miRTarBase - #MIRT756038


—
pre-miRNA Information
pre-miRNA mmu-let-7f-1   
Genomic Coordinates chr13: 48537829 - 48537917
Synonyms Mirlet7f1, Mirnlet7f1, Mirlet7f-1
Description Mus musculus let-7f-1 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure
pre-miRNA mmu-let-7f-2   
Genomic Coordinates chrX: 151912346 - 151912428
Synonyms Mirlet7f2, Mirnlet7f2, Mirlet7f-2
Description Mus musculus let-7f-2 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA mmu-let-7f-5p
Sequence 8| UGAGGUAGUAGAUUGUAUAGUU |29
Evidence Experimental
Experiments Cloned
Putative Targets

Gene Information
Gene Symbol Rbfox2   
Synonyms Fbm2, Fxh, Hrnbp2, Rbm9
Description RNA binding protein, fox-1 homolog (C. elegans) 2
Transcript NM_001110827   
Other Transcripts NM_001110828 , NM_001110829 , NM_001110830 , NM_053104 , NM_175387   
Expression
Putative miRNA Targets on Rbfox2
3'UTR of Rbfox2
(miRNA target sites are highlighted)		 
>Rbfox2|NM_001110827|3'UTR
   1 AGTGACGTGAGACCCCTGCAAATGGGACAGCCCCCAGTTCATGAGGCCTGGCTATTGCAATATTTACTAGTAGAGGACTC
  81 TATAGCAAGATGAAGAGGAAAACAAACAAAAAAGAGAGAATACTTTTTTATACCTCACTATGTTCTTTGAATATGTATTT
 161 TTTCCTTTAAATTTCTGCCTTTAATTCTTTTGTTCCAAAGATTGTGCTTTTTTTGTTTTGTTTTGTTTTTTTTGAATTTT
 241 TGTTTTTGTTTGGAGGGGGGTTGGTTTTTTGGGGGTTTTTTGTTTTGTTTTTTGTTTGGGAATTTTTTTGTTGTTTTTAT
 321 TTTTGCTTTTTTTAAAACTGTGGTTAAAAAAAAAAAAAGATAGTGCATTTCCACGTCTGTATGTCCACACTTAGCTTATT
 401 CTGTTGGTCACAGAGGAGACAGTCGAGGAGGAAGGAGCTGATACATGTATTTGATCAGAAGCCAGCAGACAGAATTACCA
 481 AAGTGGATCTGGTGCTGATGGCTGGGGGGATAAGCAGAGTGGAGGCCAGCTCTGCAGCAGTGTGCCCTCCTGGCCTGGCT
 561 GTGGCTGGAGGCTCTGACTGGCTGTGGCTGGAATCCACATGCCTTTAGGTAGGAGTTTGTGCTTGCAAAACAGGAGAATT
 641 TAAAAGATTCTTTTCTCTCCTCTTCCCTCCTGCCTTCATATTCTTTTTACAATCATTTACAGGCACAGCCTGAGAGTGTT
 721 TGGCATGGTTTTTGGAGTTACAGTGCTGGTATTTCCAAGCACGCTCTCAGACTGTGGATGAGAAACACCTCAGTACAACA
 801 GTGATCTTGGAGTGAGCTCCAGAATAGGAAAACACTTGTTTCTTTTCTTTTCAGAAACCTCAGCATTCCTGCTGGGCTGC
 881 TGCCCCTTTAATTGAGCCACTGTGCAACTCCTCTGTTCTTTTATTAACATGCTGCTCCCATGTCCTCAAGATTCAGGGAT
 961 TTGGGATCCAGGAACCGAAGAATGAATAGTCAGTGGCCAGATTTCCCCCCAGGTATCTGGGCACAGTATGAGGATTAAAA
1041 GTACAAATTGTTCAGAGCCATTAAAGAGTGTGTAGAAGAGAAAAGGGGGGTGTTCAATCGATATCCCTTCGTTTTCTTGC
1121 AGCACGAAGTCAGTACAGAGTAAGAAAGGCATCAGAAAGCCTCTGCTGGGGCAGGGTAAGGAACCAAGCCCCTAGGCTGG
1201 CTGTCCTACCAGTGTACTGATGAGGACCAGTAAGGGCAGGCAGAGGCAGTTTGTCCTCACTCCAAAGCCATAGGAATTTC
1281 CATCTTCCAGAGCCTCTGTGAGTCTCCAGCCCTTGTGGTCACTGCATCCAGCTTCACAGTGTCCTCTAGAGTCACAGCCA
1361 AGCACCTGGACCCCTCGGGGAACGTTAAGAAGACAGGCCGTGGACTTTAAGCCTTTTAACCTTGGAAGGAGGATGTAAAA
1441 TGGCAAGGGTCCTTCTGCAGGGGCCATGGCAGTGAAACCTGGCTTCAGATTTGTTTCCAAAGGACTTCTTTCTCCCCCAA
