pre-miRNA Information
pre-miRNA hsa-mir-134   
Genomic Coordinates chr14: 101054687 - 101054759
Description Homo sapiens miR-134 stem-loop
Comment miR-134 was first identified by cloning studies in mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-134-3p
Sequence 46| CCUGUGGGCCACCUAGUCACCAA |68
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 23 14 + 101054754 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs773121278 7 dbSNP
rs760717795 8 dbSNP
rs1415917765 9 dbSNP
rs1278249300 10 dbSNP
rs765201848 11 dbSNP
rs1212462908 14 dbSNP
rs752580711 18 dbSNP
rs752786233 23 dbSNP
Putative Targets

Gene Information
Gene Symbol GPR137   
Synonyms C11orf4, GPR137A, TM7SF1L1
Description G protein-coupled receptor 137
Transcript NM_001177358   
Other Transcripts NM_001170726 , NM_001170881 , NM_001170880 , NM_020155   
Expression
Putative miRNA Targets on GPR137
3'UTR of GPR137
(miRNA target sites are highlighted)
>GPR137|NM_001177358|3'UTR
   1 GCCGGGCTGGTATGGGGGCAGCCAGACGAAGACCACTCCTCTGCTCTTCTCCCAGGTGCCAGGACCAGGCGGCCACCACC
  81 ACAGTCTCTACTCCACCCCACAGACGTGATCCCCCTCCCTCCCCCACAGAATACCCAGGCCCCAGTCCCCCTCACCCTAG
 161 GCCCCTGTGCCAAGTTTGTCTGCCGCTTCTTGCCCAGGATCCTGGGGGTCGTGGCTACCCCCTCCTCTGGCCGGCTCCTT
 241 GCTGCTCCTGTCATAGTGAGCTTGTGCCGTCCCCCTAGGATGGGGGGCATGGCCCTGGCTGCCAGATGCCCACAGCACCC
 321 TGGCATGACCTGCCACCTCTGCTTCCACACCGGAGCCAGCTACCTCTCCTGTGCCTGCCACTCAATAAACAGTGTCTGCG
 401 CCCCACAGTTGTGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' aaccACUGA---UCCACCGGGUGUCc 5'
              ||:||   || | |||||||| 
Target 5' gcccTGGCTGCCAGAT-GCCCACAGc 3'
292 - 316 158.00 -17.70
2
miRNA  3' aacCACUGAUCCACCGGGUGUCc 5'
             ||| ||  | | ||||||| 
Target 5' acaGTGTCT--GCGCCCCACAGt 3'
389 - 409 156.00 -15.20
3
miRNA  3' aacCACU-----GAUCCACCGGGUGUCc 5'
             ||||     ||   |  ||||||| 
Target 5' gacGTGATCCCCCTCCCTCCCCCACAGa 3'
103 - 130 144.00 -11.81
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM8180494 4 COSMIC
COSM6274281 5 COSMIC
COSM8882147 8 COSMIC
COSM7568038 28 COSMIC
COSM8881302 29 COSMIC
COSM7323562 41 COSMIC
COSM7643078 42 COSMIC
COSM1704197 52 COSMIC
COSM3398012 55 COSMIC
COSM1317285 71 COSMIC
COSM3451406 75 COSMIC
COSM9833566 86 COSMIC
COSM4462369 94 COSMIC
COSM8075815 96 COSMIC
COSM8075787 97 COSMIC
COSM9833568 98 COSMIC
COSM1660149 104 COSMIC
COSM3416094 106 COSMIC
COSM9718914 109 COSMIC
COSM3869837 112 COSMIC
COSM7414850 112 COSMIC
COSM9833570 113 COSMIC
COSM1188283 116 COSMIC
COSM3451408 118 COSMIC
COSM7983007 119 COSMIC
COSM9682190 123 COSMIC
COSM3451409 125 COSMIC
COSM7084094 125 COSMIC
COSM8799759 126 COSMIC
COSM9833571 127 COSMIC
COSM8694828 139 COSMIC
COSM9882110 143 COSMIC
COSM7481635 144 COSMIC
COSM9847200 145 COSMIC
COSM4687996 147 COSMIC
COSM4035103 149 COSMIC
COSM9462586 150 COSMIC
COSM8241286 156 COSMIC
COSM5909114 157 COSMIC
COSM5909113 158 COSMIC
COSM5958764 159 COSMIC
COSM3451410 164 COSMIC
COSM9847942 167 COSMIC
COSM1676140 172 COSMIC
COSM9192036 179 COSMIC
COSM6673716 185 COSMIC
COSM4687997 190 COSMIC
COSM689733 190 COSMIC
COSM2163362 195 COSMIC
