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dbESI_EC_001
MIB2
RING-Singlemotif
dbESI_EC_002
MDM4
RING-Singlemotif
dbESI_EC_003
MARCHF2
RING-Singlemotif
dbESI_EC_004
ZSWIM2
RING-Singlemotif
dbESI_EC_005
CBLB
RING-Singlemotif
dbESI_EC_006
TRIM33
RING-Singlemotif
dbESI_EC_007
RNF6
RING-Singlemotif
dbESI_EC_008
LRSAM1
RING-Singlemotif
dbESI_EC_009
UHRF2
RING-Singlemotif
dbESI_EC_010
TRIM31
RING-Singlemotif
dbESI_EC_011
MSL2
RING-Singlemotif
dbESI_EC_012
RFWD3
RING-Singlemotif
dbESI_EC_013
PIAS4
RING-Singlemotif
dbESI_EC_014
RNF135
RING-Singlemotif
dbESI_EC_015
RFFL
RING-Singlemotif
dbESI_EC_016
LNX1
RING-Singlemotif
dbESI_EC_017
RNF8
RING-Singlemotif
dbESI_EC_018
RNF180
RING-Singlemotif
dbESI_EC_019
TRIM63
RING-Singlemotif
dbESI_EC_020
TRIM22
RING-Singlemotif
dbESI_EC_021
BIRC2
RING-Singlemotif
dbESI_EC_022
SH3RF1
RING-Singlemotif
dbESI_EC_023
RBCK1
RING-Singlemotif
dbESI_EC_024
RNF138
RING-Singlemotif
dbESI_EC_025
MARCHF11
RING-Singlemotif
dbESI_EC_026
BRAP
RING-Singlemotif
dbESI_EC_027
TRIM32
RING-Singlemotif
dbESI_EC_028
RBBP6
RING-Singlemotif
dbESI_EC_029
SHPRH
RING-Singlemotif
dbESI_EC_030
TRAF6
RING-Singlemotif
dbESI_EC_031
MAP3K1
RING-Singlemotif
dbESI_EC_032
RNF115
RING-Singlemotif
dbESI_EC_033
RNF34
RING-Singlemotif
dbESI_EC_034
PDZRN3
RING-Singlemotif
dbESI_EC_035
FANCL
RING-Singlemotif
dbESI_EC_036
TOPORS
RING-Singlemotif
dbESI_EC_037
RNF111
RING-Singlemotif
dbESI_EC_038
MYLIP
RING-Singlemotif
dbESI_EC_039
MARCHF1
RING-Singlemotif
dbESI_EC_040
PDLIM2
RING-Singlemotif
dbESI_EC_041
MIB1
RING-Singlemotif
dbESI_EC_042
TRIM41
RING-Singlemotif
dbESI_EC_043
MARCHF8
RING-Singlemotif
dbESI_EC_044
TRIM28
RING-Singlemotif
dbESI_EC_045
SIAH2
RING-Singlemotif
dbESI_EC_046
MARCHF6
RING-Singlemotif
dbESI_EC_047
TANK
RING-Singlemotif
dbESI_EC_048
CHFR
RING-Singlemotif
dbESI_EC_049
TRIM25
RING-Singlemotif
dbESI_EC_050
AMFR
RING-Singlemotif
dbESI_EC_051
MKRN1
RING-Singlemotif
dbESI_EC_052
CBLL1
RING-Singlemotif
dbESI_EC_053
SYVN1
RING-Singlemotif
dbESI_EC_054
MARCHF7
RING-Singlemotif
dbESI_EC_055
MARCHF5
RING-Singlemotif
dbESI_EC_056
VPS18
RING-Singlemotif
dbESI_EC_057
RNF182
RING-Singlemotif
dbESI_EC_058
CNOT4
RING-Singlemotif
dbESI_EC_059
RNF125
RING-Singlemotif
dbESI_EC_060
MDM2
RING-Singlemotif
dbESI_EC_061
CCNB1IP1
RING-Singlemotif
dbESI_EC_062
PIAS2
RING-Singlemotif
dbESI_EC_063
TRIM11
RING-Singlemotif
dbESI_EC_064
RLIM
RING-Singlemotif
dbESI_EC_065
TRIM17
RING-Singlemotif
dbESI_EC_066
BIRC3
RING-Singlemotif
dbESI_EC_067
TRIM5
RING-Singlemotif
dbESI_EC_068
RC3H1
RING-Singlemotif
dbESI_EC_069
RCHY1
RING-Singlemotif
dbESI_EC_070
MARCHF4
RING-Singlemotif
dbESI_EC_071
CBL
RING-Singlemotif
dbESI_EC_072
RNF128
RING-Singlemotif
