pre-miRNA Information
pre-miRNA hsa-mir-216a   
Genomic Coordinates chr2: 55988950 - 55989059
Description Homo sapiens miR-216a stem-loop
Comment This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-216a-5p
Sequence 19| UAAUCUCAGCUGGCAACUGUGA |40
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 15 2 - 55989027 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757094946 2 dbSNP
rs746980700 8 dbSNP
rs1249388997 12 dbSNP
rs1188616124 15 dbSNP
rs1490501989 19 dbSNP
rs1465789697 20 dbSNP
rs370221981 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Tissue .
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma MiRNA qPCR analyses
Gene Information
Gene Symbol SDAD1   
Synonyms -
Description SDA1 domain containing 1
Transcript NM_018115   
Expression
Putative miRNA Targets on SDAD1
3'UTR of SDAD1
(miRNA target sites are highlighted)
>SDAD1|NM_018115|3'UTR
   1 CTTCCTGGCAAGTTTTCCATTCCTAGAAGAATGCTAAGTTTGTGTCCTTGCTCTGAAAATTGGTAAATCAAGCATGTTTG
  81 TTTACATTAAAAAGTCCAGACACACTGTATTGTGAAAACTGCTGAACATGTGGCAGCAATTTTGTGTTTTTATTTTGGAG
 161 ACGGCTAATGGTAGGAATGTTAATGTAAATAGTGGTGGTAATGTAAAATCATTTCATTTATCATTCATGCAAAAAAAAGT
 241 ATGTATTGAGTGCCTATTCATTGTCACTGTAGATGCAAAACGAATGAGCTGTAACCCCTTCACTCAAGGCATTGACAGCT
 321 TAGCTGTGAGGGTGGACACACATATGTGTATTTACAGTGCAGTGTAAATAGTTCTGTAGTAGAGGTTAACTCCATATTTC
 401 TGTGAGGTCACTGAGGCCTTATGGACTAACTCTGTGAGGATAGGAGTTATATATTCTTATAAGACAAAACAAAACAGGAC
 481 AATGTTACAAGAGTAAGAGGTTCTTACTTGTACATAGGCTTTCCTGCTGAAAACAGGCCCCTGCTGTACAGATTTTGGGT
 561 ACATAATTTAGCTCTTTTAGTCAATCCAAGAGATTTAAGTGACCCCCCCCCCCCCGTGTTTTTTTTGTTTTTGTTTTTGT
 641 TTTGAATGCCATGTAAAGGCTTTTTGGTTAAGACCTCACTTTTAAAACTGCCTTAAGTATAAATAGTACCTTTGGAATAT
 721 ATTTAGTTCATCATTTGAGCTGCCTTCATACTGGTTTCCTCAGCCTTCCTTCAGCCTGTAATATTTTCAGCCCACTGTTT
 801 ACCTTGTCTCAATAAAAGGTTTCTAATGCCAAATACGTACCTTTAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agUGUCAACG-GUCGACUCUAAu 5'
            |:|||| : :||: |||:|| 
Target 5' aaATAGTTCTGTAGTAGAGGTTa 3'
366 - 388 120.00 -13.10
2
miRNA  3' agUGUCAACGGUCGAC---UCUAAu 5'
            ||||   || ||||   ||||| 
Target 5' aaACAGGCCCCTGCTGTACAGATTt 3'
531 - 555 120.00 -15.00
3
miRNA  3' agugucaacggucgaCUCUAAu 5'
                         |||||| 
Target 5' ttttagtcaatccaaGAGATTt 3'
575 - 596 120.00 -7.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM9084040 8 COSMIC
COSM8867387 9 COSMIC
COSN30457413 47 COSMIC
COSN30517504 53 COSMIC
COSN30493356 84 COSMIC
COSN30135391 100 COSMIC
COSN31559370 117 COSMIC
COSN31611464 127 COSMIC
COSN30492830 129 COSMIC
COSN31962290 141 COSMIC
COSN31611816 181 COSMIC
COSN30136128 199 COSMIC
COSN28017476 231 COSMIC
COSN30527262 244 COSMIC
COSN25176351 353 COSMIC
COSN24300528 481 COSMIC
COSN31608599 491 COSMIC
COSN31548634 566 COSMIC
COSN26465367 627 COSMIC
COSN31537482 634 COSMIC
COSN6581823 697 COSMIC
COSN26665188 741 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs372196702 4 dbSNP
rs758738214 9 dbSNP
rs534578726 19 dbSNP
rs755565714 22 dbSNP
rs754313844 35 dbSNP
rs766442852 36 dbSNP
rs756285326 38 dbSNP
rs567174662 46 dbSNP
rs767894050 47 dbSNP
rs1047653913 49 dbSNP
rs184602971 50 dbSNP
rs775416881 52 dbSNP
rs764958072 53 dbSNP
rs537130432 57 dbSNP
rs972403572 60 dbSNP
rs776461257 61 dbSNP
rs1447376569 64 dbSNP
rs770422154 65 dbSNP
rs369113207 69 dbSNP