COSM9546452 199 COSMIC
COSM7209803 203 COSMIC
COSM3869838 211 COSMIC
COSM4515860 221 COSMIC
COSM8206636 223 COSMIC
COSM9708433 225 COSMIC
COSM6673695 226 COSMIC
COSM7580067 233 COSMIC
COSM3451411 238 COSMIC
COSM3451412 239 COSMIC
COSM1492658 268 COSMIC
COSM1637738 269 COSMIC
COSM8182231 270 COSMIC
COSM3451413 275 COSMIC
COSM9218292 275 COSMIC
COSM8111609 276 COSMIC
COSM8829409 279 COSMIC
COSN30469961 284 COSMIC
COSN30188201 287 COSMIC
COSN30107885 288 COSMIC
COSN30469020 292 COSMIC
COSN31503584 292 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs777861223 4 dbSNP
rs747052522 5 dbSNP
rs1449324744 6 dbSNP
rs1415330135 7 dbSNP
rs770946965 9 dbSNP
rs1382251589 13 dbSNP
rs1418345657 17 dbSNP
rs1332268770 22 dbSNP
rs777165681 23 dbSNP
rs746413073 24 dbSNP
rs770271373 26 dbSNP
rs776067760 28 dbSNP
rs373825093 29 dbSNP
rs1451505093 34 dbSNP
rs763418203 36 dbSNP
rs771796172 37 dbSNP
rs1166944212 38 dbSNP
rs1236328445 42 dbSNP
rs772766864 43 dbSNP
rs951153328 46 dbSNP
rs139944159 48 dbSNP
rs765843037 53 dbSNP
rs1445906977 54 dbSNP
rs1164892448 70 dbSNP
rs112280262 71 dbSNP
rs948264309 72 dbSNP
rs759525423 77 dbSNP
rs1179510675 80 dbSNP
rs1404201706 80 dbSNP
rs1442775336 85 dbSNP
rs1019360953 87 dbSNP
rs1240322587 91 dbSNP
rs765010882 92 dbSNP
rs1212997040 94 dbSNP
rs752421079 95 dbSNP
rs1378691774 97 dbSNP
rs59138617 101 dbSNP
rs778003446 106 dbSNP
rs561497512 107 dbSNP
rs751769598 113 dbSNP
rs757339612 115 dbSNP
rs551479017 116 dbSNP
rs775817851 116 dbSNP
rs1402109886 117 dbSNP
rs1278785438 121 dbSNP
rs763190870 121 dbSNP
rs764247546 121 dbSNP
rs1327313394 124 dbSNP
rs746374868 126 dbSNP
rs1305733573 127 dbSNP
rs1331561479 130 dbSNP
rs780722823 131 dbSNP
rs749624824 133 dbSNP
rs1183505174 136 dbSNP
rs1473109439 138 dbSNP
rs1232267506 145 dbSNP
rs1202123637 146 dbSNP
rs768937513 148 dbSNP
rs200570583 152 dbSNP
rs1258885599 153 dbSNP
rs141281150 162 dbSNP
rs1332746164 163 dbSNP
rs1479807355 166 dbSNP
rs776069574 168 dbSNP
rs759049381 169 dbSNP
rs1435360083 171 dbSNP
rs765100830 172 dbSNP
rs1278316492 174 dbSNP
rs1429279303 175 dbSNP
rs752653816 181 dbSNP
rs1444742381 184 dbSNP
rs762705422 185 dbSNP
rs183799439 186 dbSNP
rs766931611 188 dbSNP
rs1460171555 190 dbSNP
rs781483598 191 dbSNP
rs376225218 194 dbSNP
rs913859262 195 dbSNP
rs1406302144 196 dbSNP
rs756288995 197 dbSNP
rs367703845 199 dbSNP
rs1218986993 201 dbSNP
rs1279878805 204 dbSNP
rs755343938 205 dbSNP
rs1407090520 207 dbSNP
rs1226978653 209 dbSNP
rs945401079 211 dbSNP
rs779201215 212 dbSNP
rs553703869 214 dbSNP
rs770421473 216 dbSNP
rs1488932917 218 dbSNP
rs776278037 219 dbSNP
rs769324867 220 dbSNP
rs775383976 221 dbSNP
rs762857960 224 dbSNP
rs763947093 226 dbSNP
rs773952568 231 dbSNP
rs761684438 233 dbSNP
rs573832958 234 dbSNP
rs756236036 239 dbSNP
rs766611027 243 dbSNP
rs1185070906 244 dbSNP
rs1359626153 248 dbSNP
rs754387631 250 dbSNP
rs755506702 254 dbSNP
rs779481487 257 dbSNP
rs371910058 262 dbSNP
rs144777699 264 dbSNP
rs780783559 266 dbSNP
rs189125968 269 dbSNP
rs769279910 270 dbSNP
rs775046189 272 dbSNP
