pre-miRNA Information
pre-miRNA hsa-mir-378g   
Genomic Coordinates chr1: 94745860 - 94745900
Description Homo sapiens miR-378g stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-378g
Sequence 2| ACUGGGCUUGGAGUCAGAAG |21
Evidence Experimental
Experiments Illumina
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CHI3L1   
Synonyms ASRT7, CGP-39, GP-39, GP39, HC-gp39, HCGP-3P, YKL-40, YKL40, YYL-40, hCGP-39
Description chitinase 3 like 1
Transcript NM_001276   
Expression
Putative miRNA Targets on CHI3L1
3'UTR of CHI3L1
(miRNA target sites are highlighted)
>CHI3L1|NM_001276|3'UTR
   1 CCCTCTGTTCTGCACACAGCACGGGGGCCAAGGATGCCCCGTCCCCCTCTGGCTCCAGCTGGCCGGGAGCCTGATCACCT
  81 GCCCTGCTGAGTCCCAGGCTGAGCCTCAGTCTCCCTCCCTTGGGGCCTATGCAGAGGTCCACAACACACAGATTTGAGCT
 161 CAGCCCTGGTGGGCAGAGAGGTAGGGATGGGGCTGTGGGGATAGTGAGGCATCGCAATGTAAGACTCGGGATTAGTACAC
 241 ACTTGTTGATTAATGGAAATGTTTACAGATCCCCAAGCCTGGCAAGGGAATTTCTTCAACTCCCTGCCCCCCAGCCCTCC
 321 TTATCAAAGGACACCATTTTGGCAAGCTCTATCACCAAGGAGCCAAACATCCTACAAGACACAGTGACCATACTAATTAT
 401 ACCCCCTGCAAAGCCCAGCTTGAAACCTTCACTTAGGAACGTAATCGTGTCCCCTATCCTACTTCCCCTTCCTAATTCCA
 481 CAGCTGCTCAATAAAGTACAAGAGCTTAACAGTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaaGACUGAGGUUCGGGUCa 5'
             |||   | |||||||| 
Target 5' cccCTG---CAAAGCCCAGc 3'
403 - 419 150.00 -14.60
2
miRNA  3' gaaGACUGAGGUUCGGGUCa 5'
             | || |:::|||:||| 
Target 5' acaCAGA-TTTGAGCTCAGc 3'
146 - 164 136.00 -11.30
3
miRNA  3' gaaGACU-GAGGUUCGGGUCa 5'
             | || | |||||||::| 
Target 5' ttaCAGATCCCCAAGCCTGGc 3'
263 - 283 129.00 -15.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30163018 10 COSMIC
COSN15796898 23 COSMIC
COSN26970640 23 COSMIC
COSN13508729 41 COSMIC
COSN31493826 42 COSMIC
COSN31500965 53 COSMIC
COSN30147340 55 COSMIC
COSN13508728 64 COSMIC
COSN30179874 65 COSMIC
COSN31519074 65 COSMIC
COSN30179820 66 COSMIC
COSN30500777 69 COSMIC
COSN31498830 95 COSMIC
COSN30518377 130 COSMIC
COSN30125599 149 COSMIC
COSN27666934 163 COSMIC
COSN30191306 169 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs763588973 1 dbSNP
rs943974779 7 dbSNP
rs746966964 8 dbSNP
rs911106440 8 dbSNP
rs780027741 11 dbSNP
rs376775749 15 dbSNP
rs200560076 22 dbSNP
rs202080664 23 dbSNP
rs758194056 25 dbSNP
rs1283284954 26 dbSNP
rs1301318330 30 dbSNP
rs1224064191 32 dbSNP
rs914557015 35 dbSNP
rs777003925 36 dbSNP
rs771065423 38 dbSNP
rs1344929090 39 dbSNP
rs747254602 40 dbSNP
rs370300790 41 dbSNP
rs749279657 45 dbSNP
rs377080511 46 dbSNP
rs756069288 47 dbSNP
rs745661413 51 dbSNP
rs1003019596 52 dbSNP
rs1288678356 55 dbSNP
rs1485166382 57 dbSNP
rs776842010 64 dbSNP
rs888073208 65 dbSNP
rs970312333 72 dbSNP
rs771350243 78 dbSNP
rs1302457863 98 dbSNP
rs1424799640 101 dbSNP
rs993848223 106 dbSNP
rs1160208822 111 dbSNP
rs895583061 113 dbSNP
rs1156260144 114 dbSNP
rs367743236 119 dbSNP
rs1452632431 121 dbSNP
rs1057478544 122 dbSNP
rs1006881968 124 dbSNP
rs55768323 127 dbSNP
rs1473776150 130 dbSNP
rs184965874 136 dbSNP
rs888152437 155 dbSNP
rs1043368621 156 dbSNP
rs947622493 161 dbSNP
rs1315541268 164 dbSNP
rs1266550566 168 dbSNP
rs1489792295 169 dbSNP
rs1267453774 171 dbSNP
rs1048521804 181 dbSNP
rs913202897 191 dbSNP
rs1440515655 192 dbSNP
rs1180774901 195 dbSNP
rs1378194547 198 dbSNP
rs988824824 200 dbSNP
rs78428658 201 dbSNP
rs1199305033 205 dbSNP
rs1452296268 207 dbSNP
rs1351545044 209 dbSNP
rs868403592 210 dbSNP
rs12408583 213 dbSNP
rs77111685 214 dbSNP
rs1350246734 223 dbSNP
rs943837653 228 dbSNP
rs1313955902 229 dbSNP
