pre-miRNA Information
pre-miRNA mmu-mir-30a   
Genomic Coordinates chr1: 23272269 - 23272339
Synonyms Mirn30a, mmu-mir-30a, Mir30a
Description Mus musculus miR-30a stem-loop
Comment Landgraf et al. confirm that the 5' mature miRNA product is the predominant one .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA mmu-miR-30a-5p
Sequence 6| UGUAAACAUCCUCGACUGGAAG |27
Evidence Experimental
Experiments Cloned
Putative Targets

Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BJYS06 miR-30a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma MiRNA microarray; RT-PCR
BGDM03 miR-30a-5p Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Urine Real-time polymerase chain reaction
Gene Information
Gene Symbol Gfra1   
Synonyms AU042498
Description glial cell line derived neurotrophic factor family receptor alpha 1
Transcript NM_010279   
Expression
Putative miRNA Targets on Gfra1
3'UTR of Gfra1
(miRNA target sites are highlighted)
>Gfra1|NM_010279|3'UTR
   1 CTGCATCCAGTATGAAAAGACAAAAGAAAACCAAGTATTCTGTCCCCTGTCCTCTTGTATATCTGAAAATCCAGTTTTAA
  81 AAGCTCGGTTGAGAAGCAGTTTCACCCAGCGGGAACTCCTTTGTTGTTTTTAAGAAAGCTTTTTGCCGCCCTCACAGGCT
 161 TCTGTTGAAGAACTGCTACAGGGCTAATTCCAAACTCAGAAAACTCTGGGGCATGGTGTGGCTTCAGGGGACTGTTTGTA
 241 ACCTGGACTGTAAAGCAAGCTGAGCTTATGTTTTTGATGGTGATGGTGGTGGTGATGATGAAGATGATAGTTTTAACAGC
 321 TTGAACCCTGTTCTCTCTACTGGCTAGGAGGAGGAGATGCTATTGATAGAGATTCTTCCGGATCTTATTTAATAGCGTTG
 401 GATTCTAAAGACATGACTGCAGCCTAGTGTGGATGGATGACAATTGGGGGTTGGCCTCAAGAGTGGACTTTGCAGACTCT
 481 ATCTTGTACTAACGTTCACCGTTCTATGTATGCTCTCCACAGAGTGTTTATGTGATCCCCAACAAAACAAAAAAGTCCCT
 561 GGTCACATCCAGATGTAGAAGCTACCATTTAGCCCAGTAGAGGAGAGTGGGTGTGGTCCTTGCACAGCACCCGGGATTGT
 641 TCACTGGTGCGCTCTCCTGAGCTTTGCTTGAGTGAGAAGCTGAATGTAGCTGAAGATCAACTCTTACCACTTCTTACACT
 721 TACGAGGTCACATGTAGAACAAGCATTACCAACTGTCAGCTCTCCAACTGTTAGCTTTCTACATTTTGAAGGCAGCGATA
 801 CCGGTCCCATGTTTTAATGATGGTTTAATACACACAGCCCTTGCCCCTCATCAGTAATACTAGCTCCAGCATCAACTTCA
 881 TGCATATGGCTCTCATTAAAAGCAGGCCCCCAAGAAGCCCAGTGCTTTAGCAGAAAGCCACATCACATTTCTGTGGACAG
 961 GCAGGATGAAATAGAGCAGCCAGCCCATGTCTCATCTGTCTTGAGATCAAGGCTGCCTATATGTAAGGAATGGTTAGATA
1041 CTTGTAAAGGGTGCCACAGTAGACAGCGCTTCTGGCAGTTGATATAGCCCCAGTACATGGGTTTTCATGTTGTCTGGCAG
1121 AGACAGCTTGGATTAGGACTGGCTGGGATGGAGATATGCTGCCCTCTCTTTCACAGTTGAGTCCTGCCAGGGCACATGGA
1201 AGTTTCTTTGCTTTTGACCACAACTTAGAACAGTTTGGATTCAAGGTCACCAAGTATCTCCTGTATTTTGCTCTGTGTCC
1281 TTCATGACAGACTGTCACACACAAAAGGAATGGTAGGTTATGGATCTAGAGGGCCAGCACAGGGTCTGGGAAGGTGAACT
1361 GAATGGCACAAGTACACAGAGCAGGAGGGGACGCTCGAGAAAAGACACACACACCATCTCCTGGAGCCCTCCTCCTTGCC
1441 TGGGCAGACCCTTAGGCATATATCTAAAGACTGCTTTACATGGTCAGGCTCAGAATTTGTTAATGGTTGCGTACTGGCAA
1521 CCATGTTTCCTGCAAAGTGAATAAGGGGGGGGGGGGAGAATCTTCCTTCCCTTGAGCCCTAGAAGTATGATCTGGCCCCT
1601 CACCCTCCCACAGAGCAGGGAGCCCTGGTGCACGGTCTCCTGATACCCGCTCTGCTCTCTGAGGTTTGCCTTTGGGATAA
1681 TAAATAACGATTCACCTGGGAGGGACTCCTCTGGTGTCTGAAGTGCATTTATATTGAAATGTTTTTGAATAACAATGTAA
1761 AATACTCAGTAGCAACCTCTTTTTCCCCTTCACAATGTTTTTGAGGGGAATGCATCCAACATCCAAGTGTACCTGATCAG
1841 TGGGACGTTCCATGAAGACTCATACATTGAATAAACATATTCGATGTGTCGGAACAGAATGGCGGTCATGAATGGGAACA
1921 TAATCTCTTACTGATCATATTTTCGTTTTAATTAAGATATATACATATATCTCCACTGCACTAATTTCATAAGGGTCTGA