dbESI_EC_073
RNF5
RING-Singlemotif
dbESI_EC_074
SIAH1
RING-Singlemotif
dbESI_EC_075
MARCHF9
RING-Singlemotif
dbESI_EC_076
RNF220
RING-Singlemotif
dbESI_EC_077
RNF4
RING-Singlemotif
dbESI_EC_078
RAG1
RING-Singlemotif
dbESI_EC_079
TTC3
RING-Singlemotif
dbESI_EC_080
RNF43
RING-Singlemotif
dbESI_EC_081
TRIM23
RING-Singlemotif
dbESI_EC_082
TRIM37
RING-Singlemotif
dbESI_EC_083
MYCBP2
RING-Singlemotif
dbESI_EC_084
NHLRC1
RING-Singlemotif
dbESI_EC_085
MUL1
RING-Singlemotif
dbESI_EC_086
RNF19B
RING-Singlemotif
dbESI_EC_087
XIAP
RING-Singlemotif
dbESI_EC_088
HLTF
RING-Singlemotif
dbESI_EC_089
TRIM56
RING-Singlemotif
dbESI_EC_090
MPG
RING-Singlemotif
dbESI_EC_091
PJA1
RING-Singlemotif
dbESI_EC_092
RNF41
RING-Singlemotif
dbESI_EC_093
PELI1
RING-Singlemotif
dbESI_EC_094
RNF126
RING-Singlemotif
dbESI_EC_095
ZNRF1
RING-Singlemotif
dbESI_EC_096
TRIM13
RING-Singlemotif
dbESI_EC_097
DZIP3
RING-Singlemotif
dbESI_EC_098
RNF146
RING-Singlemotif
dbESI_EC_099
RNF185
RING-Singlemotif
dbESI_EC_100
RNF149
RING-Singlemotif
dbESI_EC_101
TRIM62
RING-Singlemotif
dbESI_EC_102
RFPL4A
RING-Singlemotif
dbESI_EC_103
BIRC7
RING-Singlemotif
dbESI_EC_104
UHRF1
RING-Singlemotif
dbESI_EC_105
NEURL1B
RING-Singlemotif
dbESI_EC_106
TRIM3
RING-Singlemotif
dbESI_EC_107
BMI1
RING-Singlemotif
dbESI_EC_108
RING1
RING-Singlemotif
dbESI_EC_109
UBR2
RING-Singlemotif
dbESI_EC_110
RNF168
RING-Singlemotif
dbESI_EC_111
DTX3L
RING-Singlemotif
dbESI_EC_112
RNF139
RING-Singlemotif
dbESI_EC_113
PELI3
RING-Singlemotif
dbESI_EC_114
TRIM36
RING-Singlemotif
dbESI_EC_115
TRIM26
RING-Singlemotif
dbESI_EC_116
RNF170
RING-Singlemotif
dbESI_EC_117
TRIM71
RING-Singlemotif
dbESI_EC_118
DTX1
RING-Singlemotif
dbESI_EC_119
TRIM8
RING-Singlemotif
dbESI_EC_120
TRIM2
RING-Singlemotif
dbESI_EC_121
RNF25
RING-Singlemotif
dbESI_EC_122
PEX12
RING-Singlemotif
dbESI_EC_123
TRIM27
RING-Singlemotif
dbESI_EC_124
BARD1
RING-Singlemotif
dbESI_EC_125
PJA2
RING-Singlemotif
dbESI_EC_126
RNF152
RING-Singlemotif
dbESI_EC_127
RNF167
RING-Singlemotif
dbESI_EC_128
RNF13
RING-Singlemotif
dbESI_EC_129
RNF26
RING-Singlemotif
dbESI_EC_130
DTX4
RING-Singlemotif
dbESI_EC_131
BFAR
RING-Singlemotif
dbESI_EC_132
TRIM65
RING-Singlemotif
dbESI_EC_133
TRIM24
RING-Singlemotif
dbESI_EC_134
TRAF7
RING-Singlemotif
dbESI_EC_135
TRIM39
RING-Singlemotif
dbESI_EC_136
RNF38
RING-Singlemotif
dbESI_EC_137
TRIM38
RING-Singlemotif
dbESI_EC_138
TRIM9
RING-Singlemotif
dbESI_EC_139
MGRN1
RING-Singlemotif
dbESI_EC_140
RNF130
RING-Singlemotif
dbESI_EC_141
OSTM1
RING-Singlemotif
dbESI_EC_142
RNF11
RING-Singlemotif
dbESI_EC_143
CBLC
RING-Singlemotif
dbESI_EC_144
RNF181
RING-Singlemotif
dbESI_EC_145
PEX10
RING-Singlemotif
dbESI_EC_146
PCGF1
