UbiNet 2.0: Data statistics

UbiNet 2.0 is a web-based system that provides a comprehensive collection of available ligating enzyme E3, E3-substrate specificities and a systematic framework for the analysis of E3 ligase regulatory networks in protein ubiquitination. Currently, UbiNet 2.0 contains experimentally verified 3332 unique E3-substrate interactions from multiple species and categorized E3 ligases. The details of data statistics are shown in the the tables belows:

1. Data statistics for categorized Human E3 Ligases

Count of Categorized Human E3 Ligases
RING 287 Single 151
Complex 136 APC/C 15
BCR 23
DCX 14
ECS 17
SCF 48
Other 19
UBOX 4 Single 4
HECT 21 Single 20
Complex 1
RBR 8 Single 6
Complex 2
Uncategorized 50
Total 370

2. Statistics of E3-substrate interactions with categorized E3s

Count of E3-Substrate Interactions with Categorized E3s
RING 1817 Single 941
Complex 876 APC/C 127
BCR 103
DCX 66
ECS 50
SCF 393
Other 137
UBOX 96 Single 96
HECT 479 Single 444
Complex 35
RBR 86 Single 17
Complex 69
Uncategorized 84

3. Data statistics for E3-substrate interactions

Resource Number of ESIs
E3Net 1671
UbiBrowser 1315
ESINetwork 1806
Publications 370
Total (redundant) 5162
Combined (unique ESIs) 3332