miRTarBase - #MIRT735816


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pre-miRNA Information
pre-miRNA mmu-mir-760   
Genomic Coordinates chr3: 122293585 - 122293703
Synonyms Mirn760, mir-760, mmu-mir-760, Mir760
Description Mus musculus miR-760 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure

Mature miRNA Information
Mature miRNA mmu-miR-760-3p
Sequence 70| CGGCUCUGGGUCUGUGGGGA |89
Evidence Experimental
Experiments Cloned
Putative Targets

Gene Information
Gene Symbol Atxn1   
Synonyms 2900016G23Rik, Atx1, C85907, Gm10786, Sca1
Description ataxin 1
Transcript NM_009124   
Expression
Putative miRNA Targets on Atxn1
3'UTR of Atxn1
(miRNA target sites are highlighted)		 
>Atxn1|NM_009124|3'UTR
   1 AGACCTTGCGGGCAGCGGAGGCCCGGGGCCTCCTTTTACTGTCTGTATCCAGATTACTGTACTGTAGGCTAAGTAACACA
  81 GTATTTACATGTTACATCCTCTTTAGGTTTGTATTCTAACCTTGTCATTAGAGTCAAACAGGTGTGTCGCAGGAGACTGG
 161 TGCGTTTGCATTGTCTGCAAGGGTCTGTTGAGGAGCTGGTGGGTGGAGGATGGTCAGAACCATGTCCATGGAGCTCCCGG
 241 GCATCCTTAGTGGCCCTGAATGTGGCTTCATCAGCCCCTGCCTTCTCCGGCAGTGTGCAGAGTCGAGGGGCATCAGTTCC
 321 CACTGGTTTCAAGAACAAACACAGTGGGAAGTATCCTGCAAGGGAGTGTCTGGGTGCGTGTCCCTTGTGAAGGAGTGCGA
 401 GTGAGGGTGTCTCTTTCTCTGCCTCTGTCTCCCTCACTTGCTCCCTCTCAGTGTGGGGTTGGGGGACCTGGGTTTCCCAC
 481 CTGCAAAGTCATCAGGGAACCCAGCTTCCAGGCATTGTAGGGAGACATCAGACAGGCAGATGGGAAACTAGTTTCAAAGA
 561 ACGTGGTTCTCTCCAACATATTTTACAATAAAAAGCAACTTTTAATCATAGATATATAGATATATATATATATTTCCCCC
 641 CATGGGGCCTGACTGCACTGAGGTTTTTTTGTTTTATTTTGTTTTGTTGGGTTTTTGTTTTTGTTCTTTTTTTTTTTTTT
 721 TTTTTTTTTTTTTTTAAGAGCAGCTGCCACTTGCAGGATTTCATTTCTGCTTTACCCGGTCCAGTCCAGTGACATCATCA
 801 GTCGTCATGGTGGGCAGGGAAAGTCCTTGCTCAGGTCACTCCTGGTCAGGCAGGTAGCAGTGGGGCGGGAGGGACGGAGG
 881 GAGCACCCACACTGGTTTCTGTGCAGTGTTAGGAAAAGCAATCAGGTTACTTGCGTTGGCTTCCAAGAAGGAAAATGCAA
 961 GCCCCGCTTCCCGCGAGAGCCAGCTTCTCCCAGCTGTGCCGGCAGCATCTTTTCTGTATTTTAGGTCTAGTACTGTTCAT
1041 GACTATGGACAACTCGGGTGCCGCTTTTTTTTTTTCTTTCTTTCTTTTTTCCTCAATCCCAGTGTGACATGAGGAGTTAG
1121 ATCTGGAAGATGCTCCTCTGTTACTTTATCTCGCAAACAGCTAAAAATGCTGTGCAGGCTTCTTAACCAAGCATCTTGGT
1201 CTGTCATTCAACAAGTACTGTATCTCACTTTCGACTCTTTTTGGGAAAAGAAAAGGAAAAAAAAAATGACAAACCTAAGT
1281 TGCTTTTGTTTTTGTTTTTGTTTTTTCTTCTCAACACTGTAACTACACTTCAGCTCTGCTCACAAGCCAGCAATCGAAAA
