pre-miRNA Information
pre-miRNA hsa-mir-134   
Genomic Coordinates chr14: 101054687 - 101054759
Description Homo sapiens miR-134 stem-loop
Comment miR-134 was first identified by cloning studies in mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-134-3p
Sequence 46| CCUGUGGGCCACCUAGUCACCAA |68
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 23 14 + 101054754 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs773121278 7 dbSNP
rs760717795 8 dbSNP
rs1415917765 9 dbSNP
rs1278249300 10 dbSNP
rs765201848 11 dbSNP
rs1212462908 14 dbSNP
rs752580711 18 dbSNP
rs752786233 23 dbSNP
Putative Targets

Gene Information
Gene Symbol MLH1   
Synonyms COCA2, FCC2, HNPCC, HNPCC2, hMLH1
Description mutL homolog 1
Transcript NM_001167617   
Other Transcripts NM_000249 , NM_001167618 , NM_001167619   
Expression
Putative miRNA Targets on MLH1
3'UTR of MLH1
(miRNA target sites are highlighted)
>MLH1|NM_001167617|3'UTR
   1 ATATGGTTATTTATGCACTGTGGGATGTGTTCTTCTTTCTCTGTATTCCGATACAAAGTGTTGTATCAAAGTGTGATATA
  81 CAAAGTGTACCAACATAAGTGTTGGTAGCACTTAAGACTTATACTTGCCTTCTGATAGTATTCCTTTATACACAGTGGAT
 161 TGATTATAAATAAATAGATGTGTCTTAACATAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' aacCAC----UGAUCCAC-CGGGUGUcc 5'
             |||    || | |||  || |||  
Target 5' agtGTGATATACAAAGTGTACCAACAta 3'
70 - 97 102.00 -6.19
2
miRNA  3' aaccacugauccaccggGUGUCc 5'
                           ||||| 
Target 5' gatagtattcctttataCACAGt 3'
134 - 156 100.00 -5.10
3
miRNA  3' aaCCACUGAUCCA--CCGGGUGUcc 5'
            ||| :| |  |  | |::|:|  
Target 5' ttGGTAGC-ACTTAAGACTTATAct 3'
102 - 125 78.00 -5.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
973410 1 ClinVar
921879 2 ClinVar
89586 4 ClinVar
388562 5 ClinVar
627657 7 ClinVar
631175 7 ClinVar
921177 7 ClinVar
924048 18 ClinVar
630433 19 ClinVar
918665 19 ClinVar
36549 30 ClinVar
135561 33 ClinVar
901875 122 ClinVar
344911 158 ClinVar
COSN30593451 19 COSMIC
COSN30490706 42 COSMIC
COSN26649668 44 COSMIC
COSN28883125 50 COSMIC
COSN30104230 62 COSMIC
COSN31601905 81 COSMIC
COSN31576802 88 COSMIC
COSN31530044 104 COSMIC
COSN31480313 135 COSMIC
COSN31599327 146 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs267607908 1 dbSNP
rs587778880 4 dbSNP
rs750794400 5 dbSNP
rs779336928 7 dbSNP
rs758561792 11 dbSNP
rs766650278 15 dbSNP
rs75682204 16 dbSNP
rs1046565300 18 dbSNP
rs1288659903 22 dbSNP
rs79406218 22 dbSNP
rs1192725744 23 dbSNP
rs1217831024 24 dbSNP
rs1388603455 26 dbSNP
rs892049206 28 dbSNP
rs1475224876 30 dbSNP
rs193922366 30 dbSNP
rs200903126 33 dbSNP
rs1375244357 34 dbSNP
rs781352547 40 dbSNP
rs772603751 42 dbSNP
rs954223482 42 dbSNP
rs749138642 43 dbSNP
rs778791265 46 dbSNP
rs745713835 50 dbSNP
rs1007307857 53 dbSNP
rs771845260 59 dbSNP
rs779892486 64 dbSNP
rs746506283 72 dbSNP
rs768003470 74 dbSNP
rs1017407837 77 dbSNP
rs1324446350 80 dbSNP
rs1299758105 82 dbSNP
rs1303794502 92 dbSNP
rs1311392464 94 dbSNP
rs776238530 96 dbSNP
rs1171427013 97 dbSNP
rs1803985 102 dbSNP
rs770302355 106 dbSNP
rs1208231152 107 dbSNP
rs773556906 110 dbSNP
rs1186418814 119 dbSNP
rs763379368 119 dbSNP
rs1194520604 120 dbSNP
rs766562208 122 dbSNP
rs751679614 123 dbSNP
rs963039575 128 dbSNP
rs1194759234 129 dbSNP
rs267607910 138 dbSNP
rs1485558939 140 dbSNP
rs1278445157 142 dbSNP
rs570963416 145 dbSNP
rs770660847 150 dbSNP
rs973488008 153 dbSNP
rs919154572 157 dbSNP
rs1336173991 158 dbSNP
rs796807655 158 dbSNP
rs201866587 163 dbSNP
rs538203686 166 dbSNP
rs56329536 166 dbSNP
rs917065097 166 dbSNP
rs587778879 168 dbSNP
rs1280032506 173 dbSNP
rs1400366298 174 dbSNP
rs1354654703 176 dbSNP
rs1300677285 185 dbSNP
rs1449836937 187 dbSNP
rs556614001 191 dbSNP
rs368443548 192 dbSNP
rs1424085679 194 dbSNP
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
64 hsa-miR-134-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT082376 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 2 6
MIRT091883 ACVR2B activin A receptor type 2B 2 4
MIRT094089 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 4
MIRT316375 PPP1R14C protein phosphatase 1 regulatory inhibitor subunit 14C 2 2
MIRT368317 E2F2 E2F transcription factor 2 2 2
MIRT446160 RPL12 ribosomal protein L12 2 2
MIRT458223 SHMT2 serine hydroxymethyltransferase 2 2 2
MIRT483575 SYT2 synaptotagmin 2 2 2
MIRT486251 FASTK Fas activated serine/threonine kinase 2 2
MIRT487556 TM6SF2 transmembrane 6 superfamily member 2 2 4
MIRT488952 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 2
