pre-miRNA Information
pre-miRNA hsa-mir-3675   
Genomic Coordinates chr1: 16858949 - 16859021
Description Homo sapiens miR-3675 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3675-5p
Sequence 12| UAUGGGGCUUCUGUAGAGAUUUC |34
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1229940041 1 dbSNP
rs1184422098 2 dbSNP
rs768029583 3 dbSNP
rs202014433 6 dbSNP
rs774834919 7 dbSNP
rs1484376029 8 dbSNP
rs771338088 8 dbSNP
rs749521347 10 dbSNP
rs773421450 12 dbSNP
rs1250672393 14 dbSNP
rs769780471 15 dbSNP
rs781028022 16 dbSNP
rs1315377622 17 dbSNP
rs754885466 18 dbSNP
rs746860289 20 dbSNP
rs1330333643 23 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FBXO46   
Synonyms 20D7-FC4, FBXO34L, Fbx46
Description F-box protein 46
Transcript NM_001080469   
Expression
Putative miRNA Targets on FBXO46
3'UTR of FBXO46
(miRNA target sites are highlighted)
>FBXO46|NM_001080469|3'UTR
   1 AGCCGGGGGAGGGGAGGGGAGAGCCCACCACGCCCACCCCTCCCCTCTCCCCCCGGGAGCCGAGGGTCCGGACTGGGCCG
  81 CCTGCCCATTCCCCTACTCCAGGCAGCATTGATCCCTCACCGGAACTGAGCTGGGGTTCAGCAGGGGTGACCCAGGAAAG
 161 CCCTCTGCTTGATCCTGTTGATTTTCTACTCTTCAGAACCAGGGCCGTGGACCCTCTGAGAAGGGTGTTTTTTTTTTTTT
 241 TATCAGCATCTCACTTTCTTCTCCATTCAGCCCCAACCCCCTCCCTGCCATGCTTTCCACCCCAAGGACCCACCAGCAGG
 321 GAGCAGACGGCAGCTAATTTTGGTACCACTTAAGGGTCCCCCCATTCTGGCCCCCATCCTCTCCCTCACCCCAATTCTTT
 401 CTCGCTGGAGCTGTTATTTCCCAAGAAGCCGCATCGCCCAAGGTTGGCACCTCTCCTAACCTGCCACACGACAGCTCTCA
 481 CCTCTCTAGGAATTGGGGGCTGTCAGGTCACAGGTGGGATCTGGCATTTTTTTATGACAGTCCATTTCTAGATGGTTTGC
 561 CTATTAAAGAAGTGGGGGGGAAATACTGTTTTCTCCTTAACCTCAAGCTACCAGTCTCTCCTCTTCCGCGTAGAGGAAGA
 641 GGGGGGCAGACAAAAAAAAAGCTGAAGTATAAAAACCCTCCTCCTCCCGTTATTATTTAAGCTACTGCCATCAACCCCAC
 721 CCCCATAAAGCTGTGAAGCCCTTTGCCTCGCTTTTGACAGCGTGGGGGGGCCCCGTGGGCAGGGACTTCGGATTTGCATT
 801 TCTGGGTTGTTTTTCCTTCCACTCTGGGGTCTCGTTCAGGCATTGGGGTCTCCTCACCCCAGCCACATGTTTCTTTAAGA
 881 ATCCTTTGGTCAACCAGGACCTTGATTTTTCAGGCATTTTGGTCTGGGGTATTTTTGTTTGTTCTCTCTGTTTTTTGTTT
 961 TCTTTTTTTTCTTTCCATCGTGGTTCTGGAAGCTTCTAGCGTGTGGCATCTGACCAATTTTGAATTGGTCCTTTCTATAA
1041 AATCAATATTTATAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cuuUAGAGAUGUCUUCGGGGUAu 5'
             ||:||   ||||||| ||| 
Target 5' gttATTTCCCAAGAAGCCGCATc 3'
413 - 435 140.00 -16.60
2
miRNA  3' cuuuAG-AGAUGU-CUUCGGGGUau 5'
              || ||| ||   |||||||  
Target 5' acttTCTTCTCCATTCAGCCCCAac 3'
253 - 277 135.00 -14.10
3
miRNA  3' cuuuagagAUGUCUUCGGGGUAu 5'
                  |: :|::|||||:| 
Target 5' tgacagcgTGGGGGGGCCCCGTg 3'
755 - 777 135.00 -19.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN19668548 23 COSMIC
COSN31488861 196 COSMIC
COSN26562265 213 COSMIC
COSN20049101 227 COSMIC
COSN27340827 228 COSMIC
COSN31541336 239 COSMIC
COSN31562708 240 COSMIC
COSN26575033 328 COSMIC