RING-Singlemotif
dbESI_EC_147
UBR1
RING-Singlemotif
dbESI_EC_148
TRIM59
RING-Singlemotif
dbESI_EC_149
NEURL1
RING-Singlemotif
dbESI_EC_150
TRIM58
RING-Singlemotif
dbESI_EC_151
RNF183
RING-Singlemotif
dbESI_EC_152
NEDD4L
HECT-NEDD4motif
dbESI_EC_153
UBR5
HECT-Othermotif
dbESI_EC_154
HERC5
HECT-HERCmotif
dbESI_EC_155
ITCH
HECT-NEDD4motif
dbESI_EC_156
WWP1
HECT-NEDD4motif
dbESI_EC_157
HECW1
HECT-NEDD4motif
dbESI_EC_158
HACE1
HECT-Othermotif
dbESI_EC_159
SMURF1
HECT-NEDD4motif
dbESI_EC_160
TRIP12
HECT-Othermotif
dbESI_EC_161
NEDD4
HECT-NEDD4motif
dbESI_EC_162
UBE3C
HECT-Othermotif
dbESI_EC_163
HECTD3
HECT-Othermotif
dbESI_EC_164
SMURF2
HECT-NEDD4motif
dbESI_EC_165
HUWE1
HECT-Othermotif
dbESI_EC_166
WWP2
HECT-NEDD4motif
dbESI_EC_167
HERC2
HECT-HERCmotif
dbESI_EC_168
HECTD2
HECT-Othermotif
dbESI_EC_169
HECTD1
HECT-Othermotif
dbESI_EC_170
HERC1
HECT-HERCmotif
dbESI_EC_171
HECW2
HECT-NEDD4motif
dbESI_EC_172
UBE3A
HECT-Othermotif
dbESI_EC_173
NOSIP
UBOXmotif
dbESI_EC_174
STUB1
UBOXmotif
dbESI_EC_175
TRAF3IP2
UBOXmotif
dbESI_EC_176
UBE4B
UBOXmotif
dbESI_EC_177
PRPF19
UBOXmotif
dbESI_EC_178
PRKN
RBRPPD Complexmotif
dbESI_EC_179
ARIH2
RBRmotif
dbESI_EC_180
RNF14
RBRmotif
dbESI_EC_181
RNF216
RBRmotif
dbESI_EC_182
RNF31
RBRLUBAC Complexmotif
dbESI_EC_183
RNF144A
RBRmotif
dbESI_EC_184
RNF144B
RBRmotif
dbESI_EC_185
RNF19A
RBRmotif
dbESI_EC_186
ANAPC1
RING-Complex-APCmotif
dbESI_EC_187
ANAPC2
RING-Complex-APCmotif
dbESI_EC_188
ANAPC10
RING-Complex-APCmotif
dbESI_EC_189
ANAPC11
RING-Complex-APCmotif
dbESI_EC_190
CDC27
RING-Complex-APCmotif
dbESI_EC_191
ANAPC7
RING-Complex-APCmotif
dbESI_EC_192
CDH1
RING-Complex-APCSubstrate-specific adaptormotif
dbESI_EC_193
CDC20
RING-Complex-APCmotif
dbESI_EC_194
FZR1
RING-Complex-APCSubstrate-specific adaptormotif
dbESI_EC_195
SPOP
RING-Complex-CRLs-BCRmotif
dbESI_EC_196
GAN
RING-Complex-CRLs-BCRSubstrate-specific adaptormotif
dbESI_EC_197
KLHL21
RING-Complex-CRLs-BCRSubstrate-specific adaptormotif
dbESI_EC_198
KLHL9
RING-Complex-CRLs-BCRSubstrate-specific adaptormotif
dbESI_EC_199
TNFAIP1
RING-Complex-CRLs-BCRSubstrate-specific adaptormotif
dbESI_EC_200
KEAP1
RING-Complex-CRLs-BCRSubstrate-specific adaptormotif
dbESI_EC_201
KLHL13
RING-Complex-CRLs-BCRSubstrate-specific adaptormotif
dbESI_EC_202
KLHL8
RING-Complex-CRLs-BCRSubstrate-specific adaptormotif
dbESI_EC_203
KCTD13
RING-Complex-CRLs-BCRSubstrate-specific adaptormotif
dbESI_EC_204
KLHL17
RING-Complex-CRLs-BCRSubstrate-recognition componentmotif
dbESI_EC_205
KLHL20
RING-Complex-CRLs-BCRSubstrate-specific adaptormotif
dbESI_EC_206
KLHL12
RING-Complex-CRLs-BCRSubstrate-specific adaptormotif
dbESI_EC_207
KCTD11
RING-Complex-CRLs-BCRSubstrate-specific adaptormotif
