pre-miRNA Information
pre-miRNA hsa-mir-4481   
Genomic Coordinates chr10: 12653138 - 12653197
Description Homo sapiens miR-4481 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4481
Sequence 1| GGAGUGGGCUGGUGGUU |17
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1299710636 5 dbSNP
rs1433739601 12 dbSNP
rs1266754238 14 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol GRAP2   
Synonyms GADS, GRAP-2, GRB2L, GRBLG, GRID, GRPL, GrbX, Grf40, Mona, P38
Description GRB2-related adaptor protein 2
Transcript NM_004810   
Expression
Putative miRNA Targets on GRAP2
3'UTR of GRAP2
(miRNA target sites are highlighted)
>GRAP2|NM_004810|3'UTR
   1 ACTCTTCAGGGGACAGAAGCTTTTTGTCTGGAGCTGCCCACAAGAAAGAGGGCAAGGAAAAAAGGCTGGACTCCATGACT
  81 ATATATACATACATCTATCTACATCTGCCTGTGTACACACACAACTTTTTATACTAGTAATTTATTGGCAATTGGGCTGG
 161 TAATTAGTTGATGCAAAAGGGAACTCAGGTGGAGAATAATATTGACACTTGCTTTTCTGCCCCCCTCAGGGGTGTGTGGA
 241 AGGCAGTGGGGGAGTTGGGAGGGGGGCAGGGAAATGAAATGGAGTTTTGTCCTGGCCTTCAGCTGTCACTGCTTCCTCCT
 321 TGTCTTGGGAATTTTCACGGAGAACAGCTAAGCAGAGACCACACCTCGGCACTGGACACAGAACAACAGGGTGGGGTTGA
 401 ACTTGGTGGGGCACGTTCTAGCTGACCTGCAAGCCCCGCTCACCTGGAGGGCTTGCAGAGCAGCTCTCCTCCTGTTCTCC
 481 AAGGGGTGGGCACTGTTGCATTAGGAATTAAGGTGCAGCCCAGTGCTGCGGGCAGCCAAGCGAGTCTGAGCGGGGATGTG
 561 AAGGCAGGACGGGGTTGGAGAGACCCTGCCTGTGCAAGGCTGGCCTCCTAGTCAACACCTAGCTGAGACATTCATCTCTG
 641 TTCAAATTAATATTCCTTGGGTCTTTCAAATGAATGTTTCAATGTGAGGAGCGAAGTACTGGGAAATCGAGGGATTTTCC
 721 ACAATCCCCAAGCAGCTTACTCAGTGGAACCTCTGTTTCCCCAGCTATGAAGGAAATAGCATCCTACATTCCGTAAAGTG
 801 CTTGAAGAAGCTCTAGCTGAGAATGCTGAATTTTACAGTCATTGTTTTATGGTTACAAGGGTATGTCTTCAGGGCTCTGT
 881 TCATTTTCCCTCTTGATTTTCTCTTTTGAAGATGCCTTGCCCAGTGGCATGGAAAGAAGCCCACTTGATGATAGGAGCCT
 961 GACTATGAATTGATTGACTAAACATGACCCCAGGTGGAAGCTGGCTTTGACACCAGCTTCCTGTTCAGTCTGACCACTGC
1041 TGTCCTCCTGCTGCCCAAGAGTTGCACCTGGAGCAAGGAACCCCACCATGGCTGTCGCTCTCCATCCCATCACGCTAGAA
1121 TCATGTGTCCAAGGGCTCACTCTGGAGGTGCACAGCACAGGTCAGCCTGGCCAGGGGCGAAGGAGACAGTAGAGAGGAAG
1201 CTCAGGGCCTTAGGGGAGGCCGGGTGCAAACCCGTTCTGCACCAAGTGCACTCGGAGTTTGTGGGTATGGGTGTGTACCC
1281 CTGCAGGTGTGCACATGTGTGCTTGCACGCACATATTTGTGCACTCCTGTGTGTATACATGTGTGCTTGTGTATGCATAT
1361 GTGTGCATTCCTGCATGTGTGGACATGTGCGTGCATGCATCTGTGTGTCTGTGTGTGTGCTGAGACAGGAAAGGGGGTGA
1441 AAGTGTTGGTGAGGGAGCCTGGAAGTTTTCTCTTCCCCAACCTCTCTTGCTCTAAGGAGGGATGGGGTTGGGGGCAGCCG
1521 TTATTGAAGGTGATCGGAGAAGAAAGATTTTCTGACTCAGAAGTGACTGCCAGTGTAGCACAAGCAGTGTCCCTTGTGAC
1601 TGTGATTCTACAGTTCTCTGATCCTCATGTTTCCTTTAGAGGAAAGAGGAAAAAAGGAACTCTGTGGTGGGTATTGGGAG
1681 GGAAAAGAAAATAGCCTGGTGGAGGCAGGAGGGAGTCGAGTGTGAGTAAGGAGCACCTGCAGCTTTTGGAAGTGAAAGCA
1761 GAGAGAGGGAAAGGTAGCTAAGACATCCAGGAGGATCAAGGGGCAGCGTGAGAGGCACAGGGGGAGGAAAGGGAGAGGGT
1841 GAGTGGGGCCAGGGAAGAGAACGGTGTGGAGTTGGTGGGCAGATGGTGCAGGAGGAGGGCTGGGCAGTGGGGAGAGGAAG
1921 AATCAGAGCAGAGAAACCGCTGCTGCGGAAGGCAGGGAGCAAAGAAGCATAAGGAAAAGAACAGGAGAAAGAACAAAGGC
2001 AGAGAAGACCTCCTCAGCTATTTTGGTGCTAGGTAATGTGAAATGCTGCAGTAAATAAAAGCCATAAGTAATGTTTGATT