COSN30569799 338 COSMIC
COSN31536847 371 COSMIC
COSN30539936 475 COSMIC
COSN30176060 504 COSMIC
COSN31595247 504 COSMIC
COSN30757225 574 COSMIC
COSN8973708 631 COSMIC
COSN20115906 651 COSMIC
COSN31588082 651 COSMIC
COSN31556784 837 COSMIC
COSN28690497 873 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs17855491 2 dbSNP
rs1421369368 4 dbSNP
rs1201443317 5 dbSNP
rs17851942 6 dbSNP
rs1284437194 8 dbSNP
rs980035162 9 dbSNP
rs1266685332 10 dbSNP
rs1040040157 15 dbSNP
rs1189601671 17 dbSNP
rs1481737992 18 dbSNP
rs748583229 22 dbSNP
rs1458190535 23 dbSNP
rs1199802091 24 dbSNP
rs1252146084 26 dbSNP
rs1045304195 28 dbSNP
rs546592728 29 dbSNP
rs1021395727 31 dbSNP
rs1265424556 35 dbSNP
rs1224591113 36 dbSNP
rs527554862 40 dbSNP
rs1476938051 41 dbSNP
rs941139700 42 dbSNP
rs761043222 45 dbSNP
rs1299974677 49 dbSNP
rs753283186 50 dbSNP
rs17851943 51 dbSNP
rs759171517 52 dbSNP
rs558715487 53 dbSNP
rs770643374 54 dbSNP
rs762712968 55 dbSNP
rs901435271 55 dbSNP
rs1041729375 60 dbSNP
rs1178335363 60 dbSNP
rs1232187013 62 dbSNP
rs966564384 62 dbSNP
rs1254184440 66 dbSNP
rs1377065315 68 dbSNP
rs772834507 69 dbSNP
rs1421008080 70 dbSNP
rs769662473 79 dbSNP
rs1178216035 80 dbSNP
rs1456613870 82 dbSNP
rs1245291246 85 dbSNP
rs1204775741 88 dbSNP
rs1196106916 89 dbSNP
rs1264414877 91 dbSNP
rs1484149390 92 dbSNP
rs531433615 92 dbSNP
rs1254806531 96 dbSNP
rs879716663 97 dbSNP
rs1230412790 104 dbSNP
rs757202274 105 dbSNP
rs1318152362 106 dbSNP
rs1055217 107 dbSNP
rs1309397881 108 dbSNP
rs889985200 114 dbSNP
rs149809518 118 dbSNP
rs1359345386 119 dbSNP
rs1374265769 121 dbSNP
rs751692253 124 dbSNP
rs548376439 131 dbSNP
rs1401381563 134 dbSNP
rs972433345 135 dbSNP
rs772133655 140 dbSNP
rs1380925322 141 dbSNP
rs1158138467 144 dbSNP
rs986710567 145 dbSNP
rs1438052374 147 dbSNP
rs1246863660 148 dbSNP
rs1387389025 150 dbSNP
rs1332814050 151 dbSNP
rs1184561496 159 dbSNP
rs1442259813 165 dbSNP
rs938379953 166 dbSNP
rs1254541725 180 dbSNP
rs1207374254 184 dbSNP
rs1486484904 186 dbSNP
rs1286090127 191 dbSNP
rs1238876119 192 dbSNP
rs1351578118 196 dbSNP
rs1351007643 199 dbSNP
rs968156410 200 dbSNP
rs1245093821 201 dbSNP
rs980450297 202 dbSNP
rs1339609699 205 dbSNP
rs1331954250 206 dbSNP
rs1022520245 207 dbSNP
rs1009797213 210 dbSNP
rs1297654426 216 dbSNP
rs1269885423 221 dbSNP
rs1417986729 223 dbSNP
rs914420843 224 dbSNP
rs1164004113 225 dbSNP
rs1472612035 226 dbSNP
rs1367021288 227 dbSNP
rs1159892803 228 dbSNP
rs1417327608 228 dbSNP
rs76683623 229 dbSNP
rs1195847327 230 dbSNP
rs1360797045 230 dbSNP
rs1291615585 231 dbSNP
rs779364368 231 dbSNP
rs1478430681 239 dbSNP
rs778977526 240 dbSNP
rs35255751 241 dbSNP
rs138545162 242 dbSNP
rs754330287 242 dbSNP
rs756157625 242 dbSNP
rs878972532 242 dbSNP
