miRTarBase - #MIRT734824


—
pre-miRNA Information
pre-miRNA mmu-mir-125a   
Genomic Coordinates chr17: 17830812 - 17830879
Description Mus musculus miR-125a stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA mmu-miR-125a-5p
Sequence 6| UCCCUGAGACCCUUUAACCUGUGA |29
Evidence Experimental
Experiments Cloned
Putative Targets

Gene Information
Gene Symbol Sox11   
Synonyms 1110038H03Rik, 6230403H02Rik, AI836553, end1
Description SRY (sex determining region Y)-box 11
Transcript NM_009234   
Expression
Putative miRNA Targets on Sox11
3'UTR of Sox11
(miRNA target sites are highlighted)		 
>Sox11|NM_009234|3'UTR
   1 GAGGCGCAGGGCTCCTCGGGAGGCAGTCGTGGCGGTCAGGATAAAGAGGATGGTGGGGGGAGGGGGAGAAGATGCTCATG
  81 GTCAGAGAGATGTGGCGCTGAGAAATTGGAAACGGTGATGAAATGTTGTTGGAGTTAAAGTGAAATGAGTAGTTTTAAAC
 161 AGATTTTCCAAGTTTTTTTTTTAATTTTTATTTTTAAAAAATTTTTTGGTCTCCCCACTCTTCCCGTCCTTTATCGTGTC
 241 TCAAGGTAGTTGCACACCTAGTCTGGAGTTGTGATTTTTTCCCCACCCGTAAAAAAACGTGTTTTGTAATTTCTATTTCT
 321 TTTTCCTGAAATTCGTGATTGCAACAAAGGCAGAGGGGACCGGGCGGGGGAGGGGAGGAGGCCCCGCTCCGGAAGGCGCT
 401 GTTTGAAGCTTGTGGCTCTTTGAAGTCTGAAAGACATCGGCAGAGGACCCTTTAGACGGCACAACTGTTACTCTAGGGAG
 481 TTGATTTTTTTTTCTTAAGAGATTTAAAAAGGAACTGGTGATTTAAAAAAAGAAAAACACAAAAAGGGACCATTGCAACC
 561 TTTTTATTTTATTTTCTTTTTTGGAGGGAGAAAGCTGATGTCTTCTATGCATCCGATTTCTTAAACTGCAGGGAGCTTGA
 641 AAAAATGCAGTCTGTACAAACGCTTACAAAAATCATAACTGTGAACTGACTTAAGACCAGAGTTTACTTTTCAGATCAAA
 721 TTGTTTATGGTTTTACAAATGTGATTTCTACTTGGCAACCTTTTTTTGGTAACTCGTTCCCTTATACCTCCTTGATTGAA
 801 TACCTTACAGCCTAGACCTCAGTACAAAAAGGTATTGAAACATTTTTGATACATAACAGACCTCAATCTTTTTTAAAAAT
 881 TAATATATTTTCAGGCGTATTTTTGTACAGTGAAAAGGGAACAATCTTGCTGTGTTTTTTCAGTAAGACTTTCAGGCACT
 961 TCTTCCCTTTTGATTTCTTTTTCTTTTTTTCTCTTCTTGTTTTTGTTTTTCTTTTTTGTTTGTTTTTTTAGCATGCAAAT
1041 ATGTTGGTACGTTATGTCCTGGTTTAAAAGGATTAAAAATTTAAAAGTAATCCTTGCATCTAAAGGCCTTGTGGTTTAAA
1121 AAAAAAAGCAAACTTTTTTGTACAGCTATAGTAGAGATTTGTTCAATATTTGTAGGTAAAGATTTATTGAAAATGGTGAC
1201 CTAGACCTCAGAGCTGTTCTTAGTTTAAGACTGTATGTACTGTATCATAGTAGGACCTATGTATCTCATCGCTGTGATGT
1281 GTGGACGGGGCCCCAGACAGAAGGTTTGAAACTGGATACGCGATTTTTATCAAAAAGAAAAAGGAAAGGCACATAGTTTA
1361 AAATTTTCTCATTTTGTGCAATATAATTAAATAAACAGACCATTGCATATTTAGTAGCAAATGGTGGCGAAGCAGACTCA
1441 ATGCACTGTCGAAGTCACCGCCGGGGTTTTTGGGTTTTTTTGTGTGTGCTGAAGTCTGTGTCTTGATTTTAATAAATCAG
1521 CAGGATCGGATAGAAGCTCGCATGGCCCTTAGTCTCTCCCGGGAGCCGCGTGTTCACCGCGCAGCGGACGCGGGTGGCGG
1601 AGGGCGGATGCCGCTTTTTGGAGCCCTTAGGCTGCCATAGGTTGCAGCCCGGTGTCCTCCCTTCTCACCCCGCCCTGCGT
1681 CTCCATCCCCGCCGTGGGCTTCGCGCTGGTCCGTGCCTGGCGAGTCTGGAGCTAGTGTCCACAGGGCTAGGCCTCCGCTT