2081 TTACAGTATTTACAAACCATATGCTTTAAACAGCCCACAAACTCCATCCAGTTGTCTGATGATGTGGGAGGACCAGCTCT
2161 AGTTAGACGGAGGTATGTGATTCGATTCTGGTGGAGACTTTGTGCCTTGAAAGGCTTCTCAGGAAAGCAGTAATAAAACA
2241 AAGTGTCCTTGTTTGGCC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uuGGUGGUCGGGUGAGg 5'
            |||  :||:||||| 
Target 5' gtCCAAGGGCTCACTCt 3'
1127 - 1143 139.00 -17.90
2
miRNA  3' uuGGUGGUC-GGGUGAGg 5'
            |::| || |||:||| 
Target 5' acCTGCAAGCCCCGCTCa 3'
425 - 442 135.00 -16.10
3
miRNA  3' uugguggUCGGGUGAGg 5'
                 ||||||||: 
Target 5' ggaaagaAGCCCACTTg 3'
931 - 947 134.00 -13.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30705877 48 COSMIC
COSN30148511 49 COSMIC
COSN30537801 49 COSMIC
COSN30118284 54 COSMIC
COSN31508460 69 COSMIC
COSN31512353 70 COSMIC
COSN31512285 74 COSMIC
COSN19269178 694 COSMIC
COSN16453004 1103 COSMIC
COSN8010716 1134 COSMIC
COSN27636202 1274 COSMIC
COSN21140833 1723 COSMIC
COSN1262130 1760 COSMIC
COSN1262131 1822 COSMIC
COSN2495209 2124 COSMIC
COSN22411618 2600 COSMIC
COSN29938124 2632 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1053131682 4 dbSNP
rs768847639 8 dbSNP
rs777202273 9 dbSNP
rs762187661 13 dbSNP
rs760334119 14 dbSNP
rs770449809 16 dbSNP
rs773890309 19 dbSNP
rs759041140 39 dbSNP
rs1284328401 40 dbSNP
rs917283700 41 dbSNP
rs182893461 42 dbSNP
rs752286200 47 dbSNP
rs760521133 49 dbSNP
rs764977193 50 dbSNP
rs377755526 51 dbSNP
rs1416664384 52 dbSNP
rs34410036 56 dbSNP
rs986370358 64 dbSNP
rs537029404 67 dbSNP
rs1393544464 71 dbSNP
rs555105080 74 dbSNP
rs1393121441 76 dbSNP
rs1417006149 82 dbSNP
rs186855841 84 dbSNP
rs1163943426 86 dbSNP
rs906020051 92 dbSNP
rs1388560536 94 dbSNP
rs1190680706 98 dbSNP
rs1465507845 103 dbSNP
rs1219791785 121 dbSNP
rs1453874322 123 dbSNP
rs1291168246 130 dbSNP
rs192909780 132 dbSNP
rs552706125 133 dbSNP
rs1402341848 134 dbSNP
rs1042913204 150 dbSNP
rs577403031 152 dbSNP
rs1291614332 153 dbSNP
rs1326170620 156 dbSNP
rs41304433 160 dbSNP
rs1328037918 173 dbSNP
rs1055636031 178 dbSNP
rs1368862212 190 dbSNP
rs1170547602 193 dbSNP
rs184893139 199 dbSNP
rs993537826 207 dbSNP
rs751659617 211 dbSNP
rs1060824 218 dbSNP
rs146500247 220 dbSNP
rs1357987360 225 dbSNP
rs1014218468 226 dbSNP
rs1189872404 228 dbSNP
rs1479181742 228 dbSNP
rs1290380417 231 dbSNP
rs1488584465 233 dbSNP
rs1205157172 237 dbSNP
rs1482352328 238 dbSNP
rs1015312527 243 dbSNP
rs1205212324 249 dbSNP
rs1311279814 250 dbSNP
rs536660482 251 dbSNP
rs1220748646 258 dbSNP
rs543764311 259 dbSNP
rs561959406 263 dbSNP
rs529341747 267 dbSNP
rs547919941 268 dbSNP
rs1407986520 269 dbSNP
rs1442999493 271 dbSNP
rs1008634550 281 dbSNP
rs1372308993 293 dbSNP
rs147575510 296 dbSNP
rs1027854493 314 dbSNP
rs755308630 316 dbSNP
rs1358826865 319 dbSNP
rs1361178791 319 dbSNP
rs953516307 319 dbSNP
rs986417799 320 dbSNP
rs1422099643 322 dbSNP
rs1019208180 325 dbSNP
rs1471918591 332 dbSNP
rs1254540063 339 dbSNP
rs781507441 340 dbSNP
rs1384838010 341 dbSNP
rs1482609288 347 dbSNP
rs1032855489 348 dbSNP