rs1489020115 243 dbSNP
rs750660858 243 dbSNP
rs1198338202 244 dbSNP
rs1295840807 245 dbSNP
rs1456105194 249 dbSNP
rs1411761005 252 dbSNP
rs1160284565 253 dbSNP
rs1031015369 255 dbSNP
rs34505186 258 dbSNP
rs1293356702 263 dbSNP
rs1408038461 264 dbSNP
rs1422943370 266 dbSNP
rs1162239490 268 dbSNP
rs1351197260 269 dbSNP
rs1461770920 272 dbSNP
rs777965708 276 dbSNP
rs1398052556 279 dbSNP
rs753212971 280 dbSNP
rs1355225766 282 dbSNP
rs1282199867 283 dbSNP
rs756547432 289 dbSNP
rs1332175702 292 dbSNP
rs1341021759 302 dbSNP
rs1277545525 310 dbSNP
rs1398098802 319 dbSNP
rs868678203 320 dbSNP
rs540253458 321 dbSNP
rs1324292239 324 dbSNP
rs1404968877 325 dbSNP
rs1226621129 331 dbSNP
rs1269555781 339 dbSNP
rs1315117371 341 dbSNP
rs753129138 354 dbSNP
rs1256539666 355 dbSNP
rs1459513941 356 dbSNP
rs1169972835 358 dbSNP
rs1466511340 362 dbSNP
rs1179539029 364 dbSNP
rs1482649192 364 dbSNP
rs1423380566 365 dbSNP
rs768139716 372 dbSNP
rs1019606778 374 dbSNP
rs1007564051 376 dbSNP
rs1169757823 376 dbSNP
rs1481707669 377 dbSNP
rs1247888698 378 dbSNP
rs1463444005 378 dbSNP
rs755550595 381 dbSNP
rs1450682892 388 dbSNP
rs1003171656 390 dbSNP
rs1197312655 392 dbSNP
rs995647026 394 dbSNP
rs1232035209 397 dbSNP
rs569049614 399 dbSNP
rs113453651 401 dbSNP
rs1347340836 402 dbSNP
rs765468183 404 dbSNP
rs1435895106 405 dbSNP
rs1320427358 407 dbSNP
rs1219562990 411 dbSNP
rs1329537479 420 dbSNP
rs1331076717 423 dbSNP
rs1278537600 426 dbSNP
rs1005407973 430 dbSNP
rs1399936693 431 dbSNP
rs1169000557 432 dbSNP
rs1037213270 435 dbSNP
rs888306992 436 dbSNP
rs1046920054 437 dbSNP
rs1477438320 439 dbSNP
rs1244501682 447 dbSNP
rs558196108 459 dbSNP
rs929914707 465 dbSNP
rs1457955406 467 dbSNP
rs1237285730 469 dbSNP
rs544789281 470 dbSNP
rs1313880627 475 dbSNP
rs762655562 477 dbSNP
rs879092287 480 dbSNP
rs772959000 487 dbSNP
rs938442344 488 dbSNP
rs575789460 497 dbSNP
rs1241085077 499 dbSNP
rs555937594 502 dbSNP
rs755318470 504 dbSNP
rs1044033344 506 dbSNP
rs1360237275 509 dbSNP
rs1419387181 515 dbSNP
rs986153534 518 dbSNP
rs946783224 520 dbSNP
rs1296601081 527 dbSNP
rs948640503 533 dbSNP
rs35591142 534 dbSNP
rs914465239 534 dbSNP
rs1274582488 539 dbSNP
rs1366178707 542 dbSNP
rs759927899 544 dbSNP
rs989953798 552 dbSNP
rs955900463 563 dbSNP
rs1215178232 572 dbSNP
rs988260286 574 dbSNP
rs1193691311 575 dbSNP
rs956991563 578 dbSNP
rs1477036578 579 dbSNP
rs535534639 580 dbSNP
rs1006870169 581 dbSNP
rs1020037998 581 dbSNP
rs965459836 581 dbSNP
rs1362717893 582 dbSNP
rs1389835059 586 dbSNP
rs1401483165 588 dbSNP
rs954292590 604 dbSNP
rs1348496683 612 dbSNP
rs1439292346 620 dbSNP
rs1291203650 621 dbSNP
rs1376759277 621 dbSNP
rs566648350 623 dbSNP
rs982198819 624 dbSNP
rs550642796 627 dbSNP
rs1023704861 628 dbSNP
