MIRT734762 [miRNA, mmu-miR-130a-3p :: Il12b, target gene]

miRTarBase - #MIRT734762

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pre-miRNA Information
pre-miRNA	mmu-mir-130a
Genomic Coordinates	chr2: 84741115 - 84741178
Description	Mus musculus miR-130a stem-loop
Comment	This sequence was named miR-130 in reference , but is renamed here to avoid confusion with miR-130b (MIR:MI0000408).
RNA Secondary Structure

Mature miRNA Information
Mature miRNA	mmu-miR-130a-3p
Sequence	42\| CAGUGCAAUGUUAAAAGGGCAU \|63
Evidence	Experimental
Experiments	Cloned
Putative Targets

Gene Information
Gene Symbol	Il12b

21 mmu-miR-130a-3p Target Genes:

Functional analysis:

Validation methods

Strong evidence

Less strong evidence

Atxn1

ataxin 1

2

1

Zfpm2

zinc finger protein, multitype 2

3

1

Meox2

mesenchyme homeobox 2

2

1

Ubap2l

ubiquitin-associated protein 2-like

1

1

Tmem25

transmembrane protein 25

1

1

Snx27

sorting nexin family member 27

1

1

Kdm2a

lysine (K)-specific demethylase 2A

1

1

Arrdc3

arrestin domain containing 3

1

1

Acbd5

acyl-Coenzyme A binding domain containing 5

1

1

Mup7

major urinary protein 7

1

1

Mup13

major urinary protein 13

1

1

Nfia

nuclear factor I/A

1

1

Timp2

tissue inhibitor of metalloproteinase 2

1

1

Fgfr1op2

FGFR1 oncogene partner 2

1

1

Homez

homeodomain leucine zipper-encoding gene

1

1

Map3k12

mitogen-activated protein kinase kinase kinase 12

1

1

Inpp5e

inositol polyphosphate-5-phosphatase E

1

1

ATG16L1

autophagy related 16 like 1

4

0

Il12b

interleukin 12b

2

0

Irf1

interferon regulatory factor 1

2

0

Trim37

tripartite motif-containing 37

3

1

miRNA-Drug Associations

miRNA	Small Melocule	FDA	CID	Detection Method	Condition	PMID	Year	Expression Pattern of miRNA
miR-130a	N-ethyl-N-nitrosourea	NULL	12967	Quantitative real-time PCR	mouse liver	21029445	2010	up-regulated
miR-130a	Reversine	NULL	210332	Quantitative real-time PCR	C2C12 myoblast cells	24513286	2014	down-regulated
miR-130a	Benzene	NULL	241	MiRNA PCR array	white blood cell	24780745	2014	down-regulated
miR-130a	Benzene	NULL	241	MiRNA PCR array	blood mononuclear cells	24780745	2014	down-regulated
miR-130a	Formaldehyde	NULL	712	Microarray	Human lung epithelial cells (A549)	21147603	2011	down-regulated
miR-130a	5-aza-2'-deoxycytidine (5-Aza-CdR)	approved	451668	Microarray	breast cancer HB2	22076154	2011	down-regulated
miR-130a	5-aza-2'-deoxycytidine (5-Aza-CdR)	approved	451668	Microarray	breast cancer MDA-MB231	22076154	2011	down-regulated
miR-130a	Progesterone	approved	5994	Microarray	Breast cancer	22330642	2012	down-regulated
miR-130a	Comfrey	NULL	6440495	Microarray	rat liver	21370286	2011	up-regulated

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