finger motifs 2 2
MIRT717611 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT721539 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT722096 SUSD1 sushi domain containing 1 2 2
MIRT722435 HRNR hornerin 2 2
MIRT722855 NEGR1 neuronal growth regulator 1 2 2
MIRT724621 SNAP25 synaptosome associated protein 25 2 2
MIRT724777 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6819 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6819-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6819-3p Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-6819-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-6819-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-6819-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6819-3p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-6819-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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