rs1005336417 629 dbSNP
rs1288945875 630 dbSNP
rs1449663226 633 dbSNP
rs1223417704 636 dbSNP
rs1253583700 639 dbSNP
rs866877827 643 dbSNP
rs897367098 644 dbSNP
rs1055220 645 dbSNP
rs1382217404 646 dbSNP
rs1003043477 649 dbSNP
rs3837965 651 dbSNP
rs113527058 652 dbSNP
rs1407468229 652 dbSNP
rs200723466 653 dbSNP
rs1400274572 659 dbSNP
rs1328767314 661 dbSNP
rs1347439343 661 dbSNP
rs796384776 661 dbSNP
rs906911089 661 dbSNP
rs1186453924 662 dbSNP
rs1283243802 667 dbSNP
rs1353777083 677 dbSNP
rs1234933435 687 dbSNP
rs756644480 688 dbSNP
rs888190652 688 dbSNP
rs761105669 689 dbSNP
rs867417748 691 dbSNP
rs1196671968 694 dbSNP
rs1240166912 696 dbSNP
rs66796860 698 dbSNP
rs1262157171 701 dbSNP
rs1188260712 704 dbSNP
rs993964842 714 dbSNP
rs901090536 717 dbSNP
rs914224538 720 dbSNP
rs1040937004 723 dbSNP
rs934574375 730 dbSNP
rs1464570895 731 dbSNP
rs1173468732 738 dbSNP
rs924471122 739 dbSNP
rs1391499241 747 dbSNP
rs1332880902 749 dbSNP
rs975904585 750 dbSNP
rs1293752831 751 dbSNP
rs1317058163 754 dbSNP
rs1216509238 758 dbSNP
rs1253012696 759 dbSNP
rs944141202 761 dbSNP
rs1199990433 762 dbSNP
rs944720993 764 dbSNP
rs1486813602 767 dbSNP
rs1211629260 769 dbSNP
rs889146240 770 dbSNP
rs1050372383 771 dbSNP
rs1196253453 771 dbSNP
rs200723937 771 dbSNP
rs1465963112 775 dbSNP
rs1171529339 778 dbSNP
rs768113545 785 dbSNP
rs954051441 787 dbSNP
rs1026984906 789 dbSNP
rs915323634 790 dbSNP
rs1272835905 799 dbSNP
rs1227927111 807 dbSNP
rs988276261 813 dbSNP
rs1232432674 815 dbSNP
rs866459353 833 dbSNP
rs1298139485 834 dbSNP
rs1211599104 839 dbSNP
rs1016179097 853 dbSNP
rs1285612738 857 dbSNP
rs1003019363 877 dbSNP
rs551431253 879 dbSNP
rs982410083 880 dbSNP
rs775032736 881 dbSNP
rs1012600124 882 dbSNP
rs1197354983 884 dbSNP
rs1364364543 887 dbSNP
rs1455196126 889 dbSNP
rs1173673660 895 dbSNP
rs1359557421 901 dbSNP
rs1301765613 904 dbSNP
rs892840600 905 dbSNP
rs1434727045 910 dbSNP
rs1385379968 916 dbSNP
rs531520842 917 dbSNP
rs183402192 923 dbSNP
rs934584165 924 dbSNP
rs1428686342 927 dbSNP
rs15361 937 dbSNP
rs549163933 941 dbSNP
rs1172216861 944 dbSNP
rs1422011987 945 dbSNP
rs528968245 946 dbSNP
rs140934505 948 dbSNP
rs1025362856 950 dbSNP
rs1488367996 950 dbSNP
rs1208366241 952 dbSNP
rs1188562675 957 dbSNP
rs1255477480 957 dbSNP
rs71352286 958 dbSNP
rs540213698 962 dbSNP
rs1193762169 971 dbSNP
rs1379147002 971 dbSNP
rs533006648 971 dbSNP
rs1249683422 972 dbSNP
rs1160853118 975 dbSNP
rs564792107 977 dbSNP
rs1204754086 979 dbSNP
rs944586359 982 dbSNP
rs544537639 993 dbSNP
rs994012420 1000 dbSNP
rs575900023 1001 dbSNP
rs1374749727 1003 dbSNP
rs1019847107 1008 dbSNP
rs1225481727 1018 dbSNP
rs919932431 1019 dbSNP
rs146533549 1025 dbSNP
rs1243099328 1027 dbSNP
rs1275403210 1034 dbSNP
rs750513842 1046 dbSNP