rs1312400855 362 dbSNP
rs559928064 363 dbSNP
rs533562772 368 dbSNP
rs1288856681 370 dbSNP
rs1392050447 372 dbSNP
rs1378442791 375 dbSNP
rs989175625 376 dbSNP
rs917250926 378 dbSNP
rs1407070810 381 dbSNP
rs978906185 385 dbSNP
rs1313741001 387 dbSNP
rs1414852648 388 dbSNP
rs950126078 391 dbSNP
rs937178061 396 dbSNP
rs980166415 403 dbSNP
rs927380880 407 dbSNP
rs189395905 408 dbSNP
rs949945597 415 dbSNP
rs1330876930 416 dbSNP
rs748548250 432 dbSNP
rs1241656106 438 dbSNP
rs570348223 439 dbSNP
rs1036387152 440 dbSNP
rs1397817904 444 dbSNP
rs1383826717 447 dbSNP
rs1038557036 448 dbSNP
rs1258934466 449 dbSNP
rs1433351246 453 dbSNP
rs1485501850 455 dbSNP
rs60628820 456 dbSNP
rs61578612 457 dbSNP
rs1457890276 458 dbSNP
rs78790084 460 dbSNP
rs1183187146 467 dbSNP
rs770012315 472 dbSNP
rs1166335123 479 dbSNP
rs1444664208 480 dbSNP
rs571203870 489 dbSNP
rs1007741433 492 dbSNP
rs1017277483 518 dbSNP
rs1248466139 526 dbSNP
rs1208985137 527 dbSNP
rs1487481496 528 dbSNP
rs1267089335 529 dbSNP
rs1019095883 530 dbSNP
rs1363790416 531 dbSNP
rs900268147 538 dbSNP
rs1405273426 543 dbSNP
rs1466991760 547 dbSNP
rs1174690379 548 dbSNP
rs145298353 551 dbSNP
rs192383952 553 dbSNP
rs1367598352 558 dbSNP
rs538429007 559 dbSNP
rs956102241 569 dbSNP
rs988734941 571 dbSNP
rs1424751591 572 dbSNP
rs1369473750 574 dbSNP
rs367953876 575 dbSNP
rs1450986494 579 dbSNP
rs1373247087 581 dbSNP
rs1197930428 585 dbSNP
rs1431172787 595 dbSNP
rs535209883 602 dbSNP
rs1010216448 609 dbSNP
rs971400266 614 dbSNP
rs980112415 617 dbSNP
rs1335732629 623 dbSNP
rs927330070 644 dbSNP
rs1203076647 646 dbSNP
rs374748515 647 dbSNP
rs556751672 660 dbSNP
rs1344624474 693 dbSNP
rs974187515 694 dbSNP
rs1233004485 705 dbSNP
rs575467130 709 dbSNP
rs184812078 710 dbSNP
rs991299432 714 dbSNP
rs1448440093 715 dbSNP
rs1305672021 717 dbSNP
rs1051330269 720 dbSNP
rs891383876 723 dbSNP
rs1304216498 725 dbSNP
rs1396781002 729 dbSNP
rs949997824 741 dbSNP
rs754289888 747 dbSNP
rs1036678058 748 dbSNP
rs1257578642 752 dbSNP
rs1379207308 754 dbSNP
rs1321092635 756 dbSNP
rs919306825 757 dbSNP
rs944340089 761 dbSNP
rs755437241 764 dbSNP
rs889219553 765 dbSNP
rs367746002 774 dbSNP
rs1459253691 776 dbSNP
rs573942548 777 dbSNP
rs541483913 784 dbSNP
rs1175612356 787 dbSNP
rs1007626720 793 dbSNP
rs9611236 794 dbSNP
rs999895927 799 dbSNP
rs1335900923 804 dbSNP
rs1332910227 808 dbSNP
rs1393973136 813 dbSNP
rs1403870131 822 dbSNP
rs1176935821 825 dbSNP
rs533501595 826 dbSNP
rs1033205741 836 dbSNP
rs1021628008 837 dbSNP
rs868819929 841 dbSNP
rs1161201829 857 dbSNP
rs1470470173 862 dbSNP
rs749530364 862 dbSNP
rs77233714 864 dbSNP
rs556653844 871 dbSNP
rs1469647782 875 dbSNP
rs1440940816 876 dbSNP
rs1245143973 878 dbSNP
rs1204723549 884 dbSNP
rs1032615450 885 dbSNP
rs773914587 891 dbSNP
rs1400654230 893 dbSNP
rs563753623 899 dbSNP
rs1351995070 901 dbSNP
rs1463148786 908 dbSNP
rs1241941085 913 dbSNP
rs531191539 917 dbSNP
rs1341920306 927 dbSNP
rs1336919139 928 dbSNP