dbESI_EC_208
KLHL22
RING-Complex-CRLs-BCRSubstrate-specific adaptormotif
dbESI_EC_209
KLHL2
RING-Complex-CRLs-BCRmotif
dbESI_EC_210
KLHL7
RING-Complex-CRLs-BCRSubstrate-specific adaptormotif
dbESI_EC_211
KLHL42
RING-Complex-CRLs-BCRSubstrate-specific adaptormotif
dbESI_EC_212
KLHL3
RING-Complex-CRLs-BCRSubstrate-specific adaptormotif
dbESI_EC_213
KLHL11
RING-Complex-CRLs-BCRmotif
dbESI_EC_214
KCTD10
RING-Complex-CRLs-BCRSubstrate-specific adaptormotif
dbESI_EC_215
KLHL40
RING-Complex-CRLs-BCRSubstrate-specific adaptormotif
dbESI_EC_216
KLHL25
RING-Complex-CRLs-BCRSubstrate-specific adaptormotif
dbESI_EC_217
KLHL18
RING-Complex-CRLs-BCRSubstrate-specific adaptormotif
dbESI_EC_218
DDB2
RING-Complex-CRLs-DCXSubstrate-recognition componentmotif
dbESI_EC_219
FBXW5
RING-Complex-CRLs-DCXSubstrate-recognition componentmotif
dbESI_EC_220
TRPC4AP
RING-Complex-CRLs-DCXSubstrate-specific adaptormotif
dbESI_EC_221
DET1
RING-Complex-CRLs-DCXmotif
dbESI_EC_222
ERCC8
RING-Complex-CRLs-DCXSubstrate-recognition componentmotif
dbESI_EC_223
DTL
RING-Complex-CRLs-DCXSubstrate-specific adaptormotif
dbESI_EC_224
DDB1
RING-Complex-CRLs-DCXmotif
dbESI_EC_225
DCAF1
RING-Complex-CRLs-DCXSubstrate-recognition componentmotif
dbESI_EC_227
CUL4A
RING-Complex-CRLs-DCXmotif
dbESI_EC_228
DCAF4
RING-Complex-CRLs-DCXSubstrate-recognition componentmotif
dbESI_EC_229
CRBN
RING-Complex-CRLs-DCXSubstrate-recognition componentmotif
dbESI_EC_230
DCAF12
RING-Complex-CRLs-DCXSubstrate-recognition componentmotif
dbESI_EC_231
DCAF15
RING-Complex-CRLs-DCXSubstrate-recognition componentmotif
dbESI_EC_232
DCAF11
RING-Complex-CRLs-DCXSubstrate-recognition componentmotif
dbESI_EC_233
SKP1
RING-Complex-CRLs-SCFmotif
dbESI_EC_234
RBX1
RING-Complex-CRLs-SCFmotif
dbESI_EC_235
CDCA3
RING-Complex-CRLs-SCFmotif
dbESI_EC_236
FBXO3
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_237
ZC3HC1
RING-Complex-CRLs-SCFmotif
dbESI_EC_238
FBXO6
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_239
FBXW7
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_240
FBXO11
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_241
SKP2
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_242
FBXO2
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_243
FBXW5
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_244
FBXO32
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_245
FBXO7
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_246
FBH1
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_247
BTRC
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_248
FBXW11
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_249
FBXO33
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_250