rs1198554823 1055 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124A_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + A ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cuUUAGAGAUGUCUUCGGGGuau 5'
            || || |   |||||||:   
Target 5' uaAAGCUGU---GAAGCCCUu-- 3'
1 - 18
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_124A_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + A
Location of target site ENST00000317683.3 | 3UTR | UAAAGCUGUGAAGCCCUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
32 hsa-miR-3675-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT366903 NONO non-POU domain containing octamer binding 2 2
MIRT453894 DUSP18 dual specificity phosphatase 18 2 2
MIRT461725 ZNF426 zinc finger protein 426 2 2
MIRT464694 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465957 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466038 TMEM189 transmembrane protein 189 2 2
MIRT471546 PAX5 paired box 5 2 2
MIRT472813 MTMR12 myotubularin related protein 12 2 2
MIRT474099 LMBR1L limb development membrane protein 1 like 2 2
MIRT480205 CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 2 2
MIRT488268 HSP90AB1 heat shock protein 90 alpha family class B member 1 2 8
MIRT491222 MRPL34 mitochondrial ribosomal protein L34 2 2
MIRT494768 AP1G1 adaptor related protein complex 1 gamma 1 subunit 2 2
MIRT497228 MORC2 MORC family CW-type zinc finger 2 2 2
MIRT501676 PFN1 profilin 1 2 6
MIRT511831 H2AFX H2A histone family member X 2 4
MIRT513880 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 2 4
MIRT519402 DNASE2 deoxyribonuclease 2, lysosomal 2 4
MIRT522627 MAP7D1 MAP7 domain containing 1 2 4
MIRT546998 PPP2CA protein phosphatase 2 catalytic subunit alpha 2 2
MIRT555119 PUM2 pumilio RNA binding family member 2 2 2
MIRT560380 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT572188 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT634822 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT641149 DNMBP dynamin binding protein 2 2
MIRT647389 ZNF616 zinc finger protein 616 2 2
MIRT670851 SFT2D2 SFT2 domain containing 2 2 2
MIRT698600 TEX261 testis expressed 261 2 2
MIRT698691 TBPL1 TATA-box binding protein like 1 2 2
MIRT708725 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT718340 SYNDIG1L synapse differentiation inducing 1 like 2 2
MIRT725514 FBXO46 F-box protein 46 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3675 Doxorubicin 31703 NSC123127 approved sensitive High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-miR-3675-5p Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)
hsa-miR-3675-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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