rs1434101561 930 dbSNP
rs1386272340 941 dbSNP
rs1295953120 950 dbSNP
rs1371936170 955 dbSNP
rs1412926052 956 dbSNP
rs1387307556 959 dbSNP
rs1162762207 963 dbSNP
rs549423288 966 dbSNP
rs1303387324 975 dbSNP
rs958470418 981 dbSNP
rs1343528326 985 dbSNP
rs1024196768 990 dbSNP
rs1464600373 992 dbSNP
rs1246621429 1002 dbSNP
rs1218344203 1012 dbSNP
rs370614311 1013 dbSNP
rs971311383 1018 dbSNP
rs745373209 1024 dbSNP
rs1360895139 1027 dbSNP
rs779127534 1028 dbSNP
rs1001497998 1031 dbSNP
rs1320284951 1038 dbSNP
rs1202611332 1043 dbSNP
rs1271757793 1051 dbSNP
rs1034349573 1076 dbSNP
rs962732138 1078 dbSNP
rs974134266 1084 dbSNP
rs971633042 1086 dbSNP
rs75696647 1088 dbSNP
rs919178101 1090 dbSNP
rs930550646 1092 dbSNP
rs1049548862 1097 dbSNP
rs1267462197 1098 dbSNP
rs951548592 1101 dbSNP
rs1246646821 1103 dbSNP
rs987380723 1109 dbSNP
rs577593575 1110 dbSNP
rs1291931881 1112 dbSNP
rs774940980 1114 dbSNP
rs540172555 1115 dbSNP
rs1274606093 1123 dbSNP
rs921591141 1123 dbSNP
rs1276404948 1124 dbSNP
rs1366727547 1126 dbSNP
rs760552236 1133 dbSNP
rs1406746293 1141 dbSNP
rs138011 1142 dbSNP
rs891552640 1143 dbSNP
rs904120285 1148 dbSNP
rs1429136267 1154 dbSNP
rs1010037845 1161 dbSNP
rs1172720996 1167 dbSNP
rs1410744136 1171 dbSNP
rs1363697288 1173 dbSNP
rs1189820438 1177 dbSNP
rs1045979357 1179 dbSNP
rs570973837 1180 dbSNP
rs1032665915 1184 dbSNP
rs907075126 1195 dbSNP
rs1180842063 1204 dbSNP
rs35940792 1213 dbSNP
rs1481746921 1217 dbSNP
rs1234111482 1218 dbSNP
rs1204849557 1222 dbSNP
rs1001439334 1223 dbSNP
rs368410924 1233 dbSNP
rs1225074260 1234 dbSNP
rs1363765202 1235 dbSNP
rs373170381 1247 dbSNP
rs1409297295 1248 dbSNP
rs1371369535 1250 dbSNP
rs1299955374 1254 dbSNP
rs995925986 1255 dbSNP
rs1358772085 1256 dbSNP
rs756851733 1257 dbSNP
rs545686059 1264 dbSNP
rs1471126545 1266 dbSNP
rs1430613472 1276 dbSNP
rs1159159920 1278 dbSNP
rs971138762 1284 dbSNP
rs972322477 1285 dbSNP
rs1177239586 1290 dbSNP
rs9607676 1303 dbSNP
rs1026124780 1309 dbSNP
rs1235334765 1310 dbSNP
rs1223943199 1311 dbSNP
rs776466675 1316 dbSNP
rs1267257491 1319 dbSNP
rs984694407 1324 dbSNP
rs1289612997 1327 dbSNP
rs910590330 1330 dbSNP
rs145144717 1332 dbSNP
rs139007738 1340 dbSNP
rs1454776341 1342 dbSNP
rs912720133 1348 dbSNP
rs964210991 1352 dbSNP
rs1320280756 1362 dbSNP
rs1452305632 1379 dbSNP
rs142274066 1380 dbSNP
rs1159221683 1385 dbSNP
rs1186266625 1386 dbSNP
rs145635816 1391 dbSNP
rs6001715 1392 dbSNP
rs935642731 1396 dbSNP
rs1444856400 1400 dbSNP
rs573119797 1401 dbSNP
rs1247239892 1417 dbSNP
rs1382780231 1421 dbSNP
rs1423966286 1422 dbSNP
rs1298680419 1423 dbSNP
rs1206554952 1424 dbSNP
rs1486826183 1426 dbSNP
rs1261190372 1427 dbSNP
rs1216594730 1430 dbSNP
rs1321265600 1433 dbSNP
rs936951694 1449 dbSNP
rs1248503983 1450 dbSNP
rs1383756128 1452 dbSNP
rs1297358269 1454 dbSNP
rs1054538151 1459 dbSNP
rs1387789837 1464 dbSNP
rs1289899932 1466 dbSNP
rs111987832 1471 dbSNP
rs1012547021 1473 dbSNP
rs541422540 1476 dbSNP