FBXL5
RING-Complex-CRLs-SCFmotif
dbESI_EC_251
FBXO45
RING-Complex-CRLs-SCFmotif
dbESI_EC_252
FBXW2
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_253
FBXO31
RING-Complex-CRLs-SCFmotif
dbESI_EC_254
FBXO4
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_255
FBXL12
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_256
FBXL7
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_257
FBXL2
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_258
FBXO44
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_259
FBXW10
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_260
CCNF
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_261
FBXL3
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_262
FBXL14
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_263
FBXO25
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_264
KDM2B
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_265
FBXO40
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_266
FBXO22
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_267
FBXL19
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_268
FBXL15
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_269
FBXO42
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_270
CUL1
RING-Complex-CRLs-SCFmotif
dbESI_EC_271
FBXO27
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_272
TRIM21
RING-Complex-CRLs-SCFmotif
dbESI_EC_273
FBXO15
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_274
FBXL22
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_275
FBXL17
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_276
FBXO10
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_277
FBXL21P
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_278
FBXO21
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_279
FBXL18
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_280
FBXW12
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_281
FBXO34
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_282
FBXO9
RING-Complex-CRLs-SCFSubstrate-recognition componentmotif
dbESI_EC_283
CISH
RING-Complex-CRLs-ECSSubstrate-recognition componentmotif
dbESI_EC_284
SOCS3
RING-Complex-CRLs-ECSSubstrate-recognition componentmotif
dbESI_EC_285
ASB2
RING-Complex-CRLs-ECSSubstrate-recognition componentmotif
dbESI_EC_286
SOCS2
RING-Complex-CRLs-ECSSubstrate-recognition componentmotif
dbESI_EC_287
SOCS5
RING-Complex-CRLs-ECSSubstrate-recognition componentmotif
dbESI_EC_288
SOCS1
RING-Complex-CRLs-ECSSubstrate-recognition componentmotif
dbESI_EC_289
WSB1
RING-Complex-CRLs-ECSSubstrate-recognition componentmotif
dbESI_EC_290
ASB9
RING-Complex-CRLs-ECSSubstrate-recognition componentmotif