1761 CTGGCTTTGGGTTTTTTCTGTTGTTGTTGGTTTTTTTTTTTTTTTTTAAATCTCCACCCCCATCCGCGGGCGGCATCGCT
1841 GCGCGCGCGCGCGCGCGCTCAATGAGATACGAGTGGAGAGGGCCGCGCCCTTCAGCGTTATCCACGCGGGTGGGGCACGA
1921 GGAAAGCAAATGCGCCTAGAGCCGCCTTCACGGTGCAGGATGGCTTTGGTTTCTTTGATGGAGCATTTGCCTCCAGGGGC
2001 CCGGTCCAGCCCTCCCCTCCCCCACTGCCCCCTCCCCCCCGCCAGCTTGTCCCTCGTGGTGTCCCGCGCGCAAGCCCAAC
2081 TCCCCAGGGCCGCGACGCACGCGACCGAGGAGCCCTTCAGCAGTGAATTGAAACTCGGTGCCCAACAGCCCGACTCTAGA
2161 CCCACAGAAACCATTACGGCGCGGGCGCTGACCGCGGGGACTTGACCAGTAGGGATCCAGGTCGGTGCCCCACGCAAGAC
2241 AGGCACTGCAGATAGAGAGCTCGCCCTCACGGAGCAGCGCGATCTCATAGCGCGTGGGTGGGGCGGCGACCCGGTGTGGC
2321 TTTTTCGGGCTTCCCTCGCCCACCCCTCCCCCACAGCGCCCTGCTGTGAGCCACGCGGGGACCTTTAAGCCGCGAATAAT
2401 TTCACCAGCGGTTTACTGGGGACAGATTCTGAAGCCTAAGGAAAAGGCATTCTGAGTGTCTTGAGTTCTTAACATTTGCA
2481 TGTGTTCCCGTTTCCCGTCGGGCGTTTTCCATGGTGAGGAAGGAACTTTTAAATAAATTAGAAAAGGAGTGAGGATCTGG
2561 CTTCAGAATGGAAGCATAGCTGCAATTTGTATTTTAAAATTATGTGGCCGAGTTTCTTGGTAGGAAAAGAAGAGACAGTT
2641 CTTGGTTGGAGATCAGGAAAAAAAGAAATCTTTTCTTTCTTTCTTTTTTTTTTTTTTTTTTTTTTTTTAAATCCCAGTTA
2721 GAACTCAGGAAAGGCGCTTGAATGCGCTTTTAACAATATTTAAAGCGGTTTCGACGAATGCATTGTGAAGACCATTCCCA
2801 GTGAACTCTATTGAATGTCTAATACACAAGGTATTCCAGCTACTGGCCAGGCTTCAATAAAAGGTTAGCTGCATTTTTTT
2881 TCCTCCTAAGTAAGTCTTATTTTTAACTGAGCATTGACAGTATCTTAAAATGGTAACGTGGGCGTGGGCGTTGTGTGCAT
2961 AGCAGTCTAGCCGGTTGGGTACCCTGCTCCTGTACCTAGTTCACAGACTCGAGTGCATTTTTTTTTGGCGAGATTTCCAT
3041 CTTTGAAGAAACAAAAAAACAAAAACACCTGAACCAGCGTTCTCTTATTCTTTAAGCTGTGGAAATAATTTCCAGTTTCT
3121 ACATTCTCGATATGCATCCTTATTAAAAAGATAATACGAATGAAAGGCAGTGTGCTTAAAGTGTGCTTTGCAAATACATG
3201 TTATGAATGACTACGGTCACTGGGCAAATTATTTGTAGAATGATTAGCCTTTAGCTAGAAAAAAAAAATCATTGCAGCTC
3281 TTTTGGGCCTGGATGGTTCTTTTTAATGTTAATGGAGGGGAAGTGATTTAAATATGCATGCTCTTAGCAGTCAGGATCTG
3361 ACTTAGTTGTTTTGAGAGAAAAAAAAATCAAAAGGCAAGGTCTACTTTTTTTCTCTGGGAATTGAAACCACAATCATCTT
3441 GATACTAGAACAGTGTAAGAAATGAACATTTGTTCTTCACTTCAGAATTCAAATGAGTTTTGCCCAAGGAATCTGGGAAA
3521 TAAGGCAAATAAGTTGCTCAATTTTCAAGTAGTCATTCAATAGAAATATACTCCATCACTCGGCTTTCTTATTCTCTGAT
3601 GGGGTATTCTGTATAGTCTCACTGTTTTCTCCTAATGGGCATATGTATCTTTGTGGACACTTGGAAGAGAGGTTTTCTTG
3681 TACTCTCTCATTTCTAGAATCTTTATACTCTTTTTCCTGCAAGGTTCTCTGCTTTTAACAGATTTCTGAGGCAACTATAT
3761 TTGTGCTTTTTTCTTATGTAGGAAGACCAGCGAAACTAGCTTACTGAGTTGTCGATTTTATCAGTAGATAAAGAAACTTT
3841 GTTTATTACAGTTTCAGGGAAGGTTTTTCAGGATATTTCTCAGTTATTCTAAGGGCCAAATTTTATATATAAAAAAAAAA
3921 AAACTTCATTAGGAATGTCAGTTTCAGATACCCTTTGTATAGCCTGTGGCCTGCAAGCACGACAGGACTGAGCCTTACAT