rs1164915790 1479 dbSNP
rs189490468 1481 dbSNP
rs1190789678 1488 dbSNP
rs1045519831 1498 dbSNP
rs993244896 1500 dbSNP
rs1026596182 1502 dbSNP
rs1190602158 1508 dbSNP
rs1487452079 1510 dbSNP
rs998935177 1510 dbSNP
rs1289734257 1513 dbSNP
rs1231377234 1514 dbSNP
rs1035719267 1515 dbSNP
rs143115126 1515 dbSNP
rs578125964 1518 dbSNP
rs138012 1521 dbSNP
rs1274115955 1523 dbSNP
rs1225707558 1525 dbSNP
rs1313052674 1536 dbSNP
rs563867686 1537 dbSNP
rs1344138975 1539 dbSNP
rs181478623 1556 dbSNP
rs745323961 1558 dbSNP
rs1240941787 1559 dbSNP
rs898421208 1564 dbSNP
rs1017535673 1573 dbSNP
rs148097685 1574 dbSNP
rs995479323 1578 dbSNP
rs561405331 1585 dbSNP
rs1165858673 1588 dbSNP
rs1288837320 1600 dbSNP
rs1445765647 1601 dbSNP
rs1373480809 1603 dbSNP
rs1026061229 1604 dbSNP
rs1215589570 1605 dbSNP
rs1201698105 1614 dbSNP
rs751702277 1616 dbSNP
rs1483374336 1619 dbSNP
rs976098728 1623 dbSNP
rs1341713612 1624 dbSNP
rs1252302974 1629 dbSNP
rs923277633 1635 dbSNP
rs1322062062 1637 dbSNP
rs1185007530 1649 dbSNP
rs1008717322 1651 dbSNP
rs1240748059 1654 dbSNP
rs1349399479 1658 dbSNP
rs945480158 1666 dbSNP
rs1019681798 1668 dbSNP
rs978192508 1671 dbSNP
rs755040984 1672 dbSNP
rs1467982062 1678 dbSNP
rs1410146125 1679 dbSNP
rs975567891 1681 dbSNP
rs528774439 1682 dbSNP
rs1158110975 1699 dbSNP
rs1177146707 1703 dbSNP
rs1472218244 1714 dbSNP
rs1307770284 1719 dbSNP
rs1179718137 1722 dbSNP
rs1359486779 1725 dbSNP
rs1032522244 1727 dbSNP
rs958535563 1730 dbSNP
rs1251454663 1734 dbSNP
rs573098071 1737 dbSNP
rs1460209772 1752 dbSNP
rs988451586 1764 dbSNP
rs916846290 1765 dbSNP
rs1447703354 1778 dbSNP
rs115372955 1783 dbSNP
rs1277298164 1785 dbSNP
rs1240498130 1795 dbSNP
rs1349174232 1802 dbSNP
rs1333010395 1808 dbSNP
rs1045397907 1809 dbSNP
rs1408104627 1811 dbSNP
rs1279817520 1815 dbSNP
rs1337127162 1817 dbSNP
rs945755156 1822 dbSNP
rs981164390 1823 dbSNP
rs1156919627 1833 dbSNP
rs1471167722 1839 dbSNP
rs1364605666 1844 dbSNP
rs570912711 1847 dbSNP
rs1183292709 1852 dbSNP
rs1442983132 1854 dbSNP
rs186049338 1860 dbSNP
rs767881637 1863 dbSNP
rs1460589549 1864 dbSNP
rs928381696 1866 dbSNP
rs550393976 1867 dbSNP
rs1282694268 1872 dbSNP
rs937123090 1874 dbSNP
rs1055635665 1884 dbSNP
rs1313715177 1890 dbSNP
rs1047471821 1894 dbSNP
rs1384508185 1895 dbSNP
rs1315513341 1897 dbSNP
rs1234048574 1898 dbSNP
rs1324633386 1899 dbSNP
rs887485584 1900 dbSNP
rs898369030 1906 dbSNP
rs1401215884 1911 dbSNP
rs1385821821 1926 dbSNP
rs1468567293 1929 dbSNP
rs1423008521 1938 dbSNP
rs568980708 1939 dbSNP
rs536037852 1940 dbSNP
rs1240712662 1943 dbSNP
rs752812220 1947 dbSNP
rs554784218 1948 dbSNP
rs1219575722 1953 dbSNP
rs1470859018 1956 dbSNP
rs1173988997 1958 dbSNP
rs1008248459 1960 dbSNP
rs1291978932 1961 dbSNP
rs1019630787 1975 dbSNP
rs1030779971 1983 dbSNP
rs189251304 1986 dbSNP
rs1334013258 1988 dbSNP
rs1330407182 1993 dbSNP
rs1302654227 1997 dbSNP
rs1403120032 2006 dbSNP
rs1442144858 2009 dbSNP