rs1321660622 71 dbSNP
rs1370579064 76 dbSNP
rs1015169699 98 dbSNP
rs1186120189 105 dbSNP
rs1305837115 108 dbSNP
rs1339839966 134 dbSNP
rs1226333946 136 dbSNP
rs1039897548 162 dbSNP
rs144188302 163 dbSNP
rs914885100 187 dbSNP
rs1266019421 191 dbSNP
rs989118076 194 dbSNP
rs1202303520 196 dbSNP
rs1195138481 204 dbSNP
rs1245778596 211 dbSNP
rs887991277 217 dbSNP
rs956645826 224 dbSNP
rs181866177 226 dbSNP
rs533166461 227 dbSNP
rs970622694 231 dbSNP
rs907311732 238 dbSNP
rs1023481831 239 dbSNP
rs1393857509 239 dbSNP
rs990696817 241 dbSNP
rs1289939326 242 dbSNP
rs1412666929 244 dbSNP
rs750765863 245 dbSNP
rs1339565906 247 dbSNP
rs963310525 249 dbSNP
rs1296023484 251 dbSNP
rs1016919113 256 dbSNP
rs1334397315 256 dbSNP
rs565926457 259 dbSNP
rs1005581888 260 dbSNP
rs1046211934 281 dbSNP
rs1397275730 282 dbSNP
rs946067546 284 dbSNP
rs1382071334 288 dbSNP
rs547396759 291 dbSNP
rs373324313 296 dbSNP
rs1458195418 308 dbSNP
rs867493458 311 dbSNP
rs1414799669 314 dbSNP
rs1054425852 316 dbSNP
rs28760388 319 dbSNP
rs998684202 322 dbSNP
rs9993585 323 dbSNP
rs781560798 329 dbSNP
rs114909003 330 dbSNP
rs985325111 334 dbSNP
rs1039866196 340 dbSNP
rs1417685610 341 dbSNP
rs933805982 342 dbSNP
rs922401660 345 dbSNP
rs1472664285 346 dbSNP
rs1453285077 347 dbSNP
rs1289281989 348 dbSNP
rs369016050 350 dbSNP
rs894089736 362 dbSNP
rs1292606495 366 dbSNP
rs1189795234 371 dbSNP
rs1355953407 373 dbSNP
rs1445362480 374 dbSNP
rs1053845385 391 dbSNP
rs972455501 394 dbSNP
rs1316015038 398 dbSNP
rs1216088992 402 dbSNP
rs1262081336 413 dbSNP
rs1487055579 414 dbSNP
rs961077907 415 dbSNP
rs935051375 416 dbSNP
rs1016556247 417 dbSNP
rs1475818080 418 dbSNP
rs1190202078 421 dbSNP
rs1409823198 426 dbSNP
rs1418529303 429 dbSNP
rs532322132 434 dbSNP
rs1365690240 439 dbSNP
rs1329819923 441 dbSNP
rs1269919830 455 dbSNP
rs116439956 456 dbSNP
rs952341994 460 dbSNP
rs1376072960 463 dbSNP
rs1284440292 477 dbSNP
rs1034999218 479 dbSNP
rs1416516932 481 dbSNP
rs1306052682 482 dbSNP
rs1001732085 483 dbSNP
rs1223788522 484 dbSNP
rs1246475183 496 dbSNP
rs949120060 500 dbSNP
rs533820 503 dbSNP
rs1232642907 510 dbSNP
rs907360423 511 dbSNP
rs541113551 512 dbSNP
rs543450755 515 dbSNP
rs963280765 516 dbSNP
rs1480353372 518 dbSNP
rs1177799672 522 dbSNP
rs572395464 524 dbSNP
rs1452808984 535 dbSNP
rs891848220 537 dbSNP
rs1016226464 539 dbSNP
rs984518003 543 dbSNP
rs1054481342 546 dbSNP
rs1324460595 559 dbSNP
rs951378155 565 dbSNP
rs1442374892 570 dbSNP
rs1000170419 572 dbSNP
rs1414899442 574 dbSNP
rs1185013514 578 dbSNP
rs1165242214 583 dbSNP
rs1439678273 588 dbSNP
rs975166513 590 dbSNP
rs1303626460 592 dbSNP
rs998253355 595 dbSNP
rs1236867161 599 dbSNP
rs34784211 602 dbSNP
rs377027882 603 dbSNP
rs1467151659 604 dbSNP
rs747296509 604 dbSNP
rs1455430814 605 dbSNP
rs531686774 605 dbSNP
rs1410434643 606 dbSNP
rs1191461157 608 dbSNP
rs1466306615 610 dbSNP
rs1007041525 611 dbSNP
rs1372651114 611 dbSNP
rs1215686041 613 dbSNP
rs1361920951 613 dbSNP
rs1275668186 614 dbSNP
rs1219212985 615 dbSNP
rs1188242171 616 dbSNP
rs1274103173 616 dbSNP
rs140415777 616 dbSNP
rs1479042335 616 dbSNP
rs35619548 616 dbSNP
rs61039777 616 dbSNP
rs762417083 616 dbSNP
rs768279226 616 dbSNP
rs796762679 616 dbSNP
rs1450845357 617 dbSNP
rs894053580 621 dbSNP
rs1054081733 627 dbSNP