1361 CTCCAATCTGGTTTAAAAGGATGAATGTGAAGTACGAACTAGCCCGTGACAATATATGACTACCGAGTACTACCTGACGG
1441 CAGGCACTTGTCACTTTGATGTTGGAGAAAGAGTTAAAGGCATATGCAGAGTTGGCAGAGAAACCGAGACAAGACACAGA
1521 GGAAAAGACACTCGGTTGTGTCCAGTGTTTTTAGGACGAACTTCTAAAGAACTTTGCGATTTGCACATCTTGAGTTTATA
1601 ATTTGTGTGATATTCCTGCAGTTTTTATCTAATAACATTGTGGGAAAGGTTTGGGAGGGTTACAAGAGCATAAATAAATG
1681 TAGCAAAATTACTTTCTAACCTGCCTAGACCCTAGGCCCTTCTTAGAAGGTTCTGTCCCCTTTGAGACTTCATTTTGTCA
1761 TCTACCACATCTGTCACCAGAAGCCAGGTCTGAGGGTCTTCTTCAGCGCCATTGAGAGTTTCCCATATAGACATTTTATA
1841 TATGTGAGCAAGTATTTTCATTTCTGGAAAAAAAAGTGTTAAATTTTTTTTTAAAAGAAACTTATGTTTCTATTTGAAAT
1921 CCAACTAGGATCTAATGTTTGGTACAAAACTCCAGAAATGGTATTTTCATAAAGTCACAAGTTTTCATTCCCAGAGGTCA
2001 AAATATCATTTGTGGGTTCTGAGTGGGTCTTAAAGTACTTTAACCCTAGTTTTATAAATGGGGAGAAGTTTTTAAACATT
2081 CTTTCTTGGCTACAACCTAAGTAAGTACTTATTTGACGTTTCTTTTTAGCAATTTAAAAAGAAAAGATTTCTTCCATTTC
2161 TCAAAATAGAAAAAAAAAAAAACCAAAAAGACCCTCCCCTGGCAACCCACATACATGTTGGCTATCCAGTCTCCATTCAC
2241 AGTGGCTTTTGTTGGGACTAATGATCTTTTTCCAGACCATTTTCTGGGATGTACCAAACACCTTTGAGTAGGTCCGGAAT
2321 AGCTGGCCTCTCCCTAAACTTCATCGCCCTCTCCGCCCGCTGGCAGAGCTGGGTGAGCCCGTTCTTGCAATCAGACGCTT
2401 ATTTAGTGCTGTGATCCTTTTGTTTTATTTTATTTTTTTTAATCTTTCTGTTCAGAGACCTTGCTTGATCTTCCCTATAT
2481 CTGCTCAGGGCACTGGCACTTACTAGGTTTTCGGTTTTGTTTTGTTTTGTTTTGTTTTAACCTCCAATGGTGAGAGGACT
2561 AGGAGGTTGCCACGGAGGCGCTGTGTGCCAGTTATCTACAACAGCCCCTGTGAGCTCAGAAAACACACACACACACACAC
2641 ACACACACACACAAACACACACTCTGCTCTCTGGCTAACTCCGAGGAGTGAACTGACTGCATCCACTAAGCTGACACTAA
2721 AACAGGTAAAAACACACATGGCTCAGAGCAATAGGAATATCATAACTTGTGGTTCTATTTCAGGTATAGGAATTATACAA
2801 ATCATTGATTCTTCCGAAGCATCCGTCCCATCTCATTCTCTGGCTCCCTTAGCATGTGCAATACTTTGTGTGCCAATAGT
2881 GTGCTATCTAGTTAAAGTTCATTCCCTTTTGGCCTTTTCCTTGTTCGGTGGGCTGACCTTTCTTCCCCTCGCTGGCCAGA
2961 GAAAGGCTGGAGGAGTGAGCCAGGAGAGGCGAGCCCCTTCCATTTCTCCTTAACACCGATGGATGCAGAGTGCTAGGGTA
3041 GGCAGCCTATGGGAGCCTGTGTGTGTCTGTCACCAGGACACAGTGAGAGCCAGCCAAGGAGACCTGAGGGAAGCACTTTG
3121 AAGGTCCGTCACCACACTCTGCAAAGGCCCCTCGCTCTGTAGTGAAGCTGGAATGGAGCCAGGAGGCGGAGTGGCTCCTA
3201 GGACGAACTCTGGAGCGGAATGGTCTTCAGTCAACTCATTTTCAGTCTCTTCTGTGTCCTTGAGACTTTGATCCCTGCCT
3281 TTGACACAAGCAACTTATTGCATATGTGTGTGTTCTGAGCATGCCCACCAGTGGCTTTGGAGGGCAACCTGGCAACCACA
3361 GTCACCATTCCCTTGGGACAGCTTTCTCTTCAAACAGGAAGAACACACAGAGGCAGGAGCCACCTCTTATTTGCAGACAT
