miRTarBase - #MIRT732643


—
pre-miRNA Information
pre-miRNA mmu-mir-351   
Genomic Coordinates chrX: 53053255 - 53053353
Synonyms Mirn351, mmu-mir-351, Mir351
Description Mus musculus miR-351 stem-loop
Comment The predominant miRNA cloned by Langraf et al. has a 3' terminal U residue, which is incompatible with the genome sequence .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA mmu-miR-351-5p
Sequence 16| UCCCUGAGGAGCCCUUUGAGCCUG |39
Evidence Experimental
Experiments Cloned
Putative Targets

Gene Information
Gene Symbol F8   
Synonyms Cf-8, Cf8, FVIII
Description coagulation factor VIII
Transcript NM_001161373   
Other Transcripts NM_001161374 , NM_007977   
Expression
Putative miRNA Targets on F8
3'UTR of F8
(miRNA target sites are highlighted)		 
>F8|NM_001161373|3'UTR
   1 GGTAGCCTCTGCATCACCTGCTTATTCCCCTTCCTCAGCTCAAAGATTGTCTTAATGTTTTATTGCTGTGAAGAGACACT
  81 ATGACCATGGCAACTCTTATAAAATAAAGCATTTAATCAGGGCTTACTTATAGTTTAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' guccgaGUUUCCCGAG-GAGUCCCu 5'
                :||||  :|:  |||||| 
Target 5' ataaaaTAAAGCATTTAATCAGGGc 3'
 99 - 123 122.00 -12.20
2 
miRNA  3' gucCGAGUUUCCCG-AGGAGUCccu 5'
             |||:|     | |||||||   
Target 5' cctGCTTATTCCCCTTCCTCAGctc 3'
 17 - 41 113.00 -13.92
3 
miRNA  3' gucCGAGUUUCCCGAGGAGUCCCU----- 5'
             ||||||||  : :||:|  |      
Target 5' tcaGCTCAAAGATTGTCTTAATGTTTTAT 3'
 35 - 63 77.00 -14.64
22 mmu-miR-351-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT005493 Tnf tumor necrosis factor 3 1
MIRT005494 Siah2 seven in absentia 2 3 1
MIRT054029 E2f3 E2F transcription factor 3 4 1
MIRT580229 Tspan12 tetraspanin 12 1 1
MIRT580251 Trim71 tripartite motif-containing 71 1 1
MIRT582369 Mtf1 metal response element binding transcription factor 1 1 1
MIRT582453 Mgat4a mannoside acetylglucosaminyltransferase 4, isoenzyme A 1 1
MIRT584883 Antxr2 anthrax toxin receptor 2 1 1
MIRT587194 Foxk1 forkhead box K1 1 1
MIRT588849 Snrnp40 small nuclear ribonucleoprotein 40 (U5) 1 1
MIRT591277 Lars2 leucyl-tRNA synthetase, mitochondrial 1 2
MIRT592913 Madd MAP-kinase activating death domain 1 1
MIRT594892 Il1rn interleukin 1 receptor antagonist 1 2
MIRT596428 Hif1an hypoxia-inducible factor 1, alpha subunit inhibitor 1 1
MIRT599144 Dqx1 DEAQ RNA-dependent ATPase 1 1
MIRT599715 Aph1c aph1 homolog C, gamma secretase subunit 1 1
MIRT600831 Gm14137 predicted gene 14137 1 1
MIRT604900 Jmy junction-mediating and regulatory protein 1 1
MIRT605442 Stat1 signal transducer and activator of transcription 1 1 1
MIRT606093 Wdr25 WD repeat domain 25 1 1
MIRT732643 F8 coagulation factor VIII 3 0
MIRT734828 Sox11 SRY (sex determining region Y)-box 11 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-351 Nicotine approved 89594 Microarray Rat adrenal pheochromocytoma PC12 cell 18845019 2009 up-regulated
miR-351 Longevinex NULL NULL Quantitative real-time PCR ischemia/reperfusion [I/R] rat model 21203465 2011 up-regulated
miR-351 Longevinex NULL NULL Quantitative real-time PCR normal heart 21203465 2011 up-regulated
miR-351 Resveratrol NULL 445154 Quantitative real-time PCR ischemia/reperfusion [I/R] rat model 21203465 2011 up-regulated
miR-351 Resveratrol NULL 445154 Quantitative real-time PCR normal heart 21203465 2011 up-regulated
miR-351 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) NULL 16078949 Microarray hepatocytes 23107762 2013 up-regulated

Error report submission