rs1345000898 627 dbSNP
rs777712136 627 dbSNP
rs1339698359 628 dbSNP
rs879091382 633 dbSNP
rs878915609 639 dbSNP
rs1293950619 643 dbSNP
rs1228582477 644 dbSNP
rs1337287414 644 dbSNP
rs369884689 650 dbSNP
rs889739344 652 dbSNP
rs751953625 653 dbSNP
rs1217616598 658 dbSNP
rs1255377403 659 dbSNP
rs694752 672 dbSNP
rs933879960 675 dbSNP
rs1188125589 677 dbSNP
rs1419368128 691 dbSNP
rs1436323867 698 dbSNP
rs922421038 702 dbSNP
rs1036784925 719 dbSNP
rs7154 720 dbSNP
rs1401704091 721 dbSNP
rs749249024 729 dbSNP
rs949090683 729 dbSNP
rs763408682 730 dbSNP
rs750832251 735 dbSNP
rs983778034 741 dbSNP
rs1169391795 748 dbSNP
rs1313959124 749 dbSNP
rs765785034 750 dbSNP
rs959276995 754 dbSNP
rs1279210771 765 dbSNP
rs1351643063 774 dbSNP
rs1225292940 777 dbSNP
rs190553448 781 dbSNP
rs916355492 791 dbSNP
rs990636243 792 dbSNP
rs941884610 804 dbSNP
rs773336631 807 dbSNP
rs769846874 808 dbSNP
rs1477678528 812 dbSNP
rs1435596348 814 dbSNP
rs1180441136 818 dbSNP
rs542943660 829 dbSNP
rs980751522 834 dbSNP
rs1470957149 835 dbSNP
rs573952761 836 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124A_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + A ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agugucaacggucgACUCUAAu 5'
                        ||||||| 
Target 5' -------------aUGAGAUUu 3'
1 - 9
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_124A_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + A
Location of target site ENST00000356260.5 | 3UTR | AUGAGAUUUUUUAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.604 8.9e-4 -0.553 2.5e-3 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.378 3.1e-2 0.206 1.6e-1 25 Click to see details
GSE38226 Liver fibrosis 0.396 3.8e-2 0.408 3.3e-2 21 Click to see details
GSE28260 Renal cortex and medulla -0.489 4.5e-2 -0.526 3.2e-2 13 Click to see details
GSE19350 CNS germ cell tumors -0.47 6.2e-2 -0.058 4.3e-1 12 Click to see details
GSE42095 Differentiated embryonic stem cells -0.3 8.2e-2 -0.132 2.7e-1 23 Click to see details
GSE27834 Pluripotent stem cells 0.304 1.3e-1 0.341 9.8e-2 16 Click to see details
GSE14794 Lymphoblastoid cells -0.12 1.3e-1 -0.181 4.4e-2 90 Click to see details
GSE21687 Ependynoma primary tumors -0.129 1.5e-1 -0.055 3.3e-1 64 Click to see details
GSE17498 Multiple myeloma 0.14 1.9e-1 0.191 1.2e-1 40 Click to see details
GSE26953 Aortic valvular endothelial cells -0.181 2.0e-1 -0.009 4.8e-1 24 Click to see details
GSE32688 Pancreatic cancer -0.096 3.0e-1 -0.007 4.8e-1 32 Click to see details
GSE21849 B cell lymphoma -0.058 3.8e-1 -0.007 4.9e-1 29 Click to see details
GSE17306 Multiple myeloma 0.039 4.0e-1 0.415 1.5e-3 49 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.021 4.6e-1 0.482 7.3e-3 25 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.005 4.9e-1 -0.083 3.6e-1 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KIRC -0.466 0.01 -0.422 0.01 29 Click to see details
PAAD -0.928 0.04 -0.800 0.1 4 Click to see details
PRAD 0.286 0.06 0.111 0.28 31 Click to see details
LIHC -0.226 0.07 -0.179 0.12 45 Click to see details
LUSC 0.304 0.1 0.332 0.08 20 Click to see details
KIRP 0.28 0.13 0.137 0.29 18 Click to see details
ESCA 0.596 0.2 0.800 0.1 4 Click to see details
HNSC 0.152 0.24 0.106 0.32 23 Click to see details