1521 ATCTGAGATGTATCCGAAAGGCAAGGGTCCCACAGAGGCTCCAAAATGAAGGCATTAGGAAATGGGAATGTCAGCTGGCT
1601 CCCTGGTCAGTTCACCTGAGGGATTGCTGCTAAAGGGAGTAGTTCAGAGACATGAGCTTTGGTTTTGTCAGGGTCTGTTT
1681 TAGGGTTATTTTATTGGGGTTTGGTTCTTCTGTTGTTGTTGTCGTTGTTGTTGTTGTTGTTGTTGTTGTTGCCTCTGCCT
1761 CTACACATTTTTGACTGATAAATGATTCATGTCCCTGAATTAAAGTGGCTGACCTTTGACTGCATCAAGCATCCTTTTGT
1841 AAGCAGGGAGGGCCTTAACCTGCAATTGACACATACCATCTTGCCCTCAGATCCTATCTCCCATGATACCTGAGGAAACA
1921 ACATGGAAGCCAGAGACCTCAGTGTAGTCACTAGTTCTGGGGCAACATGTGGAATAGGAGACAAGACTGCCTGCCTGCTG
2001 GCCACTTATGGATTCCCTTCCCCCAAGCCAAAGTTTGGTTTGTTGTTGCTATTAGGACAGTTTTCATTGTATGTACATAA
2081 ATATTTTAGTAAGGGGAAGGGATGGGCTGGGGCCTTTTGGAGTTCTAGAGAATGGGGGCAGAGGGGTTTTTCTTTCTCTT
2161 GTTTCTTTTTGAGAAAATTTACTGGCTAAAGGAACAGACATTTTGGGTCTTTGTTTAATAAGGGCCATTCTCACAGAAAG
2241 GCAAGCCCTTCACCTAGTGGAGACGAGGCCAGTCTCTCAACAGTTGTATCCACAGATGGTAGGAAGGGAGAGAGAGTTGA
2321 AGAAGGCTTCTTCTTTCCTAGACAGGAAAGGGTGGCCACGCAGGGTGAAGAGGACAGTCCCATGGCCCATGCTGCAGGGC
2401 CTGAGGGGCCTTCATGCACTTCAGTTCAGCTGGTTCTGGCTGAGGCCTCCAAGGCCAGTCTGTTTGCCAGTGCATCTCTG
2481 CTGCGTGGACAAGGACACTCTCCGATGCCACTTCCTCAGGCCCTTTTCCAAGGAAGACTAGATGGAGTTGGCTTTTTATG
2561 CAAAGGTCGTTGGATTTCAGGGTGAGCACTGAGAGCTGGCTCCCCCAAGTGTCTGGATTTCACTATGTTGGCCTCATGGT
2641 TGATCCTCAAGGCCACTGTGCTGGCTTGTTGGACTGATTTAGGAAGCAGGCTAGAGGAGACGGGCATTTTATGACTCTGT
2721 TAGAGGATTCTGGGTGATGATTTCAAAAAGATGGCTGACGCTGAATCGCAGTGTGAGAAGGGTGTTTGCAGTTTTGCAGG
2801 CCTCTGTGGCCTGGGCTTTCTATGCTGCGAATATTACTAGAAGCTGGATTCCTTTAAGGAGACTTGTAGTGAAAATGTTT
2881 GTCTGGATGTTCCTCTTTCAGCCCGGAGAGCTGCCTTAGGTCTTTTCTAGAATTTCTGTGTTACTTAGTTCAACCTCAGC
2961 CCAGAAGCACCATGCTCCTTGTCATTTTAAGGCTCTCAGGTTTCCAGGAACCTCCACCACCGCCACCCTGCAGCAGCCGC
3041 TGTCTGAACTGAGCCGTGTTTCCTTCCCTTGGAAACTGCCTGGCGCTTGGCTCTTAGTTTAAGGAGAGCTTGTGGCTTTT
3121 CCTCAAGCATGGACTCCTCGGGGCTGAACTGTTTGGTTTAGGCTGTGCTTTCTTTGAGGCACAGCGGGCAGGTCCGCGAC
3201 CACCTCCGTCCTGTACCTAGTCATGTAGCTTCCAGACACTGAGATGAGAAGGATGTGAGCCTATGCAAGAAGAGCATAGT
3281 GCGCCCCTCCCTGCGCCAGGCGAACAAGGCCAATCAAGGGCAGTCTGGAACTCGGGTGTGCCAGGAAGGGGGGGAGGGGG
3361 CGGGAAGCTGCCTGGCCAACCTTCCCCTCTGGCCCAGCCAGTTCTCCACTACTCAAACCTCTAGCATGGCAATGTTTGCA
3441 AAATTGCAGACTTTTCTCCCAGATATTAGGAGGAAAGGGACTTTGGGGGGTGGGGAAGGGGTCTTGGTGTTTAAAGCATA
3521 AGTTACCTGTTTGCACTGTTTTCAAATAGGAAACAATAGTGGGCACGGTGAACATCTAATGTAAACGTGTGTTTTCTTTT
3601 GTCATGCTCTTGAGAATGTCTGATCATTTGTAGTATACACCAGTGACACTTGATTCTCTGTTTCATAAAACACTATATTT
3681 TTGGAAATGTTGCTGTCCGGAAGCCTCTTCCCACCCATCCCCTCTCCTGTGTACCTCCTTTCTCCTTGCTTCCTCATCAG
3761 CCAGGCAGTTGCCATCCCTGGGCTAGAGCGGGAAACAGGGCCCCATCCCAAGCAGGCTCTGGGTGTCCTAAGCCAGCATG