MIRT489232 ASCL2 achaete-scute family bHLH transcription factor 2 2 4
MIRT491923 WNK2 WNK lysine deficient protein kinase 2 2 2
MIRT504191 FAM127B retrotransposon Gag like 8A 2 2
MIRT517340 ZNF529 zinc finger protein 529 2 4
MIRT528964 FAM19A3 family with sequence similarity 19 member A3, C-C motif chemokine like 2 2
MIRT530497 FADS6 fatty acid desaturase 6 2 2
MIRT539575 UPP2 uridine phosphorylase 2 2 2
MIRT549348 ARC activity regulated cytoskeleton associated protein 2 2
MIRT554316 SHMT1 serine hydroxymethyltransferase 1 2 2
MIRT555311 PPP2R5C protein phosphatase 2 regulatory subunit B'gamma 2 2
MIRT558029 EXT1 exostosin glycosyltransferase 1 2 2
MIRT564075 KIAA1191 KIAA1191 2 2
MIRT569986 TMEM184A transmembrane protein 184A 2 2
MIRT570669 INSIG1 insulin induced gene 1 2 2
MIRT571911 LSM14A LSM14A, mRNA processing body assembly factor 2 4
MIRT574042 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT574076 RNF152 ring finger protein 152 2 2
MIRT575774 Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b 2 2
MIRT576510 Slc35e2 solute carrier family 35, member E2 2 2
MIRT609004 PYGO1 pygopus family PHD finger 1 2 2
MIRT619992 NPAP1 nuclear pore associated protein 1 2 2
MIRT630308 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT636261 RRAGC Ras related GTP binding C 2 2
MIRT638834 CRTAP cartilage associated protein 2 2
MIRT639813 TMED8 transmembrane p24 trafficking protein family member 8 2 2
MIRT641938 SCOC short coiled-coil protein 2 2
MIRT644770 TXNRD3NB thioredoxin reductase 3 neighbor 2 2
MIRT650082 MTL5 testis expressed metallothionein like protein 2 2
MIRT651539 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT653695 SLC25A33 solute carrier family 25 member 33 2 2
MIRT654579 PXMP4 peroxisomal membrane protein 4 2 2
MIRT655804 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT662741 LRRC3C leucine rich repeat containing 3C 2 2
MIRT667588 LONRF2 LON peptidase N-terminal domain and ring finger 2 2 2
MIRT667730 KIAA1456 KIAA1456 2 2
MIRT667909 ING1 inhibitor of growth family member 1 2 2
MIRT675875 ATP1B4 ATPase Na+/K+ transporting family member beta 4 2 2
MIRT684043 FOLR1 folate receptor 1 2 2
MIRT686239 ZMIZ1 zinc finger MIZ-type containing 1 2 2
MIRT710043 POLL DNA polymerase lambda 2 2
MIRT711988 EXTL3 exostosin like glycosyltransferase 3 2 2
MIRT714061 VHLL VHL like 2 2
MIRT715879 ACIN1 apoptotic chromatin condensation inducer 1 2 2
MIRT716779 C1orf229 chromosome 1 open reading frame 229 2 2
MIRT717104 PXDC1 PX domain containing 1 2 2
MIRT723567 ZBTB34 zinc finger and BTB domain containing 34 2 2
MIRT725668 ABI2 abl interactor 2 2 2
MIRT735690 SYT11 synaptotagmin 11 1 0
MIRT736843 CCND1 cyclin D1 2 0
MIRT736981 MLH1 mutL homolog 1 1 0
MIRT737413 FOXM1 forkhead box M1 3 0
MIRT756143 GPR137 G protein-coupled receptor 137 3 1
MIRT756411 SOX9 SRY-box 9 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-134 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-134 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miR-134 Gefitinib approved 123631 Quantitative real-time PCR lung adenocarcinoma cells 24258346 2014 up-regulated
miR-134 Ascorbate approved 54670067 Microarray Metastatic melanoma cell lines 25202679 2014 up-regualted
miR-134 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) NULL NULL Microarray T24 human bladder cancer cells 16766263 2006 up-regulated
miR-134 Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 up-regulated
miR-134 Testosterone approved 6013 Microarray prostate cancer 21592394 2011 up-regulated
miR-134 Testosterone + 1,25-Dihydroxyvitamin D3 approved NULL Microarray prostate cancer 21592394 2011 up-regulated
miR-134 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-134 1alpha,25-Dihydroxyvitamin D3 approved 5280453 Microarray prostate cancer 21592394 2011 up-regulated
miR-134 Goserelin approved 47725 Microarray prostate 22674191 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-134 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-134 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-mir-134 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-134-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-134-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-134-3p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-134-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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