2001 TTGGATGTGATCCGCCATAGGAGGCTATTGATTACCTCTGCAGTATAATGCAGCTGTCATTAGCTTCAGAGGGTCAGAGA
2081 GGAAACAGGAGCCCTGTGCTAACAAGGGGACTTCAGCAAGAACTCGTAGATAGGCAACATACAAATTAAACTTTGAAGAG
2161 CACTGTCACCAGTAAAAATTGCATTTTCCTTTAGAGATAAAAGCGACTGAGAGTTACCAAATCCTCGATTTGAAAACAAG
2241 TTGCTGATGAAATAAAATAGTGAGAAGGACCCCATTTAGGGACATGTCAGAGATGGCTACAAAACCAAGGCAAGCATATA
2321 GGTCTTCCATTTGCTGTGGCCTCCTCGACAAAGCGCTTGCTTCATCTCAAGACTAGAACAGGGAAACTTGGCCATCTGTT
2401 ATGCACTCGACTTCCTCTTGGAGCGCCGCCCATGAGCGGAAGTGATTCCCTGCTTTCCCTGGTCAGAGACAGTTTTCGTC
2481 TGCTGAGGTTGGGTTCCTTACAGAAAGTCCTTTGCGAAGTTGATTTTACTGACAGTTGCGTCCACACAGTGACTCGGAAT
2561 CCAGCCTACGTCGGGGAGAGACAAAGGTGATGGAGCCACTTTGAGCAGAAGCACATTCATTCTGTTTGACCTTGAATGTC
2641 CTTGAGAAGATGGAGTTTGAGAGTCTTTTTAAGAGAGCACACGAGAGGACAAGTGCACAACACAGAGGGAATTTGGAATG
2721 CTGGCTGTTTATATTTCCACATCTGATTTTTTTCCAAACCTCAAATAAAAAAAATATAGACATTAAAGATGGCATAGGTT
2801 ATTTTTCAAC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaAGGUCAGCUCCUACAAAUGu 5'
            ||||  | || :||||||: 
Target 5' tcTCCA--C-AGAGTGTTTATg 3'
514 - 532 139.00 -9.00
2
miRNA  3' gaaggucagcuCCUACAAAUGu 5'
                     || ||||||: 
Target 5' tttggaatgctGGCTGTTTATa 3'
2712 - 2733 131.00 -7.90
3
miRNA  3' gaAGGUCAGCUCCU-ACAAAUGu 5'
            |:||   |:||| |||||:: 
Target 5' gcTTCA---GGGGACTGTTTGTa 3'
221 - 240 125.00 -15.20
57 mmu-miR-30a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT003714 Ak1 adenylate kinase 1 4 1
MIRT003715 Tnrc6a trinucleotide repeat containing 6a 4 1
MIRT003716 Abcb1b ATP-binding cassette, sub-family B (MDR/TAP), member 1B 3 1
MIRT003717 Inhba inhibin beta-A 3 1
MIRT003718 Egfr epidermal growth factor receptor 4 2
MIRT004770 Bdnf brain derived neurotrophic factor 5 2
MIRT007045 Snai1 snail family zinc finger 1 2 1
MIRT054524 Ccne2 cyclin E2 2 1
MIRT054525 Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 2 1
MIRT054526 Mdm2 transformed mouse 3T3 cell double minute 2 2 1
MIRT054527 Mtdh metadherin 3 2
MIRT054528 Smad1 SMAD family member 1 2 1
MIRT054529 Twf1 twinfilin actin binding protein 1 2 1
MIRT054530 Timp3 tissue inhibitor of metalloproteinase 3 2 1
MIRT577999 Pgr progesterone receptor 1 1
MIRT578189 Narg2 interactor of little elongation complex ELL subunit 2 1 1
MIRT578280 Mesdc2 mesoderm development LRP chaperone 1 1
MIRT578462 Ints12 integrator complex subunit 12 1 1
MIRT578487 Il18r1 interleukin 18 receptor 1 1 2
MIRT580036 Wdr89 WD repeat domain 89 1 3
MIRT580042 Wdr44 WD repeat domain 44 1 1
MIRT580299 Tomm70a translocase of outer mitochondrial membrane 70 homolog A (yeast) 1 1
MIRT581001 Six4 sine oculis-related homeobox 4 1 1
MIRT581268 Rrad Ras-related associated with diabetes 1 1
MIRT582213 Nfatc3 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 1 1
MIRT582448 Mgea5 meningioma expressed antigen 5 (hyaluronidase) 1 1
MIRT583057 Hoxb3 homeobox B3 1 1
MIRT583627 Strip1 striatin interacting protein 1 1 1
MIRT583684 Amer1 APC membrane recruitment 1 1 1
MIRT583926 Dpy19l1 dpy-19-like 1 (C. elegans) 1 1
MIRT584694 Cep170b centrosomal protein 170B 1 3
MIRT585022 Gskip GSK3B interacting protein 1 1
MIRT585237 Zfp446 zinc finger protein 446 1 1
MIRT586099 Reep4 receptor accessory protein 4 1 2
MIRT587711 Cd300a CD300A molecule 1 2