THCA -0.065 0.33 -0.172 0.12 47 Click to see details
KICH 0.136 0.35 -0.018 0.48 11 Click to see details
BRCA -0.076 0.36 -0.067 0.38 25 Click to see details
STAD 0.074 0.38 0.377 0.05 20 Click to see details
CHOL -0.128 0.38 -0.143 0.37 8 Click to see details
UCEC -0.077 0.42 -0.030 0.47 10 Click to see details
BLCA -0.019 0.48 -0.006 0.49 10 Click to see details
LUAD -0.017 0.48 -0.067 0.43 9 Click to see details
LUAD -0.017 0.48 -0.067 0.43 9 Click to see details
LUAD -0.017 0.48 -0.067 0.43 9 Click to see details
148 hsa-miR-216a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000534 PTEN phosphatase and tensin homolog 4 3
MIRT005018 SIRT1 sirtuin 1 3 1
MIRT005964 CDC42 cell division cycle 42 2 1
MIRT005969 CD44 CD44 molecule (Indian blood group) 2 1
MIRT007154 SMAD7 SMAD family member 7 1 1
MIRT054887 BECN1 beclin 1 5 3
MIRT067588 METAP2 methionyl aminopeptidase 2 2 6
MIRT099144 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT162313 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT230668 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT256274 PHAX phosphorylated adaptor for RNA export 2 2
MIRT386817 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT386825 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT438816 HNF4A hepatocyte nuclear factor 4 alpha 1 1
MIRT464699 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465962 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466046 TMEM189 transmembrane protein 189 2 2
MIRT466482 TECPR2 tectonin beta-propeller repeat containing 2 2 7
MIRT472209 NGFRAP1 brain expressed X-linked 3 2 4
MIRT472562 NACC1 nucleus accumbens associated 1 2 4
MIRT478921 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT480121 CALR calreticulin 2 2
MIRT497754 OXGR1 oxoglutarate receptor 1 2 2
MIRT497967 TWISTNB TWIST neighbor 2 2
MIRT502882 CDK4 cyclin dependent kinase 4 2 8
MIRT510191 MON1B MON1 homolog B, secretory trafficking associated 2 4
MIRT512407 CD84 CD84 molecule 2 2
MIRT513739 PSD3 pleckstrin and Sec7 domain containing 3 2 4
MIRT526257 DROSHA drosha ribonuclease III 2 2
MIRT528968 FAM19A3 family with sequence similarity 19 member A3, C-C motif chemokine like 2 2
MIRT529599 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT529776 ZNF486 zinc finger protein 486 2 2
MIRT530110 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530504 FADS6 fatty acid desaturase 6 2 2
MIRT531437 PAK1 p21 (RAC1) activated kinase 1 2 2
MIRT534445 SDR16C5 short chain dehydrogenase/reductase family 16C member 5 2 2
MIRT537286 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT538451 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT543085 ACTB actin beta 2 2
MIRT550982 ZNF254 zinc finger protein 254 2 2
MIRT556259 MAPRE2 microtubule associated protein RP/EB family member 2 2 2
MIRT556639 LAMC1 laminin subunit gamma 1 2 2
MIRT559127 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT561405 TUBB2A tubulin beta 2A class IIa 2 2
MIRT569677 SEC23B Sec23 homolog B, coat complex II component 2 4
MIRT574660 KLHL15 kelch like family member 15 2 2
MIRT575030 Tecpr2 tectonin beta-propeller repeat containing 2 2 5
MIRT617683 JRKL JRK like 2 2
MIRT618540 SEMA5A semaphorin 5A 2 2
MIRT620805 C1orf27 chromosome 1 open reading frame 27 2 2