3841 TGCCCTCTAGATTACTGAGTGCAGGACAGTCCCTTGGCAACTTTCCTTTCGAAAGGCTCACCAACTACCACAGATTGCCA
3921 AACTCTTCAGCGAGGCAATAGAAGTGAGTCAGGGGGCGCGGGTCCCTGAAGTATTGTGGTTGGCTGTGGAAGCCATGTTC
4001 TTATGCAAGTTACCGAAACTGTAGCCAGTTACAGTGTACTCAGGAAAAAACGGTAGATGAGTTCAGCCATGGCGGTGCTG
4081 GCTGGCAGGGATTGGTAACTGAGAACTGCCCATCAGCCAAAACTCACCCTTGCCTTTGCAGAGACCTCCCACCTCGGGGG
4161 CAGCCCTCTGTACTTGCCAGCGCTGGGTGGGGCTGCTTTCACCCTGGCAGGCAAAAAGGGAACAGCGATGCTCTTTCCTT
4241 CCCTCCCTCTTCCGGTTACCAATGCCAGATTCCCAGGGGCACGCGAGTTTTTGAGTTTTTCAGAAAATGCTTTTGGTTTG
4321 TCTTTTCCGGGGACTGACGCGCTTTAGTCGCTGTCTGTCCCCATCAGGACTCCTAGCTTAGGTGGTTTCTTGTATTTTCT
4401 GTTAACAGTATTTCTTGTGTGCGTGCTTGTTGGGCAGCCCGTTTGGCTGCGTTATATAGCGAGTGATGAGCTGATCCTTT
4481 CCCCTAAGAGACATGACTTCCCTCCGTCAGCATTCAGCCTGTGAATAGCTAGAGCCACCCTGGGGCGGACACGTGCAAGT
4561 TAGAGCTGCAGAGTGAACTGAGGCTCTCAGGTTTTGAGTCTCTCTCTTTTCAAGGCTCAAAAGTACCACAGAACCTCGCT
4641 CTTCTCCACACCCCTGTGGCAGGGAGTGGCCTGCCTGGCACATGTGGCTTCCCCATGCAGGACAGGCACCACTGGGACAT
4721 GGGGGGCACATGCGGATGCTTGTCCAGCTGACCACCCCGCTGTGTCTCCTTCCCTCCCACCATCCTCTCCCAGAATCACC
4801 TCCTAGGGCACCCGAGCTGCTTGCCCAGGGTCCTGTTTCCCTGCTAACTCCAGAGAAGCACCCAGGGCGTTGTGACAGTC
4881 TCTAACTCCCTCCCTCCCTCCCTCCCTCTTCCTCCTTAAGAATCATATTGTATAGTAGCTTTCAGACCATACAGTATTCA
4961 TTGGGTTACTCCTATTATCAAGTAGCTGGAATTGTGAAGGTTGAGTAGTTAGATCTTTAGCTTTTATTCATTATTTTTTG
5041 TATTACTCTCCATGTGTATAAATTATTGATCATGTTGCTGGCTTTTATAAACTCTTAGCAAAGGAGGGGCCCTGCCTCAG
5121 CCTTTGCAAATGGTAATGAAGCACTGTTTTTAAATAAAAGAGAGAAACACCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuGAUA-UGUUAGA---UGAUGGAGu 5'
            :|:| |||:|||   ||| |||| 
Target 5' cgTTGTGACAGTCTCTAACTCCCTCc 3'
 4868 - 4893 136.00 -14.10
2 
miRNA  3' uugaUAUGUUAGA---------U--GAUGGAGu 5'
              |||| ||||         |  |||:||| 
Target 5' acacATACCATCTTGCCCTCAGATCCTATCTCc 3'
 1869 - 1901 132.00 -10.71
3 
miRNA  3' uuGAUAUGUUA-GAUGAUGGAGu 5'
            || | |:|| | ||| |||| 
Target 5' caCTCTCCGATGCCACTTCCTCa 3'
 2496 - 2518 132.00 -11.80
17 mmu-let-7f-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT578153 Nf2 neurofibromin 2 1 2
MIRT578702 Gnl3l guanine nucleotide binding protein-like 3 (nucleolar)-like 1 2
MIRT579032 Cts8 cathepsin 8 1 2
MIRT579380 Apc2 adenomatosis polyposis coli 2 1 3
MIRT582392 Msi2 musashi RNA-binding protein 2 1 1
MIRT583576 Fbxl14 F-box and leucine-rich repeat protein 14 1 1
MIRT586729 Lins lines homolog 1 1 1
MIRT592557 Mup17 major urinary protein 17 1 1
MIRT592598 Mup11 major urinary protein 11 1 1
MIRT592946 Armc2 armadillo repeat containing 2 1 2
MIRT594650 Meis2 Meis homeobox 2 1 1
MIRT596612 Zfp444 zinc finger protein 444 1 1