3441 TGGTGGGGTCCTCCAGGCTCCCGGAGCACCTTTGGTCAACTGTGTAGGGAGCACGGTAATAGCAGTGCCCTCATCGGACA
3521 AGGATCAGCCACGCGCCTCTGTACCTGTCCTCTTTGCAATATTTACCAACAGCCGACTTTTCCTTCTTCTCTTTCCTGCT
3601 TTCCATTTTAAAACAAAGTAACAGCAGGCCTTTTTTGTGTTTACAACGGAACACAATCACCAAGAAATTAGTCAGGGCAA
3681 AAAGAAAACATAGTAATATTACTCATAAGAAATCAGCAAACAAGAACCTCTTTCTAGGGATTTCTAAATACACAACAACG
3761 TGACTGTTCCTTAGACTGTTTAACTTTAGAATTATTTCAGTTTGTCTGGGCCACCTTGGGGGTCAGTGGGATGGGGTAGG
3841 GACTGGGGTGGGGGAAGGCCAGGGATACCACTTACCTCAAATCTTTTTAAAAGTGGAAATCCAAATTGCATTTGGGGGAG
3921 GGTGGGGAGGGGGGACTTGCAGGATAATCGTCTATGTTGGTCACATTTTGCTTTTCTCGATTCATCCAACTCAGTTTGGG
4001 ATGGCCTGATGTTTGTGGTGGTGGCAACAGAACGTCCTTAACTCTGAACCCCAACCTTGTATGTTTTCTGTTAGGTGAGC
4081 TTGTTGGGTTCCTCCCCACCCCCTTACCCCATAAGGAAGTGGCAGCGTCCTTTCTCCCTTGCAAGGAACCCTGCAGAACC
4161 TTCCACACCTCTTACTCAGGGATGGGGCTGGTGTGTGTGTGTGGAACACAGATGTGTTCAGCAACAGCACTTTGGACTGC
4241 TCTGGAGTAGGGTTGTACAATTTCAAGGAATGTTTGGATCTCCCCGCACAGTGTGGATTGCTCCTTAGCTACTGCACAGA
4321 TTGCAATATAATGCTGCACGTTCAAGACGAGCAGTAGCTCCTCATAATCAGAAGAAAAAAAATATATCCACTCTTTGCAC
4401 ATAGTTTGATCTTTACTGAAATATGTTGCCAAAATCTGTTTTTGTTCTAGCTTTGTATCTTTTCATTTCTTTCTTTCTCT
4481 CTCTCTCTCTTTTTTCTTTTAAGGAAACAATTGATAATACCTTGTAACATCTGTGACTACTAAGGAAACCTATTTTGTAG
4561 ATGCTTTTGAAGACACTAACACCTATTTCAGACACGGGTGAGGAGGCAGAGCTCTTGGGATAGAAAGCCAGACTTTGTAA
4641 GTTGAGTTGGCATGGCAACTGTTTCCTGAGCCACAAGACCCTCAACCAACTGGTCTGCTCTCTCTCTCGAGAGCCCTTCG
4721 CTCCTCATTTCCCAGTCACCCCCTTTGACTCCAGGGGAATACAGGGCCTCCAGTCTCCGGGTCCTATCCAGTTTCTTTAG
4801 TGGTTGAGATGAACGGCAAGAGAATCATATTTTGTTGTTTTAAAAGTGGAGCAAAGGCCTTTGCATCCACAGTTGTGTTT
4881 TGATGCCAGGATTTCCGAAATAGAAAATTTAAGGAAAAATCGAGTAATAACTATAGAGAATTTACTTTTCTTTTAATAAA
4961 GCACATGCGTATGACCTGTTGAGTTGGGTTGGTTTTCTCCCTGTCCATGAACAGTGTTGTATTTCTGTTCCTAAGGCAAC
5041 TCGAAACAGTTTGCACACCTCTACTCTGGAGCTGGGATTTCTTTCATAGATGACCTCGCTTCAAATGTTACCTTACTGAT
5121 AGGCTTTTTCTTGTAGCGCTATACCTTGTGGGAAGTTTTTTTGTTTTGTTTTGTTTTTTTCTTTAAAGTACACCCAATTT
5201 GAGCAGCTGGGGGGTGGGGGAGGGAGGGTTGAGACACTCACTTTGGGGGTGGGTGGGTTACAGATAATTTTTTTTTAAAA
5281 AAATTGCACAAAAGAAAAATGAATGTTGAAATGATTCATTCAGTGTTTGAAAGAGACAGATCTGTTGAAACTATGAGTTT
5361 CATATTTTGTGTGTAAAAAAAACAAAAAAACAAAACAAAAAAAACAAAACAGAGGAGGGGTTTGAAAGTTACATGTTTGG
5441 GGGTTTATTTTTCCTGTATATAGCAATTTGTTGTCTTGATCATCAAATTTGTATGGTTATGGCCTGGAAGAATTATGATG