4001 GTGTCCGAACAGGAATTCATAAGTCCCCAAAGTAAACGTCTCCATGTAACGATTCTTGACGTGTTTCTCTGAGAGTTGGC
4081 TTATTTTGATTATCAATTCTTTCTCACTGTCCATTCCTATTGATTTATCCTGCCATATCTCTTTGGGTTTGATGAGCTCA
4161 ACATTTTTTGCTCTTTGATAACAACTCAGGTTTTGGTTTGGGGTTTTTCATGCCCCCTTTGTGTGTTGCTTATGTTTTCC
4241 ACCACAGTATAAAAGTACTGAAGCCAAGCCACTTCCCATTCATTCCTTTACTGCTGCCTCCCTTTCCCCAACTCCCAACT
4321 CCTAACACACCTTCATTTTTTTCCCATCGTCTTCTTCTTCTTCTTTTTTTTTAACACTACCTAGATGCGTTAGCTGCCTG
4401 ATTAGTTTATCTATTCCATGTGGATGCAGTGAGTTTATAAGAGAATTTCACAAACAAGTAGTTTTTTAGTGAACTTAAAC
4481 AGAATTTTAAAGGAGACCTATTTTTATACTCAATAAAAGCACAAAACGTGCATAAAATATAGCATGGCGTACAAAGGGAA
4561 ATCCACTCATAACGTTCCATGTATAGAAGTAATAATTTTCTTGGATAGCGATATTCTTTGAAGACCCAGTGCCTGTCTGC
4641 CTGTGCCCAGACAGGGTGGTTTCCACACACTGGGAACTTCCGGTTGCCGGCACTTGACAAACACAGTTCACCACAGCCAC
4721 AAAGAGCAATAGGTAGGAGCTGAGGTGTGCCTCCTGATGAGCAGTCGGCCACTAGGCAACCTGGATGTGCCCATGTGGAG
4801 GCTCCAGCCTCACTGTTTGATCAAACTTCTTTTATGTAGTCTCTTCTGTGAAAAAAAAAAAAAAAAAGACCAAACAAAGC
4881 AATAGGACAAGTTTGAAAATGCATTTGAACATAGGATTTCCTCCAGGGTCCTCAAAGAGATTTTAAAAAAAAAAACAACA
4961 ACAAAAAAAAACGTGACACTTAAGTTTAGTAGGCACATTACATTCCCCTCCCCTTCAAAAACAGAACGACTGGAAATAAT
5041 CAAGACATAGCGTAAAAAGAATTTTGATCAAATGGATATTGACAAAGGGCCCTCGATCCCATTTCTCTTCACCCAGCTTG
5121 TGTTCAAAAACCTTATGCCTCGTCCCCTGAATCACACAGGGAGAAGCGTCCTATGCCATTGTCATGGACTCCCCACTTTG
5201 TCTACTTTTGCTCTTGTACATATGTTGTGGGTATCAGTTGTTCCCATTTGTTCTGTAACACCCTTGTTTGAATGGACTGT
5281 TTTGAAACGGAGGCCTGTGTCTCAGGTATGGGACACCTAGTGGTCGTGGCAACCCATCCCGTGATGCTTTGTTTCCCGGG
5361 ACAGAGCCACCTGAAGTCTGAGAGTAGTTATCAGCATGGCACTGTTAACAAGTGTTCTGTTTTCCAAGGCCGAGAAAAAA
5441 AGAAAAAGAAAAAAGGAAAAAAAAAAAAAAGCAACTTTCACAGCTGCTCCAGGTTTGGGAGAGGAATAGCTGGAAAGCCC
5521 TTTTGTTTAGAAGTCTGAGTGGGTTATGGGGGGACTTTTATAGAGTTTGCATGCCAGCGCAGGACCTGTTGCTGTCAGAC
5601 AGAGAGAAGGAGAAGCTACCTGAGGCAGTGCGCTGGGGGACTACGTAAGTGTCCCGTAGCACTAGGGCAGCAAATGCATG
5681 GTGAAGTCATGTCTTCTGGTAGAGGTTATCTAGCATGCAGAGTGTAGTGTGTTGAAACTGTATGACGTTGCTGTATCAAA
5761 GTTGTAAAATTAAGCATTATTTATTGAAAACTATGTATTTTTTTGTAAAAACCTGATCACACAAGAGAGTATCAGTGGCT
5841 TGTGCTTTGTGCTTCAATCAAACCAGCTTCGTGACCGCCCTCCTTGGAATGCAGTGTTAATGCTCAGGGTTGAATTCATA
5921 CACTCCAATGTCTCTTTTTGCAGGAGTTTTTCACAGAGGAATACATTTGTTCAAAAGACCAATAAAAATCGTGTGATCAA
6001 TCTCCACATGTGGCTTTTATGTGACTTTTTTGTTTTGTTTTTGATTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTTTGTT
6081 TATCTTTCCCACTTTGCATTGGGTAACTACTGTGTGACTCCTAAAGTGTTGTCTCGAAGCTGAGAGATTTGAAAAGTCTT
6161 GGTGTCTCAGCATCCAACCAGGACCCACAGCTTGGGCAGGACTGGGGCCCTCAGGAAGTGATGCTTAGGGCAGGCTGCGA
6241 GCTGCCCACAGTGGAATAAGCATGGTGATCGTGTCTTGGTATTTTTAACTGGCCAATAGAGTAAATAAAAAGCATAGGCA