rs748834114 273 dbSNP
rs768418179 274 dbSNP
rs1354838704 277 dbSNP
rs774364513 279 dbSNP
rs1446101502 280 dbSNP
rs1439205183 281 dbSNP
rs1055326545 282 dbSNP
rs1294942484 282 dbSNP
rs751647893 282 dbSNP
rs938150220 282 dbSNP
rs995533683 283 dbSNP
rs761472135 284 dbSNP
rs113784844 288 dbSNP
rs773551093 292 dbSNP
rs556487730 296 dbSNP
rs1011415557 298 dbSNP
rs766565977 299 dbSNP
rs753904634 307 dbSNP
rs755100658 309 dbSNP
rs374962452 311 dbSNP
rs1450766111 318 dbSNP
rs753279054 321 dbSNP
rs1398512475 328 dbSNP
rs1021836209 337 dbSNP
rs1026572970 338 dbSNP
rs140507132 341 dbSNP
rs1003899014 352 dbSNP
rs998804841 353 dbSNP
rs1008243697 363 dbSNP
rs1035595384 366 dbSNP
rs965128401 372 dbSNP
rs776905944 378 dbSNP
rs991540784 384 dbSNP
rs1211667297 389 dbSNP
rs544258954 400 dbSNP
rs564638244 401 dbSNP
rs1280269739 402 dbSNP
rs1028151412 406 dbSNP
rs957874690 412 dbSNP
rs1302954865 413 dbSNP
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
64 hsa-miR-134-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT082376 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 2 6
MIRT091883 ACVR2B activin A receptor type 2B 2 4
MIRT094089 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 4
MIRT316375 PPP1R14C protein phosphatase 1 regulatory inhibitor subunit 14C 2 2
MIRT368317 E2F2 E2F transcription factor 2 2 2
MIRT446160 RPL12 ribosomal protein L12 2 2
MIRT458223 SHMT2 serine hydroxymethyltransferase 2 2 2
MIRT483575 SYT2 synaptotagmin 2 2 2
MIRT486251 FASTK Fas activated serine/threonine kinase 2 2
MIRT487556 TM6SF2 transmembrane 6 superfamily member 2 2 4
MIRT488952 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 2
MIRT489232 ASCL2 achaete-scute family bHLH transcription factor 2 2 4
MIRT491923 WNK2 WNK lysine deficient protein kinase 2 2 2
MIRT504191 FAM127B retrotransposon Gag like 8A 2 2
MIRT517340 ZNF529 zinc finger protein 529 2 4
MIRT528964 FAM19A3 family with sequence similarity 19 member A3, C-C motif chemokine like 2 2
MIRT530497 FADS6 fatty acid desaturase 6 2 2
MIRT539575 UPP2 uridine phosphorylase 2 2 2
MIRT549348 ARC activity regulated cytoskeleton associated protein 2 2
MIRT554316 SHMT1 serine hydroxymethyltransferase 1 2 2
MIRT555311 PPP2R5C protein phosphatase 2 regulatory subunit B'gamma 2 2
MIRT558029 EXT1 exostosin glycosyltransferase 1 2 2
MIRT564075 KIAA1191 KIAA1191 2 2
MIRT569986 TMEM184A transmembrane protein 184A 2 2
MIRT570669 INSIG1 insulin induced gene 1 2 2
MIRT571911 LSM14A LSM14A, mRNA processing body assembly factor 2 4
MIRT574042 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT574076 RNF152 ring finger protein 152 2 2
MIRT575774 Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b 2 2
MIRT576510 Slc35e2 solute carrier family 35, member E2 2 2
MIRT609004 PYGO1 pygopus family PHD finger 1 2 2
MIRT619992 NPAP1 nuclear pore associated protein 1 2 2
MIRT630308 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT636261 RRAGC Ras related GTP binding C 2 2
MIRT638834 CRTAP cartilage associated protein 2 2