rs978456731 2010 dbSNP
rs1164517944 2013 dbSNP
rs1276011096 2016 dbSNP
rs749656331 2033 dbSNP
rs925397137 2038 dbSNP
rs958088049 2044 dbSNP
rs1476046892 2049 dbSNP
rs1262848269 2050 dbSNP
rs1268744037 2056 dbSNP
rs990968959 2064 dbSNP
rs1490678329 2065 dbSNP
rs1322408981 2066 dbSNP
rs1195982402 2072 dbSNP
rs1032470254 2078 dbSNP
rs1274892483 2085 dbSNP
rs1305368234 2085 dbSNP
rs916730317 2089 dbSNP
rs1322747792 2092 dbSNP
rs958265468 2094 dbSNP
rs1281223437 2099 dbSNP
rs1225259715 2100 dbSNP
rs534104293 2114 dbSNP
rs988786616 2123 dbSNP
rs1294164366 2129 dbSNP
rs1021223741 2139 dbSNP
rs967419084 2144 dbSNP
rs1435623771 2146 dbSNP
rs757815284 2154 dbSNP
rs1269607658 2159 dbSNP
rs779338078 2169 dbSNP
rs928329470 2170 dbSNP
rs937069011 2174 dbSNP
rs745391560 2178 dbSNP
rs1428255992 2184 dbSNP
rs562051904 2185 dbSNP
rs1047814343 2191 dbSNP
rs919740357 2192 dbSNP
rs1169819968 2202 dbSNP
rs1176082583 2203 dbSNP
rs181193443 2214 dbSNP
rs1409494365 2221 dbSNP
rs544301916 2229 dbSNP
rs900327811 2231 dbSNP
rs1460757591 2232 dbSNP
rs1261007328 2234 dbSNP
rs887045525 2249 dbSNP
rs775234375 2252 dbSNP
rs1030249990 2259 dbSNP
rs1403568226 2262 dbSNP
rs1371473466 2264 dbSNP
rs966992764 2265 dbSNP
rs1283080195 2267 dbSNP
rs562091251 2268 dbSNP
rs1230045197 2272 dbSNP
rs117854879 2280 dbSNP
rs1471259626 2283 dbSNP
rs1337041116 2285 dbSNP
rs1194795676 2287 dbSNP
rs1360199392 2293 dbSNP
rs958140407 2294 dbSNP
rs1291790933 2295 dbSNP
rs1409525484 2299 dbSNP
rs557151311 2306 dbSNP
rs1490820568 2309 dbSNP
rs1041027565 2310 dbSNP
rs899883930 2311 dbSNP
rs749191408 2316 dbSNP
rs970868951 2317 dbSNP
rs1461730957 2321 dbSNP
rs1371622071 2326 dbSNP
rs982649856 2336 dbSNP
rs376009422 2337 dbSNP
rs544681346 2338 dbSNP
rs1387123867 2339 dbSNP
rs1053828303 2342 dbSNP
rs1313400817 2343 dbSNP
rs983162244 2344 dbSNP
rs1303130954 2346 dbSNP
rs5750889 2356 dbSNP
rs776357185 2357 dbSNP
rs1423638920 2363 dbSNP
rs1382955050 2365 dbSNP
rs1316658581 2367 dbSNP
rs1185214582 2373 dbSNP
rs1444944966 2379 dbSNP
rs1009749854 2390 dbSNP
rs1184773930 2391 dbSNP
rs1021590736 2394 dbSNP
rs1226161588 2400 dbSNP
rs141870963 2401 dbSNP
rs1360918060 2402 dbSNP
rs1289774665 2408 dbSNP
rs1003834761 2412 dbSNP
rs1243111780 2424 dbSNP
rs1035345730 2425 dbSNP
rs933173409 2436 dbSNP
rs1291000079 2440 dbSNP
rs1351306609 2442 dbSNP
rs1298305787 2443 dbSNP
rs186489864 2457 dbSNP
rs991218303 2459 dbSNP
rs1446668910 2461 dbSNP
rs919706630 2464 dbSNP
rs1458088301 2465 dbSNP
rs902448017 2468 dbSNP
rs999833371 2470 dbSNP
rs761642378 2476 dbSNP
rs982646022 2495 dbSNP
rs908418248 2496 dbSNP
rs540532395 2514 dbSNP
rs1490225311 2516 dbSNP
rs943955409 2518 dbSNP
rs893802493 2522 dbSNP
rs1012326199 2526 dbSNP
rs1488911546 2532 dbSNP
rs1251135890 2537 dbSNP
rs1442896216 2539 dbSNP
rs374432333 2540 dbSNP
rs970752926 2549 dbSNP
rs562990072 2553 dbSNP
rs921252077 2554 dbSNP
rs531977501 2558 dbSNP
rs190896361 2562 dbSNP
rs1304412835 2571 dbSNP
rs150641114 2574 dbSNP