6321 AAGTATAGAGGGGTAGGTTAGCCTGTTTGTCAGAGTTAGAGGATGAAGGGATTATTCAGGGGCAGTTGCTGATGTTGAAT
6401 CCAATGCCAGCAAACTCCATTCCTCAGTGTCTTTTTTTTTCCCCCTCTATAAGCAATTTACATTGTAAATGTATTTTGAC
6481 ATAGAAACCATTCTGTATTGAAACTCTTGCTATAAGATGTTTTTATGAAAGCCTGTAAGTGGTCCTTGGAATTATTATCA
6561 GATTTTTTTAAAGATGTGTTTACATGGTGAGTGTTTGTTGCATATTAATTAAATTTGGTTTTGTAGAAACATCTGTGTCG
6641 TATCATGACGGATCTCTATGGGCACGGCTTACACACTCACATGCGTGGCTCACACACCCACTTCTGGGCCCCTGGTAAGA
6721 CCAATGTCAACTTTAAGCAAAAGAACAAATACCCAGCTCCATGTGTTGGACAGCTCTCTGGTTTTTATATAAGACATTTT
6801 TACTTCATAGATGACTTTCAAAGGGTGTCACCCTTTCATAGGATTTGACTTTTATTTTGAAAGAAAACAAGATAGACTAC
6881 ATACAGCCTTTCATCTTAAAGTAGATGTTTTTTTTGTAAGAATTCAACAAATAAATTCATTGACATTTCTGGC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agUGUC-CAAUUUCCCAGAGUCCCu 5'
            :||| ||||| |   ||||||| 
Target 5' atGCAGTGTTAATG---CTCAGGGt 3'
 5889 - 5910 163.00 -19.50
2 
miRNA  3' agUGUCCAAUUUCCC--A-GAGUCCCu 5'
            | ||| |:|||||  | :|||||| 
Target 5' ttAGAGGATGAAGGGATTATTCAGGGg 3'
 6356 - 6382 156.00 -25.50
3 
miRNA  3' aguguccAAUUUCCCAGAGUCCCu 5'
                 ||| |  ||:|||||| 
Target 5' ttgtttaTTACA--GTTTCAGGGa 3'
 3839 - 3860 141.00 -15.70
28 mmu-miR-125a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT001716 Lin28a lin-28 homolog A (C. elegans) 1 1
MIRT005597 Trim71 tripartite motif-containing 71 4 3
MIRT006310 Cbx7 chromobox 7 2 1
MIRT006967 4632428N05Rik V-set immunoregulatory receptor 2 1
MIRT054177 Ptpn18 protein tyrosine phosphatase, non-receptor type 18 2 1
MIRT054178 Ptpn7 protein tyrosine phosphatase, non-receptor type 7 2 1
MIRT054179 Ppp1ca protein phosphatase 1, catalytic subunit, alpha isoform 2 1
MIRT054180 Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform 2 1
MIRT054570 Traf6 TNF receptor-associated factor 6 3 1
MIRT580227 Tspan12 tetraspanin 12 2 2
MIRT582368 Mtf1 metal response element binding transcription factor 1 2 2
MIRT582450 Mgat4a mannoside acetylglucosaminyltransferase 4, isoenzyme A 2 2
MIRT584884 Antxr2 anthrax toxin receptor 2 2 2
MIRT587193 Foxk1 forkhead box K1 2 2
MIRT588848 Snrnp40 small nuclear ribonucleoprotein 40 (U5) 2 2
MIRT591275 Lars2 leucyl-tRNA synthetase, mitochondrial 2 4
MIRT592914 Madd MAP-kinase activating death domain 2 2
MIRT594893 Il1rn interleukin 1 receptor antagonist 2 4
MIRT596427 Hif1an hypoxia-inducible factor 1, alpha subunit inhibitor 3 3
MIRT599142 Dqx1 DEAQ RNA-dependent ATPase 2 2
MIRT599717 Aph1c aph1 homolog C, gamma secretase subunit 2 2
MIRT600832 Gm14137 predicted gene 14137 2 2