rs1324005678 231 dbSNP
rs192635263 233 dbSNP
rs1272578831 236 dbSNP
rs1049707590 238 dbSNP
rs1231404854 243 dbSNP
rs1282605415 253 dbSNP
rs1025238486 255 dbSNP
rs1474167736 256 dbSNP
rs993815624 260 dbSNP
rs1423665735 261 dbSNP
rs895539958 264 dbSNP
rs1167996468 267 dbSNP
rs1353544511 272 dbSNP
rs1315624981 273 dbSNP
rs567550831 276 dbSNP
rs905993607 278 dbSNP
rs141536984 279 dbSNP
rs989201520 280 dbSNP
rs1427605916 282 dbSNP
rs892072752 289 dbSNP
rs1049451 294 dbSNP
rs533698461 299 dbSNP
rs571121302 302 dbSNP
rs923348112 306 dbSNP
rs552222824 307 dbSNP
rs1187068579 308 dbSNP
rs1446486261 310 dbSNP
rs970252131 311 dbSNP
rs1049452 312 dbSNP
rs540660421 313 dbSNP
rs1418217303 314 dbSNP
rs1414640970 319 dbSNP
rs1177814347 349 dbSNP
rs1377590326 364 dbSNP
rs79819896 371 dbSNP
rs1006500880 387 dbSNP
rs1341669808 400 dbSNP
rs1402456222 402 dbSNP
rs952376641 403 dbSNP
rs114943381 405 dbSNP
rs1219986133 407 dbSNP
rs769420439 407 dbSNP
rs1281015154 414 dbSNP
rs1025543021 419 dbSNP
rs1209871356 422 dbSNP
rs866568105 432 dbSNP
rs1286531900 437 dbSNP
rs550138054 440 dbSNP
rs1219527174 441 dbSNP
rs1190974208 445 dbSNP
rs372580019 446 dbSNP
rs1268337538 452 dbSNP
rs530085748 453 dbSNP
rs376137032 462 dbSNP
rs959775713 466 dbSNP
rs1322187902 486 dbSNP
rs1453485085 491 dbSNP
rs796227676 496 dbSNP
rs1361623751 499 dbSNP
rs1402916345 501 dbSNP
rs1019281955 503 dbSNP
rs1316871213 505 dbSNP
rs112644498 515 dbSNP
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
68 hsa-miR-378g Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT444739 SMYD1 SET and MYND domain containing 1 2 2
MIRT456104 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT458683 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT465802 TMEM91 transmembrane protein 91 2 2
MIRT470843 PLXND1 plexin D1 2 2
MIRT497263 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT497674 SYNGR1 synaptogyrin 1 2 2
MIRT498218 TLN2 talin 2 2 2
MIRT498309 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT504046 TOMM5 translocase of outer mitochondrial membrane 5 2 2
MIRT518196 CLEC4E C-type lectin domain family 4 member E 2 2
MIRT533143 WNT10A Wnt family member 10A 2 2
MIRT533540 TPR translocated promoter region, nuclear basket protein 2 2
MIRT533679 TMEM86A transmembrane protein 86A 2 2
MIRT540892 SRSF9 serine and arginine rich splicing factor 9 2 2
MIRT541329 G3BP1 G3BP stress granule assembly factor 1 2 2
MIRT541850 PLIN5 perilipin 5 2 2
MIRT551431 F2 coagulation factor II, thrombin 2 2
MIRT552105 PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 2 2
MIRT564912 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT568605 ACVR2A activin A receptor type 2A 2 2
MIRT572604 PAPLN papilin, proteoglycan like sulfated glycoprotein 2 2
MIRT574234 DMRT2 doublesex and mab-3 related transcription factor 2 2 2
MIRT575688 Map1b microtubule-associated protein 1B 2 2
MIRT576643 Mill2 MHC I like leukocyte 2 1 1
MIRT609877 RAD54L2 RAD54 like 2 2 4
MIRT610057 MYBPC1 myosin binding protein C, slow type 2 2
MIRT610791 KLK2 kallikrein related peptidase 2 2 2
MIRT617175 GOSR2 golgi SNAP receptor complex member 2 2 2
MIRT617707 RUSC2 RUN and SH3 domain containing 2 2 2
MIRT620577 WBSCR27 methyltransferase like 27 2 4
MIRT622657 POU2F3 POU class 2 homeobox 3 2 4
MIRT624561 BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 2 2
MIRT634255 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT634677 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT635254 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT637081 SELPLG selectin P ligand 2 2