MIRT597963 Nup214 nucleoporin 214 1 1
MIRT601173 Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 1 1
MIRT601465 Tnfrsf26 tumor necrosis factor receptor superfamily, member 26 1 1
MIRT605692 Ifnar1 interferon (alpha and beta) receptor 1 1 1
MIRT756038 Rbfox2 RNA binding protein, fox-1 homolog (C. elegans) 2 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
let-7f Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
let-7f Oleic acid NULL 445639 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
let-7f Hydroxamic acid HDACi LAQ824 NULL NULL Microarray breast cancer cell line SKBr3 16452179 2006 down-regulated
let-7f 17beta-estradiol (E2) approved 5757 Microarray MCF-7 breast cancer cells 19528081 2009 up-regulated
let-7f 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR MCF-7 breast cancer cells 19528081 2009 up-regulated
let-7f Bisphenol A NULL 6623 Microarray immortalized cytotrophoblast cell lines 3A 20417706 2010 up-regulated
let-7f Bisphenol A NULL 6623 Microarray immortalized cytotrophoblast cell lines HTR-8 20417706 2010 up-regulated
let-7f Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
let-7f 5-Fluorouracil approved 3385 Microarray MCF-7 breast cancer cells 21506117 2011 up-regulated
let-7f Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
let-7f 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer MDA-MB231 22076154 2011 down-regulated
let-7f 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer SKBR3 22076154 2011 down-regulated
let-7f 17beta-estradiol (E2) approved 5757 Microarray MCF-7 breast cancer cell line 22403704 2012 down-regulated
let-7f Bisphenol A NULL 6623 Microarray MCF-7 breast cancer cell line 22403704 2012 down-regulated
let-7f Letrozole approved 3902 Quantitative real-time PCR breast cancer stromal cells 22403704 2012 up-regulated
let-7f Vitamin D3 approved 5280795 Quantitative real-time PCR Plasma 22594500 2012 up-regulated
let-7f Vitamin D3 approved 5280795 Quantitative real-time PCR Plasma 22594500 2012 up-regulated
let-7f 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) NULL 16078949 Microarray hepatocytes 23107762 2013 down-regulated
let-7f Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
let-7f Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse liver 19270793 2009 down-regulated
let-7f Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 down-regulated
let-7f Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
let-7f Hesperidin NULL 10621 Microarray apoE−/− mice 22253797 2012 down-regulated

Error report submission