5521 TCAGAGGCTCTTCAACTATACCGTACCTATGCTTACTGTTCTGTTTTTGTTACACACGGCTCTTGTGTGAAGGATGGGGG
5601 AACTCTGTATTCCGCTATTTGAGGATACTGTCCATTCCTAGGCCGAAAGTACTTCCCTAAGTTCCCTTCTTAAGCCATTG
5681 CAACTTTACTTTGGATGATGTCTGACATTTTCAGCACTTCCTGTTCCTATCAACCCAAAGAATATAATCCTGAACATGAA
5761 GTGTTTCTAAAAGGGATCCTCCTTCCCAGTAGACAGAAAAAAGTCGAGCCTTTCTTCTGCCTCCCACCCCAGACCTCATT
5841 CCTACAGGGGTAGAACACCCATTTTGGCTTGAATGCCTGGCTTTTGTTTTGATGTTTCTCAAGTAGAGGCCAGACGAAAT
5921 GCAGAACGGTTTCTCAGAGTTATATTCCAGCTCAGCAGTTGCGCTGGGTGGTGCAAACCAGACAGCGTGGGGGCAGTAAA
6001 CAGACCCTACCTTTAATTCTTCAATTTGGGTTCATGTCCCCTCCCTTAAGGCGCAAGTTCTTATTGCTTAGATTGACCTT
6081 GACAAAGGCAGAAGCGAGACATCGGGTCAGCTTTTCACATCCTGACACGTGCATACAGGAACTTCACCTGTATTCAGATG
6161 AAGTGTGTTTGGCCAATAGATACCGTCTACATGATACCAGTCTCTAAGAACTTCCCTAACACTTTTTAACTGAAAGGAGT
6241 TAAGTCTTCCACTACAGATCACTTGGAGACTCCATCCACGCATGTCCTCTTGTCCCTTTGCTTGCCTGGATGGCTCATGT
6321 GAAGGCCTGTGTGGGAAGCACTGTTTACAGTAACCCTTACCAAGATAATATACTGTCCCCTAGACTACCGAGCTGAGGTG
6401 ACACTGGCTTAGAACTGTTGGAGTGAAAGATCAGTTACTAAGAAGGTTGGTGCACAGGTTTTCTCCAGTTCTTACAGGAG
6481 CCCCTTGCTCGGAAGTTATTCTCCAGTCCAAGGGTGGGATGCACTGTTGAGTCCATGATGAGGCGTAACCATGGCAACCC
6561 ACCACAGTCCCATTCTGTGACTACTGCCCCCTCCCCAACCCACACTGCTCAAGTGTGACCCAGGTAGTGTCAGCAGAAAG
6641 GGGGTTGCGGTGGAGTCCTGTCAGTATTTATGGTGGCCTTTCGGTAAGACAGTCTACATCTCTAACCAGTGGAGTCTTGG
6721 CCCTCCGGAACCTGAGATCTGCACCAGTTGAAGGGTTTTAACATCAGGTTCCCAGACCCTCCAATTTCCATTCATTGCCT
6801 CCCCACAGGCCAAGCGGAAACAGACACCAAAACTTGGGCTAAGGGTACTACCATGTGGAGAACTAGGGAAAACAAAATGG
6881 TTTTTTTTTTTGCACCTTATTGAAAAGAAACTTTTAAGTGCATACATAGTTAAGAGCTTTTATCGTGACAGGAGAACGTT
6961 TCCATATGCGTGCATACTCTCTGTAATTCCAGTGTAAAATGTTGTATTTGCACTAGCTTTTTTAAAACAAATATTAAAAA
7041 AATGGAAGAATTCATATTCTATTTTCTAATCGTGGTGTGTCTATTTGTAGGATACACTCGAGTCTGTTTATTGAATTTTA
7121 TGGTCCCTTTCTTTGATGGTGCTTGCAGGTTTTCTAGGTAGAAATTATTTCATTATTATAATAAAACAATGTTTGATTCA
7201 AAATTTGAACAAAATTGTTTTAAATAAATTGTCTGTATACCAGTACAAGTTTATTGTATAATACTCGTACTACTAATAAA
7281 ATAACAGTGCCAATTGCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agGGGUGU-CUGGGUCUCGgc 5'
            | |||| |:|:||||||  
Target 5' aaCACACATGGCTCAGAGCaa 3'
 2731 - 2751 146.00 -21.20
2 
miRNA  3' agGGGUGUC-UGGGUCUCGGc 5'
            || :||| :: |||||:| 
Target 5' ctCCGGCAGTGTGCAGAGTCg 3'
 285 - 305 138.00 -23.00
3 
miRNA  3' agGGGUGUCUGGGUCUCGGc 5'