MIRT639021 AAK1 AP2 associated kinase 1 2 2
MIRT640396 ZNF785 zinc finger protein 785 2 2
MIRT642441 CLUAP1 clusterin associated protein 1 2 2
MIRT645666 ADK adenosine kinase 2 2
MIRT646083 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT650513 UFM1 ubiquitin fold modifier 1 2 2
MIRT652474 TMEM181 transmembrane protein 181 2 2
MIRT652584 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT654763 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 2
MIRT655200 PHAX phosphorylated adaptor for RNA export 2 2
MIRT658353 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT661820 PRPSAP1 phosphoribosyl pyrophosphate synthetase associated protein 1 2 2
MIRT662190 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT664375 CYB5A cytochrome b5 type A 2 2
MIRT665025 ELK1 ELK1, ETS transcription factor 2 2
MIRT666492 SBNO1 strawberry notch homolog 1 2 2
MIRT668480 EXOSC2 exosome component 2 2 2
MIRT682768 TMEM120B transmembrane protein 120B 2 2
MIRT689628 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT691846 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT696490 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT712480 FSTL3 follistatin like 3 2 2
MIRT712780 ZNF154 zinc finger protein 154 2 2
MIRT716607 MPPED1 metallophosphoesterase domain containing 1 2 2
MIRT719357 ITPKB inositol-trisphosphate 3-kinase B 2 2
MIRT719739 SLC39A11 solute carrier family 39 member 11 2 2
MIRT722569 C1orf95 stum, mechanosensory transduction mediator homolog 2 2
MIRT722838 C17orf102 chromosome 17 open reading frame 102 2 2
MIRT733138 LINC00963 long intergenic non-protein coding RNA 963 3 0
MIRT733139 CHI3L1 chitinase 3 like 1 3 0
MIRT736944 TARBP2 TARBP2, RISC loading complex RNA binding subunit 2 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-378g Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378g Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-378g Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-378g Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-378g Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (500nM)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (500nM)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (2uM)
hsa-miR-378g Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (2uM)
hsa-miR-378g Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-378g Trametinib 11707110 NSC758246 approved sensitive High Melanoma cell line
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line
hsa-miR-378g Dabrafenib + Trametinib sensitive High Melanoma cell line
hsa-miR-378g Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line
hsa-mir-378g Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-378g Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-378g Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-378g Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-378g Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-378g Tripterygium wilfordii Hook F resistant tissue
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM36)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-378g Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-378g Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-378g Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-378g Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-378g Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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