MIRT639813 TMED8 transmembrane p24 trafficking protein family member 8 2 2
MIRT641938 SCOC short coiled-coil protein 2 2
MIRT644770 TXNRD3NB thioredoxin reductase 3 neighbor 2 2
MIRT650082 MTL5 testis expressed metallothionein like protein 2 2
MIRT651539 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT653695 SLC25A33 solute carrier family 25 member 33 2 2
MIRT654579 PXMP4 peroxisomal membrane protein 4 2 2
MIRT655804 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT662741 LRRC3C leucine rich repeat containing 3C 2 2
MIRT667588 LONRF2 LON peptidase N-terminal domain and ring finger 2 2 2
MIRT667730 KIAA1456 KIAA1456 2 2
MIRT667909 ING1 inhibitor of growth family member 1 2 2
MIRT675875 ATP1B4 ATPase Na+/K+ transporting family member beta 4 2 2
MIRT684043 FOLR1 folate receptor 1 2 2
MIRT686239 ZMIZ1 zinc finger MIZ-type containing 1 2 2
MIRT710043 POLL DNA polymerase lambda 2 2
MIRT711988 EXTL3 exostosin like glycosyltransferase 3 2 2
MIRT714061 VHLL VHL like 2 2
MIRT715879 ACIN1 apoptotic chromatin condensation inducer 1 2 2
MIRT716779 C1orf229 chromosome 1 open reading frame 229 2 2
MIRT717104 PXDC1 PX domain containing 1 2 2
MIRT723567 ZBTB34 zinc finger and BTB domain containing 34 2 2
MIRT725668 ABI2 abl interactor 2 2 2
MIRT735690 SYT11 synaptotagmin 11 1 0
MIRT736843 CCND1 cyclin D1 2 0
MIRT736981 MLH1 mutL homolog 1 1 0
MIRT737413 FOXM1 forkhead box M1 3 0
MIRT756143 GPR137 G protein-coupled receptor 137 3 1
MIRT756411 SOX9 SRY-box 9 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-134 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-134 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miR-134 Gefitinib approved 123631 Quantitative real-time PCR lung adenocarcinoma cells 24258346 2014 up-regulated
miR-134 Ascorbate approved 54670067 Microarray Metastatic melanoma cell lines 25202679 2014 up-regualted
miR-134 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) NULL NULL Microarray T24 human bladder cancer cells 16766263 2006 up-regulated
miR-134 Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 up-regulated
miR-134 Testosterone approved 6013 Microarray prostate cancer 21592394 2011 up-regulated
miR-134 Testosterone + 1,25-Dihydroxyvitamin D3 approved NULL Microarray prostate cancer 21592394 2011 up-regulated
miR-134 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-134 1alpha,25-Dihydroxyvitamin D3 approved 5280453 Microarray prostate cancer 21592394 2011 up-regulated
miR-134 Goserelin approved 47725 Microarray prostate 22674191 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-134 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-134 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-mir-134 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-134-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-134-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-134-3p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-134-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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