            |||:| |:  ||||||: 
Target 5' cgCCCGCTGG--CAGAGCTg 3'
 2354 - 2371 138.00 -22.90
15 mmu-miR-760-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT578903 Erap1 endoplasmic reticulum aminopeptidase 1 2 2
MIRT579317 BC003965 cDNA sequence BC003965 2 4
MIRT581108 Sept8 septin 8 2 2
MIRT583747 Ephb3 Eph receptor B3 2 10
MIRT591924 Dmrta1 doublesex and mab-3 related transcription factor like family A1 2 2
MIRT592957 Zdhhc3 zinc finger, DHHC domain containing 3 2 2
MIRT593008 Axl AXL receptor tyrosine kinase 2 2
MIRT593326 Fbxl16 F-box and leucine-rich repeat protein 16 2 4
MIRT593766 Pax2 paired box 2 2 2
MIRT594492 Cspg4 chondroitin sulfate proteoglycan 4 2 2
MIRT594696 Asxl2 additional sex combs like 2 (Drosophila) 2 2
MIRT595337 Gabpa GA repeat binding protein, alpha 2 2
MIRT599115 Ecd ecdysoneless homolog (Drosophila) 2 2
MIRT600132 Zfp553 zinc finger protein 553 2 2
MIRT735816 Atxn1 ataxin 1 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-760 Ursodeoxycholic acid (UDCA) approved 31401 Microarray rat Liver 20689055 2010 up-regulated
miR-760 Atorvastatin approved 60823 Microarray PC3 prostate cancer cells 23936432 2013 up-regualted
miR-760 Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 down-regulated
miR-760 Glucose NULL 5793 Microarray proximal tubule cell line HK-2 20067797 2010 up-regulated
miR-760 Mistletoe lectin-I NULL NULL Microarray colorectal cancer cells CLY cells 20955366 2011 down-regulated
miR-760 Mistletoe lectin-I NULL NULL Microarray colorectal cancer cells HT-29 cells 20955366 2011 down-regulated
miR-760 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) NULL NULL Quantitative real-time PCR gastric cancer AGS cell lines 21960261 2011 up-regulated
miR-760 Longevinex NULL NULL Quantitative real-time PCR ischemia/reperfusion [I/R] rat model 21203465 2011 up-regulated
miR-760 Longevinex NULL NULL Quantitative real-time PCR normal heart 21203465 2011 up-regulated
miR-760 Resveratrol NULL 445154 Quantitative real-time PCR ischemia/reperfusion [I/R] rat model 21203465 2011 up-regulated
miR-760 Resveratrol NULL 445154 Quantitative real-time PCR normal heart 21203465 2011 up-regulated

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