MIRT604902 Jmy junction-mediating and regulatory protein 2 2
MIRT605441 Stat1 signal transducer and activator of transcription 1 2 2
MIRT606092 Wdr25 WD repeat domain 25 2 2
MIRT732537 Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 4 0
MIRT734700 VDR vitamin D receptor 2 0
MIRT734824 Sox11 SRY (sex determining region Y)-box 11 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-125a Budesonide approved 5281004 Microarray neonatal mice liver 20145010 2010 down-regulated
miR-125a Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice lung 20145010 2010 down-regulated
miR-125a Chaihu Shugan San NULL NULL Microarray hippocampus 23947143 2013 down-regualted
miR-125a Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 down-regulated
miR-125a Hydroxamic acid HDACi LAQ824 NULL NULL Microarray breast cancer cell line SKBr3 16452179 2006 up-regulated
miR-125a Enoxacin approved 3229 Quantitative real-time PCR HEK293 cells 18641635 2008 up-regulated
miR-125a 4-hydroxynonenal NULL 5283344 Microarray human leukemic HL-60 cell 19022373 2009 up-regulated
miR-125a Valproate approved 3121 Quantitative real-time PCR CD4+, CD25- T cells 20427269 2010 down-regulated
miR-125a Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-125a Enoxacin approved 3229 Northern blot HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
miR-125a Enoxacin approved 3229 Quantitative real-time PCR HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
miR-125a 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer MDA-MB231 22076154 2011 down-regulated
miR-125a-5p Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-125a-5p Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse liver 19270793 2009 down-regulated
miR-125a-5p Curcumin NULL 969516 Microarray HONE1 cells 24896104 2014 down-regulated
miR-125a-5p 5-Fluorouracil approved 3385 Microarray MCF-7 breast cancer cells 21506117 2011 down-regulated
miR-125a-5p Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-125a-5p Trastuzumab approved NULL Microarray SKBR3 cells. 22384020 2012 up-regulated
miR-125a-5p Glucocorticoid NULL NULL TaqMan low-density array Eosinophilic esophagitis 22815788 2012 up-regulated
miR-125a-5p Marine fungal metabolite 1386A NULL NULL Microarray MCF-7 breast cancer cells. 22159329 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
mmu-miR-125a-5p Paclitaxel 36314 NSC125973 approved sensitive Low Colon Cancer tissue and cell line (HT-29)

Error report submission