MIRT621569 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT622133 SP4 Sp4 transcription factor 2 2
MIRT624913 CTCFL CCCTC-binding factor like 2 2
MIRT625010 PAK4 p21 (RAC1) activated kinase 4 2 2
MIRT626644 ZNF551 zinc finger protein 551 2 2
MIRT626646 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 2 2
MIRT626672 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT627945 NNT nicotinamide nucleotide transhydrogenase 2 2
MIRT627963 NLK nemo like kinase 2 2
MIRT628767 SRSF7 serine and arginine rich splicing factor 7 2 2
MIRT629261 KDM2B lysine demethylase 2B 2 2
MIRT629422 ADM2 adrenomedullin 2 2 2
MIRT630238 SORD sorbitol dehydrogenase 2 2
MIRT631272 CENPM centromere protein M 2 4
MIRT631793 CLK4 CDC like kinase 4 2 2
MIRT632058 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT632485 RPS15A ribosomal protein S15a 2 2
MIRT632611 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632708 MTA3 metastasis associated 1 family member 3 2 2
MIRT632815 INO80 INO80 complex subunit 2 2
MIRT635956 PLA2G12A phospholipase A2 group XIIA 2 2
MIRT636152 UBXN2A UBX domain protein 2A 2 2
MIRT636899 C5orf45 MRN complex interacting protein 2 4
MIRT636930 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT637457 ZNF324B zinc finger protein 324B 2 2
MIRT637900 SLC19A3 solute carrier family 19 member 3 2 2
MIRT639826 ZNF638 zinc finger protein 638 2 2
MIRT640445 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT640681 ARSK arylsulfatase family member K 2 2
MIRT641611 CAPN7 calpain 7 2 2
MIRT641676 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT646786 IL23R interleukin 23 receptor 2 2
MIRT648352 A2ML1 alpha-2-macroglobulin like 1 2 2
MIRT649144 SPATA5 spermatogenesis associated 5 2 2
MIRT649254 TRIM65 tripartite motif containing 65 2 2
MIRT652491 TMEM178B transmembrane protein 178B 2 2
MIRT653308 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT653945 SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 2 2
MIRT654212 RNF19B ring finger protein 19B 2 2
MIRT654839 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT655159 PHF21A PHD finger protein 21A 2 2
MIRT655316 PDCD11 programmed cell death 11 2 2
MIRT655375 PAX3 paired box 3 2 2
MIRT657301 HOXB5 homeobox B5 2 2
MIRT657593 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT658460 FAM117B family with sequence similarity 117 member B 2 2
MIRT658716 ELOVL4 ELOVL fatty acid elongase 4 2 2
MIRT661640 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT661712 MTO1 mitochondrial tRNA translation optimization 1 2 4
MIRT661833 ZNF793 zinc finger protein 793 2 2
MIRT663805 BET1L Bet1 golgi vesicular membrane trafficking protein like 2 2
MIRT663884 CXorf56 chromosome X open reading frame 56 2 2
MIRT664672 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 2
MIRT665814 TMEM168 transmembrane protein 168 2 2
MIRT668159 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT668430 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT672306 GP2 glycoprotein 2 2 2
MIRT673101 SYNPO2L synaptopodin 2 like 2 2
MIRT673437 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT673584 KDELC2 KDEL motif containing 2 2 2
MIRT673718 SLU7 SLU7 homolog, splicing factor 2 2
MIRT673777 MRPL17 mitochondrial ribosomal protein L17 2 2