dbESI_EC_291
VHL
RING-Complex-CRLs-ECSmotif
dbESI_EC_292
ASB3
RING-Complex-CRLs-ECSSubstrate-recognition componentmotif
dbESI_EC_293
SOCS4
RING-Complex-CRLs-ECSSubstrate-recognition componentmotif
dbESI_EC_294
ASB4
RING-Complex-CRLs-ECSSubstrate-recognition componentmotif
dbESI_EC_295
SPSB2
RING-Complex-CRLs-ECSSubstrate-recognition componentmotif
dbESI_EC_296
NEURL2
RING-Complex-CRLs-ECSSubstrate-recognition componentmotif
dbESI_EC_297
CUL5
RING-Complex-CRLs-ECSmotif
dbESI_EC_298
ARIH2
RING-Complex-CRLs-ECSmotif
dbESI_EC_299
ASB11
RING-Complex-CRLs-ECSSubstrate-recognition componentmotif
dbESI_EC_300
TRAF2
RING-Complex-OtherTRAF1-TRAF2 Complexmotif
dbESI_EC_301
RNF123
RING-Complex-OtherKPC Complexmotif
dbESI_EC_302
ARID1B
RING-Complex-OtherBAF250B-ElonginC-CUL2 Complexmotif
dbESI_EC_303
BMI1
RING-Complex-OtherPRC1 Complexmotif
dbESI_EC_304
RNF2
RING-Complex-OtherPRC1 Complexmotif
dbESI_EC_305
BRCA1
RING-Complex-OtherBRCA1-BARD1 Complexmotif
dbESI_EC_306
RAD18
RING-Complex-OtherUBE2B-RAD18 ubiquitin ligase complexmotif
dbESI_EC_307
RNF40
RING-Complex-OtherRNF20/40 E3 ubiquitin-protein ligase complexmotif
dbESI_EC_308
RNF20
RING-Complex-OtherRNF20/40 E3 ubiquitin-protein ligase complexmotif
dbESI_EC_309
ARIH1
RING-Complex-OtherCRLs Complexmotif
dbESI_EC_310
TRAF3
RING-Complex-Othermotif
dbESI_EC_311
FBXW8
RING-Complex-OtherSubstrate-recognition component of Cul7-RING ubiquitin-protein ligase complexmotif
dbESI_EC_312
RICTOR
RING-Complex-OtherRICTOR-CUL1-RBX1 Complexmotif
dbESI_EC_313
KLHL10
RING-Complex-OtherSubstrate-specific adaptor of CUL3-based E3 ubiquitin ligase complexmotif
dbESI_EC_314
CUL7
RING-Complex-OtherCul7-RING ubiquitin-protein ligasemotif
dbESI_EC_315
KCTD17
RING-Complex-OtherCUL3-RING ubiquitin ligase complexesmotif
dbESI_EC_316
KLHL15
RING-Complex-OtherSubstrate-specific adaptor of CUL3 E3 ubiquitin-protein ligase complexmotif
dbESI_EC_317
TBL1X
RING-Complex-OtherSIAH1-CACYBP-SKP1-APC-TBL1X Complexmotif
dbESI_EC_318
CACYBP
RING-Complex-OtherSIAH1-CACYBP-SKP1-APC-TBL1X Complexmotif
dbESI_EC_319
SIAH1
RING-Complex-OtherSIAH1-CACYBP-SKP1-APC-TBL1X Complexmotif
dbESI_EC_320
SKP1
RING-Complex-OtherSIAH1-CACYBP-SKP1-APC-TBL1X Complexmotif
dbESI_EC_321
APC
RING-Complex-OtherSIAH1-CACYBP-SKP1-APC-TBL1X Complexmotif
dbESI_EC_322
FBXO8
Uncategorizedmotif
dbESI_EC_323
AMBRA1
Uncategorizedmotif
dbESI_EC_324
RHOBTB3
Uncategorizedmotif
dbESI_EC_325
RACK1
Uncategorizedmotif
dbESI_EC_326
AHR
Uncategorizedmotif
dbESI_EC_327
FBXL4
Uncategorizedmotif
dbESI_EC_328
UCHL1
Uncategorizedmotif
dbESI_EC_329
UBR4
Uncategorizedmotif
dbESI_EC_330
RHOBTB1
Uncategorizedmotif
dbESI_EC_331
KLHL41
Uncategorizedmotif
dbESI_EC_332
PPARA