rs1395271648 2575 dbSNP
rs984770238 2578 dbSNP
rs908916667 2585 dbSNP
rs1010109754 2588 dbSNP
rs941677571 2592 dbSNP
rs1042557936 2593 dbSNP
rs1427335647 2605 dbSNP
rs1201036732 2606 dbSNP
rs1250014309 2607 dbSNP
rs1384654232 2610 dbSNP
rs1194443588 2611 dbSNP
rs1459423848 2619 dbSNP
rs1259095454 2633 dbSNP
rs974370634 2634 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124A_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + A ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uugguggucgggUGAGg 5'
                      |||| 
Target 5' ggguggucuugaACUCc 3'
3 - 19
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_124A_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + A
Location of target site ENST00000344138.4 | 3UTR | CAGGGUGGUCUUGAACUCCUGACCUCAGGUGAUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
84 hsa-miR-4481 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT100715 TJAP1 tight junction associated protein 1 2 2
MIRT183589 ZC3H11A zinc finger CCCH-type containing 11A 2 2
MIRT338033 DAZAP2 DAZ associated protein 2 2 4
MIRT395796 SPCS3 signal peptidase complex subunit 3 2 2
MIRT443947 LRIT3 leucine rich repeat, Ig-like and transmembrane domains 3 2 2
MIRT450580 HIST1H2BG histone cluster 1 H2B family member g 2 6
MIRT451617 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT452331 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT453279 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT455212 GNL1 G protein nucleolar 1 (putative) 2 2
MIRT455470 LYPLA2 lysophospholipase II 2 2
MIRT456503 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2 2
MIRT456687 LDB1 LIM domain binding 1 2 2
MIRT456915 DDA1 DET1 and DDB1 associated 1 2 2
MIRT457603 IDS iduronate 2-sulfatase 2 2
MIRT457848 RNASEH2B ribonuclease H2 subunit B 2 4
MIRT458455 RPRM reprimo, TP53 dependent G2 arrest mediator homolog 2 2
MIRT460179 UNK unkempt family zinc finger 2 6
MIRT461465 SLC19A3 solute carrier family 19 member 3 2 2
MIRT464739 UBE2Q1 ubiquitin conjugating enzyme E2 Q1 2 2
MIRT465279 TRIM28 tripartite motif containing 28 2 2
MIRT468450 SETD1B SET domain containing 1B 2 2
MIRT468620 SUMO1 small ubiquitin-like modifier 1 2 6
MIRT469152 RNF121 ring finger protein 121 2 2
MIRT470073 PTGES2 prostaglandin E synthase 2 2 2
MIRT470172 PSMD11 proteasome 26S subunit, non-ATPase 11 2 4
MIRT473156 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT474308 LAMC1 laminin subunit gamma 1 2 2
MIRT474782 KIAA0895L KIAA0895 like 2 2
MIRT476484 GATAD2A GATA zinc finger domain containing 2A 2 2
MIRT477613 EFNA3 ephrin A3 2 2
MIRT479525 CDCA4 cell division cycle associated 4 2 2
MIRT479973 CARD10 caspase recruitment domain family member 10 2 2
MIRT480410 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT480426 C17orf85 nuclear cap binding subunit 3 2 2
MIRT483573 SYT2 synaptotagmin 2 2 2
MIRT483664 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT484532 POLD3 DNA polymerase delta 3, accessory subunit 2 2