MIRT674316 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT674820 FAM229B family with sequence similarity 229 member B 2 2
MIRT675179 BPTF bromodomain PHD finger transcription factor 2 2
MIRT675586 WWC1 WW and C2 domain containing 1 2 2
MIRT675812 MED28 mediator complex subunit 28 2 2
MIRT677632 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT683914 PSMB9 proteasome subunit beta 9 2 2
MIRT687135 QPCTL glutaminyl-peptide cyclotransferase like 2 2
MIRT691973 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT693078 AS3MT arsenite methyltransferase 2 2
MIRT694084 RNASEH2B ribonuclease H2 subunit B 2 2
MIRT696292 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT696541 C3 complement C3 2 2
MIRT701955 MITF melanogenesis associated transcription factor 2 2
MIRT703276 GNG12 G protein subunit gamma 12 2 2
MIRT706852 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 2 2
MIRT706993 XPO5 exportin 5 2 2
MIRT710716 KRTAP6-1 keratin associated protein 6-1 2 2
MIRT711305 ACOX1 acyl-CoA oxidase 1 2 2
MIRT711514 ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 2 2
MIRT711648 LIPG lipase G, endothelial type 2 2
MIRT711772 CCDC59 coiled-coil domain containing 59 2 2
MIRT714280 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT715048 PRPF38A pre-mRNA processing factor 38A 2 2
MIRT716934 INCENP inner centromere protein 2 2
MIRT717220 OTUD3 OTU deubiquitinase 3 2 2
MIRT717865 BICD2 BICD cargo adaptor 2 2 2
MIRT718836 SNX20 sorting nexin 20 2 2
MIRT720243 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT721969 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 2
MIRT724000 LMTK2 lemur tyrosine kinase 2 2 2
MIRT725193 SDAD1 SDA1 domain containing 1 2 2
MIRT731669 CBL Cbl proto-oncogene 3 1
MIRT732776 AQP4 aquaporin 4 3 0
MIRT733158 ITGA5 integrin subunit alpha 5 1 0
MIRT735623 TLR4 toll like receptor 4 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-216a Curcumin NULL 969516 Quantitative real-time PCR Y79 RB cells. 22510010 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-216a Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3, 2008, OVCAR10, OVCAR3, HeLa, MCF7, MDA-MB-468)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved sensitive High Small Cell Lung Cancer cell line (NCI-H69)
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant Low Hepatocellular Carcinoma tissue and cell line (HepG2, Hep3B, Huh-7, PLC/PRF/5, HCCLM3, Bel-7404, HLE, SK-HEP-1, SNU-449)
hsa-miR-216a-5p Fluorouracil 3385 NSC19893 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (Huh-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant Low Small Cell Lung Cancer cell line (H69, H446)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant Low Ovarian Cancer cell line (SKOV3, OVCA433)
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant Low Gastric Cancer cell line (MGC, SGC)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM11)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-216a-5p Exemestane 60198 NSC713563 approved sensitive cell line (MCF-7)
hsa-miR-216a-5p Testosterone+Tamoxifen sensitive cell line (MCF-7)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-216a-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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