Uncategorizedmotif
dbESI_EC_333
TRIM49
Uncategorizedmotif
dbESI_EC_334
CDC34
Uncategorizedmotif
dbESI_EC_335
SAG
Uncategorizedmotif
dbESI_EC_336
TOM1
Uncategorizedmotif
dbESI_EC_337
SIVA1
Uncategorizedmotif
dbESI_EC_338
BIRC6
Uncategorizedmotif
dbESI_EC_339
F12
Uncategorizedmotif
dbESI_EC_340
NAT10
Uncategorizedmotif
dbESI_EC_341
PPARG
Uncategorizedmotif
dbESI_EC_342
FAF2
Uncategorizedmotif
dbESI_EC_343
LNX2
Uncategorizedmotif
dbESI_EC_344
ING4
Uncategorizedmotif
dbESI_EC_345
TRAF4
Uncategorizedmotif
dbESI_EC_346
MEX3B
Uncategorizedmotif
dbESI_EC_347
DYRK2
Uncategorizedmotif
dbESI_EC_348
PAXIP1
Uncategorizedmotif
dbESI_EC_349
BIN2
Uncategorizedmotif
dbESI_EC_350
LHX1
Uncategorizedmotif
dbESI_EC_351
MAGEA3
Uncategorizedmotif
dbESI_EC_352
CARD16
Uncategorizedmotif
dbESI_EC_353
FBXO5
Uncategorizedmotif
dbESI_EC_354
HEYL
Uncategorizedmotif
dbESI_EC_355
CA11
Uncategorizedmotif
dbESI_EC_356
KLHL6
Uncategorizedmotif
dbESI_EC_357
FBRS
Uncategorizedmotif
dbESI_EC_358
IL17RB
Uncategorizedmotif
dbESI_EC_359
CCAR1
Uncategorizedmotif
dbESI_EC_360
CGRRF1
Uncategorizedmotif
dbESI_EC_361
FBXO28
Uncategorizedmotif
dbESI_EC_362
KLHL24
Uncategorizedmotif
dbESI_EC_363
SARM1
Uncategorizedmotif
dbESI_EC_364
KLHL31
Uncategorizedmotif
dbESI_EC_365
MALT1
Uncategorizedmotif
dbESI_EC_366
E4F1
Uncategorizedmotif
dbESI_EC_367
IRAK1
Uncategorizedmotif
dbESI_EC_368
ZFP91
Uncategorizedmotif
dbESI_EC_369
IRAK4
Uncategorizedmotif
dbESI_EC_370
EP300
Uncategorizedmotif
dbESI_EC_371
TNFAIP3
Uncategorizedmotif
motif

Descriptions

The classification was performed on two levels. On the first level, mechanisms of ubiquitin transfer divide the E3 ligases into 3 major classes, namely RING, HECT, and RBR. Based on characteristic domains, the three major classes can be further divided into 4 minor classes, namely RING E3s, U-box E3s, HECT E3s, and RBR E3s. On the second level, E3s are classified into categories with distinct mechanisms of substrate recognition. The rules for classification are customized for each minor class from the first level. RING E3s can be found in two forms—single polypeptide or E3 complex. The numerous RING E3 complexes include anaphase-promoting complex (APC/C), cullin-RING ligases (CRLs), and other complexes. CRLs is the largest family of E3 with different substrate-recognition modules discovered for complexes with different cullin domains. The conformationally diverse N-terminal of HECT E3s determines substrate specificities, according to which the HECT E3s can be classified into NEDD4 family, HERC family, and other HECT E3s. U-box E3s and RBR E3s are not classified on the second level because there are only a few members within the classes.