MIRT588338 Zfp711 zinc finger protein 711 1 1
MIRT588632 Tnrc6b trinucleotide repeat containing 6b 1 3
MIRT589298 Pigh phosphatidylinositol glycan anchor biosynthesis, class H 1 1
MIRT590161 Eno2 enolase 2, gamma neuronal 1 1
MIRT592638 Lpar3 lysophosphatidic acid receptor 3 1 2
MIRT593645 Tbc1d5 TBC1 domain family, member 5 1 1
MIRT595042 Camk4 calcium/calmodulin-dependent protein kinase IV 1 1
MIRT595217 Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 1 1
MIRT595451 Ptrhd1 peptidyl-tRNA hydrolase domain containing 1 1 1
MIRT595826 Fam227a family with sequence similarity 227, member A 1 1
MIRT596025 Cdk13 cyclin-dependent kinase 13 1 1
MIRT596356 Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 1 1
MIRT596419 Ing1 inhibitor of growth family, member 1 1 1
MIRT596513 Zfp9 zinc finger protein 9 1 1
MIRT599308 Csf1 colony stimulating factor 1 (macrophage) 1 1
MIRT603175 Trp53rk transformation related protein 53 regulating kinase B 1 1
MIRT731329 IL21R interleukin 21 receptor 1 1
MIRT733494 Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 1 0
MIRT735519 SOCS1 suppressor of cytokine signaling 1 2 0
MIRT755305 Runx2 runt related transcription factor 2 2 1
MIRT755548 SOCS3 suppressor of cytokine signaling 3 3 1
MIRT755880 NCAM1 neural cell adhesion molecule 1 1 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-30a Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-30a Polylysine NULL 162282 Quantitative real-time PCR 293T(FLAG AGO2) cells 20529860 2010 down-regulated
miR-30a Trypaflavine NULL NULL Quantitative real-time PCR 293T(FLAG AGO2) cells 20529860 2010 down-regulated
miR-30a Arsenic trioxide approved 14888 Microarray HepG-2 human hepatocellular carcinoma cell line 21175813 2011 up-regulated
miR-30a Arsenic trioxide approved 14888 Quantitative real-time PCR HepG-2 human hepatocellular carcinoma cell line 21175813 2011 up-regulated
miR-30a Arsenic trioxide approved 14888 Quantitative real-time PCR HepG-2 human hepatocellular carcinoma cell line 21175813 2011 up-regulated
miR-30a Enoxacin approved 3229 Quantitative real-time PCR HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
miR-30a 5-Fluorouracil approved 3385 Microarray MCF-7 breast cancer cells 21506117 2011 down-regulated
miR-30a 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 up-regulated
miR-30a Ginsenoside Rh2 NULL 119307 Microarray NSCLC cell line A549 23152132 2013 down-regulated
miR-30a Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miR-30a Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-30a Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse liver 19270793 2009 up-regulated
miR-30a-5p Paclitaxel approved 36314 Microarray Ovarian cancer cell lines 24220856 2014 up-regulated
miR-30a-5p Nicotine approved 89594 Microarray Rat adrenal pheochromocytoma PC12 cell 18845019 2009 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
mmu-miR-30a-5p Cisplatin 5460033 NSC119875 approved sensitive Low Gastric Cancer tissue and cell line (SGC7092, SGC7091)
mmu-miR-30a-5p Cisplatin 5460033 NSC119875 approved sensitive Low Ovarian Cancer tissue and cell line (HCT-116)

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