MIRT484616 SIX3 SIX homeobox 3 2 6
MIRT485897 ZFP36 ZFP36 ring finger protein 2 2
MIRT486505 MYH11 myosin heavy chain 11 2 2
MIRT487505 GRK5 G protein-coupled receptor kinase 5 2 2
MIRT488852 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT489464 MSC musculin 2 2
MIRT491170 LRP3 LDL receptor related protein 3 2 2
MIRT496627 TMEM67 transmembrane protein 67 2 2
MIRT497616 ANG angiogenin 2 2
MIRT497766 KIAA0895 KIAA0895 2 2
MIRT499680 MRE11A MRE11 homolog, double strand break repair nuclease 2 6
MIRT499774 SLC29A2 solute carrier family 29 member 2 2 2
MIRT501745 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT504995 ZNF652 zinc finger protein 652 2 2
MIRT511664 HIST1H3C histone cluster 1 H3 family member c 2 2
MIRT511690 HIST1H2BO histone cluster 1 H2B family member o 2 4
MIRT511703 HIST1H2BL histone cluster 1 H2B family member l 2 4
MIRT511734 HIST1H2BE histone cluster 1 H2B family member e 2 8
MIRT512858 TBC1D13 TBC1 domain family member 13 2 2
MIRT513444 EMP1 epithelial membrane protein 1 2 6
MIRT515681 TFPI tissue factor pathway inhibitor 2 2
MIRT523529 GLUL glutamate-ammonia ligase 2 2
MIRT525546 PHB2 prohibitin 2 2 4
MIRT526209 SNX24 sorting nexin 24 2 2
MIRT531554 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT533764 TMEM135 transmembrane protein 135 2 2
MIRT545582 SNRPA1 small nuclear ribonucleoprotein polypeptide A' 2 2
MIRT552434 ZNF460 zinc finger protein 460 2 2
MIRT561159 BCL2L12 BCL2 like 12 2 2
MIRT562345 EXOSC2 exosome component 2 2 2
MIRT570659 KDM6B lysine demethylase 6B 2 2
MIRT571076 TCHHL1 trichohyalin like 1 2 2
MIRT571330 TPCN2 two pore segment channel 2 2 2
MIRT571603 TOB2 transducer of ERBB2, 2 2 2
MIRT573013 RPP25 ribonuclease P and MRP subunit p25 2 2
MIRT609041 EP300 E1A binding protein p300 2 2
MIRT613398 DNAH17 dynein axonemal heavy chain 17 2 2
MIRT635589 TTC9C tetratricopeptide repeat domain 9C 2 2
MIRT661118 FPR1 formyl peptide receptor 1 2 2
MIRT690103 PNMA2 paraneoplastic Ma antigen 2 2 2
MIRT694972 PLAC8 placenta specific 8 2 2
MIRT695515 ALPI alkaline phosphatase, intestinal 2 2
MIRT695578 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT699570 SIT1 signaling threshold regulating transmembrane adaptor 1 2 2
MIRT701991 MIER3 MIER family member 3 2 2
MIRT725464 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4481 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-mir-4481 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-4481 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4481 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4481 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4481 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4481 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4481 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4481 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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